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Aliases for FAM196B Gene

Aliases for FAM196B Gene

  • Family With Sequence Similarity 196 Member B 2 3 5
  • C5orf57 3 4
  • Family With Sequence Similarity 196, Member B 2
  • Chromosome 5 Open Reading Frame 57 2
  • Protein FAM196B 3

External Ids for FAM196B Gene

Previous HGNC Symbols for FAM196B Gene

  • C5orf57

Previous GeneCards Identifiers for FAM196B Gene

  • GC05M169225
  • GC05M164388

Summaries for FAM196B Gene

GeneCards Summary for FAM196B Gene

FAM196B (Family With Sequence Similarity 196 Member B) is a Protein Coding gene. An important paralog of this gene is FAM196A.

Additional gene information for FAM196B Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM196B Gene

Genomics for FAM196B Gene

GeneHancer (GH) Regulatory Elements for FAM196B Gene

Promoters and enhancers for FAM196B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05I169975 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 580.9 +2.2 2207 5.5 ATF1 ZSCAN4 SIN3A BATF ZNF2 RAD21 ZNF335 ZNF366 HSF1 SCRT2 FAM196B ENSG00000253269 DOCK2
GH05I169922 Promoter 0.5 EPDnew 550.2 +57.7 57738 0.1 FAM196B ENSG00000253269 DOCK2
GH05I169969 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 28.4 +9.7 9736 2.8 JUN MAX ATF2 NR2F2 SP1 ZNF23 JUND GATA3 CREB1 FOSL2 FAM196B ENSG00000253269 RANBP17 DOCK2
GH05I169944 Enhancer 1 Ensembl ENCODE dbSUPER 10.3 +34.8 34842 2.3 ZNF664 LCORL NFIC SMAD1 ZNF544 NFIB ZNF24 ZIC2 FAM196B ENSG00000253269 DOCK2
GH05I169881 Enhancer 0.8 FANTOM5 Ensembl dbSUPER 10.1 +98.8 98835 0.6 NFE2 FAM196B DOCK2 LCP2 ENSG00000253269
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around FAM196B on UCSC Golden Path with GeneCards custom track

Genomic Locations for FAM196B Gene

Genomic Locations for FAM196B Gene
chr5:169,861,291-169,980,740
(GRCh38/hg38)
Size:
119,450 bases
Orientation:
Minus strand
chr5:169,290,719-169,407,744
(GRCh37/hg19)

Genomic View for FAM196B Gene

Genes around FAM196B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM196B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM196B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM196B Gene

Proteins for FAM196B Gene

  • Protein details for FAM196B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NMK8-F196B_HUMAN
    Recommended name:
    Protein FAM196B
    Protein Accession:
    A6NMK8

    Protein attributes for FAM196B Gene

    Size:
    535 amino acids
    Molecular mass:
    59204 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FAM196B Gene

Post-translational modifications for FAM196B Gene

No Post-translational modifications

Other Protein References for FAM196B Gene

No data available for DME Specific Peptides for FAM196B Gene

Domains & Families for FAM196B Gene

Gene Families for FAM196B Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FAM196B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM196B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A6NMK8

UniProtKB/Swiss-Prot:

F196B_HUMAN :
  • Belongs to the FAM196 family.
Family:
  • Belongs to the FAM196 family.
genes like me logo Genes that share domains with FAM196B: view

Function for FAM196B Gene

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM196B Gene

Localization for FAM196B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM196B gene
Compartment Confidence
nucleus 3

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for FAM196B Gene

Pathways & Interactions for FAM196B Gene

SuperPathways for FAM196B Gene

No Data Available

Interacting Proteins for FAM196B Gene

Gene Ontology (GO) - Biological Process for FAM196B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FAM196B Gene

Drugs & Compounds for FAM196B Gene

No Compound Related Data Available

Transcripts for FAM196B Gene

mRNA/cDNA for FAM196B Gene

(4) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FAM196B Gene

Family with sequence similarity 196, member B:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM196B Gene

No ASD Table

Relevant External Links for FAM196B Gene

GeneLoc Exon Structure for
FAM196B
ECgene alternative splicing isoforms for
FAM196B

Expression for FAM196B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM196B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FAM196B Gene



NURSA nuclear receptor signaling pathways regulating expression of FAM196B Gene:

FAM196B

SOURCE GeneReport for Unigene cluster for FAM196B Gene:

Hs.721917
genes like me logo Genes that share expression patterns with FAM196B: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM196B Gene

Orthologs for FAM196B Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM196B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM196B 33 34
  • 99.19 (n)
dog
(Canis familiaris)
Mammalia FAM196B 33 34
  • 88.16 (n)
cow
(Bos Taurus)
Mammalia FAM196B 33 34
  • 85.3 (n)
mouse
(Mus musculus)
Mammalia Fam196b 33 16 34
  • 82.06 (n)
rat
(Rattus norvegicus)
Mammalia Fam196b 33
  • 81.18 (n)
oppossum
(Monodelphis domestica)
Mammalia FAM196B 34
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FAM196B 34
  • 60 (a)
OneToOne
chicken
(Gallus gallus)
Aves FAM196B 33 34
  • 58.27 (n)
lizard
(Anolis carolinensis)
Reptilia FAM196B 34
  • 47 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101734510 33
  • 71.68 (n)
zebrafish
(Danio rerio)
Actinopterygii FAM196B 34
  • 17 (a)
OneToOne
Species where no ortholog for FAM196B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM196B Gene

ENSEMBL:
Gene Tree for FAM196B (if available)
TreeFam:
Gene Tree for FAM196B (if available)

Paralogs for FAM196B Gene

Paralogs for FAM196B Gene

genes like me logo Genes that share paralogs with FAM196B: view

Variants for FAM196B Gene

Sequence variations from dbSNP and Humsavar for FAM196B Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000015028 -- 169,862,884(-) C/A/T 3_prime_UTR_variant, genic_downstream_transcript_variant
rs1000022789 -- 169,941,230(-) T/C intron_variant
rs1000025409 -- 169,945,429(-) C/A intron_variant
rs1000041994 -- 169,962,234(-) G/A intron_variant
rs1000113997 -- 169,968,676(-) C/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for FAM196B Gene

Variant ID Type Subtype PubMed ID
nsv969011 CNV duplication 23825009
nsv600259 CNV loss 21841781
nsv474386 CNV novel sequence insertion 20440878
nsv328128 CNV deletion 16902084
esv988430 CNV insertion 20482838
esv3607560 CNV loss 21293372
esv3607559 CNV gain 21293372
esv3607558 CNV loss 21293372
esv3607554 CNV loss 21293372
esv3566992 CNV deletion 23714750
esv2731060 CNV deletion 23290073

Variation tolerance for FAM196B Gene

Gene Damage Index Score: 6.13; 75.62% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FAM196B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM196B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM196B Gene

Disorders for FAM196B Gene

Additional Disease Information for FAM196B

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for FAM196B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM196B Gene

Publications for FAM196B Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The DNA sequence and comparative analysis of human chromosome 5. (PMID: 15372022) Schmutz J … Rubin EM (Nature 2004) 3 4 58
  4. Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris. (PMID: 24927181) Navarini AA … Barker JN (Nature communications 2014) 3 58
  5. A second-generation genomewide screen for asthma-susceptibility alleles in a founder population. (PMID: 11022011) Ober C … Cox NJ (American journal of human genetics 2000) 44 58

Products for FAM196B Gene

Sources for FAM196B Gene

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