Aliases for FAM13C Gene

Aliases for FAM13C Gene

  • Family With Sequence Similarity 13 Member C 2 3 5
  • Family With Sequence Similarity 13, Member C1 2 3
  • Protein FAM13C 3 4
  • FAM13C1 3 4
  • Family With Sequence Similarity 13, Member C 2
  • FAM13C 5

External Ids for FAM13C Gene

Previous HGNC Symbols for FAM13C Gene

  • FAM13C1

Previous GeneCards Identifiers for FAM13C Gene

  • GC10M060676
  • GC10M061005
  • GC10M054996

Summaries for FAM13C Gene

GeneCards Summary for FAM13C Gene

FAM13C (Family With Sequence Similarity 13 Member C) is a Protein Coding gene. Diseases associated with FAM13C include Endometrial Mixed Adenocarcinoma and Griscelli Syndrome, Type 3. An important paralog of this gene is FAM13A.

Additional gene information for FAM13C Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FAM13C Gene

Genomics for FAM13C Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for FAM13C Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J059360 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 600.7 +1.1 1077 3.5 PRDM10 ZNF692 FOXA1 ZIC2 ZSCAN4 POLR2A PATZ1 ZNF501 ZNF561 SOX13 FAM13C ENSG00000287969 PHYHIPL
GH10J059535 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 600.1 -174.3 -174265 3.5 FOXA1 POLR2A RFX1 JUND FOXA2 FOS NR2F2 JUN LOC107984235 FAM13C piR-38352-058 SLC16A9
GH10J059364 Enhancer 0.3 dbSUPER 600.7 -1.4 -1358 0.6 ZSCAN5C CBX8 FAM13C MN309169 SLC16A9
GH10J059322 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 22.7 +39.9 39941 2.2 GATAD2A ATF7 REST FOXA1 RXRB SP1 SOX13 TCF7 RFX1 FOXA2 LOC102724778 lnc-PHYHIPL-6 FAM13C ENSG00000236556 lnc-SLC16A9-5 PHYHIPL
GH10J058967 Enhancer 1.6 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 10.8 +395.2 395180 1.6 HNRNPL GATAD2A TEAD4 RCOR2 BACH1 ZIC2 RBFOX2 POLR2A RXRB IRF2 PHYHIPL FAM13C HSALNG0078190 piR-31210-006 BICC1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FAM13C on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FAM13C

Top Transcription factor binding sites by QIAGEN in the FAM13C gene promoter:
  • AML1a
  • FOXI1
  • HFH-3
  • POU2F1
  • POU2F1a

Genomic Locations for FAM13C Gene

Genomic Locations for FAM13C Gene
chr10:59,245,933-59,363,181
(GRCh38/hg38)
Size:
117,249 bases
Orientation:
Minus strand
chr10:61,005,889-61,122,939
(GRCh37/hg19)
Size:
117,051 bases
Orientation:
Minus strand

Genomic View for FAM13C Gene

Genes around FAM13C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM13C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM13C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM13C Gene

Proteins for FAM13C Gene

  • Protein details for FAM13C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NE31-FA13C_HUMAN
    Recommended name:
    Protein FAM13C
    Protein Accession:
    Q8NE31
    Secondary Accessions:
    • B7ZB77
    • Q5T631
    • Q6P2M3
    • Q99787

    Protein attributes for FAM13C Gene

    Size:
    585 amino acids
    Molecular mass:
    65727 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FAM13C Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FAM13C Gene

Post-translational modifications for FAM13C Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FAM13C Gene

Domains & Families for FAM13C Gene

Gene Families for FAM13C Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FAM13C Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM13C Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ54631, highly similar to Protein FAM13C1 (B7Z2K3_HUMAN)
  • cDNA, FLJ79441, highly similar to Protein FAM13C1 (B7ZB77_HUMAN)
  • Protein FAM13C (FA13C_HUMAN)
  • Family with sequence similarity 13, member C1 (Q5T630_HUMAN)
  • Family with sequence similarity 13, member C1 (Q5T632_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8NE31

UniProtKB/Swiss-Prot:

FA13C_HUMAN :
  • Belongs to the FAM13 family.
Family:
  • Belongs to the FAM13 family.
genes like me logo Genes that share domains with FAM13C: view

Function for FAM13C Gene

Phenotypes From GWAS Catalog for FAM13C Gene

Gene Ontology (GO) - Molecular Function for FAM13C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with FAM13C: view
genes like me logo Genes that share phenotypes with FAM13C: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FAM13C

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM13C Gene

Localization for FAM13C Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM13C gene
Compartment Confidence
nucleus 3
cytosol 2
extracellular 1
plasma membrane 0
cytoskeleton 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FAM13C Gene

Pathways & Interactions for FAM13C Gene

PathCards logo

SuperPathways for FAM13C Gene

No Data Available

Gene Ontology (GO) - Biological Process for FAM13C Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FAM13C Gene

Drugs & Compounds for FAM13C Gene

No Compound Related Data Available

Transcripts for FAM13C Gene

mRNA/cDNA for FAM13C Gene

16 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
20 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FAM13C

