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Aliases for FAM187B Gene

Aliases for FAM187B Gene

  • Family With Sequence Similarity 187 Member B 2 3 5
  • Transmembrane Protein 162 2 3 4
  • Protein FAM187B 3 4
  • TMEM162 3 4
  • Family With Sequence Similarity 187, Member B 2

External Ids for FAM187B Gene

Previous HGNC Symbols for FAM187B Gene

  • TMEM162

Previous GeneCards Identifiers for FAM187B Gene

  • GC19M040409
  • GC19M035715
  • GC19M032224
  • GC19M035225
  • GC19M035837
  • GC19M038984
  • GC19M035931
  • GC19M036795
  • GC19M037395
  • GC19M037729
  • GC19M038025
  • GC19M038317
  • GC19M038616
  • GC19M038858

Summaries for FAM187B Gene

GeneCards Summary for FAM187B Gene

FAM187B (Family With Sequence Similarity 187 Member B) is a Protein Coding gene. An important paralog of this gene is FAM187A.

Additional gene information for FAM187B Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM187B Gene

Genomics for FAM187B Gene

GeneHancer (GH) Regulatory Elements for FAM187B Gene

Promoters and enhancers for FAM187B Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FAM187B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FAM187B gene promoter:
  • AP-1
  • AP-4
  • AREB6
  • c-Fos
  • c-Jun
  • Evi-1
  • Ik-3
  • LyF-1
  • Pax-4a

Genomic Locations for FAM187B Gene

Genomic Locations for FAM187B Gene
3,930 bases
Minus strand
3,930 bases
Minus strand

Genomic View for FAM187B Gene

Genes around FAM187B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM187B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM187B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM187B Gene

Proteins for FAM187B Gene

  • Protein details for FAM187B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein FAM187B
    Protein Accession:
    Secondary Accessions:
    • Q8N7G6

    Protein attributes for FAM187B Gene

    369 amino acids
    Molecular mass:
    42387 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FAM187B Gene

Post-translational modifications for FAM187B Gene

  • Glycosylation at posLast=130130, isoforms=45, and posLast=6868
  • Modification sites at PhosphoSitePlus

Other Protein References for FAM187B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FAM187B Gene

Domains & Families for FAM187B Gene

Gene Families for FAM187B Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for FAM187B Gene


Suggested Antigen Peptide Sequences for FAM187B Gene

GenScript: Design optimal peptide antigens:
  • Transmembrane protein 162 (F187B_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the FAM187 family.
  • Belongs to the FAM187 family.
genes like me logo Genes that share domains with FAM187B: view

Function for FAM187B Gene

Phenotypes From GWAS Catalog for FAM187B Gene

genes like me logo Genes that share phenotypes with FAM187B: view

Animal Model Products

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for FAM187B - Now 50% OFF >
  • * FAM187B as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * FAM187B tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FAM187B Gene

Localization for FAM187B Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM187B Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM187B gene
Compartment Confidence
plasma membrane 1
extracellular 1
mitochondrion 1
peroxisome 1
cytosol 1
endoplasmic reticulum 0

Gene Ontology (GO) - Cellular Components for FAM187B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with FAM187B: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for FAM187B Gene

Pathways & Interactions for FAM187B Gene

PathCards logo

SuperPathways for FAM187B Gene

No Data Available

Gene Ontology (GO) - Biological Process for FAM187B Gene


No data available for Pathways by source and SIGNOR curated interactions for FAM187B Gene

Drugs & Compounds for FAM187B Gene

No Compound Related Data Available

Transcripts for FAM187B Gene

mRNA/cDNA for FAM187B Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(12) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Unigene Clusters for FAM187B Gene

Family with sequence similarity 187, member B:
Representative Sequences:

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for FAM187B - Now 50% OFF >
  • * FAM187B as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * FAM187B tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for FAM187B Gene

No ASD Table

Relevant External Links for FAM187B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAM187B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM187B Gene

mRNA differential expression in normal tissues according to GTEx for FAM187B Gene

This gene is overexpressed in Testis (x50.1).

NURSA nuclear receptor signaling pathways regulating expression of FAM187B Gene:


SOURCE GeneReport for Unigene cluster for FAM187B Gene:


Evidence on tissue expression from TISSUES for FAM187B Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with FAM187B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM187B Gene

Orthologs for FAM187B Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM187B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FAM187B 35 34
  • 97.2 (n)
(Canis familiaris)
Mammalia FAM187B 35 34
  • 76.48 (n)
(Bos Taurus)
Mammalia FAM187B 35 34
  • 70.7 (n)
(Rattus norvegicus)
Mammalia Fam187b 34
  • 65.19 (n)
(Mus musculus)
Mammalia Fam187b 35
  • 49 (a)
(Monodelphis domestica)
Mammalia FAM187B 35
  • 26 (a)
(Anolis carolinensis)
Reptilia FAM187B 35
  • 26 (a)
Species where no ortholog for FAM187B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FAM187B Gene

Gene Tree for FAM187B (if available)
Gene Tree for FAM187B (if available)
Evolutionary constrained regions (ECRs) for FAM187B: view image

Paralogs for FAM187B Gene

Paralogs for FAM187B Gene Pseudogenes for FAM187B Gene

genes like me logo Genes that share paralogs with FAM187B: view

Variants for FAM187B Gene

Sequence variations from dbSNP and Humsavar for FAM187B Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000059930 -- 35,228,812(-) TTTTGTTTTGT/TTTTGT upstream_transcript_variant
rs1001389321 -- 35,224,502(-) T/C/G downstream_transcript_variant
rs1001779959 -- 35,228,722(-) C/T 5_prime_UTR_variant
rs1003165856 -- 35,226,496(-) A/G intron_variant
rs1006164245 -- 35,225,431(-) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for FAM187B Gene

Variant ID Type Subtype PubMed ID
esv2758758 CNV loss 17122850
esv2763203 CNV gain 21179565
esv3644228 CNV gain 21293372
esv3644229 CNV gain 21293372
esv3893200 CNV loss 25118596
nsv1066553 CNV gain 25217958
nsv510765 CNV deletion 20534489

Variation tolerance for FAM187B Gene

Residual Variation Intolerance Score: 94.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.93; 95.96% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FAM187B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM187B Gene

Disorders for FAM187B Gene

Additional Disease Information for FAM187B

No disorders were found for FAM187B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM187B Gene

Publications for FAM187B Gene

  1. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58

Products for FAM187B Gene

  • Biorbyt antibodies for FAM187B

Sources for FAM187B Gene

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