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Aliases for FAM153A Gene

Aliases for FAM153A Gene

  • Family With Sequence Similarity 153 Member A 2 3 5
  • Renal Carcinoma Antigen NY-REN-7 3 4
  • NY REN 7 Antigen 2 3
  • Family With Sequence Similarity 153, Member A 2
  • Protein FAM153A 3
  • NY-REN-7 3
  • KIAA0752 4

External Ids for FAM153A Gene

Previous GeneCards Identifiers for FAM153A Gene

  • GC05M177071
  • GC05P172197
  • GC05M177134

Summaries for FAM153A Gene

GeneCards Summary for FAM153A Gene

FAM153A (Family With Sequence Similarity 153 Member A) is a Protein Coding gene. An important paralog of this gene is FAM153B.

Additional gene information for FAM153A Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM153A Gene

Genomics for FAM153A Gene

GeneHancer (GH) Regulatory Elements for FAM153A Gene

Promoters and enhancers for FAM153A Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05I177768 Promoter 0.5 EPDnew 550.4 +14.9 14885 0.1 FAM153A ENSG00000249109 PIR47344
GH05I177783 Enhancer 0.2 Ensembl 550.8 -0.1 -103 0.2 ENSG00000249109 FAM153A LOC100419951
GH05I177552 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 7.3 +229.2 229214 3.2 FOXA2 ARNT ARID4B SIN3A ZNF2 YY1 ZNF766 E2F8 ZNF143 SP3 FAM193B GC05P177553 LOC105377750 DOK3 DDX41 TMED9 B4GALT7 FAM153A
GH05I177515 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 4.9 +266.3 266277 3 HDGF FOXA2 PKNOX1 CLOCK SMAD1 ARNT ARID4B NEUROD1 SIN3A DMAP1 DDX41 LOC202181 B4GALT7 HNRNPAB NSD1 DOK3 FAM153A
GH05I177606 Enhancer 0.8 ENCODE 9.1 +175.9 175937 1.9 RB1 ARID4B KLF17 SIN3A ZNF2 ZNF48 RAD21 ZNF335 SCRT2 ZNF143 B4GALT7 FAM153C LOC202181 FAM153A TMED9 ENSG00000247679
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around FAM153A on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FAM153A gene promoter:

Genomic Locations for FAM153A Gene

Genomic Locations for FAM153A Gene
75,418 bases
Minus strand

Genomic View for FAM153A Gene

Genes around FAM153A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM153A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM153A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM153A Gene

Proteins for FAM153A Gene

  • Protein details for FAM153A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein FAM153A
    Protein Accession:
    Secondary Accessions:
    • A8K0F3
    • O94852

    Protein attributes for FAM153A Gene

    310 amino acids
    Molecular mass:
    34712 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA34472.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for FAM153A Gene

Post-translational modifications for FAM153A Gene

No Post-translational modifications

No data available for DME Specific Peptides for FAM153A Gene

Domains & Families for FAM153A Gene

Gene Families for FAM153A Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FAM153A Gene


Suggested Antigen Peptide Sequences for FAM153A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the FAM153 family.
  • Belongs to the FAM153 family.
genes like me logo Genes that share domains with FAM153A: view

Function for FAM153A Gene

Phenotypes for FAM153A Gene

GenomeRNAi human phenotypes for FAM153A:
genes like me logo Genes that share phenotypes with FAM153A: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FAM153A Gene

Localization for FAM153A Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM153A gene
Compartment Confidence
nucleus 3
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for FAM153A Gene

Pathways & Interactions for FAM153A Gene

SuperPathways for FAM153A Gene

No Data Available

Interacting Proteins for FAM153A Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: ENSP00000353887 Q9UHL3-F153A_HUMAN for FAM153A Gene via STRING IID

Gene Ontology (GO) - Biological Process for FAM153A Gene


No data available for Pathways by source and SIGNOR curated interactions for FAM153A Gene

Drugs & Compounds for FAM153A Gene

No Compound Related Data Available

Transcripts for FAM153A Gene

mRNA/cDNA for FAM153A Gene

Unigene Clusters for FAM153A Gene

Family with sequence similarity 153, member A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM153A Gene

No ASD Table

Relevant External Links for FAM153A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAM153A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM153A Gene

mRNA differential expression in normal tissues according to GTEx for FAM153A Gene

This gene is overexpressed in Brain - Cerebellum (x4.8), Brain - Cerebellar Hemisphere (x4.4), and Spleen (x4.3).

