Aliases for FAM153B Gene

Aliases for FAM153B Gene

  • Family With Sequence Similarity 153 Member B 2 3 5
  • Protein FAM153B 3 4
  • Family With Sequence Similarity 153, Member B 2
  • FAM153B 5

External Ids for FAM153B Gene

Previous GeneCards Identifiers for FAM153B Gene

  • GC05P175444
  • GC05P175511
  • GC05P170477

Summaries for FAM153B Gene

GeneCards Summary for FAM153B Gene

FAM153B (Family With Sequence Similarity 153 Member B) is a Protein Coding gene. Diseases associated with FAM153B include Sotos Syndrome 1. An important paralog of this gene is ENSG00000285476.

Additional gene information for FAM153B Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FAM153B Gene

Genomics for FAM153B Gene

GeneHancer (GH) Regulatory Elements Pubs


GeneHancers around FAM153B on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FAM153B

Top Transcription factor binding sites by QIAGEN in the FAM153B gene promoter:
  • c-Myb
  • E47
  • HOXA5
  • NF-AT
  • NF-AT1
  • NF-AT2
  • NF-AT3
  • NF-AT4
  • RORalpha1
  • STAT1

Genomic Locations for FAM153B Gene

Genomic Locations for FAM153B Gene
chr5:176,060,689-176,116,015
(GRCh38/hg38)
Size:
55,327 bases
Orientation:
Plus strand
chr5:175,487,692-175,559,261
(GRCh37/hg19)
Size:
71,570 bases
Orientation:
Plus strand

Genomic View for FAM153B Gene

Genes around FAM153B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM153B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM153B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM153B Gene

Proteins for FAM153B Gene

  • Protein details for FAM153B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0C7A2-F153B_HUMAN
    Recommended name:
    Protein FAM153B
    Protein Accession:
    P0C7A2
    Secondary Accessions:
    • A8MTI1

    Protein attributes for FAM153B Gene

    Size:
    387 amino acids
    Molecular mass:
    43591 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH28606.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for FAM153B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FAM153B Gene

Post-translational modifications for FAM153B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM153B Gene

No data available for DME Specific Peptides for FAM153B Gene

Domains & Families for FAM153B Gene

Gene Families for FAM153B Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FAM153B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM153B Gene

GenScript: Design optimal peptide antigens:
  • Protein FAM153B (F153B_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P0C7A2

UniProtKB/Swiss-Prot:

F153B_HUMAN :
  • Belongs to the FAM153 family.
Family:
  • Belongs to the FAM153 family.
genes like me logo Genes that share domains with FAM153B: view

Function for FAM153B Gene

Phenotypes From GWAS Catalog for FAM153B Gene

genes like me logo Genes that share phenotypes with FAM153B: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FAM153B

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM153B Gene

Localization for FAM153B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM153B gene
Compartment Confidence
nucleus 2
mitochondrion 1
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for FAM153B Gene

Pathways & Interactions for FAM153B Gene

PathCards logo

SuperPathways for FAM153B Gene

No Data Available

Gene Ontology (GO) - Biological Process for FAM153B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FAM153B Gene

Drugs & Compounds for FAM153B Gene

No Compound Related Data Available

Transcripts for FAM153B Gene

mRNA/cDNA for FAM153B Gene

2 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
15 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FAM153B

Alternative Splicing Database (ASD) splice patterns (SP) for FAM153B Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6
SP1: -
SP2: - -
SP3: - - - - -
SP4:

Relevant External Links for FAM153B Gene

GeneLoc Exon Structure for
FAM153B

Expression for FAM153B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FAM153B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

  • Testis (Reproductive System)

mRNA differential expression in normal tissues according to GTEx for FAM153B Gene

This gene is overexpressed in Brain - Cerebellum (x5.7), Brain - Cerebellar Hemisphere (x5.2), and Ovary (x4.6).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FAM153B

SOURCE GeneReport for Unigene cluster for FAM153B Gene:

Hs.368516
genes like me logo Genes that share expression patterns with FAM153B: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM153B Gene

Orthologs for FAM153B Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for FAM153B Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia FAM153B 30
  • 97.63 (n)
-- 31
  • 97 (a)
ManyToMany
-- 31
  • 75 (a)
ManyToMany
Species where no ortholog for FAM153B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for FAM153B Gene

ENSEMBL:
Gene Tree for FAM153B (if available)
TreeFam:
Gene Tree for FAM153B (if available)

Paralogs for FAM153B Gene

Paralogs for FAM153B Gene

(2) SIMAP similar genes for FAM153B Gene using alignment to 4 proteins:

  • F153B_HUMAN
  • D6RF84_HUMAN
  • H0YL08_HUMAN
  • H0YMR7_HUMAN
genes like me logo Genes that share paralogs with FAM153B: view

Variants for FAM153B Gene

Additional dbSNP identifiers (rs#s) for FAM153B Gene

Structural Variations from Database of Genomic Variants (DGV) for FAM153B Gene

Variant ID Type Subtype PubMed ID
dgv5832n100 CNV gain 25217958
dgv5833n100 CNV gain 25217958
dgv5834n100 CNV gain 25217958
dgv5835n100 CNV gain+loss 25217958
dgv5836n100 CNV loss 25217958
dgv5837n100 CNV loss 25217958
dgv5838n100 CNV gain 25217958
esv2421778 CNV duplication 20811451
esv2658103 CNV deletion 23128226
esv2759395 CNV gain 17122850
esv2760985 CNV gain+loss 21179565
esv3428875 CNV duplication 20981092
esv34563 CNV gain 17911159
esv3570567 CNV loss 25503493
esv3575900 CNV gain 25503493
esv3607661 CNV loss 21293372
esv3607662 CNV gain 21293372
esv3607663 CNV loss 21293372
esv3607664 CNV loss 21293372
esv3607665 CNV gain 21293372
nsv1017719 CNV gain 25217958
nsv1023853 CNV gain 25217958
nsv10778 CNV loss 18304495
nsv1078562 CNV duplication 25765185
nsv1078563 CNV duplication 25765185
nsv1124928 CNV duplication 24896259
nsv1128920 CNV duplication 24896259
nsv1132616 CNV duplication 24896259
nsv1149049 CNV duplication 26484159
nsv1149555 CNV duplication 26484159
nsv428131 CNV gain 18775914
nsv441977 CNV gain 18776908
nsv950716 CNV deletion 24416366
nsv950718 CNV duplication 24416366
nsv964973 CNV duplication 23825009
nsv964974 CNV duplication 23825009
nsv964975 CNV duplication 23825009
nsv968274 CNV duplication 23825009
nsv968275 CNV duplication 23825009
nsv968347 CNV duplication 23825009
nsv968348 CNV duplication 23825009
nsv969018 CNV duplication 23825009
nsv980756 CNV duplication 23825009
nsv980757 CNV duplication 23825009
nsv980828 CNV duplication 23825009

Variation tolerance for FAM153B Gene

Residual Variation Intolerance Score: 60.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.70; 14.83% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FAM153B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM153B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for FAM153B Gene

Disorders for FAM153B Gene

MalaCards: The human disease database

(1) MalaCards diseases for FAM153B Gene - From: DISEASES

Disorder Aliases PubMed IDs
sotos syndrome 1
  • sotos1
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with FAM153B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FAM153B Gene

Publications for FAM153B Gene

  1. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3

Products for FAM153B Gene

  • Biorbyt antibodies for FAM153B

Sources for FAM153B Gene