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Aliases for FAM149A Gene

Aliases for FAM149A Gene

  • Family With Sequence Similarity 149 Member A 2 3 5
  • Family With Sequence Similarity 149, Member A 2
  • Protein FAM149A 3
  • MSTP119 3
  • MST119 3

External Ids for FAM149A Gene

Previous GeneCards Identifiers for FAM149A Gene

  • GC04P187304
  • GC04P187026
  • GC04P182817

Summaries for FAM149A Gene

GeneCards Summary for FAM149A Gene

FAM149A (Family With Sequence Similarity 149 Member A) is a Protein Coding gene. Diseases associated with FAM149A include Acute Mountain Sickness. An important paralog of this gene is FAM149B1.

Additional gene information for FAM149A Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM149A Gene

Genomics for FAM149A Gene

GeneHancer (GH) Regulatory Elements for FAM149A Gene

Promoters and enhancers for FAM149A Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J186143 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE 687.2 +40.5 40501 1.9 CTCF MAX SIN3A ZIC2 ZNF2 YY1 ZNF335 ZFHX2 POLR2A PATZ1 FAM149A CYP4V2 TLR3 ENSG00000253013 RPSAP70
GH04J186104 Promoter/Enhancer 1.5 FANTOM5 Ensembl ENCODE 659.9 +1.1 1140 2.6 ATF1 GLI4 ZNF335 GLIS2 ZNF213 ZNF366 HSF1 SCRT2 ZFP91 ATF7 FAM149A PIR33423 SORBS2
GH04J186189 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 30.4 +86.9 86909 4.4 ARID4B SIN3A ZNF2 YY1 POLR2B ZNF213 E2F8 ZNF207 ZNF143 KLF13 CYP4V2 FLJ38576 FAM149A KLKB1 SNX25 ORAOV1P1
GH04J185531 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 4.5 -570.5 -570504 5.5 ATF1 BMI1 ZNF48 ZNF335 ATF7 EGR2 ZNF174 SP3 ZEB2 NR2F2 PDLIM3 PRIMPOL ENSG00000233110 FAM149A GC04M185529
GH04J186150 Enhancer 0.5 ENCODE 17.2 +45.8 45763 0.2 CTCF XRCC5 IKZF1 ZNF143 RAD21 NR2F2 FAM149A ENSG00000253013 CYP4V2 TLR3 RPSAP70
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FAM149A on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FAM149A gene promoter:
  • GR-alpha
  • GR
  • Cart-1
  • Sox9
  • En-1
  • ATF-2
  • Zic3

Genomic Locations for FAM149A Gene

Genomic Locations for FAM149A Gene
68,249 bases
Plus strand
68,249 bases
Plus strand

Genomic View for FAM149A Gene

Genes around FAM149A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM149A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM149A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM149A Gene

Proteins for FAM149A Gene

  • Protein details for FAM149A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein FAM149A
    Protein Accession:
    Secondary Accessions:
    • B5MDB8
    • Q2TAN6
    • Q7Z2S5
    • Q9Y4T9

    Protein attributes for FAM149A Gene

    773 amino acids
    Molecular mass:
    82698 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAI10817.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAQ13641.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAQ13641.1; Type=Frameshift; Positions=635; Evidence={ECO:0000305};

    Alternative splice isoforms for FAM149A Gene


neXtProt entry for FAM149A Gene

Post-translational modifications for FAM149A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FAM149A Gene

Domains & Families for FAM149A Gene

Gene Families for FAM149A Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FAM149A Gene


Suggested Antigen Peptide Sequences for FAM149A Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the FAM149 family.
  • Belongs to the FAM149 family.
genes like me logo Genes that share domains with FAM149A: view

Function for FAM149A Gene

genes like me logo Genes that share phenotypes with FAM149A: view

Animal Model Products

miRNA for FAM149A Gene

miRTarBase miRNAs that target FAM149A

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM149A Gene

Localization for FAM149A Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM149A gene
Compartment Confidence
nucleus 3
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FAM149A Gene

Pathways & Interactions for FAM149A Gene

SuperPathways for FAM149A Gene

No Data Available

Interacting Proteins for FAM149A Gene

Selected Interacting proteins: A5PLN7-F149A_HUMAN for FAM149A Gene via IID

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for FAM149A Gene


No data available for Pathways by source and SIGNOR curated interactions for FAM149A Gene

Drugs & Compounds for FAM149A Gene

No Compound Related Data Available

Transcripts for FAM149A Gene

mRNA/cDNA for FAM149A Gene

Unigene Clusters for FAM149A Gene

Family with sequence similarity 149, member A:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM149A Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b · 13c
SP2: -
SP3: -

Relevant External Links for FAM149A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAM149A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM149A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FAM149A Gene

This gene is overexpressed in Testis (52.5) and Adipocyte (13.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FAM149A Gene

Protein tissue co-expression partners for FAM149A Gene

NURSA nuclear receptor signaling pathways regulating expression of FAM149A Gene:


