Aliases for FAM178B Gene

Aliases for FAM178B Gene

  • Family With Sequence Similarity 178 Member B 2 3 5
  • Protein FAM178B 3 4
  • Family With Sequence Similarity 178, Member B 2

External Ids for FAM178B Gene

Previous GeneCards Identifiers for FAM178B Gene

  • GC02M097541
  • GC02M091501

Summaries for FAM178B Gene

GeneCards Summary for FAM178B Gene

FAM178B (Family With Sequence Similarity 178 Member B) is a Protein Coding gene. An important paralog of this gene is SLF2.

Additional gene information for FAM178B Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FAM178B Gene

Genomics for FAM178B Gene

GeneHancer (GH) Regulatory Elements for FAM178B Gene

Promoters and enhancers for FAM178B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J096894 Promoter/Enhancer 1.9 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 763.9 +90.9 90934 2.5 SMARCE1 ZNF217 CC2D1A L3MBTL2 DACH1 MNT TEAD4 ZNF148 GTF2F1 ZFX FAM178B SNRNP200 KANSL3 ANKRD36B ANKRD36 CNNM3 CIAO1 ENSG00000277701 STARD7-AS1 FAHD2B
GH02J096988 Enhancer 0.2 Ensembl 750.6 -1.1 -1100 0.2 FAM178B lnc-ANKRD36-13 LOC100420569
GH02J096984 Enhancer 0.2 Ensembl 750.6 +1.7 1700 0.6 FAM178B RF01210-207
GH02J097094 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE CraniofacialAtlas 12.1 -108.2 -108200 2 L3MBTL2 CREB1 ZBTB8A ATF1 PKNOX1 ATF7 POLR2A SUPT5H ZNF335 ATF2 FAHD2B ENSG00000279791 lnc-ANKRD36-4 lnc-FAM178B-4 ENSG00000230606 FAM178B SNRNP200 piR-57014-003
GH02J096905 Enhancer 1 ENCODE CraniofacialAtlas dbSUPER 18.6 +79.4 79381 2.5 MNT SP1 GLIS2 ZIC2 RXRA ZFX SCRT2 RNF2 USF1 ZNF217 FAM178B SEMA4C ANKRD23 ANKRD39 SNRNP200 ENSG00000286654 HSALNG0017094
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FAM178B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FAM178B gene promoter:
  • ATF-2
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4
  • E2F-5
  • FOXC1
  • FOXI1
  • HFH-3

Genomic Locations for FAM178B Gene

Genomic Locations for FAM178B Gene
chr2:96,875,882-96,986,601
(GRCh38/hg38)
Size:
110,720 bases
Orientation:
Minus strand
chr2:97,541,619-97,684,175
(GRCh37/hg19)
Size:
142,557 bases
Orientation:
Minus strand

Genomic View for FAM178B Gene

Genes around FAM178B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM178B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM178B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM178B Gene

Proteins for FAM178B Gene

  • Protein details for FAM178B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IXR5-F178B_HUMAN
    Recommended name:
    Protein FAM178B
    Protein Accession:
    Q8IXR5
    Secondary Accessions:
    • A8MXN2
    • E9PD86
    • Q8IUY0
    • Q9P0P4

    Protein attributes for FAM178B Gene

    Size:
    827 amino acids
    Molecular mass:
    93514 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAF36154.1; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence={ECO:0000305}; Sequence=AAF36154.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305};

    Alternative splice isoforms for FAM178B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FAM178B Gene

Post-translational modifications for FAM178B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FAM178B Gene

Domains & Families for FAM178B Gene

Gene Families for FAM178B Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FAM178B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM178B Gene

GenScript: Design optimal peptide antigens:
  • Protein FAM178B (F178B_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8IXR5

UniProtKB/Swiss-Prot:

F178B_HUMAN :
  • Belongs to the FAM178 family.
Family:
  • Belongs to the FAM178 family.
genes like me logo Genes that share domains with FAM178B: view

Function for FAM178B Gene

Phenotypes From GWAS Catalog for FAM178B Gene

genes like me logo Genes that share phenotypes with FAM178B: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FAM178B Gene

Localization for FAM178B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM178B gene
Compartment Confidence
plasma membrane 1
mitochondrion 1
peroxisome 1
cytosol 1
extracellular 0
endoplasmic reticulum 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (1)
  • Nuclear speckles (1)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FAM178B Gene

