Aliases for FAM181A Gene

Aliases for FAM181A Gene

  • Family With Sequence Similarity 181 Member A 2 3 5
  • Protein FAM181A 3 4
  • C14orf152 3 4
  • Family With Sequence Similarity 181, Member A 2
  • Chromosome 14 Open Reading Frame 152 2
  • FAM181A 5

External Ids for FAM181A Gene

Previous HGNC Symbols for FAM181A Gene

  • C14orf152

Previous GeneCards Identifiers for FAM181A Gene

  • GC14P093456
  • GC14P094385
  • GC14P074566

Summaries for FAM181A Gene

GeneCards Summary for FAM181A Gene

FAM181A (Family With Sequence Similarity 181 Member A) is a Protein Coding gene. An important paralog of this gene is FAM181B.

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FAM181A Gene

Genomics for FAM181A Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for FAM181A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14J093927 Promoter/Enhancer 1.1 EPDnew Ensembl CraniofacialAtlas 250.4 +8.1 8133 1.7 CEBPA CEBPG HLF RFX1 RBFOX2 FAM181A-AS1 FAM181A ASB2 CCDC197
GH14J093916 Enhancer 0.5 ENCODE 268.8 -2.0 -1992 1.2 FOXA2 MAFF FOXA1 MAFK ZNF24 KLF4 FAM181A FAM181A-AS1 ENSG00000279593 PRIMA1
GH14J093880 Enhancer 0.9 Ensembl ENCODE 6.4 -39.7 -39693 3.2 FEZF1 ZIC2 ZNF341 ZNF843 PRDM6 ZNF189 GLIS1 ZNF140 TRIM28 KLF1 LOC105370631 BTBD7 FAM181A MOAP1 piR-31292-061 PRIMA1
GH14J094646 Enhancer 0.5 Ensembl 6.2 +727.8 727825 0.4 RARA JUND ELF3 EGR2 ZFHX2 SERPINA3 FAM181A lnc-SERPINA3-3 SERPINA13P piR-36393-160 GSC
GH14J093655 Enhancer 0.3 FANTOM5 2.5 -263.2 -263215 0.1 CTCF FAM181A PRIMA1 ENSG00000277826 HSALNG0103314 COX8C UNC79
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FAM181A on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FAM181A

Top Transcription factor binding sites by QIAGEN in the FAM181A gene promoter:
  • Arnt
  • ARP-1
  • GATA-1
  • HOXA5
  • HOXA9
  • HOXA9B
  • MyoD
  • RFX1
  • RREB-1
  • STAT5B

Genomic Locations for FAM181A Gene

Latest Assembly
chr14:93,918,894-93,929,608
(GRCh38/hg38)
Size:
10,715 bases
Orientation:
Plus strand

Previous Assembly
chr14:94,385,240-94,395,954
(GRCh37/hg19 by Entrez Gene)
Size:
10,715 bases
Orientation:
Plus strand

chr14:94,385,240-94,395,954
(GRCh37/hg19 by Ensembl)
Size:
10,715 bases
Orientation:
Plus strand

Genomic View for FAM181A Gene

Genes around FAM181A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM181A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM181A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM181A Gene

Proteins for FAM181A Gene

  • Protein details for FAM181A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N9Y4-F181A_HUMAN
    Recommended name:
    Protein FAM181A
    Protein Accession:
    Q8N9Y4
    Secondary Accessions:
    • B2RD39
    • Q96GY1

    Protein attributes for FAM181A Gene

    Size:
    354 amino acids
    Molecular mass:
    38724 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for FAM181A Gene

    Alternative splice isoforms for FAM181A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FAM181A Gene

Post-translational modifications for FAM181A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FAM181A Gene

Domains & Families for FAM181A Gene

Gene Families for FAM181A Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FAM181A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM181A Gene

GenScript: Design optimal peptide antigens:
  • Protein FAM181A (F181A_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8N9Y4

UniProtKB/Swiss-Prot:

