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Aliases for FAM198B Gene

Aliases for FAM198B Gene

  • Family With Sequence Similarity 198 Member B 2 3 5
  • Expressed In Nerve And Epithelium During Development 2 3 4
  • C4orf18 3 4
  • ENED 3 4
  • Family With Sequence Similarity 198, Member B 2
  • Chromosome 4 Open Reading Frame 18 2
  • Protein FAM198B 3
  • AD021 3
  • AD036 3

External Ids for FAM198B Gene

Previous HGNC Symbols for FAM198B Gene

  • C4orf18

Previous GeneCards Identifiers for FAM198B Gene

  • GC04M159266
  • GC04M159048
  • GC04M154797

Summaries for FAM198B Gene

GeneCards Summary for FAM198B Gene

FAM198B (Family With Sequence Similarity 198 Member B) is a Protein Coding gene. An important paralog of this gene is FAM198A.

Gene Wiki entry for FAM198B Gene

Additional gene information for FAM198B Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM198B Gene

Genomics for FAM198B Gene

GeneHancer (GH) Regulatory Elements for FAM198B Gene

Promoters and enhancers for FAM198B Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J158168 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 652.8 +1.7 1718 7.2 ELF3 ARID4B SIN3A DMAP1 THRB ZNF48 RAD21 ZNF614 ZNF143 CREM FAM198B-AS1 FAM198B TMEM144
GH04J158229 Promoter/Enhancer 0.7 EPDnew dbSUPER 650.2 -55.4 -55360 0.1 FAM198B GC04P158212 TMEM144 LOC646890
GH04J158006 Enhancer 1 FANTOM5 Ensembl ENCODE 6 +165.0 164965 4.5 RFX1 POLR2A JUN HLF BMI1 WT1 YY1 FAM198B-AS1 TMEM144 FAM198B ENSG00000250475 LOC105377509
GH04J158032 Enhancer 0.9 FANTOM5 Ensembl ENCODE 6.2 +139.7 139722 1.9 JUND TFAP4 JUN MIXL1 FAM198B FAM198B-AS1 LOC105377509 ENSG00000250475
GH04J158176 Enhancer 0.9 Ensembl ENCODE dbSUPER 0.7 -3.0 -2983 0.2 JUND GATA3 NFIB DPF2 FOS FAM198B LOC101928007 FAM198B-AS1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FAM198B on UCSC Golden Path with GeneCards custom track

Genomic Locations for FAM198B Gene

Genomic Locations for FAM198B Gene
48,845 bases
Minus strand
48,845 bases
Minus strand

Genomic View for FAM198B Gene

Genes around FAM198B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM198B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM198B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM198B Gene

Proteins for FAM198B Gene

  • Protein details for FAM198B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein FAM198B
    Protein Accession:
    Secondary Accessions:
    • Q498Z3
    • Q6IAF9
    • Q6ZMF2
    • Q86XL0

    Protein attributes for FAM198B Gene

    519 amino acids
    Molecular mass:
    57552 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FAM198B Gene


neXtProt entry for FAM198B Gene

Post-translational modifications for FAM198B Gene

  • Glycosylation at Asn289 and Ser137
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for FAM198B Gene

Domains & Families for FAM198B Gene

Gene Families for FAM198B Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for FAM198B Gene


Suggested Antigen Peptide Sequences for FAM198B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the FAM198 family.
  • Belongs to the FAM198 family.
genes like me logo Genes that share domains with FAM198B: view

Function for FAM198B Gene

Phenotypes From GWAS Catalog for FAM198B Gene

genes like me logo Genes that share phenotypes with FAM198B: view

Animal Model Products

  • Taconic Biosciences Mouse Models for FAM198B

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FAM198B

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM198B Gene

Localization for FAM198B Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM198B Gene

Golgi apparatus membrane; Single-pass type II membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM198B gene
Compartment Confidence
golgi apparatus 5
mitochondrion 2
nucleus 2
cytosol 2
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
  • Nucleoli fibrillar center (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for FAM198B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005794 Golgi apparatus IDA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with FAM198B: view

