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Aliases for FAM155B Gene

Aliases for FAM155B Gene

  • Family With Sequence Similarity 155 Member B 2 3 5
  • Transmembrane Protein 28 2 3 4
  • TMEM28 3 4
  • TED 3 4
  • Family With Sequence Similarity 155, Member B 2
  • Chromosome X Open Reading Frame 63 2
  • Transmembrane Protein FAM155B 3
  • BB57D9.1 (TED Protein) 3
  • Protein TED 4
  • BB57D9.1 3
  • CXorf63 3

External Ids for FAM155B Gene

Previous HGNC Symbols for FAM155B Gene

  • TMEM28
  • CXorf63

Previous GeneCards Identifiers for FAM155B Gene

  • GC0XP068643
  • GC0XP062546
  • GC0XP068725

Summaries for FAM155B Gene

Entrez Gene Summary for FAM155B Gene

  • This gene encodes a product belonging to a family of proteins with unknown function. The presence of two transmembrane domains suggests that this protein is a multi-pass membrane protein. [provided by RefSeq, Sep 2011]

GeneCards Summary for FAM155B Gene

FAM155B (Family With Sequence Similarity 155 Member B) is a Protein Coding gene. Diseases associated with FAM155B include Marantic Endocarditis and Exophthalmos. An important paralog of this gene is FAM155A.

Additional gene information for FAM155B Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM155B Gene

Genomics for FAM155B Gene

GeneHancer (GH) Regulatory Elements for FAM155B Gene

Promoters and enhancers for FAM155B Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XI069503 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 567.7 -0.8 -752 2.3 ELF3 ARID4B KLF17 SIN3A DMAP1 ZNF335 GLIS2 KLF7 EGR2 ZNF280D FAM155B CYCSP43
GH0XI069284 Enhancer 1 Ensembl ENCODE 4.9 -219.4 -219380 1.7 RB1 KLF17 RAD21 GLIS2 EGR1 ZNF143 EGR2 ZNF654 ZBTB11 REST YIPF6 FAM155B PIR50037 GC0XM069229
GH0XI068681 Enhancer 0.5 Ensembl ENCODE 5.4 -823.6 -823630 0.8 EBF1 FAM155B STARD8 ACTR3P2
GH0XI069395 Enhancer 0.2 ENCODE 4.3 -109.7 -109683 0.9 SERBP1P1 FAM155B GC0XM069229 PIR50037
GH0XI069538 Enhancer 0.7 Ensembl 0.3 +33.4 33406 0.8 CTCF ZNF777 RB1 SAP130 ARID4B KLF17 BACH1 ZNF175 ZNF48 RAD21 EDA STARD8 ENSG00000228160 FAM155B
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around FAM155B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FAM155B gene promoter:

Genomic Locations for FAM155B Gene

Genomic Locations for FAM155B Gene
27,308 bases
Plus strand

Genomic View for FAM155B Gene

Genes around FAM155B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM155B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM155B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM155B Gene

Proteins for FAM155B Gene

  • Protein details for FAM155B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane protein FAM155B
    Protein Accession:
    Secondary Accessions:
    • B1ALV6
    • B9EGK1
    • D3DVU1

    Protein attributes for FAM155B Gene

    473 amino acids
    Molecular mass:
    52605 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FAM155B Gene


neXtProt entry for FAM155B Gene

Post-translational modifications for FAM155B Gene

  • Glycosylation at Asn120 and posLast=193193

Other Protein References for FAM155B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FAM155B Gene

Domains & Families for FAM155B Gene

Gene Families for FAM155B Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for FAM155B Gene


Suggested Antigen Peptide Sequences for FAM155B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the FAM155 family.
  • Belongs to the FAM155 family.
genes like me logo Genes that share domains with FAM155B: view

Function for FAM155B Gene

Phenotypes From GWAS Catalog for FAM155B Gene

Gene Ontology (GO) - Molecular Function for FAM155B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015275 contributes_to stretch-activated, cation-selective, calcium channel activity IBA --
genes like me logo Genes that share ontologies with FAM155B: view

Phenotypes for FAM155B Gene

genes like me logo Genes that share phenotypes with FAM155B: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM155B Gene

