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Aliases for FAM151A Gene

Aliases for FAM151A Gene

  • Family With Sequence Similarity 151 Member A 2 3 5
  • C1orf179 3 4
  • Family With Sequence Similarity 151, Member A 2
  • Chromosome 1 Open Reading Frame 179 2
  • Hyporthetical Protein MGC27169 3
  • Protein FAM151A 3

External Ids for FAM151A Gene

Previous HGNC Symbols for FAM151A Gene

  • C1orf179

Previous GeneCards Identifiers for FAM151A Gene

  • GC01M054847
  • GC01M055074
  • GC01M053189

Summaries for FAM151A Gene

GeneCards Summary for FAM151A Gene

FAM151A (Family With Sequence Similarity 151 Member A) is a Protein Coding gene. An important paralog of this gene is FAM151B.

Additional gene information for FAM151A Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM151A Gene

Genomics for FAM151A Gene

GeneHancer (GH) Regulatory Elements for FAM151A Gene

Promoters and enhancers for FAM151A Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I054623 Promoter 0.8 EPDnew 550.8 +0.0 11 0.1 RXRA HNF4G HNF4A RAD21 ZNF7 FAM151A ENSG00000230728 ACOT11
GH01I054610 Enhancer 0.4 ENCODE 4.9 +12.9 12945 0.5 RFX1 MAX BMI1 MROH7 ENSG00000237453 TTC22 FAM151A ACOT11
GH01I054611 Enhancer 0.4 ENCODE 4.8 +13.3 13253 0.2 RFX1 MAX BMI1 MROH7 ENSG00000237453 TTC22 FAM151A ACOT11
GH01I054593 Enhancer 0.3 dbSUPER 5 +29.3 29277 1.5 NRF1 MROH7 CDCP2 FAM151A ACOT11
GH01I054612 Enhancer 0.3 dbSUPER 4.9 +11.8 11844 0.9 POLR2A MROH7 TTC22 ENSG00000237453 FAM151A ACOT11
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around FAM151A on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FAM151A gene promoter:

Genomic Locations for FAM151A Gene

Genomic Locations for FAM151A Gene
14,380 bases
Minus strand

Genomic View for FAM151A Gene

Genes around FAM151A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM151A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM151A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM151A Gene

Proteins for FAM151A Gene

  • Protein details for FAM151A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein FAM151A
    Protein Accession:
    Secondary Accessions:
    • Q5VUG5
    • Q6DKH5
    • Q6UWV0
    • Q8NAX9
    • Q96KY5

    Protein attributes for FAM151A Gene

    585 amino acids
    Molecular mass:
    64028 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FAM151A Gene


neXtProt entry for FAM151A Gene

Post-translational modifications for FAM151A Gene

No Post-translational modifications

Other Protein References for FAM151A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FAM151A Gene

Domains & Families for FAM151A Gene

Gene Families for FAM151A Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FAM151A Gene


Suggested Antigen Peptide Sequences for FAM151A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the FAM151 family.
  • Belongs to the FAM151 family.
genes like me logo Genes that share domains with FAM151A: view

Function for FAM151A Gene

Gene Ontology (GO) - Molecular Function for FAM151A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with FAM151A: view
genes like me logo Genes that share phenotypes with FAM151A: view

Animal Models for FAM151A Gene

MGI Knock Outs for FAM151A:

Animal Model Products

miRNA for FAM151A Gene

miRTarBase miRNAs that target FAM151A

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FAM151A Gene

Localization for FAM151A Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM151A Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM151A gene
Compartment Confidence
extracellular 5
plasma membrane 2
nucleus 2
endoplasmic reticulum 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for FAM151A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane NAS 12975309
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome HDA,IDA 19056867
genes like me logo Genes that share ontologies with FAM151A: view

Pathways & Interactions for FAM151A Gene

SuperPathways for FAM151A Gene

No Data Available

Interacting Proteins for FAM151A Gene

Gene Ontology (GO) - Biological Process for FAM151A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with FAM151A: view

No data available for Pathways by source and SIGNOR curated interactions for FAM151A Gene

Drugs & Compounds for FAM151A Gene

No Compound Related Data Available

Transcripts for FAM151A Gene

mRNA/cDNA for FAM151A Gene

Unigene Clusters for FAM151A Gene

Family with sequence similarity 151, member A:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM151A Gene

No ASD Table

Relevant External Links for FAM151A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAM151A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM151A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FAM151A Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (x22.9) and Kidney - Cortex (x20.2).

