Aliases for FAM168B Gene

Aliases for FAM168B Gene

  • Family With Sequence Similarity 168 Member B 2 3 5
  • MANI 2 3 4
  • Myelin-Associated Neurite-Outgrowth Inhibitor 3 4
  • KIAA0280L 2 4
  • Myelin Associated Neurite Outgrowth Inhibitor 2
  • Family With Sequence Similarity 168, Member B 2
  • Protein FAM168B 3
  • FAM168B 5
  • Mani 4
  • P20 4

External Ids for FAM168B Gene

Previous GeneCards Identifiers for FAM168B Gene

  • GC02M131524
  • GC02M131805
  • GC02M123873

Summaries for FAM168B Gene

GeneCards Summary for FAM168B Gene

FAM168B (Family With Sequence Similarity 168 Member B) is a Protein Coding gene. An important paralog of this gene is FAM168A.

UniProtKB/Swiss-Prot Summary for FAM168B Gene

  • Inhibitor of neuronal axonal outgrowth. Acts as a negative regulator of CDC42 and STAT3 and a positive regulator of STMN2. Positive regulator of CDC27.

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FAM168B Gene

Genomics for FAM168B Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for FAM168B Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FAM168B on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FAM168B

Top Transcription factor binding sites by QIAGEN in the FAM168B gene promoter:
  • AhR
  • Arnt
  • E4BP4

Genomic Locations for FAM168B Gene

Latest Assembly
45,593 bases
Minus strand

Previous Assembly
(GRCh37/hg19 by Entrez Gene)
45,585 bases
Minus strand

(GRCh37/hg19 by Ensembl)
45,585 bases
Minus strand

Genomic View for FAM168B Gene

Genes around FAM168B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM168B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM168B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM168B Gene

Proteins for FAM168B Gene

  • Protein details for FAM168B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Myelin-associated neurite-outgrowth inhibitor
    Protein Accession:
    Secondary Accessions:
    • Q2TAZ6
    • Q6NZ40

    Protein attributes for FAM168B Gene

    195 amino acids
    Molecular mass:
    20324 Da
    Quaternary structure:
    • May form homodimers. May interact with DAZAP2, FAM168A, PRDX6, RBM6, TMTC1 and YPEL2. Interacts with CDC27.

    Alternative splice isoforms for FAM168B Gene


neXtProt entry for FAM168B Gene

Post-translational modifications for FAM168B Gene

No data available for DME Specific Peptides for FAM168B Gene

Domains & Families for FAM168B Gene

Gene Families for FAM168B Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FAM168B Gene


Suggested Antigen Peptide Sequences for FAM168B Gene

GenScript: Design optimal peptide antigens:
  • p20 (F168B_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the FAM168 family.
  • Belongs to the FAM168 family.
genes like me logo Genes that share domains with FAM168B: view

Function for FAM168B Gene

Molecular function for FAM168B Gene

UniProtKB/Swiss-Prot Function:
Inhibitor of neuronal axonal outgrowth. Acts as a negative regulator of CDC42 and STAT3 and a positive regulator of STMN2. Positive regulator of CDC27.

Phenotypes for FAM168B Gene

genes like me logo Genes that share phenotypes with FAM168B: view

Animal Models for research

  • Taconic Biosciences Mouse Models for FAM168B

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FAM168B

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM168B Gene

Localization for FAM168B Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM168B Gene

Cytoplasm, perinuclear region. Cell membrane. Multi-pass membrane protein. Cell projection, axon. Note=Expressed in neuronal cell bodies and axonal fibers. {ECO:0000250 UniProtKB:Q80XQ8}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM168B gene
Compartment Confidence
extracellular 4
plasma membrane 3
mitochondrion 1
nucleus 1
cytosol 1
peroxisome 0

Gene Ontology (GO) - Cellular Components for FAM168B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0030424 axon IEA --
genes like me logo Genes that share ontologies with FAM168B: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for FAM168B Gene

Pathways & Interactions for FAM168B Gene

PathCards logo

SuperPathways for FAM168B Gene

No Data Available

Interacting Proteins for FAM168B Gene

Gene Ontology (GO) - Biological Process for FAM168B Gene


No data available for Pathways by source and SIGNOR curated interactions for FAM168B Gene

Drugs & Compounds for FAM168B Gene

No Compound Related Data Available

Transcripts for FAM168B Gene

mRNA/cDNA for FAM168B Gene

14 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FAM168B

Alternative Splicing Database (ASD) splice patterns (SP) for FAM168B Gene

No ASD Table

Relevant External Links for FAM168B Gene

GeneLoc Exon Structure for

Expression for FAM168B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FAM168B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FAM168B Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FAM168B

SOURCE GeneReport for Unigene cluster for FAM168B Gene:


mRNA Expression by UniProt/SwissProt for FAM168B Gene:

Tissue specificity: Expressed in the brain, within neuronal axonal fibers and associated with myelin sheets (at protein level). Expression tends to be lower in the brain of Alzheimer disease patients compared to healthy individuals (at protein level).

