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Aliases for FAM160B2 Gene

Aliases for FAM160B2 Gene

  • Family With Sequence Similarity 160 Member B2 2 3 5
  • Retinoic Acid-Induced Protein 16 3 4
  • Retinoic Acid Induced 16 2 3
  • Protein FAM160B2 3 4
  • RAI16 3 4
  • Family With Sequence Similarity 160, Member B2 2

External Ids for FAM160B2 Gene

Previous HGNC Symbols for FAM160B2 Gene

  • RAI16

Previous GeneCards Identifiers for FAM160B2 Gene

  • GC08P022003
  • GC08P020466
  • GC08P021947

Summaries for FAM160B2 Gene

GeneCards Summary for FAM160B2 Gene

FAM160B2 (Family With Sequence Similarity 160 Member B2) is a Protein Coding gene. An important paralog of this gene is FAM160B1.

Additional gene information for FAM160B2 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM160B2 Gene

Genomics for FAM160B2 Gene

GeneHancer (GH) Regulatory Elements for FAM160B2 Gene

Promoters and enhancers for FAM160B2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FAM160B2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FAM160B2 gene promoter:
  • AML1a
  • C/EBPalpha
  • CREB
  • deltaCREB
  • ER-alpha
  • MyoD
  • NF-kappaB1
  • PPAR-alpha
  • Spz1
  • ZIC2

Genomic Locations for FAM160B2 Gene

Genomic Locations for FAM160B2 Gene
15,762 bases
Plus strand
15,740 bases
Plus strand

Genomic View for FAM160B2 Gene

Genes around FAM160B2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM160B2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM160B2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM160B2 Gene

Proteins for FAM160B2 Gene

  • Protein details for FAM160B2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein FAM160B2
    Protein Accession:
    Secondary Accessions:
    • B2RDQ5
    • B3KNX1
    • Q2M211
    • Q71JB5
    • Q7L3J6
    • Q969T0
    • Q9H6W4

    Protein attributes for FAM160B2 Gene

    743 amino acids
    Molecular mass:
    82340 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH52237.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAI12148.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAI12148.2; Type=Frameshift; Positions=291; Evidence={ECO:0000305}; Sequence=AAQ06676.1; Type=Frameshift; Positions=258, 727; Evidence={ECO:0000305}; Sequence=BAB15137.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAG38002.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAG51483.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for FAM160B2 Gene

Post-translational modifications for FAM160B2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FAM160B2 Gene

Domains & Families for FAM160B2 Gene

Gene Families for FAM160B2 Gene

Protein Domains for FAM160B2 Gene


Suggested Antigen Peptide Sequences for FAM160B2 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ55841, highly similar to Homo sapiens retinoic acid induced 16 (RAI16), mRNA (A6NNC3_HUMAN)
  • Retinoic acid-induced protein 16 (F16B2_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the UPF0518 family.
  • Belongs to the UPF0518 family.
genes like me logo Genes that share domains with FAM160B2: view

Function for FAM160B2 Gene

Phenotypes From GWAS Catalog for FAM160B2 Gene

Phenotypes for FAM160B2 Gene

genes like me logo Genes that share phenotypes with FAM160B2: view

Animal Model Products

CRISPR Products

miRNA for FAM160B2 Gene

miRTarBase miRNAs that target FAM160B2

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FAM160B2

Clone Products

  • Applied Biological Materials (abm): Clones for FAM160B2 - Now 50% OFF >
  • * FAM160B2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * FAM160B2 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM160B2 Gene

Localization for FAM160B2 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM160B2 gene
Compartment Confidence
nucleus 2
cytosol 2
peroxisome 1
plasma membrane 0
extracellular 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FAM160B2 Gene

Pathways & Interactions for FAM160B2 Gene

PathCards logo

SuperPathways for FAM160B2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FAM160B2 Gene


No data available for Pathways by source and SIGNOR curated interactions for FAM160B2 Gene

Drugs & Compounds for FAM160B2 Gene

No Compound Related Data Available

Transcripts for FAM160B2 Gene

mRNA/cDNA for FAM160B2 Gene

Unigene Clusters for FAM160B2 Gene

Family with sequence similarity 160, member B2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FAM160B2

Clone Products

  • Applied Biological Materials (abm): Clones for FAM160B2 - Now 50% OFF >
  • * FAM160B2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * FAM160B2 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for FAM160B2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b · 12c ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b · 16c ^ 17a ·
SP1: - - -
SP6: -
SP9: -

