Aliases for FAM170B Gene

Aliases for FAM170B Gene

  • Family With Sequence Similarity 170 Member B 2 3 5
  • Acrosome-Related Protein 3 4
  • Protein FAM170B 3 4
  • C10orf73 3 4
  • Family With Sequence Similarity 170, Member B 2
  • Chromosome 10 Open Reading Frame 73 2
  • Putative Protein FAM170B 3

External Ids for FAM170B Gene

Previous HGNC Symbols for FAM170B Gene

  • C10orf73

Previous GeneCards Identifiers for FAM170B Gene

  • GC10M050010
  • GC10M050339
  • GC10M044603

Summaries for FAM170B Gene

GeneCards Summary for FAM170B Gene

FAM170B (Family With Sequence Similarity 170 Member B) is a Protein Coding gene.

UniProtKB/Swiss-Prot Summary for FAM170B Gene

Additional gene information for FAM170B Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FAM170B Gene

Genomics for FAM170B Gene

GeneHancer (GH) Regulatory Elements for FAM170B Gene

Promoters and enhancers for FAM170B Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J049134 Enhancer 1 FANTOM5 Ensembl ENCODE 774.3 -1.3 -1254 2.9 IKZF1 PRDM10 TRIM22 ZNF629 ATF7 IKZF2 ZNF184 FOXA2 ATF2 ZMYM3 FAM170B VSTM4 LRRC18 TMEM273 FAM170B-AS1 lnc-FAM170B-1
GH10J049113 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 17 +19.3 19269 2.5 ZBTB40 CTCF ZBTB6 L3MBTL2 PRDM1 ZIC2 REST ZNF639 ZNF24 POLR2A VSTM4 FAM170B RNA5SP317 TIMM23B-AGAP6 LRRC18 FAM170B-AS1 piR-33313-002
GH10J049108 Enhancer 0.9 Ensembl ENCODE CraniofacialAtlas dbSUPER 29.3 +23.8 23819 2.8 POLR2A NR2F2 KLF1 FAM170B FAM170B-AS1 VSTM4 piR-33313-002
GH10J049137 Enhancer 1 FANTOM5 Ensembl ENCODE 20.1 -5.6 -5563 3.6 SMARCA4 IKZF1 IKZF2 ZNF316 HDGF FOS FOSL1 CREM FOSL2 ATF1 FAM170B TMEM273 FAM170B-AS1 lnc-FAM170B-1
GH10J049106 Enhancer 0.7 Ensembl dbSUPER 25.5 +27.0 27019 1.2 FOXA1 SP1 RXRA FOXA2 JUND RAD21 HNF4A HNF4G ZBTB33 FAM170B FAM170B-AS1 piR-33313-002 VSTM4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FAM170B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FAM170B gene promoter:
  • AP-4
  • FOXO4
  • GATA-6
  • Lhx3a
  • LHX3b
  • Nkx2-5
  • POU2F1
  • POU2F1a
  • POU3F1
  • RORalpha2

Genomic Locations for FAM170B Gene

Genomic Locations for FAM170B Gene
2,867 bases
Minus strand
2,867 bases
Minus strand

Genomic View for FAM170B Gene

Genes around FAM170B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM170B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM170B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM170B Gene

Proteins for FAM170B Gene

  • Protein details for FAM170B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein FAM170B
    Protein Accession:
    Secondary Accessions:
    • Q86WY6
    • Q8N6K8

    Protein attributes for FAM170B Gene

    283 amino acids
    Molecular mass:
    32092 Da
    Quaternary structure:
    • Interacts with GOPC.
    • Sequence=AAH29839.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAH47597.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for FAM170B Gene

Post-translational modifications for FAM170B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM170B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FAM170B Gene

Domains & Families for FAM170B Gene

Gene Families for FAM170B Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FAM170B Gene


Suggested Antigen Peptide Sequences for FAM170B Gene

GenScript: Design optimal peptide antigens:
  • Putative protein FAM170B (F170B_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the FAM170 family.
  • Belongs to the FAM170 family.
genes like me logo Genes that share domains with FAM170B: view

Function for FAM170B Gene

Molecular function for FAM170B Gene

UniProtKB/Swiss-Prot Function:
Plays a role in fertilization through the acrosome reaction.

