Free for academic non-profit institutions. Other users need a Commercial license

Aliases for FAM160B2 Gene

Aliases for FAM160B2 Gene

  • Family With Sequence Similarity 160 Member B2 2 3 5
  • Retinoic Acid-Induced Protein 16 3 4
  • Retinoic Acid Induced 16 2 3
  • RAI16 3 4
  • Family With Sequence Similarity 160, Member B2 2
  • Protein FAM160B2 3

External Ids for FAM160B2 Gene

Previous HGNC Symbols for FAM160B2 Gene

  • RAI16

Previous GeneCards Identifiers for FAM160B2 Gene

  • GC08P022003
  • GC08P020466
  • GC08P021947

Summaries for FAM160B2 Gene

GeneCards Summary for FAM160B2 Gene

FAM160B2 (Family With Sequence Similarity 160 Member B2) is a Protein Coding gene. An important paralog of this gene is FAM160B1.

Additional gene information for FAM160B2 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM160B2 Gene

Genomics for FAM160B2 Gene

GeneHancer (GH) Regulatory Elements for FAM160B2 Gene

Promoters and enhancers for FAM160B2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08I022088 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 576.8 +0.7 745 2.7 HDGF ARID4B SIN3A GLI4 ZNF2 GLIS2 ZNF143 ATF7 ZNF202 SP3 FAM160B2 ENSG00000253200 POLR3D CCAR2 C8orf58 NUDT18 SORBS3 ENSG00000251034 GC08M022104
GH08I022692 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 55.7 +605.4 605424 3.6 HDGF ARID4B SIN3A YBX1 ZNF2 ZBTB7B POLR2B ZNF213 E2F8 ZNF416 EGR3 LOC105379321 LOC105379322 FAM160B2 ENSG00000253200 BMP1 LOC107986927 LOXL2 XPO7 C8orf58
GH08I022450 Enhancer 0.9 dbSUPER 126.8 +361.3 361319 0.9 ZNF493 ZNF529 ZFP64 MZF1 ZEB1 ZNF213 ZNF354C ZNF202 ZNF654 ZNF680 ENSG00000253200 FAM160B2 BMP1 SORBS3 POLR3D C8orf58 CCAR2 LOC107986927 LOXL2 XPO7
GH08I022603 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 37.2 +515.8 515849 3.6 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 NFYC CCAR2 GC08P022605 PIR42411 PIR62346 PIR54985 C8orf58 ENSG00000253200 FAM160B2 ENTPD4 BIN3
GH08I023073 Enhancer 1.5 Ensembl ENCODE dbSUPER 29.2 +985.7 985742 2.6 HDGF PKNOX1 MLX ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ENSG00000253616 ENSG00000253200 C8orf58 FAM160B2 LOC107986927 CHMP7 BMP1 LOXL2 PHYHIP CCAR2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around FAM160B2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FAM160B2 gene promoter:

Genomic Locations for FAM160B2 Gene

Genomic Locations for FAM160B2 Gene
15,740 bases
Plus strand

Genomic View for FAM160B2 Gene

Genes around FAM160B2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM160B2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM160B2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM160B2 Gene

Proteins for FAM160B2 Gene

  • Protein details for FAM160B2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein FAM160B2
    Protein Accession:
    Secondary Accessions:
    • B2RDQ5
    • B3KNX1
    • Q2M211
    • Q71JB5
    • Q7L3J6
    • Q969T0
    • Q9H6W4

    Protein attributes for FAM160B2 Gene

    743 amino acids
    Molecular mass:
    82340 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH52237.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAI12148.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAI12148.2; Type=Frameshift; Positions=291; Evidence={ECO:0000305}; Sequence=AAQ06676.1; Type=Frameshift; Positions=258, 727; Evidence={ECO:0000305}; Sequence=BAB15137.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAG38002.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAG51483.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for FAM160B2 Gene

Post-translational modifications for FAM160B2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for FAM160B2 Gene

Domains & Families for FAM160B2 Gene

Gene Families for FAM160B2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FAM160B2 Gene

Suggested Antigen Peptide Sequences for FAM160B2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the UPF0518 family.
  • Belongs to the UPF0518 family.
genes like me logo Genes that share domains with FAM160B2: view

Function for FAM160B2 Gene

Phenotypes From GWAS Catalog for FAM160B2 Gene

Phenotypes for FAM160B2 Gene

GenomeRNAi human phenotypes for FAM160B2:
genes like me logo Genes that share phenotypes with FAM160B2: view

Animal Model Products

CRISPR Products

miRNA for FAM160B2 Gene

miRTarBase miRNAs that target FAM160B2

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM160B2 Gene

Localization for FAM160B2 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM160B2 gene
Compartment Confidence
nucleus 3
cytosol 3
plasma membrane 1
extracellular 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FAM160B2 Gene

