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Aliases for FAM149B1 Gene

Aliases for FAM149B1 Gene

  • Family With Sequence Similarity 149 Member B1 2 3 5
  • KIAA0974 2 3 4
  • Family With Sequence Similarity 149, Member B1 2
  • Protein FAM149B1 3

External Ids for FAM149B1 Gene

Previous HGNC Symbols for FAM149B1 Gene

  • KIAA0974

Previous GeneCards Identifiers for FAM149B1 Gene

  • GC10U900852
  • GC10P074597
  • GC10P074927
  • GC10P068921

Summaries for FAM149B1 Gene

GeneCards Summary for FAM149B1 Gene

FAM149B1 (Family With Sequence Similarity 149 Member B1) is a Protein Coding gene. An important paralog of this gene is FAM149A.

Additional gene information for FAM149B1 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM149B1 Gene

Genomics for FAM149B1 Gene

GeneHancer (GH) Regulatory Elements for FAM149B1 Gene

Promoters and enhancers for FAM149B1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J073166 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 650.7 -0.1 -91 2.4 PKNOX1 SMAD1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 IRF4 YY1 ECD FAM149B1 NUDT13 NDST2 ZSWIM8 DNAJB12 SEC24C ZSWIM8-AS1 AP3M1 VCL
GH10J072270 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 32.5 -893.3 -893328 8.5 CLOCK MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 DDIT4-AS1 DDIT4 ECD DNAJB12 ENSG00000227540 FAM149B1 DNAJC9 RPL17P50 ENSG00000272630 ASCC1
GH10J073729 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 11.5 +562.8 562759 2.9 MLX DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 MEF2D SSRP1 VCL ENSG00000242288 GLUD1P3 BMS1P4 DUSP8P5 FUT11 ECD ZSWIM8-AS1 NDST2 FAM149B1
GH10J072314 Enhancer 1.9 FANTOM5 Ensembl ENCODE dbSUPER 12.5 -847.9 -847870 11.7 CLOCK MLX FEZF1 DMAP1 YBX1 IRF4 YY1 ZNF213 E2F8 ZNF143 DNAJB12 ECD DDIT4 RPL17P50 ENSG00000227540 PSAP FAM149B1 DNAJC9 ENSG00000272630 NUDT13
GH10J072212 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 4.2 -951.6 -951579 7.1 CLOCK MLX DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 SSRP1 ANAPC16 ASCC1 DNAJB12 ECD ENSG00000272630 RPL15P14 NUDT13 FAM149B1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FAM149B1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FAM149B1 gene promoter:
  • ATF
  • Pax-4a
  • ER-alpha
  • POU3F2 (N-Oct-5b)
  • POU3F2 (N-Oct-5a)
  • POU3F2
  • GATA-1
  • ATF-2
  • ATF6

Genomic Locations for FAM149B1 Gene

Genomic Locations for FAM149B1 Gene
76,410 bases
Plus strand
76,386 bases
Plus strand

Genomic View for FAM149B1 Gene

Genes around FAM149B1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM149B1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM149B1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM149B1 Gene

Proteins for FAM149B1 Gene

  • Protein details for FAM149B1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein FAM149B1
    Protein Accession:
    Secondary Accessions:
    • Q9Y2I0

    Protein attributes for FAM149B1 Gene

    582 amino acids
    Molecular mass:
    64618 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH15394.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for FAM149B1 Gene


neXtProt entry for FAM149B1 Gene

Post-translational modifications for FAM149B1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FAM149B1 Gene

Domains & Families for FAM149B1 Gene

Gene Families for FAM149B1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FAM149B1 Gene


Suggested Antigen Peptide Sequences for FAM149B1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the FAM149 family.
  • Belongs to the FAM149 family.
genes like me logo Genes that share domains with FAM149B1: view

Function for FAM149B1 Gene

Phenotypes From GWAS Catalog for FAM149B1 Gene

genes like me logo Genes that share phenotypes with FAM149B1: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FAM149B1 Gene

