Aliases for FAM177B Gene

Aliases for FAM177B Gene

  • Family With Sequence Similarity 177 Member B 2 3 5
  • Protein FAM177B 3 4
  • Family With Sequence Similarity 177, Member B 2
  • RP11-452F19.2 2
  • FLJ43505 2
  • FAM177B 5

External Ids for FAM177B Gene

Previous GeneCards Identifiers for FAM177B Gene

  • GC01P220978
  • GC01P222910
  • GC01P193584

Summaries for FAM177B Gene

GeneCards Summary for FAM177B Gene

FAM177B (Family With Sequence Similarity 177 Member B) is a Protein Coding gene. An important paralog of this gene is FAM177A1.

Additional gene information for FAM177B Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FAM177B Gene

Genomics for FAM177B Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for FAM177B Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J222736 Enhancer 0.7 Ensembl ENCODE 250.7 -1.0 -986 3.6 FOXA2 MAFF ZNF316 ZNF205 MAFK FOXA1 MAFG ZNF140 HLF FOS FAM177B BROX ENSG00000272750 TAF1A CICP13 MIA3 HHIPL2 lnc-FAM177B-1 AIDA ENSG00000287684
GH01J222710 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 7.5 -24.7 -24701 4.6 TBP SP1 ZBTB10 FEZF1 SIX5 NR2C1 MNT IKZF1 SMAD5 ETS1 BROX AIDA lnc-FAM177B-3 CICP13 TAF1A ENSG00000272750 MIA3 HHIPL2 CAPN2 DISP1
GH01J222771 Promoter/Enhancer 0.9 Ensembl ENCODE 13.2 +35.6 35642 1.8 BCL11A EBF1 MYC MAX ELF1 IKZF1 TCF12 ZNF202 HLF RAD51 ENSG00000287684 HSALNG0010857 LOC105372984 CICP13 TAF1A FAM177B DISP1 MIA3 BROX
GH01J222738 Enhancer 0.6 ENCODE 9.9 +2.1 2072 1.9 CTCF CEBPB REST TRIM22 RXRA SMC3 RAD21 HNF4A CEBPG HNF4G ENSG00000272750 FAM177B HSALNG0010855 ENSG00000287684 DISP1
GH01J222767 Enhancer 0.5 Ensembl 13.3 +30.3 30299 1 IKZF1 IKZF2 MTA2 DPF2 RELB ENSG00000272750 FAM177B DISP1 HSALNG0010857 ENSG00000287684 LOC105372984 HSALNG0010855
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FAM177B on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FAM177B

Top Transcription factor binding sites by QIAGEN in the FAM177B gene promoter:
  • AREB6
  • HNF-3beta
  • HOXA9
  • HOXA9B
  • Meis-1
  • Meis-1b
  • Pax-6
  • POU2F1
  • POU2F1a
  • RP58

Genomic Locations for FAM177B Gene

Latest Assembly
34,992 bases
Plus strand

Previous Assembly
(GRCh37/hg19 by Entrez Gene)
13,604 bases
Plus strand

(GRCh37/hg19 by Ensembl)
13,599 bases
Plus strand

Genomic View for FAM177B Gene

Genes around FAM177B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM177B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM177B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM177B Gene

Proteins for FAM177B Gene

  • Protein details for FAM177B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein FAM177B
    Protein Accession:
    Secondary Accessions:
    • Q6ZUN8

    Protein attributes for FAM177B Gene

    158 amino acids
    Molecular mass:
    18145 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FAM177B Gene


neXtProt entry for FAM177B Gene

Post-translational modifications for FAM177B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FAM177B Gene

Domains & Families for FAM177B Gene

Gene Families for FAM177B Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FAM177B Gene


Suggested Antigen Peptide Sequences for FAM177B Gene

GenScript: Design optimal peptide antigens:
  • Protein FAM177B (F177B_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the FAM177 family.
  • Belongs to the FAM177 family.
genes like me logo Genes that share domains with FAM177B: view