SOURCE GeneReport for Unigene cluster for FAM149A Gene:


Evidence on tissue expression from TISSUES for FAM149A Gene

  • Nervous system(2.2)
genes like me logo Genes that share expression patterns with FAM149A: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM149A Gene

Orthologs for FAM149A Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM149A Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FAM149A 33
  • 98.5 (n)
(Canis familiaris)
Mammalia FAM149A 34 33
  • 79.9 (n)
(Bos Taurus)
Mammalia FAM149A 34 33
  • 77.8 (n)
(Rattus norvegicus)
Mammalia Fam149a 33
  • 73.88 (n)
(Mus musculus)
Mammalia Fam149a 16 34 33
  • 73.7 (n)
(Monodelphis domestica)
Mammalia FAM149A 34
  • 38 (a)
(Ornithorhynchus anatinus)
Mammalia FAM149A 34
  • 35 (a)
(Gallus gallus)
Aves FAM149A 34 33
  • 59.96 (n)
(Anolis carolinensis)
Reptilia FAM149A 34
  • 37 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fam149a 33
  • 59.27 (n)
(Danio rerio)
Actinopterygii si:ch211-51g4.5 33
  • 48.61 (n)
FAM149A 34
  • 23 (a)
Species where no ortholog for FAM149A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM149A Gene

Gene Tree for FAM149A (if available)
Gene Tree for FAM149A (if available)
Evolutionary constrained regions (ECRs) for FAM149A: view image

Paralogs for FAM149A Gene

Paralogs for FAM149A Gene

genes like me logo Genes that share paralogs with FAM149A: view

Variants for FAM149A Gene

Sequence variations from dbSNP and Humsavar for FAM149A Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs1000009613 -- 186,142,692(+) A/G genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000034332 -- 186,134,393(+) T/G genic_upstream_transcript_variant, intron_variant
rs1000059101 -- 186,148,513(+) C/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000124193 -- 186,150,009(+) G/A intron_variant
rs1000174645 -- 186,103,622(+) G/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for FAM149A Gene

Variant ID Type Subtype PubMed ID
dgv1052e214 CNV gain 21293372
dgv135e180 CNV gain 20482838
dgv1555e212 CNV loss 25503493
dgv1556e212 CNV loss 25503493
dgv3152e59 CNV duplication 20981092
dgv47n50 CNV loss 21212237
dgv683n27 CNV gain 19166990
dgv916n67 CNV loss 20364138
dgv9426n54 CNV gain 21841781
dgv9430n54 CNV loss 21841781
dgv9431n54 CNV gain 21841781
dgv996e199 CNV deletion 23128226
dgv99n16 CNV deletion 17901297
esv2568129 CNV deletion 19546169
esv2728928 CNV deletion 23290073
esv27795 CNV gain 19812545
esv32667 CNV gain 17666407
esv33576 CNV gain 17666407
esv3565194 CNV deletion 23714750
esv3603517 CNV gain 21293372
esv3603522 CNV loss 21293372
esv3894090 CNV gain 25118596
esv991339 CNV deletion 20482838
nsv1016120 CNV gain 25217958
nsv1028146 CNV gain 25217958
nsv1074252 CNV deletion 25765185
nsv461864 CNV gain 19166990
nsv4642 CNV deletion 18451855
nsv470097 CNV gain 18288195
nsv508340 CNV deletion 20534489
nsv514284 CNV loss 21397061
nsv524972 CNV loss 19592680
nsv596392 CNV gain 21841781
nsv596400 CNV loss 21841781
nsv596401 CNV loss 21841781
nsv596403 CNV gain+loss 21841781
nsv820150 CNV gain 19587683
nsv820551 CNV deletion 20802225
nsv830172 CNV loss 17160897

Variation tolerance for FAM149A Gene

Residual Variation Intolerance Score: 99.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.96; 87.29% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FAM149A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM149A Gene

Disorders for FAM149A Gene

MalaCards: The human disease database

(1) MalaCards diseases for FAM149A Gene - From: GeneCards

Disorder Aliases PubMed IDs
acute mountain sickness
  • altitude anoxia
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for FAM149A

genes like me logo Genes that share disorders with FAM149A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FAM149A Gene

Publications for FAM149A Gene

  1. A Preliminary Genome-Wide Association Study of Acute Mountain Sickness Susceptibility in a Group of Nepalese Pilgrims Ascending to 4380 m. (PMID: 26600424) MacInnis MJ … Koehle MS (High altitude medicine & biology 2015) 3 58
  2. A genome-wide short hairpin RNA screening of jurkat T-cells for human proteins contributing to productive HIV-1 replication. (PMID: 19460752) Yeung ML … Jeang KT (The Journal of biological chemistry 2009) 3 58
  3. The full-ORF clone resource of the German cDNA Consortium. (PMID: 17974005) Bechtel S … Schupp I (BMC genomics 2007) 4 58
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 58
  5. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 4 58

Products for FAM149A Gene

Sources for FAM149A Gene

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