Localization for FAM149B1 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM149B1 gene
Compartment Confidence
nucleus 3
mitochondrion 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FAM149B1 Gene

Pathways & Interactions for FAM149B1 Gene

SuperPathways for FAM149B1 Gene

No Data Available

Interacting Proteins for FAM149B1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: Q96BN6-F149B_HUMAN ENSP00000242505 for FAM149B1 Gene via IID STRING

Gene Ontology (GO) - Biological Process for FAM149B1 Gene


No data available for Pathways by source and SIGNOR curated interactions for FAM149B1 Gene

Drugs & Compounds for FAM149B1 Gene

No Compound Related Data Available

Transcripts for FAM149B1 Gene

mRNA/cDNA for FAM149B1 Gene

(11) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(8) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FAM149B1 Gene

Family with sequence similarity 149, member B1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM149B1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b
SP1: - - - - -
SP2: - - -
SP3: -
SP4: - -
SP5: -

Relevant External Links for FAM149B1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAM149B1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM149B1 Gene

Protein differential expression in normal tissues from HIPED for FAM149B1 Gene

This gene is overexpressed in Breast (51.1) and Placenta (15.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FAM149B1 Gene

Protein tissue co-expression partners for FAM149B1 Gene

NURSA nuclear receptor signaling pathways regulating expression of FAM149B1 Gene:


SOURCE GeneReport for Unigene cluster for FAM149B1 Gene:

genes like me logo Genes that share expression patterns with FAM149B1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM149B1 Gene

Orthologs for FAM149B1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM149B1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FAM149B1 34 33
  • 99.43 (n)
(Canis familiaris)
Mammalia FAM149B1 34 33
  • 88.47 (n)
(Bos Taurus)
Mammalia FAM149B1 34 33
  • 88.3 (n)
(Mus musculus)
Mammalia Fam149b 16 34 33
  • 83.8 (n)
(Rattus norvegicus)
Mammalia Fam149b1 33
  • 82.33 (n)
(Monodelphis domestica)
Mammalia FAM149B1 34
  • 73 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 60 (a)
-- 34
  • 58 (a)
(Gallus gallus)
Aves FAM149B1 34 33
  • 63.03 (n)
(Anolis carolinensis)
Reptilia FAM149B1 34
  • 48 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fam149b1 33
  • 54.07 (n)
(Danio rerio)
Actinopterygii fam149b1 34 33
  • 54.04 (n)
Species where no ortholog for FAM149B1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM149B1 Gene

Gene Tree for FAM149B1 (if available)
Gene Tree for FAM149B1 (if available)
Evolutionary constrained regions (ECRs) for FAM149B1: view image

Paralogs for FAM149B1 Gene

Paralogs for FAM149B1 Gene Pseudogenes for FAM149B1 Gene

genes like me logo Genes that share paralogs with FAM149B1: view

Variants for FAM149B1 Gene

Sequence variations from dbSNP and Humsavar for FAM149B1 Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs1000063595 -- 73,237,556(+) A/G genic_downstream_transcript_variant, intron_variant
rs1000066286 -- 73,240,814(+) A/T genic_downstream_transcript_variant, intron_variant
rs1000070960 -- 73,199,583(+) C/A/G intron_variant
rs1000073724 -- 73,193,123(+) G/A intron_variant
rs1000124413 -- 73,232,622(+) A/C genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for FAM149B1 Gene

Variant ID Type Subtype PubMed ID
nsv7132 CNV deletion 18451855
nsv948065 CNV duplication 23825009

Variation tolerance for FAM149B1 Gene

Gene Damage Index Score: 13.21; 95.23% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FAM149B1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM149B1 Gene

Disorders for FAM149B1 Gene

Additional Disease Information for FAM149B1

No disorders were found for FAM149B1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM149B1 Gene

Publications for FAM149B1 Gene

  1. Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10231032) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1999) 2 3 4 58
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 58
  5. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P … Rogers J (Nature 2004) 4 58

Products for FAM149B1 Gene

Sources for FAM149B1 Gene

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