Pathways & Interactions for FAM160B2 Gene

SuperPathways for FAM160B2 Gene

No Data Available

Interacting Proteins for FAM160B2 Gene

Gene Ontology (GO) - Biological Process for FAM160B2 Gene


No data available for Pathways by source and SIGNOR curated interactions for FAM160B2 Gene

Drugs & Compounds for FAM160B2 Gene

No Compound Related Data Available

Transcripts for FAM160B2 Gene

Unigene Clusters for FAM160B2 Gene

Family with sequence similarity 160, member B2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM160B2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b · 12c ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b · 16c ^ 17a ·
SP1: - - -
SP6: -
SP9: -

ExUns: 17b · 17c · 17d

Relevant External Links for FAM160B2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAM160B2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM160B2 Gene

Protein differential expression in normal tissues from HIPED for FAM160B2 Gene

This gene is overexpressed in Bone (62.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FAM160B2 Gene

NURSA nuclear receptor signaling pathways regulating expression of FAM160B2 Gene:


SOURCE GeneReport for Unigene cluster for FAM160B2 Gene:


Evidence on tissue expression from TISSUES for FAM160B2 Gene

  • Nervous system(3.2)
  • Spleen(2)
genes like me logo Genes that share expression patterns with FAM160B2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM160B2 Gene

Orthologs for FAM160B2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM160B2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FAM160B2 33 34
  • 99.46 (n)
(Bos Taurus)
Mammalia FAM160B2 33 34
  • 85.98 (n)
(Canis familiaris)
Mammalia FAM160B2 33 34
  • 84.93 (n)
(Mus musculus)
Mammalia Fam160b2 33 16 34
  • 83.89 (n)
(Rattus norvegicus)
Mammalia Fam160b2 33
  • 83.49 (n)
(Monodelphis domestica)
Mammalia FAM160B2 34
  • 77 (a)
(Ornithorhynchus anatinus)
Mammalia FAM160B2 34
  • 66 (a)
(Gallus gallus)
Aves FAM160B2 34
  • 42 (a)
(Anolis carolinensis)
Reptilia FAM160B2 34
  • 41 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fam160b2 33
  • 58.36 (n)
(Danio rerio)
Actinopterygii fam160b2 33 34
  • 55.9 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5399 33
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 34 (a)
Species where no ortholog for FAM160B2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM160B2 Gene

Gene Tree for FAM160B2 (if available)
Gene Tree for FAM160B2 (if available)

Paralogs for FAM160B2 Gene

Paralogs for FAM160B2 Gene

(1) SIMAP similar genes for FAM160B2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with FAM160B2: view

Variants for FAM160B2 Gene

Sequence variations from dbSNP and Humsavar for FAM160B2 Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1000278986 -- 22,093,598(+) A/G genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000409059 -- 22,098,300(+) G/T coding_sequence_variant, missense_variant, non_coding_transcript_variant
rs1000814521 -- 22,088,499(+) C/T upstream_transcript_variant
rs1000886131 -- 22,093,500(+) G/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000935564 -- 22,087,160(+) T/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for FAM160B2 Gene

Variant ID Type Subtype PubMed ID
nsv951112 CNV deletion 24416366
nsv831264 CNV gain+loss 17160897
nsv831263 CNV loss 17160897
nsv610765 CNV loss 21841781
nsv610764 CNV loss 21841781
nsv528590 CNV loss 19592680
nsv470204 CNV loss 18288195
nsv465613 CNV loss 19166990
esv2759604 CNV loss 17122850
esv2736745 CNV deletion 23290073
esv1008033 CNV deletion 20482838
dgv881n27 CNV loss 19166990
dgv450n21 CNV loss 19592680
dgv12055n54 CNV loss 21841781
dgv12054n54 CNV loss 21841781

Variation tolerance for FAM160B2 Gene

Residual Variation Intolerance Score: 55.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.00; 90.00% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FAM160B2 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM160B2 Gene

Disorders for FAM160B2 Gene

Additional Disease Information for FAM160B2

No disorders were found for FAM160B2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM160B2 Gene

Publications for FAM160B2 Gene

  1. Retinoic acid induced 16 enhances tumorigenesis and serves as a novel tumor marker for hepatocellular carcinoma. (PMID: 22971576) Wang W … Qi ZT (Carcinogenesis 2012) 2 3 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. Are gene expression microarray analyses reliable? A review of studies of retinoic acid responsive genes. (PMID: 15626329) van der Spek PJ … Walker MG (Genomics, proteomics & bioinformatics 2003) 2 3 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. Anchoring of both PKA-RIIα and 14-3-3θ regulates retinoic acid induced 16 mediated phosphorylation of heat shock protein 70. (PMID: 25900241) Ding CL … Wang W (Oncotarget 2015) 3 58

Products for FAM160B2 Gene

Sources for FAM160B2 Gene

Loading form....