Aliases for FAM169A Gene

Aliases for FAM169A Gene

  • Family With Sequence Similarity 169 Member A 2 3 5
  • Soluble Lamin-Associated Protein Of 75 KDa 3 4
  • Soluble Lamina-Associated Protein Of 75 KD 2 3
  • Protein FAM169A 3 4
  • SLAP75 3 4
  • Family With Sequence Similarity 169, Member A 2
  • KIAA0888 4

External Ids for FAM169A Gene

Previous GeneCards Identifiers for FAM169A Gene

  • GC05M074111
  • GC05M069278

Summaries for FAM169A Gene

GeneCards Summary for FAM169A Gene

FAM169A (Family With Sequence Similarity 169 Member A) is a Protein Coding gene. Diseases associated with FAM169A include Emery-Dreifuss Muscular Dystrophy 4, Autosomal Dominant and Emery-Dreifuss Muscular Dystrophy 2, Autosomal Dominant. An important paralog of this gene is FAM169B.

Additional gene information for FAM169A Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FAM169A Gene

Genomics for FAM169A Gene

GeneHancer (GH) Regulatory Elements for FAM169A Gene

Promoters and enhancers for FAM169A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05J074863 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 504.8 -0.3 -268 6.9 FOXK2 ZNF217 POLR2G NCOR1 PHF8 TEAD4 ZFX ZIC2 POLR2A CLOCK FAM169A ENSG00000271714 LOC441086 NSA2 ENSG00000242198 GFM2 RF00017-4723
GH05J074848 Promoter 0.8 EPDnew 500.4 +18.1 18123 0.1 TEAD1 OSR2 SAP130 BCL6 HOMEZ PRDM6 RARA KDM1A THRB HMG20A FAM169A RNU6-1330P ENSG00000271714 LOC441086 RF00998-107
GH05J074684 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 10.2 +180.8 180844 3.8 HNRNPK NRF1 USF1 POLR2G RBAK PHF8 JUND FOS ZFX ZNF10 HEXB RNU6-658P RNU6-1330P FAM169A NONHSAG040727.2 piR-43106-165
GH05J074764 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 6.9 +100.3 100281 4.2 ZBTB40 ZNF217 EP300 CTCF SIN3A MYC TCF12 POLR2G SP1 GTF2E2 NSA2 GFM2 POLK ENSG00000272040 RNU6-658P FAM169A
GH05J074849 Promoter/Enhancer 1.1 Ensembl ENCODE 6.1 +15.9 15875 3.6 POLR2G TCF7 TEAD1 CEBPB ZNF316 MAFF FOS SAP130 MAFK RBM22 NSA2 RNU6-1330P FAM169A LOC441086 ENSG00000271714 RF00998-107
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FAM169A on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FAM169A

Top Transcription factor binding sites by QIAGEN in the FAM169A gene promoter:
  • Cdc5
  • Evi-1
  • HOXA9
  • HOXA9B
  • Meis-1
  • Meis-1a
  • MyoD
  • MZF-1
  • RORalpha1
  • Sox5

Genomic Locations for FAM169A Gene

Genomic Locations for FAM169A Gene
chr5:74,777,574-74,866,966
(GRCh38/hg38)
Size:
89,393 bases
Orientation:
Minus strand
chr5:74,073,399-74,162,776
(GRCh37/hg19)
Size:
89,378 bases
Orientation:
Minus strand

Genomic View for FAM169A Gene

Genes around FAM169A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM169A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM169A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM169A Gene

Proteins for FAM169A Gene

  • Protein details for FAM169A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y6X4-F169A_HUMAN
    Recommended name:
    Soluble lamin-associated protein of 75 kDa
    Protein Accession:
    Q9Y6X4
    Secondary Accessions:
    • A8K1T9
    • Q6MZT0
    • Q9H989

    Protein attributes for FAM169A Gene

    Size:
    670 amino acids
    Molecular mass:
    74955 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA74911.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; Sequence=BAB14344.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=CAE45948.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};

    Alternative splice isoforms for FAM169A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FAM169A Gene

Post-translational modifications for FAM169A Gene

  • Ubiquitination at Lys226
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for FAM169A Gene

Domains & Families for FAM169A Gene

Gene Families for FAM169A Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FAM169A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM169A Gene

GenScript: Design optimal peptide antigens:
  • Protein FAM169A (F169A_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9Y6X4

UniProtKB/Swiss-Prot:

F169A_HUMAN :
  • Belongs to the FAM169 family.
Family:
  • Belongs to the FAM169 family.
genes like me logo Genes that share domains with FAM169A: view

Function for FAM169A Gene

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM169A Gene

Localization for FAM169A Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM169A Gene

