Aliases for FAM163A Gene

Aliases for FAM163A Gene

  • Family With Sequence Similarity 163 Member A 2 3 5
  • Cebelin 2 3 4
  • NDSP 2 3 4
  • Neuroblastoma Derived Secretory Protein 2 3
  • Protein FAM163A 3 4
  • C1orf76 3 4
  • Family With Sequence Similarity 163, Member A 2
  • Neuroblastoma-Derived Secretory Protein 4
  • Chromosome 1 Open Reading Frame 76 2
  • MGC16664 2
  • FAM163A 5

External Ids for FAM163A Gene

Previous HGNC Symbols for FAM163A Gene

  • C1orf76

Previous GeneCards Identifiers for FAM163A Gene

  • GC01P177980
  • GC01P179712
  • GC01P150944

Summaries for FAM163A Gene

GeneCards Summary for FAM163A Gene

FAM163A (Family With Sequence Similarity 163 Member A) is a Protein Coding gene. Diseases associated with FAM163A include Neuroblastoma and Acute Contagious Conjunctivitis.

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FAM163A Gene

Genomics for FAM163A Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for FAM163A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J179742 Promoter 1.1 EPDnew Ensembl 274.6 +15.7 15738 1.4 ZBTB48 GLIS1 L3MBTL2 ZBTB8A EZH2 CTCF GLIS2 ZBTB20 ZBTB26 ZNF335 FAM163A TDRD5 AXDND1 ENSG00000243062 HSALNG0008775 TOR1AIP2
GH01J179730 Promoter 0.3 EPDnew 250.7 +2.4 2406 0.1 ENSG00000243062 FAM163A LOC105371635 TOR1AIP2
GH01J179709 Enhancer 0.9 Ensembl ENCODE 18.5 -18.0 -17962 2.8 BCL11A MAFF RXRA EBF1 ZNF316 ZBTB40 MAFK MAFG IKZF1 MTA3 HSALNG0008772 FAM163A ENSG00000243062 AXDND1 TDRD5 ENSG00000227141 LOC105371635
GH01J179880 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 4 +155.1 155059 4.7 CHD2 TBP MXD4 ZBTB10 SP1 BCL11A CEBPA SIX5 NR2C1 MNT TOR1AIP1 ENSG00000272906 LHX4 LHX4-AS1 CEP350 ENSG00000261831 TOR1AIP2 FAM163A AXDND1 lnc-CEP350-2
GH01J179875 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 4 +149.3 149337 3.8 TBP SP1 CEBPA SIX5 MNT SMAD5 ETS1 MBD2 ZNF217 POLR2A TOR1AIP2 lnc-NPHS2-7 ENSG00000261831 FAM163A lnc-TOR1AIP1-1 lnc-NPHS2-6
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FAM163A on the GeneHancer Hub at the UCSC Golden Path

Top Transcription factor binding sites by QIAGEN in the FAM163A gene promoter:
  • AML1a
  • AP-1
  • AREB6
  • MRF-2
  • POU2F1
  • POU2F1a
  • POU6F1 (c2)
  • SREBP-1a
  • SREBP-1b
  • SREBP-1c

Genomic Locations for FAM163A Gene

Latest Assembly
chr1:179,727,763-179,816,198
(GRCh38/hg38)
Size:
88,436 bases
Orientation:
Plus strand

Previous Assembly
chr1:179,696,911-179,785,333
(GRCh37/hg19 by Entrez Gene)
Size:
88,423 bases
Orientation:
Plus strand

chr1:179,712,298-179,785,333
(GRCh37/hg19 by Ensembl)
Size:
73,036 bases
Orientation:
Plus strand

Genomic View for FAM163A Gene

Genes around FAM163A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM163A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM163A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM163A Gene

Proteins for FAM163A Gene

  • Protein details for FAM163A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96GL9-F163A_HUMAN
    Recommended name:
    Protein FAM163A
    Protein Accession:
    Q96GL9
    Secondary Accessions:
    • A8K8R7

    Protein attributes for FAM163A Gene

    Size:
    167 amino acids
    Molecular mass:
    17641 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FAM163A Gene

Post-translational modifications for FAM163A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FAM163A Gene

Domains & Families for FAM163A Gene

Gene Families for FAM163A Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for FAM163A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM163A Gene

GenScript: Design optimal peptide antigens:
  • cDNA, FLJ94522 (A8K8R7_HUMAN)
  • Neuroblastoma-derived secretory protein (F163A_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q96GL9

UniProtKB/Swiss-Prot:

F163A_HUMAN :
  • Belongs to the FAM163 family.
Family:
  • Belongs to the FAM163 family.
genes like me logo Genes that share domains with FAM163A: view

Function for FAM163A Gene

Phenotypes From GWAS Catalog for FAM163A Gene

Gene Ontology (GO) - Molecular Function for FAM163A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 32296183
genes like me logo Genes that share ontologies with FAM163A: view
genes like me logo Genes that share phenotypes with FAM163A: view

Animal Models for FAM163A Gene

MGI Knock Outs for FAM163A:

