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Aliases for FAM184A Gene

Aliases for FAM184A Gene

  • Family With Sequence Similarity 184 Member A 2 3 5
  • C6orf60 3 4
  • Family With Sequence Similarity 184, Member A 2
  • Chromosome 6 Open Reading Frame 60 2
  • Protein FAM184A 3

External Ids for FAM184A Gene

Previous HGNC Symbols for FAM184A Gene

  • C6orf60

Previous GeneCards Identifiers for FAM184A Gene

  • GC06M119323
  • GC06M116863
  • GC06M119280

Summaries for FAM184A Gene

GeneCards Summary for FAM184A Gene

FAM184A (Family With Sequence Similarity 184 Member A) is a Protein Coding gene. An important paralog of this gene is FAM184B.

Additional gene information for FAM184A Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM184A Gene

Genomics for FAM184A Gene

GeneHancer (GH) Regulatory Elements for FAM184A Gene

Promoters and enhancers for FAM184A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06I119077 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE 562.2 +71.0 71004 2.6 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZNF766 E2F8 FOS FAM184A MCM9 MIR548B
GH06I119146 Promoter/Enhancer 2 EPDnew FANTOM5 Ensembl ENCODE 552 +1.4 1417 3.3 PKNOX1 FOXA2 ARNT IRF4 CBX5 ZNF213 ZNF143 FOS JUNB REST FAM184A MIR548B
GH06I118890 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 6.4 +255.2 255155 6.8 CLOCK MLX DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 NFYC ASF1A MCM9 CEP85L ENSG00000253194 FAM184A
GH06I119034 Enhancer 1 Ensembl ENCODE 15.3 +113.6 113626 2.1 HDAC1 RAD21 CHAMP1 TCF12 RXRA NCOA1 ZEB2 PPARG NR2F2 NFIC FAM184A MCM9 ENSG00000222649 GC06M118991
GH06I119095 Enhancer 0.6 Ensembl ENCODE 21.9 +52.5 52545 2 ZNF189 CEBPB FAM184A MIR548B
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around FAM184A on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FAM184A gene promoter:

Genomic Locations for FAM184A Gene

Genomic Locations for FAM184A Gene
chr6:118,959,763-119,149,387
(GRCh38/hg38)
Size:
189,625 bases
Orientation:
Minus strand
chr6:119,280,928-119,470,552
(GRCh37/hg19)

Genomic View for FAM184A Gene

Genes around FAM184A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM184A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM184A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM184A Gene

Proteins for FAM184A Gene

  • Protein details for FAM184A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NB25-F184A_HUMAN
    Recommended name:
    Protein FAM184A
    Protein Accession:
    Q8NB25
    Secondary Accessions:
    • B9DI75
    • F8W8D6
    • Q5TBS9
    • Q7Z323
    • Q96GY8
    • Q9H0J8
    • Q9H851

    Protein attributes for FAM184A Gene

    Size:
    1140 amino acids
    Molecular mass:
    132965 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB14769.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAC03719.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for FAM184A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FAM184A Gene

Post-translational modifications for FAM184A Gene

  • Ubiquitination at posLast=11101110
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for FAM184A Gene

Domains & Families for FAM184A Gene

Gene Families for FAM184A Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FAM184A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM184A Gene

Graphical View of Domain Structure for InterPro Entry

Q8NB25

UniProtKB/Swiss-Prot:

F184A_HUMAN :
  • Belongs to the FAM184 family.
Family:
  • Belongs to the FAM184 family.
genes like me logo Genes that share domains with FAM184A: view

Function for FAM184A Gene

Phenotypes From GWAS Catalog for FAM184A Gene

Gene Ontology (GO) - Molecular Function for FAM184A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 24407287
genes like me logo Genes that share ontologies with FAM184A: view
genes like me logo Genes that share phenotypes with FAM184A: view

Animal Model Products

miRNA for FAM184A Gene

miRTarBase miRNAs that target FAM184A

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM184A Gene

Localization for FAM184A Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM184A gene
Compartment Confidence
extracellular 5
cytosol 3
cytoskeleton 2
nucleus 2
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (3)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for FAM184A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA,IDA 22664934
genes like me logo Genes that share ontologies with FAM184A: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for FAM184A Gene

Pathways & Interactions for FAM184A Gene

SuperPathways for FAM184A Gene

No Data Available

Interacting Proteins for FAM184A Gene

Gene Ontology (GO) - Biological Process for FAM184A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with FAM184A: view

No data available for Pathways by source and SIGNOR curated interactions for FAM184A Gene

