Aliases for FAM186A Gene

Aliases for FAM186A Gene

  • Family With Sequence Similarity 186 Member A 2 3 5
  • Protein FAM186A 3 4
  • Family With Sequence Similarity 186, Member A 2

External Ids for FAM186A Gene

Previous GeneCards Identifiers for FAM186A Gene

  • GC12M049009
  • GC12M050721
  • GC12M047754

Summaries for FAM186A Gene

GeneCards Summary for FAM186A Gene

FAM186A (Family With Sequence Similarity 186 Member A) is a Protein Coding gene.

Additional gene information for FAM186A Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FAM186A Gene

Genomics for FAM186A Gene

GeneHancer (GH) Regulatory Elements for FAM186A Gene

Promoters and enhancers for FAM186A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J050395 Enhancer 1 Ensembl ENCODE 750.6 -0.1 -148 2 NR2F6 ATF1 CREB1 MIXL1 ZNF362 ZNF652 ZNF280D RERE ELF3 TFE3 FAM186A piR-57460-126 LIMA1 COX14 LARP4
GH12J050394 Enhancer 0.8 FANTOM5 Ensembl ENCODE 750.6 +1.7 1697 1.5 ZNF362 ZNF384 TEAD1 TEAD3 FAM186A LIMA1 DIP2B LARP4
GH12J050399 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 20.7 -5.0 -4997 4.5 ZNF785 SIN3A SP1 ZBTB40 GATA3 SREBF1 SIX5 LCORL SMARCE1 POLR2A LARP4 LIMA1 SMARCD1 BCDIN3D CSRNP2 PRPF40B ATF1 ENSG00000257298 LOC100422296 TFCP2
GH12J051019 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 10.3 -627.9 -627930 11.1 ZNF785 SP1 CTCF SREBF1 ZBTB6 FOXA1 MLX RBPJ SMARCE1 POLR2A SLC11A2 lnc-CSRNP2-2 SMARCD1 LETMD1 CSRNP2 TFCP2 HNRNPA3P10 ATF1 ENSG00000257298 LIMA1
GH12J051237 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 10.3 -843.6 -843572 4.8 SIN3A SP1 ZBTB40 SREBF1 RBPJ POLR2A USF2 ATF1 FOS CREB1 DAZAP2 HNRNPA3P10 ATF1 TFCP2 LIMA1 SCN8A LETMD1 CSRNP2 FAM186A POU6F1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FAM186A on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FAM186A gene promoter:
  • AP-4
  • AREB6
  • Arnt
  • c-Ets-1
  • C/EBPbeta
  • COMP1
  • E47
  • HEN1
  • Sox9

Genomic Locations for FAM186A Gene

Genomic Locations for FAM186A Gene
chr12:50,326,230-50,396,635
(GRCh38/hg38)
Size:
70,406 bases
Orientation:
Minus strand
chr12:50,720,013-50,790,405
(GRCh37/hg19)
Size:
70,393 bases
Orientation:
Minus strand

Genomic View for FAM186A Gene

Genes around FAM186A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM186A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM186A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM186A Gene

Proteins for FAM186A Gene

  • Protein details for FAM186A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NE01-F186A_HUMAN
    Recommended name:
    Protein FAM186A
    Protein Accession:
    A6NE01

    Protein attributes for FAM186A Gene

    Size:
    2351 amino acids
    Molecular mass:
    262758 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FAM186A Gene

Post-translational modifications for FAM186A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM186A Gene

No data available for DME Specific Peptides for FAM186A Gene

Domains & Families for FAM186A Gene

Gene Families for FAM186A Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FAM186A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM186A Gene

GenScript: Design optimal peptide antigens:
  • FAM186A protein (B9EIJ5_HUMAN)
  • Protein FAM186A (F186A_HUMAN)

Graphical View of Domain Structure for InterPro Entry

A6NE01

UniProtKB/Swiss-Prot:

F186A_HUMAN :
  • Belongs to the FAM186 family.
Family:
  • Belongs to the FAM186 family.
genes like me logo Genes that share domains with FAM186A: view

Function for FAM186A Gene

Phenotypes From GWAS Catalog for FAM186A Gene

genes like me logo Genes that share phenotypes with FAM186A: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FAM186A

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM186A Gene

Localization for FAM186A Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM186A gene
Compartment Confidence
nucleus 2
cytosol 1
mitochondrion 0

