Free for academic non-profit institutions. Other users need a Commercial license

Aliases for FAM153C Gene

Aliases for FAM153C Gene

  • Family With Sequence Similarity 153 Member C 2 3 5
  • Family With Sequence Similarity 153, Member C 2
  • Protein FAM153C 3
  • NY-REN-7-Like 3

External Ids for FAM153C Gene

Previous GeneCards Identifiers for FAM153C Gene

  • GC05P177369
  • GC05P177435
  • GC05P172169
  • GC05P177437
  • GC05P177440
  • GC05P177445
  • GC05P177448
  • GC05P177451

Summaries for FAM153C Gene

GeneCards Summary for FAM153C Gene

FAM153C (Family With Sequence Similarity 153 Member C) is a Protein Coding gene. An important paralog of this gene is FAM153B.

Additional gene information for FAM153C Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM153C Gene

Genomics for FAM153C Gene

GeneHancer (GH) Regulatory Elements for FAM153C Gene

Promoters and enhancers for FAM153C Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05I178006 Enhancer 0.2 Ensembl 550.8 +0.1 96 0.2 FAM153C LOC100288656 PIR57455
GH05I177591 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 17.2 -414.0 -413975 1.8 SMAD1 ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B ZNF766 ZNF207 ZNF143 TMED9 FAM153C B4GALT7
GH05I177606 Enhancer 0.8 ENCODE 18.6 -398.9 -398944 1.9 RB1 ARID4B KLF17 SIN3A ZNF2 ZNF48 RAD21 ZNF335 SCRT2 ZNF143 B4GALT7 FAM153C LOC202181 FAM153A TMED9 ENSG00000247679
GH05I178077 Enhancer 1 Ensembl ENCODE 10.1 +72.0 72002 1.2 HDGF PKNOX1 CLOCK NFIB NEUROD1 SIN3A ZBTB7B EGR1 E2F8 FOS FAM193B ZNF354B RMND5B N4BP3 NSD1 LOC202181 HNRNPAB RPL21P60 ENSG00000247679 FAM153C
GH05I178086 Enhancer 1 ENCODE dbSUPER 7.8 +80.1 80109 0.7 HDGF PKNOX1 NFIB SIN3A ZBTB7B RFX5 ELK1 EGR1 HSF1 FOS N4BP3 RMND5B FAM153C RPL19P9 LOC105377754 PIR41367
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around FAM153C on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FAM153C gene promoter:

Genomic Locations for FAM153C Gene

Genomic Locations for FAM153C Gene
chr5:178,006,405-178,055,559
(GRCh38/hg38)
Size:
49,155 bases
Orientation:
Plus strand
chr5:177,433,406-177,482,560
(GRCh37/hg19)

Genomic View for FAM153C Gene

Genes around FAM153C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM153C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM153C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM153C Gene

Proteins for FAM153C Gene

  • Protein details for FAM153C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q494X1-F153C_HUMAN
    Recommended name:
    Protein FAM153C
    Protein Accession:
    Q494X1
    Secondary Accessions:
    • A4IF33
    • B2RUV5
    • B7ZW12

    Protein attributes for FAM153C Gene

    Size:
    144 amino acids
    Molecular mass:
    16640 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FAM153C Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FAM153C Gene

Post-translational modifications for FAM153C Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM153C Gene

No data available for DME Specific Peptides for FAM153C Gene

Domains & Families for FAM153C Gene

Gene Families for FAM153C Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FAM153C Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM153C Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q494X1

UniProtKB/Swiss-Prot:

F153C_HUMAN :
  • Belongs to the FAM153 family.
Family:
  • Belongs to the FAM153 family.
genes like me logo Genes that share domains with FAM153C: view

Function for FAM153C Gene

Phenotypes From GWAS Catalog for FAM153C Gene

Gene Ontology (GO) - Molecular Function for FAM153C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with FAM153C: view

Phenotypes for FAM153C Gene

GenomeRNAi human phenotypes for FAM153C:
genes like me logo Genes that share phenotypes with FAM153C: view

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FAM153C Gene

Localization for FAM153C Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM153C gene
Compartment Confidence
nucleus 2
cytosol 2
extracellular 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for FAM153C Gene

Pathways & Interactions for FAM153C Gene

SuperPathways for FAM153C Gene

No Data Available

Interacting Proteins for FAM153C Gene

Selected Interacting proteins: Q494X1-F153C_HUMAN for FAM153C Gene via IID UniProtKB

Gene Ontology (GO) - Biological Process for FAM153C Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FAM153C Gene

Drugs & Compounds for FAM153C Gene

No Compound Related Data Available

Transcripts for FAM153C Gene

mRNA/cDNA for FAM153C Gene

(2) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(13) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FAM153C Gene

Family with sequence similarity 153, member C, pseudogene:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM153C Gene

No ASD Table

Relevant External Links for FAM153C Gene

GeneLoc Exon Structure for
FAM153C
ECgene alternative splicing isoforms for
FAM153C

Expression for FAM153C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM153C Gene

mRNA differential expression in normal tissues according to GTEx for FAM153C Gene

This gene is overexpressed in Brain - Cerebellum (x8.7), Brain - Cerebellar Hemisphere (x8.0), Testis (x5.2), and Pituitary (x5.0).

NURSA nuclear receptor signaling pathways regulating expression of FAM153C Gene:

FAM153C

SOURCE GeneReport for Unigene cluster for FAM153C Gene:

Hs.652193
genes like me logo Genes that share expression patterns with FAM153C: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM153C Gene

Orthologs for FAM153C Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for FAM153C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 34
  • 97 (a)
ManyToMany
-- 34
  • 35 (a)
ManyToMany
Species where no ortholog for FAM153C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FAM153C Gene

ENSEMBL:
Gene Tree for FAM153C (if available)
TreeFam:
Gene Tree for FAM153C (if available)

Paralogs for FAM153C Gene

Paralogs for FAM153C Gene

(2) SIMAP similar genes for FAM153C Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with FAM153C: view

Variants for FAM153C Gene

Sequence variations from dbSNP and Humsavar for FAM153C Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000040781 -- 178,024,758(+) T/G intron_variant
rs1000300940 -- 178,044,264(+) A/G intron_variant
rs1000339723 -- 178,005,583(+) A/G upstream_transcript_variant
rs1000481726 -- 178,016,005(+) A/G intron_variant
rs1000496265 -- 178,015,820(+) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for FAM153C Gene

Variant ID Type Subtype PubMed ID
dgv5844n100 CNV gain 25217958
nsv1115711 CNV duplication 24896259
nsv1120062 OTHER inversion 24896259
nsv509105 CNV insertion 20534489
nsv950729 CNV deletion 24416366
nsv968283 CNV duplication 23825009
nsv968284 CNV duplication 23825009
nsv969026 CNV duplication 23825009
nsv969092 CNV duplication 23825009
nsv980768 CNV duplication 23825009

Variation tolerance for FAM153C Gene

Gene Damage Index Score: 0.07; 1.61% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FAM153C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM153C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM153C Gene

Disorders for FAM153C Gene

Additional Disease Information for FAM153C

No disorders were found for FAM153C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM153C Gene

Publications for FAM153C Gene

  1. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58

Products for FAM153C Gene

Sources for FAM153C Gene

Content
Loading form....