Aliases for FAM186A Gene

Aliases for FAM186A Gene

  • Family With Sequence Similarity 186 Member A 2 3 5
  • Protein FAM186A 3 4
  • Family With Sequence Similarity 186, Member A 2

External Ids for FAM186A Gene

Previous GeneCards Identifiers for FAM186A Gene

  • GC12M049009
  • GC12M050721
  • GC12M047754

Summaries for FAM186A Gene

GeneCards Summary for FAM186A Gene

FAM186A (Family With Sequence Similarity 186 Member A) is a Protein Coding gene. Diseases associated with FAM186A include Cerebral Atherosclerosis and Fanconi Anemia, Complementation Group E.

Additional gene information for FAM186A Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FAM186A Gene

Genomics for FAM186A Gene

GeneHancer (GH) Regulatory Elements for FAM186A Gene

Promoters and enhancers for FAM186A Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J050395 Enhancer 1 Ensembl ENCODE 500.7 -0.1 -148 2 EP300 FOXK2 TCF12 NCOR1 FOXA1 SKI TEAD1 ATF2 TBX3 CREB1 FAM186A piR-57460-126 LIMA1 COX14 LARP4
GH12J050394 Enhancer 0.8 FANTOM5 Ensembl ENCODE 500.7 +1.7 1697 1.5 TEAD1 ZNF384 TEAD3 ZNF362 JUN FAM186A LIMA1 DIP2B LARP4
GH12J050399 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 12.2 -5.0 -4997 4.5 FOXK2 ZBTB40 ZNF217 EP300 ZSCAN5C TCF12 MYC USF1 POLR2G SP1 LARP4 LIMA1 PRPF40B LOC100422296 ENSG00000257298 ENSG00000257964 CERS5 BCDIN3D SMARCD1 FAM186A
GH12J050762 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 9.4 -368.2 -368161 5.6 EP300 HNRNPK ZBTB40 ZNF217 CTCF ZSCAN5C NRF1 POLR2G USF1 NCOR1 ATF1 lnc-SLC11A2-7 lnc-SLC11A2-8 SLC11A2 HNRNPA3P10 LIMA1 RNU6-1273P RNU6-769P FAM186A LARP4
GH12J050279 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 9.3 +114.5 114521 5.4 CTCF TCF12 NRF1 USF1 POLR2G GTF2E2 PHF8 ZFX POLR2A ZBTB11 LARP4 LIMA1 lnc-LARP4-6 CERS5 FAM186A DIP2B piR-32214-122
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FAM186A on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FAM186A

Top Transcription factor binding sites by QIAGEN in the FAM186A gene promoter:
  • AP-4
  • AREB6
  • Arnt
  • c-Ets-1
  • C/EBPbeta
  • COMP1
  • E47
  • HEN1
  • Sox9

Genomic Locations for FAM186A Gene

Genomic Locations for FAM186A Gene
70,406 bases
Minus strand
70,393 bases
Minus strand

Genomic View for FAM186A Gene

Genes around FAM186A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM186A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM186A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM186A Gene

Proteins for FAM186A Gene

  • Protein details for FAM186A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein FAM186A
    Protein Accession:

    Protein attributes for FAM186A Gene

    2351 amino acids
    Molecular mass:
    262758 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FAM186A Gene

Post-translational modifications for FAM186A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM186A Gene

No data available for DME Specific Peptides for FAM186A Gene

Domains & Families for FAM186A Gene

Gene Families for FAM186A Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FAM186A Gene


Suggested Antigen Peptide Sequences for FAM186A Gene

GenScript: Design optimal peptide antigens:
  • FAM186A protein (B9EIJ5_HUMAN)
  • Protein FAM186A (F186A_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the FAM186 family.
  • Belongs to the FAM186 family.
genes like me logo Genes that share domains with FAM186A: view

Function for FAM186A Gene

Phenotypes From GWAS Catalog for FAM186A Gene

genes like me logo Genes that share phenotypes with FAM186A: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FAM186A

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM186A Gene

Localization for FAM186A Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM186A gene
Compartment Confidence
nucleus 2
cytosol 1
mitochondrion 0

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for FAM186A Gene

Pathways & Interactions for FAM186A Gene

PathCards logo

SuperPathways for FAM186A Gene

No Data Available

Interacting Proteins for FAM186A Gene

STRING Interaction Network Preview (showing top 2 STRING interactants - click image to see details)
STRING Interaction Network
Selected Interacting proteins: ENSP00000329995 A6NE01-F186A_HUMAN for FAM186A Gene via STRING IID


