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Aliases for FAM160B1 Gene

Aliases for FAM160B1 Gene

  • Family With Sequence Similarity 160 Member B1 2 3 5
  • KIAA1600 2 3 4
  • Family With Sequence Similarity 160, Member B1 2
  • Protein FAM160B1 3
  • BA106M7.3 3

External Ids for FAM160B1 Gene

Previous HGNC Symbols for FAM160B1 Gene

  • KIAA1600

Previous GeneCards Identifiers for FAM160B1 Gene

  • GC10P116572
  • GC10P110207

Summaries for FAM160B1 Gene

GeneCards Summary for FAM160B1 Gene

FAM160B1 (Family With Sequence Similarity 160 Member B1) is a Protein Coding gene. An important paralog of this gene is FAM160B2.

Additional gene information for FAM160B1 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM160B1 Gene

Genomics for FAM160B1 Gene

GeneHancer (GH) Regulatory Elements for FAM160B1 Gene

Promoters and enhancers for FAM160B1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10I114820 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 565.2 +2.4 2408 6.8 PKNOX1 FOXA2 ARNT SIN3A IRF4 YY1 GLIS2 ZNF207 ZNF143 ATF7 FAM160B1 ATRNL1 TRUB1 ABLIM1 RPL15P13
GH10I113851 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE 12.8 -967.6 -967604 5.9 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B IRF4 DCLRE1A NHLRC2 CCDC186 FAM160B1 LOC105378488 TCF7L2 ENSG00000212589
GH10I114937 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 11.2 +116.9 116929 2.2 PKNOX1 FOXA2 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF207 ZNF143 SP3 TRUB1 ATRNL1 FAM160B1 RNU6-1121P
GH10I114647 Enhancer 1.3 Ensembl ENCODE dbSUPER 15.7 -173.6 -173608 2 FEZF1 ZNF2 BRCA1 YY1 ZNF213 FOS DEK RXRA TSHZ1 REST FAM160B1 CCDC186 PPIAP19 ENSG00000229668 ABLIM1
GH10I114239 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE 13 -582.0 -581976 1.4 SIN3A RAD21 ZNF48 GLIS2 ZNF366 SCRT2 ZNF362 ZEB2 ZNF843 ZFP69B VWA2 TDRD1 FAM160B1 CCDC186 AURKAPS2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around FAM160B1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FAM160B1 gene promoter:

Genomic Locations for FAM160B1 Gene

Genomic Locations for FAM160B1 Gene
chr10:114,821,744-114,899,832
(GRCh38/hg38)
Size:
78,089 bases
Orientation:
Plus strand
chr10:116,581,503-116,659,591
(GRCh37/hg19)

Genomic View for FAM160B1 Gene

Genes around FAM160B1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM160B1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM160B1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM160B1 Gene

Proteins for FAM160B1 Gene

  • Protein details for FAM160B1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5W0V3-F16B1_HUMAN
    Recommended name:
    Protein FAM160B1
    Protein Accession:
    Q5W0V3
    Secondary Accessions:
    • Q5H9P7
    • Q5W0V2
    • Q8IY76
    • Q9HCH2

    Protein attributes for FAM160B1 Gene

    Size:
    765 amino acids
    Molecular mass:
    86558 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FAM160B1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FAM160B1 Gene

Post-translational modifications for FAM160B1 Gene

  • Ubiquitination at Lys163
  • Modification sites at PhosphoSitePlus

Other Protein References for FAM160B1 Gene

No data available for DME Specific Peptides for FAM160B1 Gene

Domains & Families for FAM160B1 Gene

Gene Families for FAM160B1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FAM160B1 Gene

Suggested Antigen Peptide Sequences for FAM160B1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5W0V3

UniProtKB/Swiss-Prot:

F16B1_HUMAN :
  • Belongs to the UPF0518 family.
Family:
  • Belongs to the UPF0518 family.
genes like me logo Genes that share domains with FAM160B1: view

Function for FAM160B1 Gene

genes like me logo Genes that share phenotypes with FAM160B1: view

Animal Model Products

miRNA for FAM160B1 Gene

miRTarBase miRNAs that target FAM160B1

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM160B1 Gene

Localization for FAM160B1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM160B1 gene
Compartment Confidence
nucleus 3
cytosol 3
extracellular 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nuclear speckles (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FAM160B1 Gene

