Free for academic non-profit institutions. Other users need a Commercial license

Aliases for FAM131B Gene

Aliases for FAM131B Gene

  • Family With Sequence Similarity 131 Member B 2 3 5
  • Family With Sequence Similarity 131, Member B 2
  • KIAA0773 4

External Ids for FAM131B Gene

Previous GeneCards Identifiers for FAM131B Gene

  • GC07M142761
  • GC07M143050
  • GC07M137387

Summaries for FAM131B Gene

GeneCards Summary for FAM131B Gene

FAM131B (Family With Sequence Similarity 131 Member B) is a Protein Coding gene. Among its related pathways are Oncogenic MAPK signaling and HIV Life Cycle. An important paralog of this gene is FAM131A.

Additional gene information for FAM131B Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM131B Gene

Genomics for FAM131B Gene

GeneHancer (GH) Regulatory Elements for FAM131B Gene

Promoters and enhancers for FAM131B Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07I143361 Promoter/Enhancer 2 EPDnew Ensembl ENCODE dbSUPER 550.4 +20.0 19971 1.4 KLF17 SIN3A ZNF2 ZNF335 ZNF121 GLIS2 ZNF213 ZNF366 ZNF391 EGR2 LOC101928397 FAM131B CLCN1
GH07I143362 Promoter/Enhancer 1.3 EPDnew ENCODE dbSUPER 550.3 +21.0 20961 0.3 MAZ ZIC2 ZFHX2 POLR2A ZNF213 VEZF1 GLIS1 ZSCAN29 PRDM1 EGR2 LOC101928397 FAM131B CLCN1
GH07I143378 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 9.5 -3.9 -3890 15.9 HDGF PKNOX1 FOXA2 SMAD1 ARNT MLX ARID4B SIN3A YBX1 ZNF2 ZYX CASP2 LOC154761 OR2A1 RN7SL535P EPHA1-AS1 EPHA1 TCAF2 HINT1P1 CLCN1
GH07I143258 Enhancer 1.2 FANTOM5 Ensembl ENCODE 11.2 +123.0 123035 2.2 HDAC1 FOXA2 YY1 FOS SP3 RXRA CAVIN1 ZEB2 ZNF592 MTA1 TMEM139 LOC105375545 CASP2 RN7SL535P EPHA1 EPHA1-AS1 FAM131B HINT1P1 CLCN1 ZYX
GH07I143248 Enhancer 1.1 Ensembl ENCODE 10.9 +132.3 132301 2.6 ELF3 MLX ARID4B RAD21 RARA ETS1 YY1 ZNF280A THAP11 MIXL1 TMEM139 CASP2 LOC105375545 RN7SL535P FAM131B EPHB6 GSTK1 LOC105375546
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around FAM131B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FAM131B gene promoter:

Genomic Locations for FAM131B Gene

Genomic Locations for FAM131B Gene
28,905 bases
Minus strand

Genomic View for FAM131B Gene

Genes around FAM131B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM131B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM131B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM131B Gene

Proteins for FAM131B Gene

  • Protein details for FAM131B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein FAM131B
    Protein Accession:
    Secondary Accessions:
    • A4D2H6
    • A6NDW3
    • A8K605
    • B8ZZN2
    • D3DXE3
    • J3KQX2
    • Q7L0D6
    • Q86T97

    Protein attributes for FAM131B Gene

    332 amino acids
    Molecular mass:
    35769 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAS07501.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for FAM131B Gene


neXtProt entry for FAM131B Gene

Post-translational modifications for FAM131B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FAM131B Gene

Domains & Families for FAM131B Gene

Gene Families for FAM131B Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted intracellular proteins

Protein Domains for FAM131B Gene


Suggested Antigen Peptide Sequences for FAM131B Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the FAM131 family.
  • Belongs to the FAM131 family.
genes like me logo Genes that share domains with FAM131B: view

Function for FAM131B Gene

Phenotypes From GWAS Catalog for FAM131B Gene

Gene Ontology (GO) - Molecular Function for FAM131B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21044950
genes like me logo Genes that share ontologies with FAM131B: view
genes like me logo Genes that share phenotypes with FAM131B: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM131B Gene

Localization for FAM131B Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM131B gene
Compartment Confidence
nucleus 5
cytosol 5