ExUns: 17b · 17c · 17d

Relevant External Links for FAM160B2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAM160B2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM160B2 Gene

Protein differential expression in normal tissues from HIPED for FAM160B2 Gene

This gene is overexpressed in Bone (62.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FAM160B2 Gene

NURSA nuclear receptor signaling pathways regulating expression of FAM160B2 Gene:


SOURCE GeneReport for Unigene cluster for FAM160B2 Gene:


Evidence on tissue expression from TISSUES for FAM160B2 Gene

  • Nervous system(3.2)
  • Spleen(2)
genes like me logo Genes that share expression patterns with FAM160B2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM160B2 Gene

Orthologs for FAM160B2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM160B2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FAM160B2 35 34
  • 99.46 (n)
(Bos Taurus)
Mammalia FAM160B2 35 34
  • 85.98 (n)
(Canis familiaris)
Mammalia FAM160B2 35 34
  • 84.93 (n)
(Mus musculus)
Mammalia Fam160b2 17 35 34
  • 83.89 (n)
(Rattus norvegicus)
Mammalia Fam160b2 34
  • 83.49 (n)
(Monodelphis domestica)
Mammalia FAM160B2 35
  • 77 (a)
(Ornithorhynchus anatinus)
Mammalia FAM160B2 35
  • 66 (a)
(Gallus gallus)
Aves FAM160B2 35
  • 42 (a)
(Anolis carolinensis)
Reptilia FAM160B2 35
  • 41 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fam160b2 34
  • 58.36 (n)
(Danio rerio)
Actinopterygii fam160b2 35 34
  • 55.9 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5399 34
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 34 (a)
Species where no ortholog for FAM160B2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM160B2 Gene

Gene Tree for FAM160B2 (if available)
Gene Tree for FAM160B2 (if available)
Evolutionary constrained regions (ECRs) for FAM160B2: view image

Paralogs for FAM160B2 Gene

Paralogs for FAM160B2 Gene

(1) SIMAP similar genes for FAM160B2 Gene using alignment to 2 proteins:

  • F16B2_HUMAN
  • F2Z2X3_HUMAN
genes like me logo Genes that share paralogs with FAM160B2: view

Variants for FAM160B2 Gene

Sequence variations from dbSNP and Humsavar for FAM160B2 Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1000278986 -- 22,093,598(+) A/G genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000409059 -- 22,098,300(+) G/T coding_sequence_variant, missense_variant, non_coding_transcript_variant
rs1000814521 -- 22,088,499(+) C/T upstream_transcript_variant
rs1000886131 -- 22,093,500(+) G/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000935564 -- 22,087,160(+) T/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for FAM160B2 Gene

Variant ID Type Subtype PubMed ID
dgv12054n54 CNV loss 21841781
dgv12055n54 CNV loss 21841781
dgv450n21 CNV loss 19592680
dgv881n27 CNV loss 19166990
esv1008033 CNV deletion 20482838
esv2736745 CNV deletion 23290073
esv2759604 CNV loss 17122850
nsv465613 CNV loss 19166990
nsv470204 CNV loss 18288195
nsv528590 CNV loss 19592680
nsv610764 CNV loss 21841781
nsv610765 CNV loss 21841781
nsv831263 CNV loss 17160897
nsv831264 CNV gain+loss 17160897
nsv951112 CNV deletion 24416366

Variation tolerance for FAM160B2 Gene

Residual Variation Intolerance Score: 55.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.00; 90.00% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FAM160B2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM160B2 Gene

Disorders for FAM160B2 Gene

Additional Disease Information for FAM160B2

No disorders were found for FAM160B2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM160B2 Gene

Publications for FAM160B2 Gene

  1. Retinoic acid induced 16 enhances tumorigenesis and serves as a novel tumor marker for hepatocellular carcinoma. (PMID: 22971576) Wang W … Qi ZT (Carcinogenesis 2012) 2 3 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. Are gene expression microarray analyses reliable? A review of studies of retinoic acid responsive genes. (PMID: 15626329) van der Spek PJ … Walker MG (Genomics, proteomics & bioinformatics 2003) 2 3 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. Anchoring of both PKA-RIIα and 14-3-3θ regulates retinoic acid induced 16 mediated phosphorylation of heat shock protein 70. (PMID: 25900241) Ding CL … Wang W (Oncotarget 2015) 3 58

Products for FAM160B2 Gene

Sources for FAM160B2 Gene

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