NURSA nuclear receptor signaling pathways regulating expression of FAM153A Gene:


SOURCE GeneReport for Unigene cluster for FAM153A Gene:

genes like me logo Genes that share expression patterns with FAM153A: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM153A Gene

Orthologs for FAM153A Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for FAM153A Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FAM153B 33
  • 97.31 (n)
-- 34
  • 96 (a)
-- 34
  • 75 (a)
Species where no ortholog for FAM153A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FAM153A Gene

Gene Tree for FAM153A (if available)
Gene Tree for FAM153A (if available)

Paralogs for FAM153A Gene

Paralogs for FAM153A Gene

(2) SIMAP similar genes for FAM153A Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with FAM153A: view

Variants for FAM153A Gene

Sequence variations from dbSNP and Humsavar for FAM153A Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000018441 -- 177,708,574(-) T/C genic_downstream_transcript_variant, intron_variant
rs1000106120 -- 177,739,350(-) T/C intron_variant
rs1000169391 -- 177,700,933(-) C/T genic_downstream_transcript_variant, intron_variant
rs1000338075 -- 177,762,576(-) C/T genic_upstream_transcript_variant, intron_variant
rs1000456208 -- 177,753,432(-) A/G genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for FAM153A Gene

Variant ID Type Subtype PubMed ID
nsv980829 CNV duplication 23825009
nsv980765 CNV duplication 23825009
nsv969023 CNV duplication 23825009
nsv968349 CNV duplication 23825009
nsv968280 CNV duplication 23825009
nsv968279 CNV duplication 23825009
nsv964983 CNV duplication 23825009
nsv964982 CNV duplication 23825009
nsv964981 CNV duplication 23825009
nsv519647 CNV loss 19592680
nsv5150 CNV deletion 18451855
nsv508389 CNV deletion 20534489
nsv442969 CNV loss 18776908
nsv1161315 OTHER complex 26073780
nsv1161314 CNV deletion 26073780
nsv1150857 CNV duplication 26484159
nsv1144123 CNV deletion 24896259
nsv1133619 CNV deletion 24896259
nsv1124929 CNV duplication 24896259
nsv1122120 CNV deletion 24896259
nsv1115709 CNV duplication 24896259
nsv1073515 CNV deletion 25765185
nsv1073514 CNV deletion 25765185
nsv1073513 CNV deletion 25765185
nsv1033211 CNV gain 25217958
esv3607693 CNV loss 21293372
esv3575930 CNV gain 25503493
esv3570574 CNV loss 25503493
esv3570569 CNV loss 25503493
esv3570568 CNV loss 25503493
esv3415012 CNV duplication 20981092
esv33718 CNV gain 17666407
esv2763927 CNV loss 21179565
esv2762571 CNV loss 21179565
esv25576 CNV gain+loss 19812545
dgv1673e212 CNV gain 25503493
dgv1672e212 CNV gain 25503493
dgv1671e212 CNV gain 25503493
dgv1670e212 CNV loss 25503493

Variation tolerance for FAM153A Gene

Gene Damage Index Score: 6.34; 76.77% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FAM153A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM153A Gene

Disorders for FAM153A Gene

Additional Disease Information for FAM153A

No disorders were found for FAM153A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM153A Gene

Publications for FAM153A Gene

  1. Antigens recognized by autologous antibody in patients with renal-cell carcinoma. (PMID: 10508479) Scanlan MJ … Old LJ (International journal of cancer 1999) 2 3 4 58
  2. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 9872452) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1998) 2 3 4 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 58

Products for FAM153A Gene

Sources for FAM153A Gene

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