Aliases for FAM180A Gene

Aliases for FAM180A Gene

  • Family With Sequence Similarity 180 Member A 2 3 5
  • Protein FAM180A 3 4
  • Family With Sequence Similarity 180, Member A 2
  • HWKM1940 3
  • UNQ1940 3

External Ids for FAM180A Gene

Previous GeneCards Identifiers for FAM180A Gene

  • GC07M135065
  • GC07M135413
  • GC07M129717

Summaries for FAM180A Gene

GeneCards Summary for FAM180A Gene

FAM180A (Family With Sequence Similarity 180 Member A) is a Protein Coding gene. Diseases associated with FAM180A include Fibrosarcomatous Osteosarcoma and Chondroblastic Osteosarcoma. An important paralog of this gene is FAM180B.

Additional gene information for FAM180A Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FAM180A Gene

Genomics for FAM180A Gene

GeneHancer (GH) Regulatory Elements for FAM180A Gene

Promoters and enhancers for FAM180A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J135747 Promoter/Enhancer 1.3 EPDnew Ensembl ENCODE dbSUPER 507.8 +0.3 335 2.4 FOS FOSL1 MCM7 ATF2 BHLHE40 USF2 SPI1 SCRT2 FAM180A RPL15P11 HSALNG0061584
GH07J135771 Enhancer 1.4 VISTA FANTOM5 Ensembl ENCODE dbSUPER 31.3 -24.4 -24434 3.4 JUND FOS ZFX ZIC2 TRIM28 CTBP1 MYC OSR2 FOXA2 MBD2 ENSG00000224746 FAM180A STMP1 SLC13A4 LOC105375522
GH07J135743 Enhancer 1.2 FANTOM5 ENCODE dbSUPER 11.2 +3.6 3561 3.2 FOS REST POLR2A ZBTB11 NR2F2 ZNF316 GABPA CEBPG PBX2 FOSL1 HSALNG0061584 STMP1 RPL15P11 FAM180A ENSG00000224746
GH07J135712 Enhancer 1 ENCODE CraniofacialAtlas 11.6 +34.8 34766 4.2 ZNF217 ZSCAN5C ZNF10 ZIC2 REST ZNF423 UBTF TRIM28 GATAD2B CTBP1 STMP1 RPL15P11 CYREN FAM180A SLC13A4 ENSG00000224746 HSALNG0061581 lnc-SLC13A4-1
GH07J135716 Enhancer 0.9 ENCODE 11.6 +31.9 31914 0.7 ZSCAN5C TCF12 JUND FOS ZNF639 ZNF10 ZIC2 REST ZNF623 ZNF423 NUP205 FAM180A ENSG00000273219 STMP1 SLC13A4 HSALNG0061581 lnc-SLC13A4-1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FAM180A on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FAM180A

Top Transcription factor binding sites by QIAGEN in the FAM180A gene promoter:
  • AML1a
  • FOXI1
  • GATA-2
  • GATA-3
  • HFH-3
  • NF-1
  • p53
  • POU2F1
  • POU2F1a
  • POU6F1 (c2)

Genomic Locations for FAM180A Gene

Genomic Locations for FAM180A Gene
chr7:135,728,348-135,748,867
(GRCh38/hg38)
Size:
20,520 bases
Orientation:
Minus strand
chr7:135,413,096-135,433,594
(GRCh37/hg19)
Size:
20,499 bases
Orientation:
Minus strand

Genomic View for FAM180A Gene

Genes around FAM180A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM180A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM180A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM180A Gene

Proteins for FAM180A Gene

  • Protein details for FAM180A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UWF9-F180A_HUMAN
    Recommended name:
    Protein FAM180A
    Protein Accession:
    Q6UWF9
    Secondary Accessions:
    • B2RP85

    Protein attributes for FAM180A Gene

    Size:
    173 amino acids
    Molecular mass:
    19733 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FAM180A Gene

Post-translational modifications for FAM180A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM180A Gene

No data available for DME Specific Peptides for FAM180A Gene

Domains & Families for FAM180A Gene

Gene Families for FAM180A Gene

Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for FAM180A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM180A Gene

GenScript: Design optimal peptide antigens:
  • Protein FAM180A (F180A_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q6UWF9

UniProtKB/Swiss-Prot:

F180A_HUMAN :
  • Belongs to the FAM180 family.
Family:
  • Belongs to the FAM180 family.
genes like me logo Genes that share domains with FAM180A: view

