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Aliases for FAM173A Gene

Aliases for FAM173A Gene

  • Family With Sequence Similarity 173 Member A 2 3 5
  • C16orf24 3 4
  • Family With Sequence Similarity 173, Member A 2
  • Chromosome 16 Open Reading Frame 24 2
  • Protein FAM173A 3

External Ids for FAM173A Gene

Previous HGNC Symbols for FAM173A Gene

  • C16orf24

Previous GeneCards Identifiers for FAM173A Gene

  • GC16P000713
  • GC16P000771
  • GC16P000693
  • GC16P000770
  • GC16P000819
  • GC16P000863
  • GC16P000878
  • GC16P000896
  • GC16P000913
  • GC16P000934
  • GC16P000952
  • GC16P000984

Summaries for FAM173A Gene

GeneCards Summary for FAM173A Gene

FAM173A (Family With Sequence Similarity 173 Member A) is a Protein Coding gene. Diseases associated with FAM173A include Myopathy, Centronuclear, 4. An important paralog of this gene is FAM173B.

Additional gene information for FAM173A Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM173A Gene

Genomics for FAM173A Gene

GeneHancer (GH) Regulatory Elements for FAM173A Gene

Promoters and enhancers for FAM173A Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J000718 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 650.7 +0.2 182 3.6 HDGF PKNOX1 SIN3A ZNF2 ZBTB7B POLR2B ZNF207 ZNF143 DEK SP3 FAM173A PIR42074 UBE2I CRAMP1 UNKL LUC7L ENSG00000268836 WDR24 CIAO3 WDR90
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FAM173A on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FAM173A gene promoter:
  • XBP-1
  • Zic3
  • USF1
  • USF-1
  • AP-1
  • AML1a
  • c-Myb
  • Zic1
  • c-Ets-1
  • FOXF2

Genomic Locations for FAM173A Gene

Genomic Locations for FAM173A Gene
2,021 bases
Plus strand
2,021 bases
Plus strand

Genomic View for FAM173A Gene

Genes around FAM173A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM173A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM173A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM173A Gene

Proteins for FAM173A Gene

  • Protein details for FAM173A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein FAM173A
    Protein Accession:
    Secondary Accessions:
    • A2IDD4

    Protein attributes for FAM173A Gene

    235 amino acids
    Molecular mass:
    25130 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FAM173A Gene

Post-translational modifications for FAM173A Gene

  • Glycosylation at Asn144
  • Modification sites at PhosphoSitePlus

Other Protein References for FAM173A Gene

No data available for DME Specific Peptides for FAM173A Gene

Domains & Families for FAM173A Gene

Gene Families for FAM173A Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for FAM173A Gene


Suggested Antigen Peptide Sequences for FAM173A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the FAM173 family.
  • Belongs to the FAM173 family.
genes like me logo Genes that share domains with FAM173A: view

Function for FAM173A Gene

genes like me logo Genes that share phenotypes with FAM173A: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FAM173A

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FAM173A Gene

Localization for FAM173A Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM173A Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM173A gene
Compartment Confidence
cytosol 3
extracellular 1
mitochondrion 1
peroxisome 1
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for FAM173A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with FAM173A: view

Pathways & Interactions for FAM173A Gene

SuperPathways for FAM173A Gene

No Data Available

Interacting Proteins for FAM173A Gene

Gene Ontology (GO) - Biological Process for FAM173A Gene


No data available for Pathways by source and SIGNOR curated interactions for FAM173A Gene

Drugs & Compounds for FAM173A Gene

No Compound Related Data Available

Transcripts for FAM173A Gene

mRNA/cDNA for FAM173A Gene

Unigene Clusters for FAM173A Gene

Family with sequence similarity 173, member A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FAM173A

Alternative Splicing Database (ASD) splice patterns (SP) for FAM173A Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c
SP1: - - -
SP2: - - - -
SP3: - -
SP4: - - -
SP5: -
SP6: -
SP7: - -

Relevant External Links for FAM173A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAM173A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM173A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FAM173A Gene

NURSA nuclear receptor signaling pathways regulating expression of FAM173A Gene:


SOURCE GeneReport for Unigene cluster for FAM173A Gene:


Evidence on tissue expression from TISSUES for FAM173A Gene

  • Eye(4)
genes like me logo Genes that share expression patterns with FAM173A: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM173A Gene

Orthologs for FAM173A Gene

This gene was present in the common ancestor of animals.

