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Aliases for FAM186B Gene

Aliases for FAM186B Gene

  • Family With Sequence Similarity 186 Member B 2 3 5
  • C12orf25 3 4
  • Family With Sequence Similarity 186, Member B 2
  • Chromosome 12 Open Reading Frame 25 2
  • Protein FAM186B 3

External Ids for FAM186B Gene

Previous HGNC Symbols for FAM186B Gene

  • C12orf25

Previous GeneCards Identifiers for FAM186B Gene

  • GC12M048270
  • GC12M049981
  • GC12M047007

Summaries for FAM186B Gene

Entrez Gene Summary for FAM186B Gene

  • This gene product is a member of the FAM186 family, however, its exact function is not known. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2009]

GeneCards Summary for FAM186B Gene

FAM186B (Family With Sequence Similarity 186 Member B) is a Protein Coding gene. Diseases associated with FAM186B include Oropharynx Cancer. An important paralog of this gene is FAM186A.

Gene Wiki entry for FAM186B Gene

Additional gene information for FAM186B Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM186B Gene

Genomics for FAM186B Gene

GeneHancer (GH) Regulatory Elements for FAM186B Gene

Promoters and enhancers for FAM186B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12I049605 Promoter 0.7 EPDnew 550.8 +0.0 12 0.1 CREB1 ATF2 FAM186B LOC100422296 PIR49185 PRPF40B
GH12I048865 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 39.3 +739.4 739420 2.2 HDGF PKNOX1 FOXA2 ZFP64 ARID4B SIN3A FEZF1 ZNF2 YY1 SLC30A9 RND1 DDX23 KMT2D KANSL2 LOC390314 CCNT1 LMBR1L SENP1 BCDIN3D PRPF40B
GH12I049702 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 31.5 -99.5 -99531 6.1 HDGF PKNOX1 SMAD1 MLX ARNT ARID4B SIN3A ZNF2 SLC30A9 ZNF213 FMNL3 FAM186B DDX23 CCNT1 LOC390314 LMBR1L KMT2D LIMA1 ENSG00000257964 CERS5
GH12I049129 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 23.7 +474.3 474283 4.6 CLOCK MLX FEZF1 DMAP1 YBX1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ENSG00000200309 GC12M049133 TUBA1B DDX23 LMBR1L KMT2D SMARCD1 LOC390314 BCDIN3D CCNT1
GH12I049740 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 17.6 -137.3 -137268 4.3 HDGF PKNOX1 FOXA2 SMAD1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 TMBIM6 PIR62478 LMBR1L DDX23 KMT2D SMARCD1 LOC390314 ENSG00000257298 BCDIN3D FAM186B
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around FAM186B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FAM186B gene promoter:

Genomic Locations for FAM186B Gene

Genomic Locations for FAM186B Gene
chr12:49,582,875-49,605,650
(GRCh38/hg38)
Size:
22,776 bases
Orientation:
Minus strand
chr12:49,976,658-49,999,433
(GRCh37/hg19)

Genomic View for FAM186B Gene

Genes around FAM186B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM186B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM186B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM186B Gene

Proteins for FAM186B Gene

  • Protein details for FAM186B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IYM0-F186B_HUMAN
    Recommended name:
    Protein FAM186B
    Protein Accession:
    Q8IYM0
    Secondary Accessions:
    • B4DZ15
    • Q8TCP7
    • Q9H0L3

    Protein attributes for FAM186B Gene

    Size:
    893 amino acids
    Molecular mass:
    103722 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FAM186B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FAM186B Gene

Post-translational modifications for FAM186B Gene

No Post-translational modifications

No data available for DME Specific Peptides for FAM186B Gene

Domains & Families for FAM186B Gene

Gene Families for FAM186B Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FAM186B Gene

ProtoNet:

Suggested Antigen Peptide Sequences for FAM186B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IYM0

UniProtKB/Swiss-Prot:

F186B_HUMAN :
  • Belongs to the FAM186 family.
Family:
  • Belongs to the FAM186 family.
genes like me logo Genes that share domains with FAM186B: view

Function for FAM186B Gene

genes like me logo Genes that share phenotypes with FAM186B: view

Animal Models for FAM186B Gene

MGI Knock Outs for FAM186B:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for FAM186B Gene

Localization for FAM186B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM186B gene
Compartment Confidence
nucleus 2
cytosol 2