Evidence on tissue expression from TISSUES for FAM168B Gene

  • Nervous system(4.9)
  • Eye(4.4)
  • Intestine(2.8)
  • Skin(2.2)
genes like me logo Genes that share expression patterns with FAM168B: view

Primer products for research

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM168B Gene

Orthologs for FAM168B Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM168B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FAM168B 29 30
  • 99.83 (n)
(Monodelphis domestica)
Mammalia FAM168B 30
  • 97 (a)
(Bos Taurus)
Mammalia FAM168B 29 30
  • 93.41 (n)
(Canis familiaris)
Mammalia FAM168B 29 30
  • 93.33 (n)
(Mus musculus)
Mammalia Fam168b 29 16 30
  • 91.58 (n)
(Rattus norvegicus)
Mammalia Fam168b 29
  • 91.24 (n)
(Ornithorhynchus anatinus)
Mammalia FAM168B 30
  • 79 (a)
(Gallus gallus)
Aves FAM168B 29 30
  • 84.44 (n)
(Anolis carolinensis)
Reptilia FAM168B 30
  • 96 (a)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia fam168b 29
  • 80.34 (n)
(Danio rerio)
Actinopterygii fam168b 29 30
  • 76.98 (n)
Species where no ortholog for FAM168B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for FAM168B Gene

Gene Tree for FAM168B (if available)
Gene Tree for FAM168B (if available)
Evolutionary constrained regions (ECRs) for FAM168B: view image
Alliance of Genome Resources:
Additional Orthologs for FAM168B

Paralogs for FAM168B Gene

Paralogs for FAM168B Gene

(1) SIMAP similar genes for FAM168B Gene using alignment to 1 proteins:

  • F168B_HUMAN
genes like me logo Genes that share paralogs with FAM168B: view

Variants for FAM168B Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for FAM168B Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for FAM168B Gene

Variant ID Type Subtype PubMed ID
dgv2032n106 OTHER inversion 24896259
dgv4074n100 CNV gain 25217958
dgv4075n100 CNV gain 25217958
dgv616e201 CNV deletion 23290073
dgv731e199 CNV deletion 23128226
esv2157663 CNV deletion 18987734
esv2497466 CNV deletion 19546169
esv2576731 CNV deletion 19546169
esv2670824 CNV deletion 23128226
esv2720778 CNV deletion 23290073
esv2759092 CNV gain+loss 17122850
esv2760576 CNV gain+loss 21179565
esv3560142 CNV deletion 23714750
esv3831 CNV loss 18987735
esv3893337 CNV loss 25118596
nsv1000507 CNV gain 25217958
nsv1005040 CNV gain 25217958
nsv1005763 CNV gain 25217958
nsv1014723 CNV loss 25217958
nsv10179 CNV loss 18304495
nsv1072455 CNV deletion 25765185
nsv1118882 CNV deletion 24896259
nsv1147463 OTHER inversion 26484159
nsv214458 CNV deletion 16902084
nsv428404 CNV loss 18775914
nsv524021 CNV loss 19592680
nsv583135 CNV loss 21841781
nsv7327 OTHER inversion 18451855
nsv953168 CNV deletion 24416366

Variation tolerance for FAM168B Gene

Residual Variation Intolerance Score: 32.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.71; 15.06% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FAM168B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
Leiden Open Variation Database (LOVD)

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for FAM168B Gene

Disorders for FAM168B Gene

Additional Disease Information for FAM168B

No disorders were found for FAM168B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM168B Gene

Publications for FAM168B Gene

  1. The novel protein MANI modulates neurogenesis and neurite-cone growth. (PMID: 20716133) Mishra M … Heese K (Journal of cellular and molecular medicine 2011) 2 3 4
  2. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  3. Endoglin Protein Interactome Profiling Identifies TRIM21 and Galectin-3 as New Binding Partners. (PMID: 31540324) Gallardo-Vara E … Bernabeu C (Cells 2019) 3
  4. RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination. (PMID: 29117863) Choudhury NR … Michlewski G (BMC biology 2017) 3
  5. Livebearing or egg-laying mammals: 27 decisive nucleotides of FAM168. (PMID: 28381702) Pramanik S … Heese K (Bioscience trends 2017) 3

Products for FAM168B Gene

Sources for FAM168B Gene