Pathways & Interactions for FAM198B Gene

SuperPathways for FAM198B Gene

No Data Available

Interacting Proteins for FAM198B Gene

Gene Ontology (GO) - Biological Process for FAM198B Gene


No data available for Pathways by source and SIGNOR curated interactions for FAM198B Gene

Drugs & Compounds for FAM198B Gene

No Compound Related Data Available

Transcripts for FAM198B Gene

Unigene Clusters for FAM198B Gene

Family with sequence similarity 198, member B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FAM198B

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM198B Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c
SP1: - - - - -
SP2: - - - - -
SP3: - - - -
SP5: -
SP6: - -

Relevant External Links for FAM198B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAM198B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM198B Gene

mRNA differential expression in normal tissues according to GTEx for FAM198B Gene

This gene is overexpressed in Adrenal Gland (x7.9).

Protein differential expression in normal tissues from HIPED for FAM198B Gene

This gene is overexpressed in Fetal testis (41.9), Liver (10.7), and Adrenal (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FAM198B Gene

Protein tissue co-expression partners for FAM198B Gene

NURSA nuclear receptor signaling pathways regulating expression of FAM198B Gene:


SOURCE GeneReport for Unigene cluster for FAM198B Gene:


Evidence on tissue expression from TISSUES for FAM198B Gene

  • Nervous system(4.7)
  • Adrenal gland(2.1)
genes like me logo Genes that share expression patterns with FAM198B: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM198B Gene

Orthologs for FAM198B Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM198B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FAM198B 34 33
  • 99.81 (n)
(Mus musculus)
Mammalia Fam198b 16 34 33
  • 81.23 (n)
(Rattus norvegicus)
Mammalia Fam198b 33
  • 80.74 (n)
(Ornithorhynchus anatinus)
Mammalia FAM198B 34
  • 75 (a)
(Canis familiaris)
Mammalia FAM198B 34
  • 74 (a)
(Monodelphis domestica)
Mammalia FAM198B 34
  • 73 (a)
(Bos Taurus)
Mammalia FAM198B 34
  • 70 (a)
(Gallus gallus)
Aves FAM198B 34 33
  • 65.68 (n)
(Anolis carolinensis)
Reptilia FAM198B 34
  • 56 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fam198b 33
  • 58.93 (n)
(Danio rerio)
Actinopterygii fam198b 34 33
  • 55.51 (n)
Species where no ortholog for FAM198B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM198B Gene

Gene Tree for FAM198B (if available)
Gene Tree for FAM198B (if available)
Evolutionary constrained regions (ECRs) for FAM198B: view image

Paralogs for FAM198B Gene

Paralogs for FAM198B Gene

(2) SIMAP similar genes for FAM198B Gene using alignment to 5 proteins:

  • F198B_HUMAN
  • K7EK71_HUMAN
  • K7EN70_HUMAN
  • L8E9X9_HUMAN
genes like me logo Genes that share paralogs with FAM198B: view

Variants for FAM198B Gene

Sequence variations from dbSNP and Humsavar for FAM198B Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs1000039515 -- 158,173,906(-) T/C upstream_transcript_variant
rs1000057714 -- 158,129,942(-) G/A intron_variant
rs1000108088 -- 158,129,649(-) G/C intron_variant
rs1000161623 -- 158,125,874(-) A/G 3_prime_UTR_variant
rs1000177518 -- 158,160,328(-) C/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for FAM198B Gene

Variant ID Type Subtype PubMed ID
esv3307783 CNV mobile element insertion 20981092
esv3388151 CNV insertion 20981092
nsv1021067 CNV gain 25217958

Variation tolerance for FAM198B Gene

Residual Variation Intolerance Score: 52.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.98; 36.68% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FAM198B Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM198B Gene

Disorders for FAM198B Gene

Additional Disease Information for FAM198B

No disorders were found for FAM198B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM198B Gene

Publications for FAM198B Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 2 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. (PMID: 11256614) Simpson JC … Wiemann S (EMBO reports 2000) 3 4 58
  4. The full-ORF clone resource of the German cDNA Consortium. (PMID: 17974005) Bechtel S … Schupp I (BMC genomics 2007) 4 58
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 58

Products for FAM198B Gene

Sources for FAM198B Gene

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