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FAM163A

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FAM163A Gene

Localization for FAM163A Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM163A Gene

Membrane. Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM163A gene
Compartment Confidence
extracellular 3
plasma membrane 2
mitochondrion 1
nucleus 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for FAM163A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with FAM163A: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for FAM163A Gene

Pathways & Interactions for FAM163A Gene

PathCards logo

SuperPathways for FAM163A Gene

No Data Available

Gene Ontology (GO) - Biological Process for FAM163A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FAM163A Gene

Drugs & Compounds for FAM163A Gene

No Compound Related Data Available

Transcripts for FAM163A Gene

mRNA/cDNA for FAM163A Gene

9 REFSEQ mRNAs :
18 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FAM163A

Alternative Splicing Database (ASD) splice patterns (SP) for FAM163A Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9a · 9b ^ 10 ^ 11
SP1: - - - -
SP2: - - - - - - -
SP3: - - - - - - - - - - - -
SP4: - - - - - - - - -
SP5: - - - - -
SP6: - -
SP7: - - - - - - - - - - - -
SP8: - -
SP9: - -
SP10:

Relevant External Links for FAM163A Gene

GeneLoc Exon Structure for
FAM163A

Expression for FAM163A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FAM163A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FAM163A Gene

This gene is overexpressed in Pituitary (x25.2) and Testis (x9.3).

Protein differential expression in normal tissues from HIPED for FAM163A Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FAM163A Gene



Protein tissue co-expression partners for FAM163A Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FAM163A

SOURCE GeneReport for Unigene cluster for FAM163A Gene:

Hs.729631

mRNA Expression by UniProt/SwissProt for FAM163A Gene:

Q96GL9-F163A_HUMAN
Tissue specificity: Highly expressed in neuroblastoma compared to other tissues, suggesting that it may be used as a marker for metastasis in bone marrow.

Evidence on tissue expression from TISSUES for FAM163A Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with FAM163A: view

Primer products for research

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM163A Gene

Orthologs for FAM163A Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM163A Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia FAM163A 30 31
  • 99.61 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia FAM163A 30 31
  • 91.82 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Fam163a 30
  • 89.56 (n)
Mouse
(Mus musculus)
Mammalia Fam163a 30 17 31
  • 88.55 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia FAM163A 30 31
  • 88.34 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia FAM163A 31
  • 70 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia FAM163A 31
  • 63 (a)
OneToOne
Chicken
(Gallus gallus)
Aves FAM163A 30 31
  • 70.09 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia FAM163A 31
  • 56 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii FAM163A (2 of 2) 31
  • 62 (a)
OneToMany
si:dkey-193b15.8 30
  • 61.31 (n)
FAM163A (1 of 2) 31
  • 53 (a)
OneToMany
Species where no ortholog for FAM163A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for FAM163A Gene

ENSEMBL:
Gene Tree for FAM163A (if available)
TreeFam:
Gene Tree for FAM163A (if available)
Aminode:
Evolutionary constrained regions (ECRs) for FAM163A: view image

Paralogs for FAM163A Gene

(1) SIMAP similar genes for FAM163A Gene using alignment to 1 proteins:

  • F163A_HUMAN
genes like me logo Genes that share paralogs with FAM163A: view

No data available for Paralogs for FAM163A Gene

Variants for FAM163A Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for FAM163A Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for FAM163A Gene

Variant ID Type Subtype PubMed ID
dgv19n21 CNV loss 19592680
dgv472n100 CNV gain 25217958
dgv473n100 CNV gain 25217958
dgv64e214 CNV gain 21293372
esv2552928 CNV deletion 19546169
esv33942 CNV loss 17666407
nsv1140428 CNV tandem duplication 24896259
nsv522044 CNV loss 19592680
nsv548339 CNV gain 21841781

Variation tolerance for FAM163A Gene

Residual Variation Intolerance Score: 74.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.27; 25.31% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FAM163A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM163A

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for FAM163A Gene

Disorders for FAM163A Gene

MalaCards: The human disease database

(3) MalaCards diseases for FAM163A Gene - From: COP and GCD

Disorder Aliases PubMed IDs
neuroblastoma
  • nb
acute contagious conjunctivitis
  • contagious opthalmia
acute conjunctivitis
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for FAM163A

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with FAM163A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FAM163A Gene

Publications for FAM163A Gene

  1. Unknown genes, Cebelin and Cebelin-like, predominantly expressed in mouse brain. (PMID: 30294689) Miwa H … Itoh N (Heliyon 2018) 2 3
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41
  3. Neuroblastoma-derived secretory protein is a novel secreted factor overexpressed in neuroblastoma. (PMID: 19671756) Vasudevan SA … Nuchtern JG (Molecular cancer therapeutics 2009) 2 3
  4. Neuroblastoma-derived secretory protein messenger RNA levels correlate with high-risk neuroblastoma. (PMID: 17208556) Vasudevan SA … Nuchtern JG (Journal of pediatric surgery 2007) 3 4
  5. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4

Products for FAM163A Gene

Sources for FAM163A Gene