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Aliases for FAM173B Gene

Aliases for FAM173B Gene

  • Family With Sequence Similarity 173 Member B 2 3 5
  • Family With Sequence Similarity 173, Member B 2
  • Protein FAM173B 3
  • JS-2 3

External Ids for FAM173B Gene

Previous GeneCards Identifiers for FAM173B Gene

  • GC05M010280

Summaries for FAM173B Gene

GeneCards Summary for FAM173B Gene

FAM173B (Family With Sequence Similarity 173 Member B) is a Protein Coding gene. An important paralog of this gene is FAM173A.

Additional gene information for FAM173B Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM173B Gene

Genomics for FAM173B Gene

GeneHancer (GH) Regulatory Elements for FAM173B Gene

Promoters and enhancers for FAM173B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05I010248 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 558.1 -0.3 -325 4.1 CLOCK MLX ZFP64 DMAP1 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC CCT5 FAM173B MARCH6 CMBL ENSG00000271980 ROPN1L ROPN1L-AS1 ENSG00000248968 GC05M010252
GH05I010304 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 6.9 -58.2 -58164 6.6 HDGF PKNOX1 SMAD1 FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B CMBL MARCH6 ROPN1L-AS1 ROPN1L FAM173B CCT5 ENSG00000271980 LOC105374651 GC05M010284
GH05I010606 Enhancer 1.4 FANTOM5 Ensembl ENCODE 10.8 -357.7 -357729 2.5 HDGF PKNOX1 ARNT FEZF1 ZNF2 IRF4 ZNF766 ZNF213 JUNB REST ANKRD33B ANKRD33B-AS1 LINC02213 ROPN1L ROPN1L-AS1 FAM173B LINC01513 ENSG00000251196 MARCH6 GC05P010606
GH05I010288 Enhancer 1.4 Ensembl ENCODE dbSUPER 8.4 -39.5 -39511 3 PKNOX1 FOXA2 CLOCK SMAD1 NEUROD1 SIN3A FEZF1 YY1 ZNF121 GLIS2 ENSG00000271980 ENSG00000272417 CMBL FAM173B CCT5 ENSG00000252341 GC05M010293 ENSG00000271715 GC05M010284
GH05I010228 Enhancer 0.4 ENCODE 24.4 +20.6 20567 1.5 CTCF FOS RAD21 GC05P010230 PIR42000 FAM173B
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around FAM173B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FAM173B gene promoter:

Genomic Locations for FAM173B Gene

Genomic Locations for FAM173B Gene
chr5:10,225,507-10,250,036
(GRCh38/hg38)
Size:
24,530 bases
Orientation:
Minus strand
chr5:10,226,438-10,250,014
(GRCh37/hg19)

Genomic View for FAM173B Gene

Genes around FAM173B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM173B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM173B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM173B Gene

Proteins for FAM173B Gene

  • Protein details for FAM173B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6P4H8-F173B_HUMAN
    Recommended name:
    Protein FAM173B
    Protein Accession:
    Q6P4H8
    Secondary Accessions:
    • B4DT41
    • B4DXK2
    • E9PBZ4

    Protein attributes for FAM173B Gene

    Size:
    233 amino acids
    Molecular mass:
    26110 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FAM173B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FAM173B Gene

Post-translational modifications for FAM173B Gene

No Post-translational modifications

Other Protein References for FAM173B Gene

No data available for DME Specific Peptides for FAM173B Gene

Domains & Families for FAM173B Gene

Gene Families for FAM173B Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for FAM173B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM173B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6P4H8

UniProtKB/Swiss-Prot:

F173B_HUMAN :
  • Belongs to the FAM173 family.
Family:
  • Belongs to the FAM173 family.
genes like me logo Genes that share domains with FAM173B: view

Function for FAM173B Gene

Phenotypes From GWAS Catalog for FAM173B Gene

genes like me logo Genes that share phenotypes with FAM173B: view

Animal Model Products

CRISPR Products

miRNA for FAM173B Gene

miRTarBase miRNAs that target FAM173B

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM173B Gene

Localization for FAM173B Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM173B Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM173B gene
Compartment Confidence
peroxisome 2
cytosol 2
plasma membrane 1
extracellular 1
mitochondrion 1
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleus (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for FAM173B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with FAM173B: view

Pathways & Interactions for FAM173B Gene

SuperPathways for FAM173B Gene

No Data Available

Interacting Proteins for FAM173B Gene

Gene Ontology (GO) - Biological Process for FAM173B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FAM173B Gene

