Aliases for FAM166C Gene

Aliases for FAM166C Gene

  • Family With Sequence Similarity 166 Member C 2 3
  • Chromosome 2 Open Reading Frame 70 2 5
  • UPF0573 Protein C2orf70 3 4
  • C2orf70 3 5
  • Hypothetical Protein LOC339778 2

External Ids for FAM166C Gene

Previous HGNC Symbols for FAM166C Gene

  • C2orf70

Summaries for FAM166C Gene

GeneCards Summary for FAM166C Gene

FAM166C (Family With Sequence Similarity 166 Member C) is a Protein Coding gene.

Additional gene information for FAM166C Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FAM166C Gene

Genomics for FAM166C Gene

GeneHancer (GH) Regulatory Elements for FAM166C Gene

Promoters and enhancers for FAM166C Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J026562 Promoter/Enhancer 1.1 Ensembl ENCODE 750.6 +0.3 274 1.3 SIN3A CTCF RBPJ ELF3 SP5 ZIC2 RFX1 RXRB REST ZNF24 FAM166C KCNK3 RF00017-3139
GH02J026717 Enhancer 1.7 VISTA FANTOM5 Ensembl ENCODE dbSUPER 10.9 +159.7 159699 10.1 GTF3C2 SIN3A ZBTB40 ZBTB6 MLX FOXA1 RBPJ SMARCE1 POLR2A TCF7L2 TMEM214 ENSG00000234072 CAD NRBP1 SLC35F6 ASXL2 CENPA SNX17 GPN1 RPS2P15
GH02J026577 Enhancer 0.9 Ensembl ENCODE 18.4 +14.9 14858 1.6 CTCF RAD21 MNT EGR1 ZIC2 ARID2 REST TRIM22 CTBP1 ZNF143 FAM166C RF00017-3139 CIB4
GH02J026490 Enhancer 1.2 FANTOM5 Ensembl ENCODE 11.3 -68.1 -68055 7.8 SMARCE1 L3MBTL2 TEAD4 SP1 SMARCA4 MTA1 IKZF1 PKNOX1 RXRA ZNF512 OTOF FAM166C DRC1 DPYSL5 RAB10 MPV17 KRTCAP3 GAREM2 lnc-ADGRF3-4 lnc-CIB4-3
GH02J026518 Enhancer 0.5 Ensembl 16.1 -42.7 -42655 1 PATZ1 ZBTB20 ZBTB17 ZNF335 ATF7 FAM166C OTOF lnc-CIB4-3 lnc-ADGRF3-4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FAM166C on UCSC Golden Path with GeneCards custom track

Genomic Locations for FAM166C Gene

Genomic Locations for FAM166C Gene
chr2:26,562,556-26,579,532
(GRCh38/hg38)
Size:
16,977 bases
Orientation:
Plus strand
chr2:26,785,450-26,802,400
(GRCh37/hg19)
Size:
16,951 bases
Orientation:
Plus strand

Genomic View for FAM166C Gene

Genes around FAM166C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM166C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM166C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM166C Gene

Proteins for FAM166C Gene

  • Protein details for FAM166C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NJV1-CB070_HUMAN
    Recommended name:
    UPF0573 protein C2orf70
    Protein Accession:
    A6NJV1

    Protein attributes for FAM166C Gene

    Size:
    201 amino acids
    Molecular mass:
    23421 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FAM166C Gene

Post-translational modifications for FAM166C Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FAM166C Gene

Domains & Families for FAM166C Gene

Gene Families for FAM166C Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FAM166C Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM166C Gene

GenScript: Design optimal peptide antigens:
  • UPF0573 protein C2orf70 (CB070_HUMAN)

Graphical View of Domain Structure for InterPro Entry

A6NJV1

UniProtKB/Swiss-Prot:

CB070_HUMAN :
  • Belongs to the UPF0573 family.
Family:
  • Belongs to the UPF0573 family.
genes like me logo Genes that share domains with FAM166C: view