Function for FAM180A Gene

Phenotypes From GWAS Catalog for FAM180A Gene

genes like me logo Genes that share phenotypes with FAM180A: view

Animal Model Products

  • Taconic Biosciences Mouse Models for FAM180A

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FAM180A

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FAM180A Gene

Localization for FAM180A Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM180A Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM180A gene
Compartment Confidence
extracellular 4
cytoskeleton 1
nucleus 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for FAM180A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with FAM180A: view

Pathways & Interactions for FAM180A Gene

PathCards logo

SuperPathways for FAM180A Gene

No Data Available

Interacting Proteins for FAM180A Gene

;

Gene Ontology (GO) - Biological Process for FAM180A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FAM180A Gene

Drugs & Compounds for FAM180A Gene

No Compound Related Data Available

Transcripts for FAM180A Gene

mRNA/cDNA for FAM180A Gene

2 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FAM180A

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM180A Gene

No ASD Table

Relevant External Links for FAM180A Gene

GeneLoc Exon Structure for
FAM180A

Expression for FAM180A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FAM180A Gene

mRNA differential expression in normal tissues according to GTEx for FAM180A Gene

This gene is overexpressed in Artery - Aorta (x12.9).

Protein differential expression in normal tissues from HIPED for FAM180A Gene

This gene is overexpressed in Serum (22.7), Bone (15.2), Esophagus (13.0), Bone marrow mesenchymal stem cell (9.9), and Lung (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FAM180A Gene



Protein tissue co-expression partners for FAM180A Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FAM180A

SOURCE GeneReport for Unigene cluster for FAM180A Gene:

Hs.55200
genes like me logo Genes that share expression patterns with FAM180A: view

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM180A Gene

Orthologs for FAM180A Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM180A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM180A 31 30
  • 99.61 (n)
OneToOne
dog
(Canis familiaris)
Mammalia FAM180A 31 30
  • 87.67 (n)
OneToOne
cow
(Bos Taurus)
Mammalia FAM180A 31 30
  • 86.32 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fam180a 30
  • 81.09 (n)
mouse
(Mus musculus)
Mammalia Fam180a 17 31 30
  • 79.73 (n)
oppossum
(Monodelphis domestica)
Mammalia FAM180A 31
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FAM180A 31
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves FAM180A 31 30
  • 72.97 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FAM180A 31
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fam180a 30
  • 63.83 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC100538098 30
  • 51.3 (n)
CABZ01068473.1 31
  • 35 (a)
OneToOne
Species where no ortholog for FAM180A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM180A Gene

ENSEMBL:
Gene Tree for FAM180A (if available)
TreeFam:
Gene Tree for FAM180A (if available)
Aminode:
Evolutionary constrained regions (ECRs) for FAM180A: view image

Paralogs for FAM180A Gene

Paralogs for FAM180A Gene

genes like me logo Genes that share paralogs with FAM180A: view

Variants for FAM180A Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for FAM180A Gene

SNP ID Clinical significance and condition Chr 07 pos Variation AA Info Type
rs3112374 - p.Val96Ile

Additional dbSNP identifiers (rs#s) for FAM180A Gene

Structural Variations from Database of Genomic Variants (DGV) for FAM180A Gene

Variant ID Type Subtype PubMed ID
nsv608460 CNV gain 21841781

Variation tolerance for FAM180A Gene

Residual Variation Intolerance Score: 83.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.17; 51.78% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FAM180A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM180A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM180A Gene

Disorders for FAM180A Gene

MalaCards: The human disease database

(3) MalaCards diseases for FAM180A Gene - From: DISEASES

Disorder Aliases PubMed IDs
fibrosarcomatous osteosarcoma
  • fibroblastic osteosarcoma
chondroblastic osteosarcoma
  • chondrosarcomatous osteogenic sarcoma
conventional central osteosarcoma
  • conventional osteosarcoma
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for FAM180A

genes like me logo Genes that share disorders with FAM180A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FAM180A Gene

Publications for FAM180A Gene

  1. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer SW … Tsui LC (Science (New York, N.Y.) 2003) 2 3 4 54
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 2 3 4 54
  3. Genome-wide association study of chronic periodontitis in a general German population. (PMID: 24024966) Teumer A … Kocher T (Journal of clinical periodontology 2013) 3 54
  4. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PMID: 23251661) Comuzzie AG … Butte NF (PloS one 2012) 3 54
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 54

Products for FAM180A Gene

Sources for FAM180A Gene