FAM178B Gene - Family With Sequence Similarity 178 Member B

Protein Coding (Updated: Nov 9, 2022)
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Aliases for FAM178B Gene

Aliases for FAM178B Gene

  • GeneCards Symbol: FAM178B 2
  • Family With Sequence Similarity 178 Member B 2 3 5
  • Protein FAM178B 3 4
  • LOC51252 2 5
  • Family With Sequence Similarity 178, Member B 2

External Ids for FAM178B Gene

Previous GeneCards Identifiers for FAM178B Gene

  • GC02M096906
  • GC02M097541
  • GC02M091501
  • GC02M097066
  • GC02M097205
  • GC02M097464
  • GC02M097780
  • GC02M098030
  • GC02M098274
  • GC02M098516

Summaries for FAM178B Gene

GeneCards Summary for FAM178B Gene

FAM178B (Family With Sequence Similarity 178 Member B) is a Protein Coding gene. Among its related pathways are 2q11.2 copy number variation syndrome. An important paralog of this gene is SLF2.

Additional gene information for FAM178B Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB Summary , Rfam classification and piRNA Summary for FAM178B Gene

Genomics for FAM178B Gene

Subsections:

  1. Promoters/Enhancers
  2. Location

GeneHancer (GH) Regulatory Elements (see citations)

Download GeneHancer 2017 data
Promoters and enhancers for FAM178B Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH02J096894 Promoter/Enhancer 1.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 263.90 442.36 +90.9 12 2.5 DPF2 NCOR1 NFIC MBD2 ZNF592 ZNF217 ARNT CTBP1 NFATC3 NKRF FAM178B SNRNP200 KANSL3 ANKRD36B CIAO1 CNNM3 STARD7-AS1 FAHD2B ACTR1B HSALNG0017094
GH02J096984 Enhancer 0.1 Ensembl 250.70 35.81 +1.7 0 0.6 FAM178B SNODB1088 LOC124906158 lnc-CNNM3-4 SEMA4C
GH02J096905 Enhancer 0.9 ENCODE CraniofacialAtlas dbSUPER 18.60 17.58 +79.4 12 2.5 ZIC2 ZNF217 SIN3A RXRA YY1 TAF1 TOE1 NFIB GLIS1 SP1 FAM178B SEMA4C ANKRD23 ANKRD39 SNRNP200 ENSG00000286654 HSALNG0017094
GH02J096879 Enhancer 1.5 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 11.30 16.79 +102.1 12 10.2 HCFC1 ZNF580 RCOR1 CTCF MBD2 NONO ZNF341 ZNF217 ZNF639 ZEB1 SNRNP200 KANSL3 ANKRD36 CNNM3 ANKRD36B LMAN2L CIAO1 C2orf92 ARID5A SEMA4C
GH02J097094 Promoter/Enhancer 1.3 EPDnew Ensembl ENCODE CraniofacialAtlas 12.10 15.96 -108.2 25 2.0 ATF1 SUPT5H CTCF ATF2 POLR2A MEIS2 L3MBTL2 CREB1 ZBTB8A RNF2 FAHD2B lnc-ANKRD36-3 ENSG00000279791 lnc-FAM178B-4 HSALNG0017111 FAM178B SNRNP200 piR-57014-003

GeneHancers around FAM178B on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FAM178B

Top Transcription factor binding sites by QIAGEN in the FAM178B gene promoter:
  • ATF-2
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4
  • E2F-5
  • FOXC1
  • FOXI1
  • HFH-3

Genomic Locations for FAM178B Gene

Latest Assembly
chr2:96,875,882-96,986,580
(GRCh38/hg38)
Size:
110,699 bases
Orientation:
Minus strand

Previous Assembly
chr2:97,541,622-97,652,317
(GRCh37/hg19 by Entrez Gene)
Size:
110,696 bases
Orientation:
Minus strand

chr2:97,541,620-97,684,175
(GRCh37/hg19 by Ensembl)
Size:
142,556 bases
Orientation:
Minus strand

Genomic View for FAM178B Gene

Genes around FAM178B on UCSC Golden Path with GeneCards custom tracks (GRCh38/hg38, GRCh37/hg19) IMPROVED

Cytogenetic band:
FAM178B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM178B Gene
Genomic Neighborhood
•
Exon Structure
•
Gene Densities
IMPROVED

RefSeq DNA sequence for FAM178B Gene

Proteins for FAM178B Gene

Subsections:

  1. 3D Structures
  2. Alternative Splicing
  3. Protein References
  4. Post-Translational Modifications

Products:

  1. Antibodies for research
  2. Protein products for research
  3. Assay products for research

  • Protein details for FAM178B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IXR5-F178B_HUMAN
    Recommended name:
    Protein FAM178B
    Protein Accession:
    Q8IXR5
    Secondary Accessions:
    • A8MXN2
    • E9PD86
    • Q8IUY0
    • Q9P0P4

    Protein attributes for FAM178B Gene

    Size:
    679 amino acids
    Molecular mass:
    76515 Da
    Quaternary structure:
    No Data Available
    Sequence caution:

    • The sequence AAF36154.1 differs from that shown. Reason: Frameshift {ECO:0000305}

    Three dimensional structure from AlphaFold (predicted) for FAM178B Gene

    NEW
    Model Confidence:
    Very high (pLDDT > 90)
    Confident (90 > pLDDT > 70)
    Low (70 > pLDDT > 50)
    Very low (pLDDT < 50)

    Alternative splice isoforms for FAM178B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FAM178B Gene

Post-translational modifications for FAM178B Gene

  • Modification sites at PhosphoSitePlus
    Q8IXR5
  • Modification sites at neXtProt
    NX_Q8IXR5

Other Protein References for FAM178B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FAM178B Gene

Domains & Families for FAM178B Gene

Gene Families for FAM178B Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FAM178B Gene

InterPro:

Suggested Antigen Peptide Sequences for FAM178B Gene

GenScript: Design optimal peptide antigens:
  • Protein FAM178B (F178B_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8IXR5

UniProtKB/Swiss-Prot:

F178B_HUMAN :
  • Belongs to the FAM178 family.
Family:
  • Belongs to the FAM178 family.
Genes that share domains with FAM178B: view

Function for FAM178B Gene

Subsections:

  1. GWAS Phenotypes
  2. MGI/GenomeRNAi Phenotypes

Products:

  1. Animal Models for research
  2. CRISPR products for research
  3. miRNA products for research
  4. Inhibitory RNAs for research
  5. Clone products for research
  6. Cell Lines for research

Phenotypes From GWAS Catalog for FAM178B Gene

Genes that share phenotypes with FAM178B: view

miRNA products for research

Clone products for research

NEW

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , NCBI Functional elements , Transcription Factor Targeted Genes and HOMER Transcription for FAM178B Gene

Localization for FAM178B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM178B gene
Compartment Confidence
cytosol 1
peroxisome 1
mitochondrion 1
plasma membrane 1
endoplasmic reticulum 0
extracellular 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (1)
  • Nuclear speckles (1)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FAM178B Gene

Pathways & Interactions for FAM178B Gene

Subsections:

  1. SuperPathways
  2. String Interactions
  3. Interacting Proteins
  4. GO Terms

Pathways by source for FAM178B Gene

1 WikiPathways pathway for FAM178B Gene

SuperPathways for FAM178B Gene

Genes that share pathways with FAM178B: view

Additional Pathway Information for FAM178B Gene

Interacting Proteins for FAM178B Gene

STRING Interaction Network Preview (showing top 1 STRING interactants - click image to see details)
STRING Interaction Network for FAM178B
Selected Interacting proteins: ENSP00000429896 Q8IXR5-F178B_HUMAN for FAM178B Gene via STRING IID

GPS-Prot Interaction Network for FAM178B

Gene Ontology (GO) - Biological Process for FAM178B Gene

IMPROVED
None

No data available for SIGNOR curated interactions for FAM178B Gene

Drugs & Compounds for FAM178B Gene

Subsections:

  1. Drugs
  2. Compounds

Products:

  1. Drug products for research

(1) Drugs for FAM178B Gene - From: PharmGKB and DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Lithium cation 22 93 Experimental 23 Pharma
Genes that share compounds with FAM178B: view

Transcripts for FAM178B Gene

Subsections:

  1. Alternative Splicing
  2. External Links

Products:

  1. CRISPR products for research
  2. miRNA products for research
  3. Inhibitory RNAs for research
  4. Clone products for research

mRNA/cDNA for FAM178B Gene

3 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

miRNA products for research

Clone products for research

NEW

Alternative Splicing Database (ASD) splice patterns (SP) for FAM178B Gene

No ASD Table

Relevant External Links for FAM178B Gene

GeneLoc Exon Structure for
FAM178B

Expression for FAM178B Gene

Subsections:

  1. Expression in stem cells

Products:

  1. Primer products for research
  2. Gene Expression Assays for research

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FAM178B Gene

mRNA expression in normal human tissues for FAM178B Gene
mRNA expression by GTEx for FAM178B GenemRNA expression by BioGPS for FAM178B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FAM178B Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x7.0), Testis (x5.2), and Nerve - Tibial (x4.0).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FAM178B

SOURCE GeneReport for Unigene cluster for FAM178B Gene:

Hs.107922

Bgee gene expression patterns for FAM178B gene:

  • Expressed in C1 segment of cervical spinal cord, tibial nerve, bone marrow and 131 other tissues.
Genes that share expression patterns with FAM178B: view

Primer products for research

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM178B Gene

Orthologs for FAM178B Gene

Subsections:

  1. CladeOScope co-evolved genes

This gene was present in the common ancestor of chordates.

