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Aliases for FAM170A Gene

Aliases for FAM170A Gene

  • Family With Sequence Similarity 170 Member A 2 3 5
  • Zinc Finger Domain-Containing Protein 3 4
  • Zinc Finger Protein ZNFD 3 4
  • ZNFD 3 4
  • Family With Sequence Similarity 170, Member A 2
  • Znf Domain Containing Protein 3
  • Protein FAM170A 3

External Ids for FAM170A Gene

Previous GeneCards Identifiers for FAM170A Gene

  • GC05P118994
  • GC05P114160

Summaries for FAM170A Gene

GeneCards Summary for FAM170A Gene

FAM170A (Family With Sequence Similarity 170 Member A) is a Protein Coding gene. An important paralog of this gene is FAM170B.

UniProtKB/Swiss-Prot for FAM170A Gene

  • Acts as a nuclear transcription factor that positively regulates the expression of heat shock genes. Binds to heat shock promoter elements (HSE).

Additional gene information for FAM170A Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM170A Gene

Genomics for FAM170A Gene

GeneHancer (GH) Regulatory Elements for FAM170A Gene

Promoters and enhancers for FAM170A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05I119629 Promoter 0.7 EPDnew 550.8 0.0 -13 0.1 CREB1 NR2C1 ATF2 FAM170A HSD17B4 FABP5P6
GH05I119451 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 12.8 -176.6 -176598 2.2 HDGF PKNOX1 FOXA2 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 HSD17B4 FAM170A RPL21P58
GH05I119410 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 9.7 -217.8 -217791 2.1 PKNOX1 ATF1 ARNT ARID4B SIN3A ZNF2 YY1 ZNF213 ARID2 ZNF143 TNFAIP8 DTWD2 ENSG00000250678 RNU6-373P HSD17B4 FAM170A DMXL1 GC05P119446 LOC102723444
GH05I119317 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 5.8 -298.0 -298013 27.1 FEZF1 IRF4 ZNF213 E2F8 ZNF143 MEF2D ZNF610 GLIS1 NBN NR2C1 TNFAIP8 DMXL1 LAMTOR3P2 LOC105379143 FAM170A HSD17B4 ENSG00000249426 GC05P119341 GC05M119307 RN7SL174P
GH05I119417 Enhancer 1.2 Ensembl ENCODE dbSUPER 10.8 -210.1 -210103 3.5 HDAC1 YBX3 PKNOX1 FOXA2 NFIB ZNF766 ATF7 IKZF2 SMAD5 GTF2B HSD17B4 FAM170A DTWD2 PTMAP2 GC05P119446 LOC102723444
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around FAM170A on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FAM170A gene promoter:

Genomic Locations for FAM170A Gene

Genomic Locations for FAM170A Gene
chr5:119,629,559-119,635,822
(GRCh38/hg38)
Size:
6,264 bases
Orientation:
Plus strand
chr5:118,965,254-118,971,517
(GRCh37/hg19)

Genomic View for FAM170A Gene

Genes around FAM170A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM170A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM170A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM170A Gene

Proteins for FAM170A Gene

  • Protein details for FAM170A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A1A519-F170A_HUMAN
    Recommended name:
    Protein FAM170A
    Protein Accession:
    A1A519
    Secondary Accessions:
    • Q66LM8
    • Q7Z4V2
    • Q8IW94

    Protein attributes for FAM170A Gene

    Size:
    330 amino acids
    Molecular mass:
    37158 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH40622.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for FAM170A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FAM170A Gene

Post-translational modifications for FAM170A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM170A Gene

No data available for DME Specific Peptides for FAM170A Gene

Domains & Families for FAM170A Gene

Gene Families for FAM170A Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FAM170A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM170A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A1A519

UniProtKB/Swiss-Prot:

F170A_HUMAN :
  • The N-terminus is necessary for nuclear localization. The C-terminus is necessary for transcriptional activity.
  • Belongs to the FAM170 family.
Domain:
  • The N-terminus is necessary for nuclear localization. The C-terminus is necessary for transcriptional activity.
Family:
  • Belongs to the FAM170 family.
genes like me logo Genes that share domains with FAM170A: view

Function for FAM170A Gene

Molecular function for FAM170A Gene

UniProtKB/Swiss-Prot Function:
Acts as a nuclear transcription factor that positively regulates the expression of heat shock genes. Binds to heat shock promoter elements (HSE).

