Aliases for FAM151B Gene

Aliases for FAM151B Gene

  • Family With Sequence Similarity 151 Member B 2 3 5
  • Protein FAM151B 3 4
  • Family With Sequence Similarity 151, Member B 2
  • AASA9217 3
  • UNQ9217 3

External Ids for FAM151B Gene

Previous GeneCards Identifiers for FAM151B Gene

  • GC05P079820
  • GC05P079783
  • GC05P074991

Summaries for FAM151B Gene

GeneCards Summary for FAM151B Gene

FAM151B (Family With Sequence Similarity 151 Member B) is a Protein Coding gene. An important paralog of this gene is FAM151A.

Additional gene information for FAM151B Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FAM151B Gene

Genomics for FAM151B Gene

GeneHancer (GH) Regulatory Elements for FAM151B Gene

Promoters and enhancers for FAM151B Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05J080487 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 500.7 +0.9 931 3.8 EP300 ZNF217 CTCF ZSCAN5C NRF1 TCF12 POLR2G PHF8 ZFX ZNF639 ENSG00000249042 FAM151B ZCCHC9 TENT2 ZFYVE16 DHFR RF00994-841 RF00017-4762
GH05J080124 Promoter/Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 3.3 -361.6 -361637 3.7 ZBTB40 SP1 NCOR1 RBAK JUND TEAD4 EP300 REST KDM6A RELA ZFYVE16 SERINC5 FAM151B ENSG00000251675 piR-30350-049
GH05J080399 Enhancer 1.1 FANTOM5 ENCODE 4.2 -88.4 -88388 0.9 HNRNPK USF1 EP300 MYC BCL11A ZNF316 CBFB USF2 GABPA CTCF ZFYVE16 RNU6-211P DHFR FAM151B lnc-ANKRD34B-7 RF00026-875
GH05J081408 Enhancer 0.7 FANTOM5 Ensembl 4.8 +921.1 921132 2.2 CEBPG CEBPB ATF4 SP1 ATF3 MZF1 ATF7 IKZF1 ACOT12 SSBP2 FAM151B ENSG00000286721 lnc-ZCCHC9-1
GH05J080122 Enhancer 0.8 FANTOM5 ENCODE dbSUPER 3.8 -365.2 -365214 0.3 SPI1 IKZF1 MAFK IKZF2 ZFYVE16 FAM151B ENSG00000251675 piR-30350-049 SERINC5
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FAM151B on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FAM151B

Top Transcription factor binding sites by QIAGEN in the FAM151B gene promoter:
  • CUTL1
  • HNF-1
  • HNF-1A
  • Lmo2
  • POU3F2
  • POU3F2 (N-Oct-5a)
  • POU3F2 (N-Oct-5b)
  • SREBP-1a
  • SREBP-1b
  • TBP

Genomic Locations for FAM151B Gene

Genomic Locations for FAM151B Gene
54,595 bases
Plus strand
54,595 bases
Plus strand

Genomic View for FAM151B Gene

Genes around FAM151B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM151B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM151B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM151B Gene

Proteins for FAM151B Gene

  • Protein details for FAM151B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein FAM151B
    Protein Accession:
    Secondary Accessions:
    • A2RRE4

    Protein attributes for FAM151B Gene

    276 amino acids
    Molecular mass:
    31367 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FAM151B Gene

Post-translational modifications for FAM151B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FAM151B Gene

Domains & Families for FAM151B Gene

Gene Families for FAM151B Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FAM151B Gene


Suggested Antigen Peptide Sequences for FAM151B Gene

GenScript: Design optimal peptide antigens:
  • Protein FAM151B (F151B_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the FAM151 family.
  • Belongs to the FAM151 family.
genes like me logo Genes that share domains with FAM151B: view

Function for FAM151B Gene

Phenotypes From GWAS Catalog for FAM151B Gene

Gene Ontology (GO) - Molecular Function for FAM151B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with FAM151B: view
genes like me logo Genes that share phenotypes with FAM151B: view

Animal Models for FAM151B Gene

MGI Knock Outs for FAM151B:
  • Fam151b Fam151b<tm1b(EUCOMM)Hmgu>

Animal Model Products

CRISPR Products

miRNA for FAM151B Gene

miRTarBase miRNAs that target FAM151B

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FAM151B Gene

Localization for FAM151B Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM151B gene
Compartment Confidence
cytosol 3
cytoskeleton 1
nucleus 1
mitochondrion 0
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FAM151B Gene