Gene Ontology (GO) - Cellular Components for FAM186B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043234 protein complex IDA --
genes like me logo Genes that share ontologies with FAM186B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for FAM186B Gene

Pathways & Interactions for FAM186B Gene

SuperPathways for FAM186B Gene

No Data Available

Interacting Proteins for FAM186B Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000257894%0d%0a9606.ENSP00000309259%0d%0a9606.ENSP00000382863%0d%0a9606.ENSP00000253457%0d%0a
Selected Interacting proteins: Q8IYM0-F186B_HUMAN ENSP00000257894 for FAM186B Gene via IID STRING

Gene Ontology (GO) - Biological Process for FAM186B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FAM186B Gene

Drugs & Compounds for FAM186B Gene

No Compound Related Data Available

Transcripts for FAM186B Gene

Unigene Clusters for FAM186B Gene

Family with sequence similarity 186, member B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM186B Gene

No ASD Table

Relevant External Links for FAM186B Gene

GeneLoc Exon Structure for
FAM186B
ECgene alternative splicing isoforms for
FAM186B

Expression for FAM186B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM186B Gene

mRNA differential expression in normal tissues according to GTEx for FAM186B Gene

This gene is overexpressed in Testis (x41.1).

Protein differential expression in normal tissues from HIPED for FAM186B Gene

This gene is overexpressed in Liver (36.2), Lung (11.5), and Gallbladder (9.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FAM186B Gene



NURSA nuclear receptor signaling pathways regulating expression of FAM186B Gene:

FAM186B

SOURCE GeneReport for Unigene cluster for FAM186B Gene:

Hs.524406

Evidence on tissue expression from TISSUES for FAM186B Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with FAM186B: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM186B Gene

Orthologs for FAM186B Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM186B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM186B 33 34
  • 98.6 (n)
dog
(Canis familiaris)
Mammalia FAM186B 33
  • 81.21 (n)
-- 34
  • 68 (a)
OneToMany
-- 34
  • 64 (a)
OneToMany
cow
(Bos Taurus)
Mammalia FAM186B 33 34
  • 80.56 (n)
rat
(Rattus norvegicus)
Mammalia Fam186b 33
  • 74.59 (n)
mouse
(Mus musculus)
Mammalia Fam186b 33 16 34
  • 72.97 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia FAM186B 34
  • 27 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 20 (a)
OneToMany
Species where no ortholog for FAM186B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FAM186B Gene

ENSEMBL:
Gene Tree for FAM186B (if available)
TreeFam:
Gene Tree for FAM186B (if available)

Paralogs for FAM186B Gene

Paralogs for FAM186B Gene

(1) SIMAP similar genes for FAM186B Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with FAM186B: view

Variants for FAM186B Gene

Sequence variations from dbSNP and Humsavar for FAM186B Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000064508 -- 49,606,604(-) T/ upstream_transcript_variant
rs1000066217 -- 49,598,893(-) C/A coding_sequence_variant, missense_variant, non_coding_transcript_variant
rs1000083730 -- 49,606,337(-) A/T upstream_transcript_variant
rs1000471861 -- 49,606,009(-) A/G upstream_transcript_variant
rs1000521519 -- 49,591,747(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for FAM186B Gene

Variant ID Type Subtype PubMed ID
nsv832406 CNV loss 17160897

Variation tolerance for FAM186B Gene

Residual Variation Intolerance Score: 88.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.07; 75.27% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FAM186B Gene

Human Gene Mutation Database (HGMD)
FAM186B
SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM186B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM186B Gene

Disorders for FAM186B Gene

MalaCards: The human disease database

(1) MalaCards diseases for FAM186B Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
oropharynx cancer
  • malignant neoplasm of junctional region of oropharynx
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for FAM186B

genes like me logo Genes that share disorders with FAM186B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FAM186B Gene

Publications for FAM186B Gene

  1. Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S … Poustka A (Genome research 2001) 2 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Defining human ERAD networks through an integrative mapping strategy. (PMID: 22119785) Christianson JC … Kopito RR (Nature cell biology 2011) 3 58
  5. The full-ORF clone resource of the German cDNA Consortium. (PMID: 17974005) Bechtel S … Schupp I (BMC genomics 2007) 4 58

Products for FAM186B Gene

Sources for FAM186B Gene

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