Aliases for FAM174C Gene

Aliases for FAM174C Gene

  • Family With Sequence Similarity 174 Member C 2 3 5
  • Protein FAM174C 3 4
  • C19orf24 3 4
  • Chromosome 19 Open Reading Frame 24 2

External Ids for FAM174C Gene

Previous HGNC Symbols for FAM174C Gene

  • C19orf24

Previous GeneCards Identifiers for FAM174C Gene

  • GC19P001326

Summaries for FAM174C Gene

GeneCards Summary for FAM174C Gene

FAM174C (Family With Sequence Similarity 174 Member C) is a Protein Coding gene.

Additional gene information for FAM174C Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FAM174C Gene

Genomics for FAM174C Gene

GeneHancer (GH) Regulatory Elements for FAM174C Gene

Promoters and enhancers for FAM174C Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FAM174C on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FAM174C

Genomic Locations for FAM174C Gene

Genomic Locations for FAM174C Gene
chr19:1,275,521-1,279,244
(GRCh38/hg38)
Size:
3,724 bases
Orientation:
Plus strand
chr19:1,275,026-1,279,248
(GRCh37/hg19)
Size:
4,223 bases
Orientation:
Plus strand

Genomic View for FAM174C Gene

Genes around FAM174C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM174C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM174C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM174C Gene

Proteins for FAM174C Gene

  • Protein details for FAM174C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BVV8-F174C_HUMAN
    Recommended name:
    Protein FAM174C
    Protein Accession:
    Q9BVV8
    Secondary Accessions:
    • Q9NWS2

    Protein attributes for FAM174C Gene

    Size:
    132 amino acids
    Molecular mass:
    14249 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA91305.1; Type=Miscellaneous discrepancy; Evidence={ECO:0000305};

neXtProt entry for FAM174C Gene

Post-translational modifications for FAM174C Gene

  • Glycosylation at Asn47
  • Modification sites at PhosphoSitePlus

Other Protein References for FAM174C Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FAM174C Gene

Domains & Families for FAM174C Gene

Gene Families for FAM174C Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for FAM174C Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM174C Gene

GenScript: Design optimal peptide antigens:
  • Uncharacterized membrane protein C19orf24 (CS024_HUMAN)
  • Chromosome 19 open reading frame 24, isoform CRA_a (D6W5Y7_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9BVV8

UniProtKB/Swiss-Prot:

F174C_HUMAN :
  • Belongs to the FAM174 family.
Family:
  • Belongs to the FAM174 family.
genes like me logo Genes that share domains with FAM174C: view

Function for FAM174C Gene

Phenotypes From GWAS Catalog for FAM174C Gene

genes like me logo Genes that share phenotypes with FAM174C: view

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM174C Gene

Localization for FAM174C Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM174C Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM174C gene
Compartment Confidence
extracellular 5
nucleus 2
golgi apparatus 2
cytosol 1
plasma membrane 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
  • Nuclear speckles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for FAM174C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IDA 16847563
GO:0005737 cytoplasm IDA 16847563
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with FAM174C: view

Pathways & Interactions for FAM174C Gene

PathCards logo

SuperPathways for FAM174C Gene

No Data Available

Interacting Proteins for FAM174C Gene

;

Gene Ontology (GO) - Biological Process for FAM174C Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FAM174C Gene

Drugs & Compounds for FAM174C Gene

No Compound Related Data Available

Transcripts for FAM174C Gene

mRNA/cDNA for FAM174C Gene

1 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM174C Gene

No ASD Table

Relevant External Links for FAM174C Gene

GeneLoc Exon Structure for
FAM174C

Expression for FAM174C Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FAM174C

SOURCE GeneReport for Unigene cluster for FAM174C Gene:

Hs.591383
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM174C Gene

Orthologs for FAM174C Gene

This gene was present in the common ancestor of mammals.

Orthologs for FAM174C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C19orf24 31
  • 98 (a)
OneToOne
C19H19orf24 30
  • 95.2 (n)
dog
(Canis familiaris)
Mammalia C19orf24 31
  • 88 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C7H19orf24 31 30
  • 81.13 (n)
OneToOne
mouse
(Mus musculus)
Mammalia 1600002K03Rik 31 30
  • 69.18 (n)
OneToOne
Fam174c 17
rat
(Rattus norvegicus)
Mammalia RGD1562114 30
  • 66.67 (n)
Species where no ortholog for FAM174C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FAM174C Gene

ENSEMBL:
Gene Tree for FAM174C (if available)
TreeFam:
Gene Tree for FAM174C (if available)

Paralogs for FAM174C Gene

No data available for Paralogs for FAM174C Gene

Variants for FAM174C Gene

Additional dbSNP identifiers (rs#s) for FAM174C Gene

Structural Variations from Database of Genomic Variants (DGV) for FAM174C Gene

Variant ID Type Subtype PubMed ID
dgv136n111 CNV deletion 26073780
esv1779341 CNV insertion 17803354
esv2758743 CNV gain+loss 17122850
esv3368458 CNV duplication 20981092
esv3395739 CNV insertion 20981092
esv3643389 CNV gain 21293372
esv3643390 CNV loss 21293372
esv3643391 CNV gain 21293372
esv990677 CNV insertion 20482838
nsv1055164 CNV gain 25217958
nsv1058677 CNV loss 25217958
nsv1060536 CNV gain 25217958
nsv1143898 CNV deletion 24896259
nsv1160555 CNV deletion 26073780
nsv138017 CNV insertion 16902084
nsv470103 CNV gain 18288195
nsv470104 CNV loss 18288195
nsv953941 CNV deletion 24416366
nsv9662 CNV gain 18304495

Variation tolerance for FAM174C Gene

Gene Damage Index Score: 0.57; 12.22% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FAM174C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM174C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for FAM174C Gene

Disorders for FAM174C Gene

No disorders were found for FAM174C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for FAM174C Gene

Publications for FAM174C Gene

  1. A novel recently evolved gene C19orf24 encodes a non-classical secreted protein. (PMID: 16847563) Wang XR … Han ZG (Cellular & molecular biology letters 2006) 2 3 54
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3 54
  5. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PMID: 20068231) Olsen JV … Mann M (Science signaling 2010) 4 54

No data available for Mastermind for FAM174C Gene

Products for FAM174C Gene

Sources for FAM174C Gene