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Aliases for FAM19A3 Gene

Aliases for FAM19A3 Gene

  • Family With Sequence Similarity 19 Member A3, C-C Motif Chemokine Like 2 3 5
  • Family With Sequence Similarity 19 (Chemokine (C-C Motif)-Like), Member A3 2 3
  • Chemokine-Like Protein TAFA-3 3 4
  • TAFA3 3 4
  • Protein FAM19A3 3
  • TAFA-3 3

External Ids for FAM19A3 Gene

Previous GeneCards Identifiers for FAM19A3 Gene

  • GC01P112976
  • GC01P113064
  • GC01P113263
  • GC01P111122

Summaries for FAM19A3 Gene

Entrez Gene Summary for FAM19A3 Gene

  • This gene is a member of the TAFA family which is composed of five highly homologous genes that encode small secreted proteins. These proteins contain conserved cysteine residues at fixed positions, and are distantly related to MIP-1alpha, a member of the CC-chemokine family. The TAFA proteins are predominantly expressed in specific regions of the brain, and are postulated to function as brain-specific chemokines or neurokines, that act as regulators of immune and nervous cells. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]

GeneCards Summary for FAM19A3 Gene

FAM19A3 (Family With Sequence Similarity 19 Member A3, C-C Motif Chemokine Like) is a Protein Coding gene. An important paralog of this gene is FAM19A2.

UniProtKB/Swiss-Prot for FAM19A3 Gene

  • Plays a role in the regulation of microglia polarization.

Additional gene information for FAM19A3 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM19A3 Gene

Genomics for FAM19A3 Gene

GeneHancer (GH) Regulatory Elements for FAM19A3 Gene

Promoters and enhancers for FAM19A3 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I112718 Enhancer 0.8 Ensembl 550.8 0.0 -18 0.8 RB1 ARID4B SIN3A ZNF2 ZNF48 RAD21 GLIS2 ZNF143 RCOR1 DEK FAM19A3 ENSG00000225075 MOV10 ENSG00000238761 GC01P112727
GH01I112794 Enhancer 0.7 ENCODE 12.2 +76.0 76007 2 HDAC1 IRF2 ATF1 LEF1 USF1 ZNF316 VEZF1 ATF7 PRDM10 CREM FAM19A3 PPM1J RHOC LRIG2 GC01P112820 GC01M112752
GH01I112722 Enhancer 0.8 Ensembl ENCODE 0.8 +3.9 3937 1.9 CTCF KLF1 NFIA BHLHE40 REST ZFHX2 POLR2A SCRT2 IKZF1 ZNF600 PPM1J FAM19A3 NUTF2P4
GH01I112735 Enhancer 0.5 ENCODE 0.4 +16.9 16889 1.5 FOSL1 JUND JUN FOSL2 FOS SLC16A1 NUTF2P4 FAM19A3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around FAM19A3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FAM19A3 gene promoter:

Genomic Locations for FAM19A3 Gene

Genomic Locations for FAM19A3 Gene
8,242 bases
Plus strand

Genomic View for FAM19A3 Gene

Genes around FAM19A3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM19A3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM19A3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM19A3 Gene

Proteins for FAM19A3 Gene

  • Protein details for FAM19A3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein FAM19A3
    Protein Accession:
    Secondary Accessions:
    • B7ZLU0
    • Q2M1P9
    • Q7Z5A6

    Protein attributes for FAM19A3 Gene

    133 amino acids
    Molecular mass:
    14776 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FAM19A3 Gene


neXtProt entry for FAM19A3 Gene

Post-translational modifications for FAM19A3 Gene

No Post-translational modifications

Other Protein References for FAM19A3 Gene

Antibody Products

  • R&D Systems Antibodies for FAM19A3 (TAFA3/FAM19A3)
  • Cloud-Clone Corp. Antibodies for FAM19A3

No data available for DME Specific Peptides for FAM19A3 Gene

Domains & Families for FAM19A3 Gene

Gene Families for FAM19A3 Gene

Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for FAM19A3 Gene


Suggested Antigen Peptide Sequences for FAM19A3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the FAM19/TAFA family.
  • Belongs to the FAM19/TAFA family.
genes like me logo Genes that share domains with FAM19A3: view

Function for FAM19A3 Gene

Molecular function for FAM19A3 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in the regulation of microglia polarization.