Pathways & Interactions for FAM151B Gene

PathCards logo

SuperPathways for FAM151B Gene

No Data Available

Gene Ontology (GO) - Biological Process for FAM151B Gene


No data available for Pathways by source and SIGNOR curated interactions for FAM151B Gene

Drugs & Compounds for FAM151B Gene

No Compound Related Data Available

Transcripts for FAM151B Gene

mRNA/cDNA for FAM151B Gene

4 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM151B Gene

No ASD Table

Relevant External Links for FAM151B Gene

GeneLoc Exon Structure for

Expression for FAM151B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FAM151B Gene

mRNA differential expression in normal tissues according to GTEx for FAM151B Gene

This gene is overexpressed in Whole Blood (x5.6).

Protein differential expression in normal tissues from HIPED for FAM151B Gene

This gene is overexpressed in Adipocyte (56.2) and Prostate (12.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FAM151B Gene

Protein tissue co-expression partners for FAM151B Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FAM151B

SOURCE GeneReport for Unigene cluster for FAM151B Gene:

genes like me logo Genes that share expression patterns with FAM151B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM151B Gene

Orthologs for FAM151B Gene

This gene was present in the common ancestor of animals.

Orthologs for FAM151B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FAM151B 31 30
  • 99.4 (n)
(Canis familiaris)
Mammalia FAM151B 31 30
  • 91.3 (n)
(Bos Taurus)
Mammalia FAM151B 31 30
  • 90.7 (n)
(Mus musculus)
Mammalia Fam151b 17 31 30
  • 83.76 (n)
(Rattus norvegicus)
Mammalia Fam151b 30
  • 81.52 (n)
(Ornithorhynchus anatinus)
Mammalia FAM151B 31
  • 77 (a)
(Monodelphis domestica)
Mammalia FAM151B 31
  • 74 (a)
(Gallus gallus)
Aves LOC100859442 30
  • 64.96 (n)
-- 31
  • 57 (a)
-- 31
  • 38 (a)
(Anolis carolinensis)
Reptilia FAM151B 31
  • 65 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fam151b 30
  • 68.48 (n)
(Danio rerio)
Actinopterygii fam151b 31 30
  • 61.53 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2294 30
fruit fly
(Drosophila melanogaster)
Insecta CG7231 31 30
  • 49.18 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007860 30
  • 46.35 (n)
(Caenorhabditis elegans)
Secernentea W01F3.1 30
  • 45.28 (n)
mnr-1 31
  • 13 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 48 (a)
Species where no ortholog for FAM151B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FAM151B Gene

Gene Tree for FAM151B (if available)
Gene Tree for FAM151B (if available)
Evolutionary constrained regions (ECRs) for FAM151B: view image

Paralogs for FAM151B Gene

Paralogs for FAM151B Gene

(1) SIMAP similar genes for FAM151B Gene using alignment to 2 proteins:

  • F151B_HUMAN
  • D6RD51_HUMAN
genes like me logo Genes that share paralogs with FAM151B: view

Variants for FAM151B Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for FAM151B Gene

SNP ID Clinical significance and condition Chr 05 pos Variation AA Info Type
rs369998 - p.Ile155Thr

Additional dbSNP identifiers (rs#s) for FAM151B Gene

Structural Variations from Database of Genomic Variants (DGV) for FAM151B Gene

Variant ID Type Subtype PubMed ID
dgv5705n100 CNV gain 25217958
esv2674716 CNV deletion 23128226
esv3605573 CNV loss 21293372
nsv1028027 CNV gain 25217958
nsv1120509 CNV tandem duplication 24896259
nsv968213 CNV duplication 23825009

Variation tolerance for FAM151B Gene

Residual Variation Intolerance Score: 80.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.65; 31.62% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FAM151B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM151B Gene

Disorders for FAM151B Gene

Additional Disease Information for FAM151B

No disorders were found for FAM151B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM151B Gene

Publications for FAM151B Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 54
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 54
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 54
  4. The DNA sequence and comparative analysis of human chromosome 5. (PMID: 15372022) Schmutz J … Rubin EM (Nature 2004) 4 54
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 54

Products for FAM151B Gene

  • Biorbyt antibodies for FAM151B

Sources for FAM151B Gene