Aliases for FAM151A Gene

Aliases for FAM151A Gene

  • Family With Sequence Similarity 151 Member A 2 3 5
  • Protein FAM151A 3 4
  • C1orf179 3 4
  • Family With Sequence Similarity 151, Member A 2
  • Chromosome 1 Open Reading Frame 179 2
  • Hyporthetical Protein MGC27169 3
  • MGC27169 2
  • FAM151A 5

External Ids for FAM151A Gene

Previous HGNC Symbols for FAM151A Gene

  • C1orf179

Previous GeneCards Identifiers for FAM151A Gene

  • GC01M054847
  • GC01M055074
  • GC01M053189

Summaries for FAM151A Gene

GeneCards Summary for FAM151A Gene

FAM151A (Family With Sequence Similarity 151 Member A) is a Protein Coding gene. Diseases associated with FAM151A include Late-Onset Retinal Degeneration. An important paralog of this gene is FAM151B.

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FAM151A Gene

Genomics for FAM151A Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for FAM151A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J054623 Promoter/Enhancer 0.9 EPDnew Ensembl 250.7 0.0 -45 0.8 RXRA HNF4A RAD21 NR2F1 SP1 NKRF ZNF217 ZNF7 HNF4G FAM151A MROH7 ENSG00000230728 ACOT11
GH01J054622 Enhancer 0.6 Ensembl 250.7 +1.0 955 0.8 BHLHE40 HDGF NR2F1 ATF2 JUNB NKRF ZNF217 IKZF1 TARDBP ZNF692 FAM151A HSALNG0003773 ENSG00000230728 ACOT11
GH01J054609 Enhancer 0.6 Ensembl ENCODE 4.9 +13.5 13495 2.1 ZIC2 BMI1 RFX1 GLIS1 SP1 HSALNG0003770 HSALNG0003771 MROH7 ENSG00000237453 TTC22 TTC4 FAM151A ACOT11
GH01J054612 Enhancer 0.3 Ensembl dbSUPER 4.9 +11.7 11743 0.6 HSALNG0003771 MROH7 FAM151A HSALNG0003773 ACOT11
GH01J054593 Enhancer 0.3 dbSUPER 5 +29.3 29277 1.5 NRF1 MROH7 CDCP2 FAM151A piR-35674-023 HSALNG0003770 ACOT11
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FAM151A on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FAM151A

Top Transcription factor binding sites by QIAGEN in the FAM151A gene promoter:
  • AP-4
  • ATF-2
  • CBF(2)
  • CBF-A
  • CBF-B
  • CBF-C
  • CP1A
  • CRE-BP1
  • PPAR-gamma1
  • PPAR-gamma2

Genomic Locations for FAM151A Gene

Latest Assembly
chr1:54,609,180-54,623,556
(GRCh38/hg38)
Size:
14,377 bases
Orientation:
Minus strand

Previous Assembly
chr1:55,074,854-55,089,198
(GRCh37/hg19 by Entrez Gene)
Size:
14,345 bases
Orientation:
Minus strand

chr1:55,074,855-55,089,229
(GRCh37/hg19 by Ensembl)
Size:
14,375 bases
Orientation:
Minus strand

Genomic View for FAM151A Gene

Genes around FAM151A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM151A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM151A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM151A Gene

Proteins for FAM151A Gene

  • Protein details for FAM151A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WW52-F151A_HUMAN
    Recommended name:
    Protein FAM151A
    Protein Accession:
    Q8WW52
    Secondary Accessions:
    • Q5VUG5
    • Q6DKH5
    • Q6UWV0
    • Q8NAX9
    • Q96KY5

    Protein attributes for FAM151A Gene

    Size:
    585 amino acids
    Molecular mass:
    64028 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FAM151A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FAM151A Gene

Post-translational modifications for FAM151A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM151A Gene

No data available for DME Specific Peptides for FAM151A Gene

Domains & Families for FAM151A Gene

Gene Families for FAM151A Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FAM151A Gene

InterPro:

Suggested Antigen Peptide Sequences for FAM151A Gene

GenScript: Design optimal peptide antigens:
  • Protein FAM151A (F151A_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8WW52

UniProtKB/Swiss-Prot:

F151A_HUMAN :
  • Belongs to the FAM151 family.
Family:
  • Belongs to the FAM151 family.
genes like me logo Genes that share domains with FAM151A: view

Function for FAM151A Gene

Phenotypes From GWAS Catalog for FAM151A Gene

Gene Ontology (GO) - Molecular Function for FAM151A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with FAM151A: view
genes like me logo Genes that share phenotypes with FAM151A: view

Animal Models for FAM151A Gene

MGI Knock Outs for FAM151A:

Animal Models for research

  • Taconic Biosciences Mouse Models for FAM151A

miRNA for FAM151A Gene

miRTarBase miRNAs that target FAM151A

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FAM151A

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FAM151A Gene

Localization for FAM151A Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM151A Gene

Membrane. Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM151A gene
Compartment Confidence
extracellular 4
nucleus 2
plasma membrane 1
endoplasmic reticulum 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for FAM151A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane NAS 12975309
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome HDA 19056867
genes like me logo Genes that share ontologies with FAM151A: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for FAM151A Gene

Pathways & Interactions for FAM151A Gene

PathCards logo

SuperPathways for FAM151A Gene

No Data Available

Interacting Proteins for FAM151A Gene

Gene Ontology (GO) - Biological Process for FAM151A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with FAM151A: view

No data available for Pathways by source and SIGNOR curated interactions for FAM151A Gene

Drugs & Compounds for FAM151A Gene

No Compound Related Data Available

Transcripts for FAM151A Gene

mRNA/cDNA for FAM151A Gene

1 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FAM151A

Alternative Splicing Database (ASD) splice patterns (SP) for FAM151A Gene

No ASD Table

Relevant External Links for FAM151A Gene

GeneLoc Exon Structure for
FAM151A

Expression for FAM151A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FAM151A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FAM151A Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (x22.9) and Kidney - Cortex (x20.2).