Drugs & Compounds for FAM173B Gene

No Compound Related Data Available

Transcripts for FAM173B Gene

Unigene Clusters for FAM173B Gene

Family with sequence similarity 173, member B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM173B Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b · 7c · 7d
SP1: - -
SP2: - - - -
SP3: - - - -
SP4: - - - - -
SP5: - - -
SP6: - - -
SP7:

Relevant External Links for FAM173B Gene

GeneLoc Exon Structure for
FAM173B
ECgene alternative splicing isoforms for
FAM173B

Expression for FAM173B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM173B Gene

Protein differential expression in normal tissues from HIPED for FAM173B Gene

This gene is overexpressed in Cervix (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FAM173B Gene



Protein tissue co-expression partners for FAM173B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FAM173B Gene:

FAM173B

SOURCE GeneReport for Unigene cluster for FAM173B Gene:

Hs.481569

Evidence on tissue expression from TISSUES for FAM173B Gene

  • Intestine(4.1)
genes like me logo Genes that share expression patterns with FAM173B: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM173B Gene

Orthologs for FAM173B Gene

This gene was present in the common ancestor of animals.

Orthologs for FAM173B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM173B 33 34
  • 99.43 (n)
dog
(Canis familiaris)
Mammalia FAM173B 33 34
  • 82.96 (n)
cow
(Bos Taurus)
Mammalia FAM173B 33 34
  • 81.26 (n)
rat
(Rattus norvegicus)
Mammalia Fam173b 33
  • 79.46 (n)
mouse
(Mus musculus)
Mammalia Fam173b 33 16 34
  • 76.78 (n)
oppossum
(Monodelphis domestica)
Mammalia FAM173B 34
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FAM173B 34
  • 62 (a)
OneToOne
chicken
(Gallus gallus)
Aves FAM173B 33 34
  • 66.67 (n)
lizard
(Anolis carolinensis)
Reptilia FAM173B 34
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fam173b 33
  • 68.16 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.29791 33
zebrafish
(Danio rerio)
Actinopterygii fam173b 33 34
  • 67.24 (n)
Dr.8653 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4845 33
fruit fly
(Drosophila melanogaster)
Insecta CG3337 33 34
  • 51.98 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002286 33
  • 50.91 (n)
worm
(Caenorhabditis elegans)
Secernentea CELE_Y39A1A.21 33
  • 50 (n)
Y39A1A.21 34
  • 43 (a)
OneToMany
Species where no ortholog for FAM173B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FAM173B Gene

ENSEMBL:
Gene Tree for FAM173B (if available)
TreeFam:
Gene Tree for FAM173B (if available)

Paralogs for FAM173B Gene

Paralogs for FAM173B Gene

(1) SIMAP similar genes for FAM173B Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for FAM173B Gene

genes like me logo Genes that share paralogs with FAM173B: view

Variants for FAM173B Gene

Sequence variations from dbSNP and Humsavar for FAM173B Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs141133834 uncertain-significance, Sensory Neuropathy with Spastic Paraplegia 10,250,426(-) T/C/G upstream_transcript_variant
rs2548546 benign, Sensory Neuropathy with Spastic Paraplegia 10,250,318(-) G/A/T upstream_transcript_variant
rs2578618 benign, Sensory Neuropathy with Spastic Paraplegia 10,250,331(-) T/A/C upstream_transcript_variant
rs552002776 uncertain-significance, Sensory Neuropathy with Spastic Paraplegia 10,250,216(-) A/C/G upstream_transcript_variant
rs574425461 uncertain-significance, Sensory Neuropathy with Spastic Paraplegia 10,250,293(-) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for FAM173B Gene

Variant ID Type Subtype PubMed ID
nsv830201 CNV gain 17160897
nsv597112 CNV gain 21841781
nsv525565 CNV loss 19592680
nsv461975 CNV gain 19166990
nsv1029129 CNV gain 25217958
esv33231 CNV loss 17666407

Variation tolerance for FAM173B Gene

Residual Variation Intolerance Score: 74.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.49; 92.91% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FAM173B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM173B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM173B Gene

Disorders for FAM173B Gene

Additional Disease Information for FAM173B

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for FAM173B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM173B Gene

Publications for FAM173B Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  4. Genome-wide association study meta-analysis of chronic widespread pain: evidence for involvement of the 5p15.2 region. (PMID: 22956598) Peters MJ … van Meurs JB (Annals of the rheumatic diseases 2013) 3 58
  5. N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. (PMID: 22814378) Van Damme P … Aldabe R (Proceedings of the National Academy of Sciences of the United States of America 2012) 4 58

Products for FAM173B Gene

Sources for FAM173B Gene

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