Gene Ontology (GO) - Biological Process for FAM186A Gene


No data available for Pathways by source and SIGNOR curated interactions for FAM186A Gene

Drugs & Compounds for FAM186A Gene

No Compound Related Data Available

Transcripts for FAM186A Gene

mRNA/cDNA for FAM186A Gene

5 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FAM186A

Alternative Splicing Database (ASD) splice patterns (SP) for FAM186A Gene

No ASD Table

Relevant External Links for FAM186A Gene

GeneLoc Exon Structure for

Expression for FAM186A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FAM186A Gene

mRNA differential expression in normal tissues according to GTEx for FAM186A Gene

This gene is overexpressed in Testis (x39.5).

Protein differential expression in normal tissues from HIPED for FAM186A Gene

This gene is overexpressed in Bone marrow stromal cell (40.2) and Serum (23.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FAM186A Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FAM186A

SOURCE GeneReport for Unigene cluster for FAM186A Gene:

genes like me logo Genes that share expression patterns with FAM186A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM186A Gene

Orthologs for FAM186A Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM186A Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FAM186A 31 30
  • 95.74 (n)
(Canis familiaris)
Mammalia FAM186A 31 30
  • 77.21 (n)
(Bos Taurus)
Mammalia FAM186A 31 30
  • 76.22 (n)
(Monodelphis domestica)
Mammalia FAM186A 31
  • 63 (a)
(Mus musculus)
Mammalia Fam186a 31
  • 53 (a)
(Ornithorhynchus anatinus)
Mammalia FAM186A 31
  • 14 (a)
(Anolis carolinensis)
Reptilia -- 31
  • 19 (a)
Species where no ortholog for FAM186A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FAM186A Gene

Gene Tree for FAM186A (if available)
Gene Tree for FAM186A (if available)
Evolutionary constrained regions (ECRs) for FAM186A: view image

Paralogs for FAM186A Gene

(1) SIMAP similar genes for FAM186A Gene using alignment to 5 proteins:

  • F186A_HUMAN
  • F5H8C1_HUMAN
genes like me logo Genes that share paralogs with FAM186A: view

No data available for Paralogs for FAM186A Gene

Variants for FAM186A Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for FAM186A Gene

SNP ID Clinical significance and condition Chr 12 pos Variation AA Info Type
rs10876023 - p.Leu1233Pro
rs10876024 - p.Arg1204Gly
rs12303082 - p.Lys187Gln
rs12809349 - p.Gln2316Glu
rs6580741 - p.His2228Gln

Additional dbSNP identifiers (rs#s) for FAM186A Gene

Structural Variations from Database of Genomic Variants (DGV) for FAM186A Gene

Variant ID Type Subtype PubMed ID
dgv1498n100 CNV gain 25217958
dgv1499n100 CNV gain 25217958
dgv275e214 CNV gain 21293372
esv1583460 CNV deletion 17803354
esv2761738 CNV gain 21179565
esv2762979 CNV loss 21179565
esv3303098 CNV tandem duplication 20981092
nsv983322 CNV duplication 23825009

Variation tolerance for FAM186A Gene

Gene Damage Index Score: 10.41; 90.90% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FAM186A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM186A Gene

Disorders for FAM186A Gene

MalaCards: The human disease database

(3) MalaCards diseases for FAM186A Gene - From: DISEASES

Disorder Aliases PubMed IDs
cerebral atherosclerosis
  • intracranial arteriosclerosis
fanconi anemia, complementation group e
  • fance
bardet-biedl syndrome 4
  • bbs4
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for FAM186A

genes like me logo Genes that share disorders with FAM186A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FAM186A Gene

Publications for FAM186A Gene

  1. The finished DNA sequence of human chromosome 12. (PMID: 16541075) Scherer SE … Baylor College of Medicine Human Genome Sequencing Center Sequence Production Team (Nature 2006) 3 4 54
  2. A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome. (PMID: 28065597) Yao Z … Stagljar I (Molecular cell 2017) 3 54
  3. A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study. (PMID: 17903299) Kathiresan S … Cupples LA (BMC medical genetics 2007) 41 54
  4. The full-ORF clone resource of the German cDNA Consortium. (PMID: 17974005) Bechtel S … Schupp I (BMC genomics 2007) 4 54
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 54

Products for FAM186A Gene

Sources for FAM186A Gene