Phenotypes for FAM19A3 Gene

GenomeRNAi human phenotypes for FAM19A3:
genes like me logo Genes that share phenotypes with FAM19A3: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM19A3 Gene

Localization for FAM19A3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM19A3 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM19A3 gene
Compartment Confidence
extracellular 5
nucleus 1

Gene Ontology (GO) - Cellular Components for FAM19A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 25595455
genes like me logo Genes that share ontologies with FAM19A3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for FAM19A3 Gene

Pathways & Interactions for FAM19A3 Gene

SuperPathways for FAM19A3 Gene

No Data Available

Interacting Proteins for FAM19A3 Gene

Gene Ontology (GO) - Biological Process for FAM19A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903979 negative regulation of microglial cell activation ISS --
GO:1903980 positive regulation of microglial cell activation ISS --
genes like me logo Genes that share ontologies with FAM19A3: view

No data available for Pathways by source and SIGNOR curated interactions for FAM19A3 Gene

Drugs & Compounds for FAM19A3 Gene

No Compound Related Data Available

Transcripts for FAM19A3 Gene

mRNA/cDNA for FAM19A3 Gene

(4) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(12) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FAM19A3 Gene

Family with sequence similarity 19 (chemokine (C-C motif)-like), member A3:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM19A3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5
SP2: -

Relevant External Links for FAM19A3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAM19A3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM19A3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FAM19A3 Gene

This gene is overexpressed in Testis (x15.7), Brain - Cerebellum (x6.5), Brain - Cerebellar Hemisphere (x6.2), and Adrenal Gland (x4.5).

NURSA nuclear receptor signaling pathways regulating expression of FAM19A3 Gene:


SOURCE GeneReport for Unigene cluster for FAM19A3 Gene:


mRNA Expression by UniProt/SwissProt for FAM19A3 Gene:

Tissue specificity: Brain-specific.

Evidence on tissue expression from TISSUES for FAM19A3 Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with FAM19A3: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM19A3 Gene

Orthologs for FAM19A3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM19A3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FAM19A3 33 34
  • 99.75 (n)
(Bos Taurus)
Mammalia FAM19A3 33
  • 87.97 (n)
(Mus musculus)
Mammalia Fam19a3 33 16 34
  • 87.28 (n)
(Rattus norvegicus)
Mammalia Fam19a3 33
  • 85.96 (n)
(Ornithorhynchus anatinus)
Mammalia FAM19A3 34
  • 51 (a)
(Canis familiaris)
Mammalia FAM19A3 34
  • 50 (a)
(Monodelphis domestica)
Mammalia FAM19A3 34
  • 24 (a)
(Gallus gallus)
Aves FAM19A3 33 34
  • 76.95 (n)
(Anolis carolinensis)
Reptilia -- 34
  • 26 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fam19a3 33
  • 66.98 (n)
(Danio rerio)
Actinopterygii si:ch211-254n4.3 33
  • 72.98 (n)
si:dkey-238f9.1 34
  • 44 (a)
Species where no ortholog for FAM19A3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM19A3 Gene

Gene Tree for FAM19A3 (if available)
Gene Tree for FAM19A3 (if available)

Paralogs for FAM19A3 Gene

Paralogs for FAM19A3 Gene

(4) SIMAP similar genes for FAM19A3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FAM19A3: view

Variants for FAM19A3 Gene

Sequence variations from dbSNP and Humsavar for FAM19A3 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000495836 -- 112,727,205(+) A/G 3_prime_UTR_variant
rs1000807781 -- 112,717,122(+) A/C upstream_transcript_variant
rs1001014954 -- 112,721,569(+) C/G intron_variant
rs1001155217 -- 112,717,298(+) G/C upstream_transcript_variant
rs1001804335 -- 112,717,782(+) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for FAM19A3 Gene

Variant ID Type Subtype PubMed ID
esv27598 CNV loss 19812545
nsv547566 CNV gain 21841781
nsv818378 CNV gain 17921354
nsv998794 CNV gain 25217958

Variation tolerance for FAM19A3 Gene

Residual Variation Intolerance Score: 78.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.64; 45.50% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FAM19A3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM19A3 Gene

Disorders for FAM19A3 Gene

Additional Disease Information for FAM19A3

No disorders were found for FAM19A3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM19A3 Gene

Publications for FAM19A3 Gene

  1. FAM19A3, a novel secreted protein, modulates the microglia/macrophage polarization dynamics and ameliorates cerebral ischemia. (PMID: 25595455) Shao Y … Wang Y (FEBS letters 2015) 2 3 4 58
  2. TAFA: a novel secreted family with conserved cysteine residues and restricted expression in the brain. (PMID: 15028294) Tom Tang Y … Rupp F (Genomics 2004) 2 3 4 58
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. Genome-wide association scan of quantitative traits for attention deficit hyperactivity disorder identifies novel associations and confirms candidate gene associations. (PMID: 18821565) Lasky-Su J … Faraone SV (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2008) 44 58

Products for FAM19A3 Gene

Sources for FAM19A3 Gene

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