Function for FAM166C Gene

Phenotypes From GWAS Catalog for FAM166C Gene

genes like me logo Genes that share phenotypes with FAM166C: view

Animal Models for FAM166C Gene

MGI Knock Outs for FAM166C:

Animal Model Products

CRISPR Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for FAM166C Gene

Localization for FAM166C Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM166C gene
Compartment Confidence
nucleus 2
cytosol 1
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear membrane (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for FAM166C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus HDA 21630459
genes like me logo Genes that share ontologies with FAM166C: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for FAM166C Gene

Pathways & Interactions for FAM166C Gene

PathCards logo

SuperPathways for FAM166C Gene

No Data Available

Interacting Proteins for FAM166C Gene

Gene Ontology (GO) - Biological Process for FAM166C Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FAM166C Gene

Drugs & Compounds for FAM166C Gene

No Compound Related Data Available

Transcripts for FAM166C Gene

mRNA/cDNA for FAM166C Gene

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM166C Gene

No ASD Table

Relevant External Links for FAM166C Gene

GeneLoc Exon Structure for
FAM166C
ECgene alternative splicing isoforms for
FAM166C

Expression for FAM166C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of FAM166C Gene:

FAM166C

SOURCE GeneReport for Unigene cluster for FAM166C Gene:

Hs.407083
genes like me logo Genes that share expression patterns with FAM166C: view

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM166C Gene

Orthologs for FAM166C Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM166C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C2AH2orf70 32
  • 97.25 (n)
C2orf70 33
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C17H2orf70 32
  • 84.58 (n)
C2orf70 33
  • 78 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C11H2orf70 33 32
  • 83.91 (n)
OneToOne
mouse
(Mus musculus)
Mammalia 1700001C02Rik 17 33 32
  • 77 (n)
rat
(Rattus norvegicus)
Mammalia RGD1559683 32
  • 76.33 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia C2orf70 33
  • 60 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia C2orf70 33
  • 60 (a)
OneToOne
chicken
(Gallus gallus)
Aves C3H2ORF70 32
  • 64.47 (n)
C2orf70 33
  • 54 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C2orf70 33
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia c2orf70 32
  • 62.25 (n)
zebrafish
(Danio rerio)
Actinopterygii si:ch211-198b3.4 32
  • 53.79 (n)
C20H2orf70 33
  • 40 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 33
  • 43 (a)
OneToOne
Species where no ortholog for FAM166C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM166C Gene

ENSEMBL:
Gene Tree for FAM166C (if available)
TreeFam:
Gene Tree for FAM166C (if available)

Paralogs for FAM166C Gene

No data available for Paralogs for FAM166C Gene

Variants for FAM166C Gene

Sequence variations from dbSNP and Humsavar for FAM166C Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000015832 -- 26,572,467(+) G/A 5_prime_UTR_variant, intron_variant
rs1000171885 -- 26,581,276(+) A/T downstream_transcript_variant
rs1000284351 -- 26,576,912(+) C/G intron_variant
rs1000435656 -- 26,581,092(+) T/C 3_prime_UTR_variant, genic_downstream_transcript_variant
rs1000766464 -- 26,571,281(+) C/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for FAM166C Gene

Variant ID Type Subtype PubMed ID
esv33316 CNV loss 17666407
esv3583675 CNV loss 25503493
nsv517800 CNV loss 19592680

Variation tolerance for FAM166C Gene

Residual Variation Intolerance Score: 95.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.63; 72.63% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FAM166C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM166C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM166C Gene

Disorders for FAM166C Gene

No disorders were found for FAM166C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for FAM166C Gene

Publications for FAM166C Gene

  1. Proteomic characterization of the human sperm nucleus. (PMID: 21630459) de Mateo S … Oliva R (Proteomics 2011) 3 56
  2. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 4 56
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 56

No data available for External Links for FAM166C Gene

Products for FAM166C Gene

Sources for FAM166C Gene