F181A_HUMAN :
  • Belongs to the FAM181 family.
Family:
  • Belongs to the FAM181 family.
genes like me logo Genes that share domains with FAM181A: view

Function for FAM181A Gene

Phenotypes From GWAS Catalog for FAM181A Gene

genes like me logo Genes that share phenotypes with FAM181A: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FAM181A

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FAM181A Gene

Localization for FAM181A Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM181A gene
Compartment Confidence
nucleus 2
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for FAM181A Gene

Pathways & Interactions for FAM181A Gene

PathCards logo

SuperPathways for FAM181A Gene

No Data Available

Interacting Proteins for FAM181A Gene

Gene Ontology (GO) - Biological Process for FAM181A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FAM181A Gene

Drugs & Compounds for FAM181A Gene

No Compound Related Data Available

Transcripts for FAM181A Gene

mRNA/cDNA for FAM181A Gene

5 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FAM181A

Alternative Splicing Database (ASD) splice patterns (SP) for FAM181A Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b · 5c · 5d · 5e
SP1: - - - -
SP2: -
SP3: - -
SP4:
SP5: - - - - -

Relevant External Links for FAM181A Gene

GeneLoc Exon Structure for
FAM181A

Expression for FAM181A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FAM181A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FAM181A Gene

This gene is overexpressed in Testis (x15.0) and Brain - Amygdala (x4.2).

Protein differential expression in normal tissues from HIPED for FAM181A Gene

This gene is overexpressed in Heart (68.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FAM181A Gene



Protein tissue co-expression partners for FAM181A Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FAM181A

SOURCE GeneReport for Unigene cluster for FAM181A Gene:

Hs.525550
genes like me logo Genes that share expression patterns with FAM181A: view

Primer products for research

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM181A Gene

Orthologs for FAM181A Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM181A Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia FAM181A 30 31
  • 99.32 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia FAM181A 30 31
  • 87.27 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia FAM181A 30 31
  • 86.76 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Fam181a 30 17 31
  • 80.25 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia RGD1309028 30
  • 80.02 (n)
Oppossum
(Monodelphis domestica)
Mammalia FAM181A 31
  • 64 (a)
OneToOne
Chicken
(Gallus gallus)
Aves FAM181A 30 31
  • 66.08 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia FAM181A 31
  • 46 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia fam181a 30
  • 56.46 (n)
Str.13648 30
Zebrafish
(Danio rerio)
Actinopterygii LOC101883716 30
  • 59.46 (n)
Species where no ortholog for FAM181A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for FAM181A Gene

ENSEMBL:
Gene Tree for FAM181A (if available)
TreeFam:
Gene Tree for FAM181A (if available)
Aminode:
Evolutionary constrained regions (ECRs) for FAM181A: view image

Paralogs for FAM181A Gene

Paralogs for FAM181A Gene

genes like me logo Genes that share paralogs with FAM181A: view

Variants for FAM181A Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for FAM181A Gene

SNP ID Clinical significance and condition Chr 14 pos Variation AA Info Type
rs10141024 - p.Ala28Thr
rs34220325 - p.Leu162Met

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for FAM181A Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for FAM181A Gene

Variant ID Type Subtype PubMed ID
nsv521206 CNV loss 19592680
nsv832861 CNV loss 17160897

Variation tolerance for FAM181A Gene

Residual Variation Intolerance Score: 77.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.02; 37.21% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FAM181A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM181A

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM181A Gene

Disorders for FAM181A Gene

Additional Disease Information for FAM181A

No disorders were found for FAM181A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM181A Gene

Publications for FAM181A Gene

  1. Analysis of the Fam181 gene family during mouse development reveals distinct strain-specific expression patterns, suggesting a role in nervous system development and function. (PMID: 26407640) Marks M … Wittler L (Gene 2016) 2 3
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L … Andersson-Svahn H (Molecular & cellular proteomics : MCP 2008) 3
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3

Products for FAM181A Gene

Sources for FAM181A Gene