Localization for FAM155B Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM155B Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM155B gene
Compartment Confidence
plasma membrane 4
extracellular 3
endoplasmic reticulum 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for FAM155B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with FAM155B: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for FAM155B Gene

Pathways & Interactions for FAM155B Gene

SuperPathways for FAM155B Gene

No Data Available

Interacting Proteins for FAM155B Gene

Selected Interacting proteins: O75949-F155B_HUMAN for FAM155B Gene via IID

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for FAM155B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0098703 calcium ion import across plasma membrane IBA --
genes like me logo Genes that share ontologies with FAM155B: view

No data available for Pathways by source and SIGNOR curated interactions for FAM155B Gene

Drugs & Compounds for FAM155B Gene

No Compound Related Data Available

Transcripts for FAM155B Gene

mRNA/cDNA for FAM155B Gene

(3) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(22) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FAM155B Gene

Family with sequence similarity 155, member B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM155B Gene

No ASD Table

Relevant External Links for FAM155B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAM155B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM155B Gene

mRNA differential expression in normal tissues according to GTEx for FAM155B Gene

This gene is overexpressed in Heart - Atrial Appendage (x17.8) and Heart - Left Ventricle (x12.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FAM155B Gene

NURSA nuclear receptor signaling pathways regulating expression of FAM155B Gene:


SOURCE GeneReport for Unigene cluster for FAM155B Gene:

genes like me logo Genes that share expression patterns with FAM155B: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM155B Gene

Orthologs for FAM155B Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM155B Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia FAM155B 33 34
  • 93.93 (n)
(Rattus norvegicus)
Mammalia Fam155b 33
  • 93.63 (n)
(Bos Taurus)
Mammalia FAM155B 33 34
  • 93.56 (n)
(Mus musculus)
Mammalia Tmem28 33 16 34
  • 93.56 (n)
(Monodelphis domestica)
Mammalia FAM155B 34
  • 53 (a)
(Gallus gallus)
Aves FAM155B 33 34
  • 67.9 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia fam155b 33
  • 64.25 (n)
(Danio rerio)
Actinopterygii fam155b 33 34
  • 54.89 (n)
Species where no ortholog for FAM155B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM155B Gene

Gene Tree for FAM155B (if available)
Gene Tree for FAM155B (if available)

Paralogs for FAM155B Gene

Paralogs for FAM155B Gene

genes like me logo Genes that share paralogs with FAM155B: view

Variants for FAM155B Gene

Sequence variations from dbSNP and Humsavar for FAM155B Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1000201144 -- 69,532,820(+) G/T downstream_transcript_variant
rs1000326156 -- 69,507,350(+) G/A 3_prime_UTR_variant, intron_variant
rs1000367749 -- 69,530,540(+) C/T 3_prime_UTR_variant, genic_downstream_transcript_variant
rs1000546733 -- 69,515,680(+) T/G genic_downstream_transcript_variant, intron_variant
rs1000593187 -- 69,526,010(+) A/G genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for FAM155B Gene

Variant ID Type Subtype PubMed ID
esv3574027 CNV loss 25503493
esv25466 CNV loss 19812545
esv23322 CNV gain 19812545
esv1584074 OTHER inversion 17803354

Variation tolerance for FAM155B Gene

Residual Variation Intolerance Score: 44.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.42; 42.72% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FAM155B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM155B Gene

Disorders for FAM155B Gene

MalaCards: The human disease database

(3) MalaCards diseases for FAM155B Gene - From: DISEASES

Disorder Aliases PubMed IDs
marantic endocarditis
  • non-bacterial thrombotic endocarditis
  • proptosis
  • enterobius vermicularis infection
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for FAM155B

genes like me logo Genes that share disorders with FAM155B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FAM155B Gene

Publications for FAM155B Gene

  1. Genome-wide association study reveals multiple loci associated with primary tooth development during infancy. (PMID: 20195514) Pillas D … Jarvelin MR (PLoS genetics 2010) 44 58
  2. Genome-wide association with bone mass and geometry in the Framingham Heart Study. (PMID: 17903296) Kiel DP … Karasik D (BMC medical genetics 2007) 44 58
  3. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58

Products for FAM155B Gene

Sources for FAM155B Gene

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