Orthologs for FAM178B Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia FAM178B 28 29
  • 98.83 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia FAM178B 28 29
  • 79.88 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia FAM178B 28 29
  • 78.99 (n)
 OneToOne
Mouse
(Mus musculus)
 Mammalia Fam178b 28 16 29
  • 77.95 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Fam178b 28
  • 72.3 (n)
Oppossum
(Monodelphis domestica)
 Mammalia FAM178B 29
  • 40 (a)
 OneToOne
Platypus
(Ornithorhynchus anatinus)
 Mammalia FAM178B 29
  • 10 (a)
 OneToOne
Chicken
(Gallus gallus)
 Aves FAM178B 28 29
  • 54.41 (n)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia FAM178B 29
  • 40 (a)
 OneToOne
Species where no ortholog for FAM178B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for FAM178B Gene

ENSEMBL:
Gene Tree for FAM178B (if available)
TreeFam:
Gene Tree for FAM178B (if available)
Aminode:
Evolutionary constrained regions (ECRs) for FAM178B: view image
Alliance of Genome Resources:
Additional Orthologs for FAM178B

CladeOScope co-evolved genes for FAM178B gene NEW

Clade Top 10 Co-Evolved Genes Normalized Phylogenetic Profile HeatMap (PPH)
Top Genes From All Clades
Eukaryota
Chordata
Mammalia
Fungi
Viridiplantae
Archelosauria
Ecdysozoa
Nematoda
Arthropoda
Platyhelminthes
Alveolata
Stramenopiles
Fungi_Incertae_Sedis
Ascomycota
Basidiomycota
Liliopsida
Eudicotyledons

Paralogs for FAM178B Gene

Paralogs for FAM178B Gene

Genes that share paralogs with FAM178B: view

Variants for FAM178B Gene

Subsections:

  1. Variation Tolerance
  2. External Links

Products:

  1. SNP Genotyping and Copy Number Assays for research

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for FAM178B Gene

IMPROVED
SNP ID Clinical significance and condition Chr 02 pos Variation AA Info # Cit Type
rs34013660 5 4 p.Arg645Cys

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for FAM178B Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for FAM178B Gene

Variant ID Type Subtype PubMed ID
dgv607e201 CNV deletion 23290073
esv3425717 CNV duplication 20981092
esv5003 OTHER complex 18987735
nsv1135873 CNV deletion 24896259
nsv4057575 CNV duplication 32461652
nsv4312591 OTHER inversion 32461652
nsv526313 CNV loss 19592680
nsv4054389 CNV deletion 32461652
nsv4058622 CNV deletion 32461652
nsv4468211 CNV alu insertion 32461652
nsv1072425 CNV deletion 25765185
nsv582497 CNV loss 21841781
esv2759077 CNV gain+loss 17122850
nsv512773 CNV insertion 21212237
nsv3377616 CNV insertion 30661756
esv32727 CNV gain+loss 17666407
nsv4565853 CNV sva insertion 32461652
nsv582498 CNV loss 21841781
nsv4058755 CNV deletion 32461652
nsv4070375 CNV deletion 32461652
nsv4057849 CNV duplication 32461652
SVs/CNVs around FAM178B on UCSC Golden Path with GeneCards custom tracks (GRCh38/hg38, GRCh37/hg19)

Variation tolerance for FAM178B Gene

Gene Damage Index Score: 6.11; 75.48% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FAM178B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM178B
Leiden Open Variation Database (LOVD)
FAM178B

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM178B Gene

Disorders for FAM178B Gene

Subsections:

  1. External links

Products:

  1. Animal Models for research

Additional Disease Information for FAM178B

Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
Cancer Target Discovery and Development
(CTD² Dashboard)

No disorders were found for FAM178B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and GENATLAS for FAM178B Gene

Publications for FAM178B Gene

  1. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang QH … Chen Z (Genome research 2000) 2 3 4
  2. Genome-scale RNAi screen for host factors required for HIV replication. (PMID: 18976975) Zhou H … Espeseth AS (Cell host & microbe 2008) 3
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3
  4. A human protein-protein interaction network: a resource for annotating the proteome. (PMID: 16169070) Stelzl U … Wanker EE (Cell 2005) 3
  5. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 4

No data available for Mastermind for FAM178B Gene

Products for FAM178B Gene

Sources for FAM178B Gene