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Aliases for FAM166A Gene

Aliases for FAM166A Gene

  • Family With Sequence Similarity 166 Member A 2 3 5
  • Family With Sequence Similarity 166, Member A 2
  • Protein FAM166A 3
  • HSD46 3

External Ids for FAM166A Gene

Previous GeneCards Identifiers for FAM166A Gene

  • GC09M139258
  • GC09M140138
  • GC09M109597

Summaries for FAM166A Gene

GeneCards Summary for FAM166A Gene

FAM166A (Family With Sequence Similarity 166 Member A) is a Protein Coding gene.

Additional gene information for FAM166A Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM166A Gene

Genomics for FAM166A Gene

GeneHancer (GH) Regulatory Elements for FAM166A Gene

Promoters and enhancers for FAM166A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09I137247 Promoter 0.7 EPDnew 550.8 +3.4 3423 0.1 GLIS2 ZBTB6 FAM166A STPG3 TUBB4B
GH09I137251 Promoter 0.5 EPDnew 550.8 -0.1 -81 0.1 STPG3 FAM166A STPG3-AS1
GH09I137193 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 11.8 +52.7 52744 9.8 HDGF PKNOX1 SMAD1 FOXA2 MLX ARID4B SIN3A DMAP1 ZNF2 ZBTB7B TPRN EHMT1 SDCCAG3 LOC651337 ANAPC2 SNAPC4 FAM166A NDOR1 INPP5E ZMYND19
GH09I136690 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 11.6 +557.6 557637 6.9 FOXA2 CLOCK MLX ARID4B SIN3A ZNF2 ZBTB7B YY1 ZNF143 FOS SNAPC4 FAM166A ANAPC2 INPP5E ZMYND19 ARRDC1-AS1 ENSG00000238058 AGPAT2 EGFL7 ABCA2
GH09I136725 Promoter/Enhancer 1.6 Ensembl ENCODE 11.8 +523.7 523745 4.1 CLOCK MLX DMAP1 IRF4 YY1 ZNF213 ZNF143 SP3 NFYC SSRP1 SNHG7 ENSG00000281808 GC09M136753 GC09M136755 GC09M136756 SNORA17B SNORA17A DPH7 EHMT1 ANAPC2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around FAM166A on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FAM166A gene promoter:

Genomic Locations for FAM166A Gene

Genomic Locations for FAM166A Gene
chr9:137,243,583-137,251,193
(GRCh38/hg38)
Size:
7,611 bases
Orientation:
Minus strand
chr9:140,138,036-140,142,222
(GRCh37/hg19)

Genomic View for FAM166A Gene

Genes around FAM166A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM166A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM166A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM166A Gene

Proteins for FAM166A Gene

  • Protein details for FAM166A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6J272-F166A_HUMAN
    Recommended name:
    Protein FAM166A
    Protein Accession:
    Q6J272
    Secondary Accessions:
    • A6NND9
    • Q8N830

    Protein attributes for FAM166A Gene

    Size:
    317 amino acids
    Molecular mass:
    36165 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FAM166A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FAM166A Gene

Post-translational modifications for FAM166A Gene

No Post-translational modifications

Other Protein References for FAM166A Gene

No data available for DME Specific Peptides for FAM166A Gene

Domains & Families for FAM166A Gene

Gene Families for FAM166A Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted intracellular proteins

Protein Domains for FAM166A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM166A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6J272

UniProtKB/Swiss-Prot:

F166A_HUMAN :
  • Belongs to the UPF0605 family.
Family:
  • Belongs to the UPF0605 family.
genes like me logo Genes that share domains with FAM166A: view

Function for FAM166A Gene

Phenotypes From GWAS Catalog for FAM166A Gene

genes like me logo Genes that share phenotypes with FAM166A: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FAM166A Gene

Localization for FAM166A Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM166A gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1

Gene Ontology (GO) - Cellular Components for FAM166A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus HDA 21630459
genes like me logo Genes that share ontologies with FAM166A: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for FAM166A Gene

Pathways & Interactions for FAM166A Gene

SuperPathways for FAM166A Gene

No Data Available

Interacting Proteins for FAM166A Gene

Gene Ontology (GO) - Biological Process for FAM166A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FAM166A Gene

Drugs & Compounds for FAM166A Gene

No Compound Related Data Available

Transcripts for FAM166A Gene

Unigene Clusters for FAM166A Gene

Family with sequence similarity 166, member A:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM166A Gene

No ASD Table

Relevant External Links for FAM166A Gene

GeneLoc Exon Structure for
FAM166A
ECgene alternative splicing isoforms for
FAM166A

Expression for FAM166A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM166A Gene

mRNA differential expression in normal tissues according to GTEx for FAM166A Gene

This gene is overexpressed in Testis (x39.3).

NURSA nuclear receptor signaling pathways regulating expression of FAM166A Gene:

FAM166A

SOURCE GeneReport for Unigene cluster for FAM166A Gene:

Hs.522530

Evidence on tissue expression from TISSUES for FAM166A Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with FAM166A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM166A Gene

Orthologs for FAM166A Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM166A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM166A 33 34
  • 98.21 (n)
dog
(Canis familiaris)
Mammalia FAM166A 33 34
  • 83.49 (n)
cow
(Bos Taurus)
Mammalia FAM166A 33 34
  • 82.49 (n)
mouse
(Mus musculus)
Mammalia Fam166a 33 16 34
  • 80.79 (n)
rat
(Rattus norvegicus)
Mammalia Fam166a 33
  • 80.49 (n)
oppossum
(Monodelphis domestica)
Mammalia FAM166A 34
  • 58 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FAM166A 34
  • 48 (a)
OneToOne
chicken
(Gallus gallus)
Aves FAM166A 33 34
  • 57.01 (n)
lizard
(Anolis carolinensis)
Reptilia FAM166A 34
  • 49 (a)
OneToOne
Species where no ortholog for FAM166A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FAM166A Gene

ENSEMBL:
Gene Tree for FAM166A (if available)
TreeFam:
Gene Tree for FAM166A (if available)

Paralogs for FAM166A Gene

No data available for Paralogs for FAM166A Gene

Variants for FAM166A Gene

Sequence variations from dbSNP and Humsavar for FAM166A Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs1000357207 -- 137,250,582(-) A/G 5_prime_UTR_variant, genic_upstream_transcript_variant
rs1000801398 -- 137,249,230(-) A/G genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1001148781 -- 137,249,393(-) T/C genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1001153927 -- 137,243,959(-) G/C downstream_transcript_variant, genic_downstream_transcript_variant, intron_variant
rs1001431152 -- 137,247,210(-) G/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for FAM166A Gene

Variant ID Type Subtype PubMed ID
dgv13009n54 CNV loss 21841781
dgv13011n54 CNV loss 21841781
esv2422220 CNV deletion 17116639
nsv1161918 CNV duplication 26073780
nsv524322 CNV loss 19592680
nsv951207 CNV deletion 24416366

Variation tolerance for FAM166A Gene

Residual Variation Intolerance Score: 82.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.82; 58.51% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FAM166A Gene

Human Gene Mutation Database (HGMD)
FAM166A
SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM166A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM166A Gene

Disorders for FAM166A Gene

Additional Disease Information for FAM166A

No disorders were found for FAM166A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM166A Gene

Publications for FAM166A Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. Proteomic characterization of the human sperm nucleus. (PMID: 21630459) de Mateo S … Oliva R (Proteomics 2011) 3 58
  3. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray SJ … Dunham I (Nature 2004) 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58

Products for FAM166A Gene

Sources for FAM166A Gene

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