Function for FAM177B Gene

Phenotypes From GWAS Catalog for FAM177B Gene

genes like me logo Genes that share phenotypes with FAM177B: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FAM177B

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FAM177B Gene

Localization for FAM177B Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM177B gene
Compartment Confidence
cytosol 2
extracellular 0
mitochondrion 0
nucleus 0

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for FAM177B Gene

Pathways & Interactions for FAM177B Gene

PathCards logo

SuperPathways for FAM177B Gene

No Data Available

Interacting Proteins for FAM177B Gene

STRING Interaction Network Preview (showing top 4 STRING interactants - click image to see details)
STRING Interaction Network
Selected Interacting proteins: ENSP00000414451 for FAM177B Gene via STRING

Gene Ontology (GO) - Biological Process for FAM177B Gene


No data available for Pathways by source and SIGNOR curated interactions for FAM177B Gene

Drugs & Compounds for FAM177B Gene

No Compound Related Data Available

Transcripts for FAM177B Gene

mRNA/cDNA for FAM177B Gene

2 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FAM177B

Alternative Splicing Database (ASD) splice patterns (SP) for FAM177B Gene

No ASD Table

Relevant External Links for FAM177B Gene

GeneLoc Exon Structure for

Expression for FAM177B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FAM177B Gene

mRNA differential expression in normal tissues according to GTEx for FAM177B Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (x14.6), Stomach (x12.2), Minor Salivary Gland (x4.4), and Colon - Transverse (x4.2).

Protein differential expression in normal tissues from HIPED for FAM177B Gene

This gene is overexpressed in Stomach (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FAM177B Gene

Protein tissue co-expression partners for FAM177B Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FAM177B

SOURCE GeneReport for Unigene cluster for FAM177B Gene:

genes like me logo Genes that share expression patterns with FAM177B: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM177B Gene

Orthologs for FAM177B Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM177B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FAM177B 30 31
  • 98.31 (n)
(Canis familiaris)
Mammalia FAM177B 30 31
  • 84.6 (n)
(Monodelphis domestica)
Mammalia FAM177B 31
  • 58 (a)
(Ornithorhynchus anatinus)
Mammalia FAM177B 31
  • 48 (a)
(Anolis carolinensis)
Reptilia FAM177B 31
  • 40 (a)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia fam177b 30
  • 58.93 (n)
(Danio rerio)
Actinopterygii FAM177B 31
  • 21 (a)
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.4574 31
  • 31 (a)
Species where no ortholog for FAM177B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for FAM177B Gene

Gene Tree for FAM177B (if available)
Gene Tree for FAM177B (if available)
Evolutionary constrained regions (ECRs) for FAM177B: view image

Paralogs for FAM177B Gene

Paralogs for FAM177B Gene

(1) SIMAP similar genes for FAM177B Gene using alignment to 3 proteins:

  • F177B_HUMAN
genes like me logo Genes that share paralogs with FAM177B: view

Variants for FAM177B Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for FAM177B Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
rs2378607 - p.Ile3Ser
rs6683071 - p.Gln143Arg

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for FAM177B Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for FAM177B Gene

Variant ID Type Subtype PubMed ID
esv3368539 CNV insertion 20981092

Variation tolerance for FAM177B Gene

Residual Variation Intolerance Score: 77.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.60; 12.85% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FAM177B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM177B Gene

Disorders for FAM177B Gene

Additional Disease Information for FAM177B

Genetic Association Database
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform

No disorders were found for FAM177B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM177B Gene

Publications for FAM177B Gene

  1. A genome-wide study of common SNPs and CNVs in cognitive performance in the CANTAB. (PMID: 19734545) Need AC … Goldstein DB (Human molecular genetics 2009) 3 41
  2. Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei. (PMID: 30021884) Fasci D … Heck AJR (Molecular & cellular proteomics : MCP 2018) 3
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 4

Products for FAM177B Gene

Sources for FAM177B Gene