Drugs & Compounds for FAM184A Gene

No Compound Related Data Available

Transcripts for FAM184A Gene

Unigene Clusters for FAM184A Gene

Family with sequence similarity 184, member A:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM184A Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18a · 18b · 18c · 18d ^
SP1: - - -
SP2: - - - - -
SP3: - - - - - - -
SP4: - -
SP5:
SP6: - -
SP7:

ExUns: 19 ^ 20
SP1: -
SP2: -
SP3: -
SP4:
SP5:
SP6: -
SP7: -

Relevant External Links for FAM184A Gene

GeneLoc Exon Structure for
FAM184A
ECgene alternative splicing isoforms for
FAM184A

Expression for FAM184A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM184A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FAM184A Gene

This gene is overexpressed in Synovial fluid (28.7), Bone (22.0), and Plasma (9.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FAM184A Gene



NURSA nuclear receptor signaling pathways regulating expression of FAM184A Gene:

FAM184A

SOURCE GeneReport for Unigene cluster for FAM184A Gene:

Hs.443789

Evidence on tissue expression from TISSUES for FAM184A Gene

  • Eye(4.7)
  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with FAM184A: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM184A Gene

Orthologs for FAM184A Gene

This gene was present in the common ancestor of animals.

Orthologs for FAM184A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM184A 33 34
  • 99.71 (n)
dog
(Canis familiaris)
Mammalia FAM184A 33 34
  • 93.25 (n)
cow
(Bos Taurus)
Mammalia FAM184A 33 34
  • 91.96 (n)
mouse
(Mus musculus)
Mammalia Fam184a 33 16 34
  • 86.02 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 84 (a)
OneToMany
-- 34
  • 81 (a)
OneToMany
-- 34
  • 77 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Fam184a 33
  • 83.63 (n)
oppossum
(Monodelphis domestica)
Mammalia FAM184A 34
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves FAM184A 33 34
  • 79.2 (n)
lizard
(Anolis carolinensis)
Reptilia FAM184A 34
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fam184a 33
  • 70.95 (n)
Str.19321 33
zebrafish
(Danio rerio)
Actinopterygii fam184a 34
  • 57 (a)
OneToMany
FAM184A (1 of 2) 34
  • 52 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea tag-278 34
  • 18 (a)
OneToMany
Species where no ortholog for FAM184A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FAM184A Gene

ENSEMBL:
Gene Tree for FAM184A (if available)
TreeFam:
Gene Tree for FAM184A (if available)

Paralogs for FAM184A Gene

Paralogs for FAM184A Gene

genes like me logo Genes that share paralogs with FAM184A: view

Variants for FAM184A Gene

Sequence variations from dbSNP and Humsavar for FAM184A Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000004854 -- 119,082,878(-) G/A genic_upstream_transcript_variant, intron_variant
rs1000008361 -- 119,011,383(-) T/C coding_sequence_variant, missense_variant
rs1000008554 -- 119,076,742(-) A/G intron_variant
rs1000008574 -- 118,990,531(-) C/A intron_variant
rs1000009042 -- 119,054,326(-) A/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for FAM184A Gene

Variant ID Type Subtype PubMed ID
dgv3370n106 CNV deletion 24896259
dgv3371n106 CNV deletion 24896259
esv1008585 CNV deletion 20482838
esv1571689 CNV insertion 17803354
esv1686491 CNV deletion 17803354
esv1958583 CNV deletion 18987734
esv2524990 CNV deletion 19546169
esv2666219 CNV deletion 23128226
esv2670982 CNV deletion 23128226
esv2732625 CNV deletion 23290073
esv2763 CNV loss 18987735
esv3304904 CNV mobile element insertion 20981092
esv3306264 CNV mobile element insertion 20981092
esv3307887 CNV mobile element insertion 20981092
esv3308804 CNV mobile element insertion 20981092
esv3346642 CNV insertion 20981092
esv3351763 CNV insertion 20981092
esv3365310 CNV insertion 20981092
esv3414197 CNV insertion 20981092
esv3540364 CNV deletion 23714750
esv3540365 CNV deletion 23714750
esv3610532 CNV loss 21293372
esv7449 CNV loss 19470904
nsv1016699 CNV loss 25217958
nsv1074956 CNV deletion 25765185
nsv1150078 CNV deletion 26484159
nsv349001 CNV deletion 16902084
nsv528632 CNV loss 19592680

Variation tolerance for FAM184A Gene

Residual Variation Intolerance Score: 35.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.32; 70.62% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FAM184A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM184A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM184A Gene

Disorders for FAM184A Gene

Additional Disease Information for FAM184A

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for FAM184A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM184A Gene

Publications for FAM184A Gene

  1. Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S … Poustka A (Genome research 2001) 2 3 4 58
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for FAM184A Gene

Sources for FAM184A Gene

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