Pathways & Interactions for FAM178B Gene

PathCards logo

SuperPathways for FAM178B Gene

No Data Available

Interacting Proteins for FAM178B Gene

Selected Interacting proteins: Q8IXR5-F178B_HUMAN for FAM178B Gene via IID

Symbol External ID(s) Details
LRSAM1
ZNF598

Gene Ontology (GO) - Biological Process for FAM178B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FAM178B Gene

Drugs & Compounds for FAM178B Gene

(1) Drugs for FAM178B Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
lithium Experimental Pharma 0
genes like me logo Genes that share compounds with FAM178B: view

Transcripts for FAM178B Gene

mRNA/cDNA for FAM178B Gene

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM178B Gene

No ASD Table

Relevant External Links for FAM178B Gene

GeneLoc Exon Structure for
FAM178B
ECgene alternative splicing isoforms for
FAM178B

Expression for FAM178B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM178B Gene

mRNA differential expression in normal tissues according to GTEx for FAM178B Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x7.0), Testis (x5.2), and Nerve - Tibial (x4.0).

NURSA nuclear receptor signaling pathways regulating expression of FAM178B Gene:

FAM178B

SOURCE GeneReport for Unigene cluster for FAM178B Gene:

Hs.107922
genes like me logo Genes that share expression patterns with FAM178B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM178B Gene

Orthologs for FAM178B Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM178B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM178B 33 32
  • 98.83 (n)
OneToOne
dog
(Canis familiaris)
Mammalia FAM178B 33 32
  • 79.88 (n)
OneToOne
cow
(Bos Taurus)
Mammalia FAM178B 33 32
  • 78.99 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Fam178b 17 33 32
  • 77.95 (n)
rat
(Rattus norvegicus)
Mammalia Fam178b 32
  • 72.3 (n)
oppossum
(Monodelphis domestica)
Mammalia FAM178B 33
  • 40 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FAM178B 33
  • 10 (a)
OneToOne
chicken
(Gallus gallus)
Aves FAM178B 33 32
  • 54.41 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FAM178B 33
  • 40 (a)
OneToOne
Species where no ortholog for FAM178B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FAM178B Gene

ENSEMBL:
Gene Tree for FAM178B (if available)
TreeFam:
Gene Tree for FAM178B (if available)
Aminode:
Evolutionary constrained regions (ECRs) for FAM178B: view image

Paralogs for FAM178B Gene

Paralogs for FAM178B Gene

genes like me logo Genes that share paralogs with FAM178B: view

Variants for FAM178B Gene

Sequence variations from dbSNP and Humsavar for FAM178B Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000061295 -- 96,956,929(-) C/A genic_upstream_transcript_variant, intron_variant
rs1000077926 -- 96,914,127(-) G/A genic_downstream_transcript_variant, genic_upstream_transcript_variant, intron_variant
rs1000131322 -- 96,913,962(-) A/C genic_downstream_transcript_variant, genic_upstream_transcript_variant, intron_variant
rs1000153589 -- 96,950,476(-) G/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000188183 -- 96,932,416(-) A/G genic_downstream_transcript_variant, genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for FAM178B Gene

Variant ID Type Subtype PubMed ID
dgv607e201 CNV deletion 23290073
esv2759077 CNV gain+loss 17122850
esv32727 CNV gain+loss 17666407
esv3425717 CNV duplication 20981092
esv5003 OTHER complex 18987735
nsv1072425 CNV deletion 25765185
nsv1135873 CNV deletion 24896259
nsv512773 CNV insertion 21212237
nsv526313 CNV loss 19592680
nsv582497 CNV loss 21841781
nsv582498 CNV loss 21841781

Variation tolerance for FAM178B Gene

Gene Damage Index Score: 6.11; 75.48% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FAM178B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM178B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM178B Gene

Disorders for FAM178B Gene

Additional Disease Information for FAM178B

No disorders were found for FAM178B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM178B Gene

Publications for FAM178B Gene

  1. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang QH … Chen Z (Genome research 2000) 2 3 4 56
  2. Genome-scale RNAi screen for host factors required for HIV replication. (PMID: 18976975) Zhou H … Espeseth AS (Cell host & microbe 2008) 3 56
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 56
  4. A human protein-protein interaction network: a resource for annotating the proteome. (PMID: 16169070) Stelzl U … Wanker EE (Cell 2005) 3 56
  5. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 4 56

Products for FAM178B Gene

Sources for FAM178B Gene