Phenotypes From GWAS Catalog for FAM170A Gene

Gene Ontology (GO) - Molecular Function for FAM170A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with FAM170A: view

Phenotypes for FAM170A Gene

GenomeRNAi human phenotypes for FAM170A:
genes like me logo Genes that share phenotypes with FAM170A: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FAM170A Gene

Localization for FAM170A Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM170A Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM170A gene
Compartment Confidence
nucleus 5
cytosol 1

Gene Ontology (GO) - Cellular Components for FAM170A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
genes like me logo Genes that share ontologies with FAM170A: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for FAM170A Gene

Pathways & Interactions for FAM170A Gene

SuperPathways for FAM170A Gene

No Data Available

Gene Ontology (GO) - Biological Process for FAM170A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006366 transcription by RNA polymerase II ISS --
GO:0045893 positive regulation of transcription, DNA-templated ISS --
genes like me logo Genes that share ontologies with FAM170A: view

No data available for Pathways by source and SIGNOR curated interactions for FAM170A Gene

Drugs & Compounds for FAM170A Gene

No Compound Related Data Available

Transcripts for FAM170A Gene

mRNA/cDNA for FAM170A Gene

(2) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(7) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FAM170A Gene

Family with sequence similarity 170, member A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM170A Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5
SP1:
SP2: -

Relevant External Links for FAM170A Gene

GeneLoc Exon Structure for
FAM170A
ECgene alternative splicing isoforms for
FAM170A

Expression for FAM170A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM170A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FAM170A Gene

This gene is overexpressed in Testis (x44.8).

Protein differential expression in normal tissues from HIPED for FAM170A Gene

This gene is overexpressed in Pancreatic juice (52.1) and Plasma (12.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FAM170A Gene



Protein tissue co-expression partners for FAM170A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FAM170A Gene:

FAM170A

SOURCE GeneReport for Unigene cluster for FAM170A Gene:

Hs.713304

mRNA Expression by UniProt/SwissProt for FAM170A Gene:

A1A519-F170A_HUMAN
Tissue specificity: Expressed strongly in testis and brain and weakly in prostate, spleen, pancreas and uterus.

Evidence on tissue expression from TISSUES for FAM170A Gene

  • Nervous system(4.9)
  • Skin(3.4)
  • Blood(2.6)
genes like me logo Genes that share expression patterns with FAM170A: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM170A Gene

Orthologs for FAM170A Gene

This gene was present in the common ancestor of mammals.

Orthologs for FAM170A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM170A 33 34
  • 99.39 (n)
mouse
(Mus musculus)
Mammalia Fam170a 33 16 34
  • 81.61 (n)
rat
(Rattus norvegicus)
Mammalia Fam170a 33
  • 81.5 (n)
dog
(Canis familiaris)
Mammalia FAM170A 34 33
  • 81.04 (n)
OneToOne
cow
(Bos Taurus)
Mammalia LOC540403 33
  • 80.65 (n)
FAM170A 34
  • 73 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FAM170A 34
  • 31 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FAM170A 34
  • 27 (a)
OneToOne
Species where no ortholog for FAM170A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FAM170A Gene

ENSEMBL:
Gene Tree for FAM170A (if available)
TreeFam:
Gene Tree for FAM170A (if available)

Paralogs for FAM170A Gene

Paralogs for FAM170A Gene

Pseudogenes.org Pseudogenes for FAM170A Gene

genes like me logo Genes that share paralogs with FAM170A: view

Variants for FAM170A Gene

Sequence variations from dbSNP and Humsavar for FAM170A Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000300582 -- 119,635,615(+) C/T intron_variant
rs1000716691 -- 119,634,973(+) T/C intron_variant
rs1001173639 -- 119,630,477(+) A/G intron_variant
rs1001353768 -- 119,635,691(+) C/T intron_variant
rs1001662829 -- 119,631,600(+) C/T intron_variant

Variation tolerance for FAM170A Gene

Residual Variation Intolerance Score: 93.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.09; 80.47% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FAM170A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM170A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for FAM170A Gene

Disorders for FAM170A Gene

Additional Disease Information for FAM170A

No disorders were found for FAM170A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM170A Gene

Publications for FAM170A Gene

  1. Isolation and characterization of a novel zinc finger gene, ZNFD, activating AP1(PMA) transcriptional activities. (PMID: 20162441) Lei C … Wang M (Molecular and cellular biochemistry 2010) 2 3 4 58
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58
  4. Genome-wide association with bone mass and geometry in the Framingham Heart Study. (PMID: 17903296) Kiel DP … Karasik D (BMC medical genetics 2007) 44 58
  5. A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study. (PMID: 17903299) Kathiresan S … Cupples LA (BMC medical genetics 2007) 44 58

Products for FAM170A Gene

Sources for FAM170A Gene

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