Orthologs for FAM173A Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FAM173A 34 33
  • 98.87 (n)
(Bos Taurus)
Mammalia FAM173A 34 33
  • 86.61 (n)
(Rattus norvegicus)
Mammalia Fam173a 33
  • 79.73 (n)
(Mus musculus)
Mammalia Fam173a 16 34 33
  • 78.37 (n)
(Monodelphis domestica)
Mammalia FAM173A 34
  • 70 (a)
(Ornithorhynchus anatinus)
Mammalia FAM173A 34
  • 67 (a)
(Gallus gallus)
Aves FAM173A 34 33
  • 66.67 (n)
(Anolis carolinensis)
Reptilia FAM173A 34
  • 57 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fam173a 33
  • 66.5 (n)
(Danio rerio)
Actinopterygii fam173a 34 33
  • 55.56 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG3337 34
  • 35 (a)
(Caenorhabditis elegans)
Secernentea Y39A1A.21 34
  • 33 (a)
Species where no ortholog for FAM173A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FAM173A Gene

Gene Tree for FAM173A (if available)
Gene Tree for FAM173A (if available)
Evolutionary constrained regions (ECRs) for FAM173A: view image

Paralogs for FAM173A Gene

Paralogs for FAM173A Gene

(1) SIMAP similar genes for FAM173A Gene using alignment to 4 proteins:

  • F173A_HUMAN
genes like me logo Genes that share paralogs with FAM173A: view

Variants for FAM173A Gene

Sequence variations from dbSNP and Humsavar for FAM173A Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs146067716 likely-benign, Myopathy, centronuclear, 4 722,978(+) C/T downstream_transcript_variant
rs148276717 benign, likely-benign, not specified, Myopathy, centronuclear, 4 722,985(+) C/T downstream_transcript_variant
rs201006875 likely-benign, Myopathy, centronuclear, 4 722,797(+) G/T downstream_transcript_variant
rs760280521 uncertain-significance, Myopathy, centronuclear, 4 722,948(+) C/T downstream_transcript_variant
rs771507948 uncertain-significance, Myopathy, centronuclear, 4 723,009(+) C/T downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for FAM173A Gene

Variant ID Type Subtype PubMed ID
dgv4825n54 CNV loss 21841781
esv2422427 CNV duplication 17116639
nsv1160325 CNV duplication 26073780
nsv1160326 CNV duplication 26073780
nsv457311 CNV loss 19166990
nsv471063 CNV loss 18288195
nsv471065 CNV gain 18288195
nsv516590 CNV loss 19592680
nsv526903 CNV loss 19592680
nsv571012 CNV loss 21841781
nsv571021 CNV loss 21841781
nsv571022 CNV loss 21841781
nsv9321 CNV gain+loss 18304495
nsv952898 CNV deletion 24416366

Variation tolerance for FAM173A Gene

Gene Damage Index Score: 3.27; 52.94% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FAM173A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM173A Gene

Disorders for FAM173A Gene

MalaCards: The human disease database

(1) MalaCards diseases for FAM173A Gene - From: GeneCards

Disorder Aliases PubMed IDs
myopathy, centronuclear, 4
  • cnm4
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for FAM173A

genes like me logo Genes that share disorders with FAM173A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FAM173A Gene

Publications for FAM173A Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  2. Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16. (PMID: 11157797) Daniels RJ … Higgs DR (Human molecular genetics 2001) 3 4 58
  3. A germline-specific class of small RNAs binds mammalian Piwi proteins. (PMID: 16751776) Girard A … Carmell MA (Nature 2006) 3 58
  4. A human protein-protein interaction network: a resource for annotating the proteome. (PMID: 16169070) Stelzl U … Wanker EE (Cell 2005) 3 58
  5. The sequence and analysis of duplication-rich human chromosome 16. (PMID: 15616553) Martin J … Pennacchio LA (Nature 2004) 4 58

Products for FAM173A Gene

Sources for FAM173A Gene

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