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (4)
  • Nucleoplasm (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for FAM131B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with FAM131B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for FAM131B Gene

Pathways & Interactions for FAM131B Gene

genes like me logo Genes that share pathways with FAM131B: view

Pathways by source for FAM131B Gene

Interacting Proteins for FAM131B Gene

Gene Ontology (GO) - Biological Process for FAM131B Gene


No data available for SIGNOR curated interactions for FAM131B Gene

Drugs & Compounds for FAM131B Gene

No Compound Related Data Available

Transcripts for FAM131B Gene

Unigene Clusters for FAM131B Gene

Family with sequence similarity 131, member B:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM131B Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b · 7c · 7d ^ 8 ^ 9a · 9b · 9c · 9d
SP1: - - - - - -
SP2: - - -
SP3: - - - - - - - -
SP4: - - - - -
SP5: - -
SP6: -
SP7: - - -

Relevant External Links for FAM131B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAM131B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM131B Gene

mRNA differential expression in normal tissues according to GTEx for FAM131B Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x6.4), Brain - Cerebellum (x5.9), Brain - Cortex (x5.6), Brain - Frontal Cortex (BA9) (x5.2), and Brain - Spinal cord (cervical c-1) (x4.8).

Protein differential expression in normal tissues from HIPED for FAM131B Gene

This gene is overexpressed in Fetal Brain (31.2), Frontal cortex (27.6), and Spinal cord (10.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FAM131B Gene

Protein tissue co-expression partners for FAM131B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FAM131B Gene:


SOURCE GeneReport for Unigene cluster for FAM131B Gene:


Evidence on tissue expression from TISSUES for FAM131B Gene

  • Nervous system(4.9)
genes like me logo Genes that share expression patterns with FAM131B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM131B Gene

Orthologs for FAM131B Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM131B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FAM131B 33 34
  • 99.63 (n)
(Canis familiaris)
Mammalia FAM131B 33 34
  • 92.07 (n)
(Monodelphis domestica)
Mammalia FAM131B 34
  • 91 (a)
(Bos Taurus)
Mammalia FAM131B 33 34
  • 90.96 (n)
(Rattus norvegicus)
Mammalia Fam131b 33
  • 90.46 (n)
(Mus musculus)
Mammalia Fam131b 33 16 34
  • 90.28 (n)
(Ornithorhynchus anatinus)
Mammalia FAM131B 34
  • 72 (a)
(Gallus gallus)
Aves FAM131B 33 34
  • 71.51 (n)
(Anolis carolinensis)
Reptilia FAM131B 34
  • 74 (a)
(Danio rerio)
Actinopterygii fam131ba 34
  • 35 (a)
fam131bb 34
  • 34 (a)
Species where no ortholog for FAM131B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM131B Gene

Gene Tree for FAM131B (if available)
Gene Tree for FAM131B (if available)

Paralogs for FAM131B Gene

Paralogs for FAM131B Gene

(2) SIMAP similar genes for FAM131B Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with FAM131B: view

Variants for FAM131B Gene

Sequence variations from dbSNP and Humsavar for FAM131B Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000019148 -- 143,381,249(-) T/C genic_upstream_transcript_variant, intron_variant
rs1000104340 -- 143,356,268(-) G/A/T 3_prime_UTR_variant
rs1000163934 -- 143,367,826(-) G/A genic_upstream_transcript_variant, intron_variant
rs1000185995 -- 143,366,181(-) C/A genic_upstream_transcript_variant, intron_variant
rs1000211478 -- 143,358,625(-) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for FAM131B Gene

Variant ID Type Subtype PubMed ID
nsv517520 CNV loss 19592680
nsv949966 CNV deletion 24416366

Variation tolerance for FAM131B Gene

Residual Variation Intolerance Score: 38.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.74; 83.18% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FAM131B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM131B Gene

Disorders for FAM131B Gene

Additional Disease Information for FAM131B

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for FAM131B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM131B Gene

Publications for FAM131B Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier LW … Wilson RK (Nature 2003) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. Genome-wide YFP fluorescence complementation screen identifies new regulators for telomere signaling in human cells. (PMID: 21044950) Lee OH … Songyang Z (Molecular & cellular proteomics : MCP 2011) 3 58

Products for FAM131B Gene

Sources for FAM131B Gene

Loading form....