Pathways & Interactions for FAM160B1 Gene

SuperPathways for FAM160B1 Gene

No Data Available

Interacting Proteins for FAM160B1 Gene

Gene Ontology (GO) - Biological Process for FAM160B1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FAM160B1 Gene

Drugs & Compounds for FAM160B1 Gene

No Compound Related Data Available

Transcripts for FAM160B1 Gene

Unigene Clusters for FAM160B1 Gene

Family with sequence similarity 160, member B1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM160B1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16
SP1:
SP2:

Relevant External Links for FAM160B1 Gene

GeneLoc Exon Structure for
FAM160B1
ECgene alternative splicing isoforms for
FAM160B1

Expression for FAM160B1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM160B1 Gene

Protein differential expression in normal tissues from HIPED for FAM160B1 Gene

This gene is overexpressed in Bone (35.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FAM160B1 Gene



Protein tissue co-expression partners for FAM160B1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FAM160B1 Gene:

FAM160B1

SOURCE GeneReport for Unigene cluster for FAM160B1 Gene:

Hs.192619
genes like me logo Genes that share expression patterns with FAM160B1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM160B1 Gene

Orthologs for FAM160B1 Gene

This gene was present in the common ancestor of animals.

Orthologs for FAM160B1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM160B1 33 34
  • 99.55 (n)
oppossum
(Monodelphis domestica)
Mammalia FAM160B1 34
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FAM160B1 34
  • 92 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FAM160B1 33 34
  • 90.68 (n)
dog
(Canis familiaris)
Mammalia FAM160B1 33 34
  • 89.85 (n)
rat
(Rattus norvegicus)
Mammalia Fam160b1 33
  • 84.38 (n)
mouse
(Mus musculus)
Mammalia Fam160b1 33 16 34
  • 83.94 (n)
chicken
(Gallus gallus)
Aves FAM160B1 33 34
  • 81.33 (n)
lizard
(Anolis carolinensis)
Reptilia FAM160B1 34
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fam160b1 33
  • 71.28 (n)
Str.20259 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.13748 33
zebrafish
(Danio rerio)
Actinopterygii fam160b1 33 34
  • 67.74 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003125 33
  • 45.35 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 44 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4709 33
Species where no ortholog for FAM160B1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM160B1 Gene

ENSEMBL:
Gene Tree for FAM160B1 (if available)
TreeFam:
Gene Tree for FAM160B1 (if available)

Paralogs for FAM160B1 Gene

Paralogs for FAM160B1 Gene

(1) SIMAP similar genes for FAM160B1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with FAM160B1: view

Variants for FAM160B1 Gene

Sequence variations from dbSNP and Humsavar for FAM160B1 Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs1000006568 -- 114,891,732(+) T/A genic_downstream_transcript_variant, intron_variant
rs1000021851 -- 114,856,491(+) G/A intron_variant
rs1000039000 -- 114,827,069(+) A/C intron_variant
rs1000058436 -- 114,876,808(+) A/G genic_downstream_transcript_variant, intron_variant
rs1000106786 -- 114,898,302(+) G/A genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for FAM160B1 Gene

Variant ID Type Subtype PubMed ID
dgv977n100 CNV gain 25217958
esv2761634 CNV gain 21179565
esv3577749 CNV gain 25503493
esv3624622 CNV gain 21293372
esv3624623 CNV gain 21293372
esv3624624 CNV gain 21293372
nsv1038050 CNV gain 25217958
nsv518081 CNV loss 19592680
nsv7211 OTHER inversion 18451855
nsv831996 CNV gain 17160897

Variation tolerance for FAM160B1 Gene

Residual Variation Intolerance Score: 6.03% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.89; 35.34% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FAM160B1 Gene

Human Gene Mutation Database (HGMD)
FAM160B1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM160B1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM160B1 Gene

Disorders for FAM160B1 Gene

Additional Disease Information for FAM160B1

No disorders were found for FAM160B1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM160B1 Gene

Publications for FAM160B1 Gene

  1. Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10997877) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 2 3 4 58
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58
  4. A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning. (PMID: 26673895) Kırlı K … Görlich D (eLife 2015) 3 58
  5. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y … Zou H (Journal of proteomics 2014) 4 58

Products for FAM160B1 Gene

Sources for FAM160B1 Gene

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