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM13C Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b · 8c · 8d ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12a · 12b · 12c · 12d ^ 13 ^
SP1: - - -
SP2: - - - -
SP3: - - -
SP4: - - - - -
SP5: - - - -
SP6:
SP7: - -
SP8: - - - - - - -
SP9:
SP10: - -
SP11:
SP12:
SP13:
SP14:

ExUns: 14 ^ 15a · 15b ^ 16 ^ 17a · 17b · 17c ^ 18a · 18b · 18c ^ 19 ^ 20a · 20b
SP1: -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7: - - -
SP8: - - - - -
SP9: - -
SP10:
SP11: - - - -
SP12: - - - -
SP13:
SP14:

Relevant External Links for FAM13C Gene

GeneLoc Exon Structure for
FAM13C

Expression for FAM13C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FAM13C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FAM13C Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x5.0).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FAM13C

SOURCE GeneReport for Unigene cluster for FAM13C Gene:

Hs.607594

Evidence on tissue expression from TISSUES for FAM13C Gene

  • Nervous system(3.7)
genes like me logo Genes that share expression patterns with FAM13C: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM13C Gene

Orthologs for FAM13C Gene

This gene was present in the common ancestor of animals.

Orthologs for FAM13C Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia FAM13C 30 31
  • 99.32 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia FAM13C 30 31
  • 90.7 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia FAM13C 30 31
  • 88.79 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Fam13c 30 17 31
  • 84.25 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Fam13c 30
  • 82.51 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia FAM13C 31
  • 77 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia FAM13C 31
  • 73 (a)
OneToOne
Chicken
(Gallus gallus)
Aves FAM13C 30 31
  • 69.84 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 63 (a)
OneToMany
-- 31
  • 7 (a)
OneToMany
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia LOC101730440 30
  • 64.57 (n)
Str.13599 30
Zebrafish
(Danio rerio)
Actinopterygii LOC100537056 30
  • 57.09 (n)
FAM13C (10 of 10) 31
  • 39 (a)
OneToMany
FAM13C (7 of 10) 31
  • 13 (a)
OneToMany
FAM13C (9 of 10) 31
  • 12 (a)
OneToMany
FAM13C (8 of 10) 31
  • 12 (a)
OneToMany
FAM13C (6 of 10) 31
  • 11 (a)
OneToMany
FAM13C (2 of 10) 31
  • 7 (a)
OneToMany
FAM13C (1 of 10) 31
  • 7 (a)
OneToMany
FAM13C (3 of 10) 31
  • 6 (a)
OneToMany
FAM13C (5 of 10) 31
  • 6 (a)
OneToMany
FAM13C (4 of 10) 31
  • 5 (a)
OneToMany
Fruit Fly
(Drosophila melanogaster)
Insecta CG6424 31
  • 14 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 7 (a)
OneToMany
Species where no ortholog for FAM13C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for FAM13C Gene

ENSEMBL:
Gene Tree for FAM13C (if available)
TreeFam:
Gene Tree for FAM13C (if available)
Aminode:
Evolutionary constrained regions (ECRs) for FAM13C: view image

Paralogs for FAM13C Gene

Paralogs for FAM13C Gene

(1) SIMAP similar genes for FAM13C Gene using alignment to 7 proteins:

  • FA13C_HUMAN
  • B7Z2K3_HUMAN
  • D6RBC7_HUMAN
  • D6RIX4_HUMAN
  • E9PFN8_HUMAN
  • H0YGW3_HUMAN
  • J3KN80_HUMAN
genes like me logo Genes that share paralogs with FAM13C: view

Variants for FAM13C Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for FAM13C Gene

SNP ID Clinical significance and condition Chr 10 pos Variation AA Info Type
rs193920897 Uncertain Significance: Malignant tumor of prostate 59,252,904(-) A/T MISSENSE_VARIANT
rs17853626 - p.Pro82His

Additional dbSNP identifiers (rs#s) for FAM13C Gene

Structural Variations from Database of Genomic Variants (DGV) for FAM13C Gene

Variant ID Type Subtype PubMed ID
esv2737429 CNV deletion 23290073
esv3305324 CNV mobile element insertion 20981092
esv3360999 CNV insertion 20981092
esv3386762 CNV insertion 20981092
esv4266 CNV loss 18987735
nsv1115395 CNV duplication 24896259
nsv467289 CNV loss 19166990
nsv477953 CNV novel sequence insertion 20440878
nsv507558 OTHER sequence alteration 20534489
nsv528505 CNV loss 19592680
nsv551148 CNV loss 21841781
nsv551149 CNV loss 21841781
nsv831888 CNV gain 17160897

Variation tolerance for FAM13C Gene

Residual Variation Intolerance Score: 52.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.98; 49.68% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FAM13C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM13C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM13C Gene

Disorders for FAM13C Gene

MalaCards: The human disease database

(2) MalaCards diseases for FAM13C Gene - From: DISEASES

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for FAM13C

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with FAM13C: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FAM13C Gene

Publications for FAM13C Gene

  1. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A … Goate A (American journal of human genetics 2006) 3 41
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  3. Large-scale concatenation cDNA sequencing. (PMID: 9110174) Yu W … Gibbs RA (Genome research 1997) 3 4
  4. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  5. Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations. (PMID: 31515488) Fragoza R … Yu H (Nature communications 2019) 3

Products for FAM13C Gene

Sources for FAM13C Gene