Nucleus envelope. Nucleus inner membrane; Peripheral membrane protein; Nucleoplasmic side. Note=Enriched at the nuclear lamina.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM169A gene
Compartment Confidence
nucleus 4
cytosol 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear membrane (4)
  • Cytosol (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for FAM169A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005635 nuclear envelope IEA --
GO:0005637 nuclear inner membrane IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with FAM169A: view

Pathways & Interactions for FAM169A Gene

PathCards logo

SuperPathways for FAM169A Gene

No Data Available

Interacting Proteins for FAM169A Gene

;

Gene Ontology (GO) - Biological Process for FAM169A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FAM169A Gene

Drugs & Compounds for FAM169A Gene

No Compound Related Data Available

Transcripts for FAM169A Gene

mRNA/cDNA for FAM169A Gene

7 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM169A Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17
SP1: - - - -
SP2: -
SP3: - - -
SP4: - - - - -
SP5: - -
SP6: -

Relevant External Links for FAM169A Gene

GeneLoc Exon Structure for
FAM169A

Expression for FAM169A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FAM169A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FAM169A Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x4.4) and Brain - Anterior cingulate cortex (BA24) (x4.2).

Protein differential expression in normal tissues from HIPED for FAM169A Gene

This gene is overexpressed in Retina (31.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FAM169A Gene



Protein tissue co-expression partners for FAM169A Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FAM169A

SOURCE GeneReport for Unigene cluster for FAM169A Gene:

Hs.91662

Evidence on tissue expression from TISSUES for FAM169A Gene

  • Nervous system(4.5)
  • Liver(4.1)
genes like me logo Genes that share expression patterns with FAM169A: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM169A Gene

Orthologs for FAM169A Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM169A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM169A 31 30
  • 99.7 (n)
OneToOne
dog
(Canis familiaris)
Mammalia FAM169A 31 30
  • 91.59 (n)
OneToOne
cow
(Bos Taurus)
Mammalia FAM169A 31 30
  • 90.3 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Fam169a 17 31 30
  • 84.41 (n)
rat
(Rattus norvegicus)
Mammalia Fam169a 30
  • 83.61 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia FAM169A 31
  • 68 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FAM169A 31
  • 63 (a)
OneToOne
chicken
(Gallus gallus)
Aves FAM169A 31 30
  • 64.55 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FAM169A 31
  • 51 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fam169a 30
  • 58.62 (n)
zebrafish
(Danio rerio)
Actinopterygii fam169aa 31
  • 41 (a)
OneToMany
fam169ab 31
  • 27 (a)
OneToMany
wufe11a06 30
Species where no ortholog for FAM169A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM169A Gene

ENSEMBL:
Gene Tree for FAM169A (if available)
TreeFam:
Gene Tree for FAM169A (if available)
Aminode:
Evolutionary constrained regions (ECRs) for FAM169A: view image

Paralogs for FAM169A Gene

Paralogs for FAM169A Gene

(1) SIMAP similar genes for FAM169A Gene using alignment to 6 proteins:

  • F169A_HUMAN
  • D6R953_HUMAN
  • D6RB01_HUMAN
  • D6RC41_HUMAN
  • D6RFI5_HUMAN
  • L8E885_HUMAN
genes like me logo Genes that share paralogs with FAM169A: view

Variants for FAM169A Gene

Additional dbSNP identifiers (rs#s) for FAM169A Gene

Structural Variations from Database of Genomic Variants (DGV) for FAM169A Gene

Variant ID Type Subtype PubMed ID
esv3329876 CNV insertion 20981092
nsv598653 CNV loss 21841781
nsv968949 CNV duplication 23825009

Variation tolerance for FAM169A Gene

Residual Variation Intolerance Score: 19.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.41; 27.74% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FAM169A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM169A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for FAM169A Gene

Disorders for FAM169A Gene

MalaCards: The human disease database

(2) MalaCards diseases for FAM169A Gene - From: DISEASES

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for FAM169A

genes like me logo Genes that share disorders with FAM169A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FAM169A Gene

Publications for FAM169A Gene

  1. A promiscuous biotin ligase fusion protein identifies proximal and interacting proteins in mammalian cells. (PMID: 22412018) Roux KJ … Burke B (The Journal of cell biology 2012) 2 3 4 54
  2. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10048485) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1998) 2 3 4 54
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  4. VIRMA mediates preferential m6A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. (PMID: 29507755) Yue Y … Liu J (Cell discovery 2018) 3 54
  5. An AP-MS- and BioID-compatible MAC-tag enables comprehensive mapping of protein interactions and subcellular localizations. (PMID: 29568061) Liu X … Varjosalo M (Nature communications 2018) 3 54

Products for FAM169A Gene

Sources for FAM169A Gene