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This gene encodes a mitochondrially localized protein that is highly conserved across species. The gene is expressed in a variety of tissues including human lymphoblast cells and rat neurosensorial epithelium of the cristaampullaris. A mutation in this gene has been associated with familial Meniere's disease, a chronic disorder of the inner ear. Several pseudogenes of this gene are found on other chromosomes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2016]
FAM136A (Family With Sequence Similarity 136 Member A) is a Protein Coding gene. Diseases associated with FAM136A include Meniere Disease and Peripheral Vertigo.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005737 | cytoplasm | IDA | -- |
ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3a | · | 3b |
---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | ||||||||||
SP2: |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | FAM136A 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | -- 31 |
|
OneToMany | |
LOC100688076 30 |
|
||||
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
Cow (Bos Taurus) |
Mammalia | FAM136A 31 |
|
OneToMany | |
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
Mouse (Mus musculus) |
Mammalia | Fam136a 30 17 31 |
|
OneToMany | |
Fam136b-ps 31 |
|
OneToMany | |||
Rat (Rattus norvegicus) |
Mammalia | Fam136a 30 |
|
||
Platypus (Ornithorhynchus anatinus) |
Mammalia | FAM136A 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
OneToMany | |
-- 31 |
|
OneToMany | |||
Chicken (Gallus gallus) |
Aves | LOC426296 30 |
|
||
FAM136A 31 |
|
OneToOne | |||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.14996 30 |
|
||
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | Str.10079 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | fam136a 31 |
|
OneToOne | |
wufb72f05 30 |
|
||||
Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.4968 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | CG5327 30 31 |
|
OneToMany | |
CG5323 31 |
|
OneToMany | |||
CG12661 31 |
|
OneToMany | |||
Worm (Caenorhabditis elegans) |
Secernentea | ZK637.2 31 |
|
OneToOne | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.5803 31 |
|
OneToOne |
Disorder | Aliases | PubMed IDs |
---|---|---|
meniere disease |
|
|
peripheral vertigo |
|
|
vestibular disease |
|
|
deafness, autosomal dominant 28 |
|
|
deafness, autosomal dominant 15 |
|
|