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for FAM186A Gene

Pathways & Interactions for FAM186A Gene

PathCards logo

SuperPathways for FAM186A Gene

No Data Available

Interacting Proteins for FAM186A Gene

STRING Interaction Network Preview (showing top 2 STRING interactants - click image to see details)
STRING Interaction Network
Selected Interacting proteins: ENSP00000329995 A6NE01-F186A_HUMAN for FAM186A Gene via STRING IID

Gene Ontology (GO) - Biological Process for FAM186A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FAM186A Gene

Drugs & Compounds for FAM186A Gene

No Compound Related Data Available

Transcripts for FAM186A Gene

mRNA/cDNA for FAM186A Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(11) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FAM186A

Alternative Splicing Database (ASD) splice patterns (SP) for FAM186A Gene

No ASD Table

Relevant External Links for FAM186A Gene

GeneLoc Exon Structure for
FAM186A
ECgene alternative splicing isoforms for
FAM186A

Expression for FAM186A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM186A Gene

mRNA differential expression in normal tissues according to GTEx for FAM186A Gene

This gene is overexpressed in Testis (x39.5).

Protein differential expression in normal tissues from HIPED for FAM186A Gene

This gene is overexpressed in Bone marrow stromal cell (40.2) and Serum (23.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FAM186A Gene



NURSA nuclear receptor signaling pathways regulating expression of FAM186A Gene:

FAM186A

SOURCE GeneReport for Unigene cluster for FAM186A Gene:

Hs.133187
genes like me logo Genes that share expression patterns with FAM186A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM186A Gene

Orthologs for FAM186A Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM186A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM186A 33 32
  • 95.74 (n)
OneToOne
dog
(Canis familiaris)
Mammalia FAM186A 33 32
  • 77.21 (n)
OneToOne
cow
(Bos Taurus)
Mammalia FAM186A 33 32
  • 76.22 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FAM186A 33
  • 63 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fam186a 33
  • 53 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FAM186A 33
  • 14 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 33
  • 19 (a)
OneToMany
Species where no ortholog for FAM186A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FAM186A Gene

ENSEMBL:
Gene Tree for FAM186A (if available)
TreeFam:
Gene Tree for FAM186A (if available)
Aminode:
Evolutionary constrained regions (ECRs) for FAM186A: view image

Paralogs for FAM186A Gene

(1) SIMAP similar genes for FAM186A Gene using alignment to 5 proteins:

  • F186A_HUMAN
  • B9EIJ5_HUMAN
  • F5GYN0_HUMAN
  • F5H8C1_HUMAN
  • H0YFA1_HUMAN
genes like me logo Genes that share paralogs with FAM186A: view

No data available for Paralogs for FAM186A Gene

Variants for FAM186A Gene

Sequence variations from dbSNP and Humsavar for FAM186A Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000000638 -- 50,388,145(-) G/T intron_variant
rs1000013187 -- 50,334,806(-) C/G intron_variant
rs1000017580 -- 50,374,747(-) C/T intron_variant
rs1000139337 -- 50,362,900(-) G/A intron_variant
rs1000151225 -- 50,382,035(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for FAM186A Gene

Variant ID Type Subtype PubMed ID
dgv1498n100 CNV gain 25217958
dgv1499n100 CNV gain 25217958
dgv275e214 CNV gain 21293372
esv1583460 CNV deletion 17803354
esv2761738 CNV gain 21179565
esv2762979 CNV loss 21179565
esv3303098 CNV tandem duplication 20981092
nsv983322 CNV duplication 23825009

Variation tolerance for FAM186A Gene

Gene Damage Index Score: 10.41; 90.90% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FAM186A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM186A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM186A Gene

Disorders for FAM186A Gene

Additional Disease Information for FAM186A

No disorders were found for FAM186A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM186A Gene

Publications for FAM186A Gene

  1. The finished DNA sequence of human chromosome 12. (PMID: 16541075) Scherer SE … Baylor College of Medicine Human Genome Sequencing Center Sequence Production Team (Nature 2006) 3 4 56
  2. A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome. (PMID: 28065597) Yao Z … Stagljar I (Molecular cell 2017) 3 56
  3. The full-ORF clone resource of the German cDNA Consortium. (PMID: 17974005) Bechtel S … Schupp I (BMC genomics 2007) 4 56
  4. A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study. (PMID: 17903299) Kathiresan S … Cupples LA (BMC medical genetics 2007) 43 56
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 56

Products for FAM186A Gene

Sources for FAM186A Gene