Aliases for FAM163B Gene

Aliases for FAM163B Gene

  • Family With Sequence Similarity 163 Member B 2 3 5
  • Protein FAM163B 3 4
  • Cebelin-Like 2 3
  • C9orf166 3 4
  • Family With Sequence Similarity 163, Member B 2
  • Chromosome 9 Open Reading Frame 166 2
  • FAM163B 5

External Ids for FAM163B Gene

Previous HGNC Symbols for FAM163B Gene

  • C9orf166

Previous GeneCards Identifiers for FAM163B Gene

  • GC09M135436
  • GC09M136444
  • GC09M105944

Summaries for FAM163B Gene

GeneCards Summary for FAM163B Gene

FAM163B (Family With Sequence Similarity 163 Member B) is a Protein Coding gene.

Additional gene information for FAM163B Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FAM163B Gene

Genomics for FAM163B Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for FAM163B Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J133609 Enhancer 0.4 FANTOM5 602.1 -0.7 -693 0.4 REST EZH2 FAM163B DBH DBH-AS1 ADAMTSL2 ENSG00000261018
GH09J133607 Enhancer 0.3 Ensembl 600.7 +1.5 1488 0.6 EZH2 FAM163B DBH DBH-AS1 SARDH ADAMTSL2 HSALNG0075019
GH09J133633 Promoter/Enhancer 1.3 EPDnew Ensembl ENCODE CraniofacialAtlas 15.1 -25.2 -25246 3.7 ZNF341 ZNF623 MAFG NR2F2 POLR2A RCOR1 YY1 GLIS1 NFE2 SMARCA4 DBH ENSG00000261018 FAM163B DBH-AS1
GH09J133508 Enhancer 1.1 ENCODE CraniofacialAtlas dbSUPER 10.9 +99.9 99891 1.2 HNRNPL PRDM10 ZNF629 ZNF692 FOXA1 ZIC2 PATZ1 SP1 ZNF600 ZNF341 FAM163B CACFD1 MN298678-154 LOC102723855 MYMK SLC2A6
GH09J133505 Enhancer 1.1 ENCODE CraniofacialAtlas 10.9 +103.0 103010 2.2 HNRNPL GATAD2A TFE3 IKZF1 NFKBIZ RCOR2 RXRB IRF2 SP1 DPF2 ADAMTSL2 MYMK FAM163B MN298678-154 LOC102723855 SLC2A6
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FAM163B on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FAM163B

Top Transcription factor binding sites by QIAGEN in the FAM163B gene promoter:
  • AP-2alpha
  • AP-2alphaA
  • AP-2beta
  • AP-2gamma
  • Arnt
  • E47
  • MyoD
  • Tal-1
  • Tal-1beta

Genomic Locations for FAM163B Gene

Genomic Locations for FAM163B Gene
32,314 bases
Minus strand
7,783 bases
Minus strand

Genomic View for FAM163B Gene

Genes around FAM163B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM163B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM163B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM163B Gene

Proteins for FAM163B Gene

  • Protein details for FAM163B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein FAM163B
    Protein Accession:
    Secondary Accessions:
    • B2RUZ5

    Protein attributes for FAM163B Gene

    166 amino acids
    Molecular mass:
    18190 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FAM163B Gene

Post-translational modifications for FAM163B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FAM163B Gene

Domains & Families for FAM163B Gene

Gene Families for FAM163B Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for FAM163B Gene


Suggested Antigen Peptide Sequences for FAM163B Gene

GenScript: Design optimal peptide antigens:
  • Protein FAM163B (F163B_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the FAM163 family.
  • Belongs to the FAM163 family.
genes like me logo Genes that share domains with FAM163B: view

Function for FAM163B Gene

Phenotypes From GWAS Catalog for FAM163B Gene

Gene Ontology (GO) - Molecular Function for FAM163B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 24550280
genes like me logo Genes that share ontologies with FAM163B: view
genes like me logo Genes that share phenotypes with FAM163B: view

Animal Model Products

  • Taconic Biosciences Mouse Models for FAM163B

CRISPR Products

miRNA for FAM163B Gene

miRTarBase miRNAs that target FAM163B

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FAM163B

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM163B Gene

Localization for FAM163B Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM163B Gene

Membrane. Single-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM163B gene
Compartment Confidence
plasma membrane 1
endoplasmic reticulum 1
extracellular 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nuclear bodies (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for FAM163B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with FAM163B: view