Protein differential expression in normal tissues from HIPED for FAM151A Gene

This gene is overexpressed in Urine (34.2), Pancreatic juice (10.2), Kidney (8.8), Fetal gut (7.3), and Lymph node (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FAM151A Gene

Protein tissue co-expression partners for FAM151A Gene

NURSA nuclear receptor signaling pathways regulating expression of FAM151A Gene:


SOURCE GeneReport for Unigene cluster for FAM151A Gene:


Evidence on tissue expression from TISSUES for FAM151A Gene

  • Kidney(4.5)
  • Intestine(4.2)
genes like me logo Genes that share expression patterns with FAM151A: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM151A Gene

Orthologs for FAM151A Gene

This gene was present in the common ancestor of animals.

Orthologs for FAM151A Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FAM151A 34 33
  • 96.24 (n)
(Canis familiaris)
Mammalia FAM151A 33 34
  • 80.34 (n)
(Mus musculus)
Mammalia Fam151a 33 16 34
  • 77.61 (n)
(Rattus norvegicus)
Mammalia Fam151a 33
  • 76.35 (n)
(Bos Taurus)
Mammalia FAM151A 34
  • 73 (a)
(Monodelphis domestica)
Mammalia FAM151A 34
  • 72 (a)
(Anolis carolinensis)
Reptilia FAM151A 34
  • 60 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fam151a 33
  • 53.86 (n)
(Danio rerio)
Actinopterygii fam151a 33 34
  • 54.03 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG7231 34
  • 26 (a)
(Caenorhabditis elegans)
Secernentea mnr-1 34
  • 15 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 43 (a)
Species where no ortholog for FAM151A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FAM151A Gene

Gene Tree for FAM151A (if available)
Gene Tree for FAM151A (if available)

Paralogs for FAM151A Gene

Paralogs for FAM151A Gene

(1) SIMAP similar genes for FAM151A Gene using alignment to 2 proteins: Pseudogenes for FAM151A Gene

genes like me logo Genes that share paralogs with FAM151A: view

Variants for FAM151A Gene

Sequence variations from dbSNP and Humsavar for FAM151A Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000138150 -- 54,623,836(-) G/A upstream_transcript_variant
rs1000157062 -- 54,623,509(-) C/T 5_prime_UTR_variant
rs1000687442 -- 54,616,687(-) T/C intron_variant
rs1000731408 -- 54,608,690(-) C/T downstream_transcript_variant
rs1000753654 -- 54,614,242(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for FAM151A Gene

Variant ID Type Subtype PubMed ID
nsv910 CNV deletion 18451855
nsv829904 CNV loss 17160897
nsv817614 CNV gain 22305530
nsv546269 CNV gain 21841781
nsv546266 CNV gain 21841781
nsv516654 CNV loss 19592680
nsv461594 CNV gain 19166990
nsv461561 CNV gain 19166990
esv3586098 CNV loss 21293372
esv33550 CNV gain+loss 17666407
esv2748330 CNV deletion 23290073
dgv36e212 CNV loss 25503493

Variation tolerance for FAM151A Gene

Residual Variation Intolerance Score: 96.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.86; 87.00% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FAM151A Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM151A Gene

Disorders for FAM151A Gene

Additional Disease Information for FAM151A

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for FAM151A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM151A Gene

Publications for FAM151A Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
  3. Localization of a gene for nonsyndromic renal hypodysplasia to chromosome 1p32-33. (PMID: 17273976) Sanna-Cherchi S … Gharavi AG (American journal of human genetics 2007) 2 3 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 58

Products for FAM151A Gene

Sources for FAM151A Gene

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