Protein differential expression in normal tissues from HIPED for FAM151A Gene

This gene is overexpressed in Urine (34.2), Pancreatic juice (10.2), Kidney (8.8), Fetal gut (7.3), and Lymph node (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FAM151A Gene



Protein tissue co-expression partners for FAM151A Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FAM151A

SOURCE GeneReport for Unigene cluster for FAM151A Gene:

Hs.234786

Evidence on tissue expression from TISSUES for FAM151A Gene

  • Kidney(4.6)
  • Intestine(4.2)
genes like me logo Genes that share expression patterns with FAM151A: view

Primer products for research

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM151A Gene

Orthologs for FAM151A Gene

This gene was present in the common ancestor of animals.

Orthologs for FAM151A Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia FAM151A 29 30
  • 96.24 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia FAM151A 29 30
  • 80.34 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Fam151a 29 16 30
  • 77.61 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Fam151a 29
  • 76.35 (n)
Cow
(Bos Taurus)
Mammalia FAM151A 30
  • 73 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia FAM151A 30
  • 72 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia FAM151A 30
  • 60 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia fam151a 29
  • 53.86 (n)
Zebrafish
(Danio rerio)
Actinopterygii fam151a 29 30
  • 54.03 (n)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta CG7231 30
  • 26 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea mnr-1 30
  • 15 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 30
  • 43 (a)
OneToMany
Species where no ortholog for FAM151A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for FAM151A Gene

ENSEMBL:
Gene Tree for FAM151A (if available)
TreeFam:
Gene Tree for FAM151A (if available)
Aminode:
Evolutionary constrained regions (ECRs) for FAM151A: view image
Alliance of Genome Resources:
Additional Orthologs for FAM151A

Paralogs for FAM151A Gene

Paralogs for FAM151A Gene

(1) SIMAP similar genes for FAM151A Gene using alignment to 2 proteins:

  • F151A_HUMAN
  • B1AQ20_HUMAN

Pseudogenes.org Pseudogenes for FAM151A Gene

genes like me logo Genes that share paralogs with FAM151A: view

Variants for FAM151A Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for FAM151A Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
rs114132415 Benign: not provided 54,611,728(-) C/T
NM_176782.3(FAM151A):c.818G>A (p.Trp273Ter)
NONSENSE,INTRON
rs142765170 Benign: not provided 54,620,003(-) A/G
NM_176782.3(FAM151A):c.123T>C (p.Cys41=)
SYNONYMOUS_VARIANT,INTRON
rs142814457 Likely Benign: not provided 54,616,168(-) G/C
NM_176782.3(FAM151A):c.267C>G (p.Asn89Lys)
MISSENSE_VARIANT,INTRON
rs147294199 Benign: not provided 54,619,932(-) C/T
NM_176782.3(FAM151A):c.194G>A (p.Arg65Gln)
MISSENSE_VARIANT,INTRON
rs147577669 Benign: not provided 54,612,637(-) T/G
NM_176782.3(FAM151A):c.649A>C (p.Thr217Pro)
MISSENSE_VARIANT,INTRON

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for FAM151A Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for FAM151A Gene

Variant ID Type Subtype PubMed ID
dgv36e212 CNV loss 25503493
esv2748330 CNV deletion 23290073
esv33550 CNV gain+loss 17666407
esv3586098 CNV loss 21293372
nsv461561 CNV gain 19166990
nsv461594 CNV gain 19166990
nsv516654 CNV loss 19592680
nsv546266 CNV gain 21841781
nsv546269 CNV gain 21841781
nsv817614 CNV gain 22305530
nsv829904 CNV loss 17160897
nsv910 CNV deletion 18451855

Variation tolerance for FAM151A Gene

Residual Variation Intolerance Score: 96.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.86; 87.00% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FAM151A Gene

Human Gene Mutation Database (HGMD)
FAM151A
SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM151A
Leiden Open Variation Database (LOVD)
FAM151A

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM151A Gene

Disorders for FAM151A Gene

MalaCards: The human disease database

(1) MalaCards diseases for FAM151A Gene - From: COP

Disorder Aliases PubMed IDs
late-onset retinal degeneration
  • lord
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for FAM151A

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with FAM151A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FAM151A Gene

Publications for FAM151A Gene

  1. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 40
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 40
  3. Localization of a gene for nonsyndromic renal hypodysplasia to chromosome 1p32-33. (PMID: 17273976) Sanna-Cherchi S … Gharavi AG (American journal of human genetics 2007) 2 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4

Products for FAM151A Gene

Sources for FAM151A Gene