Pathways & Interactions for FAM163B Gene

PathCards logo

SuperPathways for FAM163B Gene

No Data Available

Interacting Proteins for FAM163B Gene

Gene Ontology (GO) - Biological Process for FAM163B Gene


No data available for Pathways by source and SIGNOR curated interactions for FAM163B Gene

Drugs & Compounds for FAM163B Gene

No Compound Related Data Available

Transcripts for FAM163B Gene

mRNA/cDNA for FAM163B Gene

4 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FAM163B

Alternative Splicing Database (ASD) splice patterns (SP) for FAM163B Gene

No ASD Table

Relevant External Links for FAM163B Gene

GeneLoc Exon Structure for

Expression for FAM163B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FAM163B Gene

mRNA differential expression in normal tissues according to GTEx for FAM163B Gene

This gene is overexpressed in Brain - Cortex (x13.0), Brain - Frontal Cortex (BA9) (x10.5), Brain - Anterior cingulate cortex (BA24) (x9.5), and Brain - Amygdala (x4.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FAM163B Gene

Protein tissue co-expression partners for FAM163B Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FAM163B

SOURCE GeneReport for Unigene cluster for FAM163B Gene:

genes like me logo Genes that share expression patterns with FAM163B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM163B Gene

Orthologs for FAM163B Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM163B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FAM163B 30
  • 99.4 (n)
-- 31
  • 98 (a)
(Canis familiaris)
Mammalia FAM163B 30
  • 90.65 (n)
-- 31
  • 90 (a)
(Bos Taurus)
Mammalia FAM163B 30
  • 89.71 (n)
-- 31
  • 88 (a)
(Mus musculus)
Mammalia Fam163b 30 17 31
  • 86.95 (n)
(Rattus norvegicus)
Mammalia Fam163b 30
  • 86.55 (n)
(Monodelphis domestica)
Mammalia -- 31
  • 86 (a)
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 66 (a)
(Gallus gallus)
Aves LOC100858326 30
  • 80.62 (n)
-- 31
  • 78 (a)
(Anolis carolinensis)
Reptilia -- 31
  • 76 (a)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia fam163b 30
  • 72.04 (n)
(Danio rerio)
Actinopterygii LOC100537920 30
  • 64.56 (n)
fam163b 31
  • 51 (a)
Species where no ortholog for FAM163B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for FAM163B Gene

Gene Tree for FAM163B (if available)
Gene Tree for FAM163B (if available)
Evolutionary constrained regions (ECRs) for FAM163B: view image

Paralogs for FAM163B Gene

(1) SIMAP similar genes for FAM163B Gene using alignment to 1 proteins:

  • F163B_HUMAN
genes like me logo Genes that share paralogs with FAM163B: view

No data available for Paralogs for FAM163B Gene

Variants for FAM163B Gene

Additional dbSNP identifiers (rs#s) for FAM163B Gene

Structural Variations from Database of Genomic Variants (DGV) for FAM163B Gene

Variant ID Type Subtype PubMed ID
dgv4157n106 CNV deletion 24896259
esv2656927 CNV deletion 23128226
esv2739138 CNV deletion 23290073
esv2759719 CNV gain+loss 17122850
nsv1075278 CNV deletion 25765185
nsv1125319 OTHER inversion 24896259
nsv428225 CNV loss 18775914
nsv951799 CNV deletion 24416366

Variation tolerance for FAM163B Gene

Gene Damage Index Score: 0.68; 14.44% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FAM163B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for FAM163B Gene

Disorders for FAM163B Gene

Additional Disease Information for FAM163B

No disorders were found for FAM163B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM163B Gene

Publications for FAM163B Gene

  1. Unknown genes, Cebelin and Cebelin-like, predominantly expressed in mouse brain. (PMID: 30294689) Miwa H … Itoh N (Heliyon 2018) 2 3
  2. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray SJ … Dunham I (Nature 2004) 3 4
  3. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  4. Proteome-wide analysis of phospho-regulated PDZ domain interactions. (PMID: 30126976) Sundell GN … Ivarsson Y (Molecular systems biology 2018) 3
  5. Large-scale interaction profiling of PDZ domains through proteomic peptide-phage display using human and viral phage peptidomes. (PMID: 24550280) Ivarsson Y … Kim PM (Proceedings of the National Academy of Sciences of the United States of America 2014) 3

Products for FAM163B Gene

Sources for FAM163B Gene