Phenotypes From GWAS Catalog for FAM170B Gene

Gene Ontology (GO) - Molecular Function for FAM170B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 26179146
genes like me logo Genes that share ontologies with FAM170B: view

Phenotypes for FAM170B Gene

genes like me logo Genes that share phenotypes with FAM170B: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FAM170B Gene

Localization for FAM170B Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM170B Gene

Cytoplasmic vesicle, secretory vesicle, acrosome. Cytoplasmic vesicle, secretory vesicle, acrosome outer membrane.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM170B gene
Compartment Confidence
nucleus 2
cytosol 2

Gene Ontology (GO) - Cellular Components for FAM170B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001669 acrosomal vesicle IDA 26179146
GO:0002081 outer acrosomal membrane ISS --
GO:0016020 membrane IEA --
GO:0031410 cytoplasmic vesicle IEA --
genes like me logo Genes that share ontologies with FAM170B: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for FAM170B Gene

Pathways & Interactions for FAM170B Gene

PathCards logo

SuperPathways for FAM170B Gene

No Data Available

Interacting Proteins for FAM170B Gene

Gene Ontology (GO) - Biological Process for FAM170B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0080154 regulation of fertilization ISS --
GO:2000344 positive regulation of acrosome reaction ISS --
genes like me logo Genes that share ontologies with FAM170B: view

No data available for Pathways by source and SIGNOR curated interactions for FAM170B Gene

Drugs & Compounds for FAM170B Gene

No Compound Related Data Available

Transcripts for FAM170B Gene

mRNA/cDNA for FAM170B Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM170B Gene

No ASD Table

Relevant External Links for FAM170B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAM170B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM170B Gene

mRNA differential expression in normal tissues according to GTEx for FAM170B Gene

This gene is overexpressed in Testis (x42.1).

NURSA nuclear receptor signaling pathways regulating expression of FAM170B Gene:


SOURCE GeneReport for Unigene cluster for FAM170B Gene:


mRNA Expression by UniProt/SwissProt for FAM170B Gene:

Tissue specificity: Exclusively expressed in adult testis.

Evidence on tissue expression from TISSUES for FAM170B Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with FAM170B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM170B Gene

Orthologs for FAM170B Gene

This gene was present in the common ancestor of mammals.

Orthologs for FAM170B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FAM170B 33 32
  • 98.36 (n)
(Bos Taurus)
Mammalia FAM170B 33 32
  • 76.8 (n)
(Canis familiaris)
Mammalia FAM170B 32
  • 75.16 (n)
-- 33
  • 15 (a)
(Rattus norvegicus)
Mammalia Fam170b 32
  • 73.21 (n)
(Mus musculus)
Mammalia Fam170b 17 33 32
  • 73.14 (n)
(Monodelphis domestica)
Mammalia FAM170B 33
  • 35 (a)
(Ornithorhynchus anatinus)
Mammalia FAM170B 33
  • 35 (a)
Species where no ortholog for FAM170B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FAM170B Gene

Gene Tree for FAM170B (if available)
Gene Tree for FAM170B (if available)
Evolutionary constrained regions (ECRs) for FAM170B: view image

Paralogs for FAM170B Gene

No data available for Paralogs for FAM170B Gene

Variants for FAM170B Gene

Sequence variations from dbSNP and Humsavar for FAM170B Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs1001928647 -- 49,135,450(-) A/G upstream_transcript_variant
rs1001937976 -- 49,134,640(-) C/T upstream_transcript_variant
rs1002098928 -- 49,130,985(-) A/C/G downstream_transcript_variant
rs1002372918 -- 49,135,272(-) G/A upstream_transcript_variant
rs1003978817 -- 49,135,754(-) A/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for FAM170B Gene

Variant ID Type Subtype PubMed ID
esv3623164 CNV loss 21293372
nsv1042677 CNV loss 25217958

Variation tolerance for FAM170B Gene

Gene Damage Index Score: 9.34; 88.35% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FAM170B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM170B Gene

Disorders for FAM170B Gene

Additional Disease Information for FAM170B

No disorders were found for FAM170B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM170B Gene

Publications for FAM170B Gene

  1. FAM170B, a novel acrosomal protein involved in fertilization in mice. (PMID: 26179146) Li Y … Gui Y (Molecular reproduction and development 2015) 2 3 4 56
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3 56
  3. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P … Rogers J (Nature 2004) 4 56
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 56
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 56

Products for FAM170B Gene

Sources for FAM170B Gene