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Aliases for FAM131A Gene

Aliases for FAM131A Gene

  • Family With Sequence Similarity 131 Member A 2 3 5
  • C3orf40 3 4
  • Family With Sequence Similarity 131, Member A 2
  • Chromosome 3 Open Reading Frame 40 2
  • Protein FAM131A 3
  • FLAT715 3
  • PRO1378 3

External Ids for FAM131A Gene

Previous HGNC Symbols for FAM131A Gene

  • C3orf40

Previous GeneCards Identifiers for FAM131A Gene

  • GC03P185538
  • GC03P184053
  • GC03P181460

Summaries for FAM131A Gene

GeneCards Summary for FAM131A Gene

FAM131A (Family With Sequence Similarity 131 Member A) is a Protein Coding gene. An important paralog of this gene is FAM131B.

Additional gene information for FAM131A Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM131A Gene

Genomics for FAM131A Gene

GeneHancer (GH) Regulatory Elements for FAM131A Gene

Promoters and enhancers for FAM131A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03I184330 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 550.8 -0.5 -522 9 PKNOX1 FOXA2 ARID4B SIN3A DMAP1 YY1 POLR2B ZNF213 E2F8 ZNF143 FAM131A ABCF3 PSMD2 VWA5B2 ECE2 DVL3 SNORD66 EIF4G1
GH03I184154 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 10.1 -179.5 -179529 4.2 HDGF FOXA2 ARID4B SIN3A DMAP1 SLC30A9 ZNF121 GLIS2 ELK1 ZNF143 DVL3 EIF2B5 RPS3P3 POLR2H ALG3 ECE2 EEF1AKMT4-ECE2 EEF1AKMT4 ABCF3 CAMK2N2
GH03I184371 Enhancer 1.1 Ensembl ENCODE 11 +35.8 35775 0.6 ELF3 PKNOX1 FOXA2 ARID4B SIN3A FEZF1 ZNF2 IRF4 ZNF48 RAD21 LINC02054 FAM131A EIF4G1 SNORD66 LINC01840 EPHB3 PSMD2 POLR2H THPO
GH03I184655 Enhancer 1.2 Ensembl ENCODE dbSUPER 10 +322.5 322526 5.7 ELF3 PKNOX1 ARID4B BATF KLF5 IRF4 ATF7 RCOR1 FOS IKZF2 MAGEF1 YEATS2 EPHB3 LINC01840 FAM131A
GH03I184524 Enhancer 1 Ensembl ENCODE 10.7 +189.7 189741 1.7 ZNF335 GLIS2 ZNF366 EGR2 SP3 ZNF398 REST ZEB2 ZNF585B GLIS1 MAGEF1 LINC02054 YEATS2 THPO CHRD LINC01840 POLR2H CLCN2 EPHB3 FAM131A
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around FAM131A on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FAM131A gene promoter:

Genomic Locations for FAM131A Gene

Genomic Locations for FAM131A Gene
chr3:184,335,926-184,348,421
(GRCh38/hg38)
Size:
12,496 bases
Orientation:
Plus strand
chr3:184,053,714-184,064,063
(GRCh37/hg19)

Genomic View for FAM131A Gene

Genes around FAM131A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM131A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM131A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM131A Gene

Proteins for FAM131A Gene

  • Protein details for FAM131A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UXB0-F131A_HUMAN
    Recommended name:
    Protein FAM131A
    Protein Accession:
    Q6UXB0
    Secondary Accessions:
    • D3DNT6
    • G5E9B1
    • Q8TA84

    Protein attributes for FAM131A Gene

    Size:
    335 amino acids
    Molecular mass:
    36108 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FAM131A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FAM131A Gene

Post-translational modifications for FAM131A Gene

No Post-translational modifications

No data available for DME Specific Peptides for FAM131A Gene

Domains & Families for FAM131A Gene

Gene Families for FAM131A Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for FAM131A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM131A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6UXB0

UniProtKB/Swiss-Prot:

F131A_HUMAN :
  • Belongs to the FAM131 family.
Family:
  • Belongs to the FAM131 family.
genes like me logo Genes that share domains with FAM131A: view

Function for FAM131A Gene

Phenotypes for FAM131A Gene

genes like me logo Genes that share phenotypes with FAM131A: view

miRNA for FAM131A Gene

miRTarBase miRNAs that target FAM131A

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM131A Gene

Localization for FAM131A Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM131A Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM131A gene
Compartment Confidence
extracellular 4
nucleus 3
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for FAM131A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with FAM131A: view

Pathways & Interactions for FAM131A Gene

SuperPathways for FAM131A Gene

No Data Available

Interacting Proteins for FAM131A Gene

Selected Interacting proteins: Q6UXB0-F131A_HUMAN for FAM131A Gene via IID

Gene Ontology (GO) - Biological Process for FAM131A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FAM131A Gene

Drugs & Compounds for FAM131A Gene

No Compound Related Data Available

Transcripts for FAM131A Gene

Unigene Clusters for FAM131A Gene

Family with sequence similarity 131, member A:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM131A Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c · 9d
SP1: - - - -
SP2: - - - - -
SP3: - - - -
SP4: - -
SP5:
SP6: - - - - - -
SP7:

Relevant External Links for FAM131A Gene

GeneLoc Exon Structure for
FAM131A
ECgene alternative splicing isoforms for
FAM131A

Expression for FAM131A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM131A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FAM131A Gene



NURSA nuclear receptor signaling pathways regulating expression of FAM131A Gene:

FAM131A

SOURCE GeneReport for Unigene cluster for FAM131A Gene:

Hs.591307

Evidence on tissue expression from TISSUES for FAM131A Gene

  • Intestine(4.1)
  • Nervous system(3.8)
genes like me logo Genes that share expression patterns with FAM131A: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM131A Gene

Orthologs for FAM131A Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM131A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM131A 33 34
  • 99 (n)
dog
(Canis familiaris)
Mammalia FAM131A 33 34
  • 93.17 (n)
cow
(Bos Taurus)
Mammalia FAM131A 33 34
  • 92.99 (n)
mouse
(Mus musculus)
Mammalia Fam131a 33 16 34
  • 89.72 (n)
rat
(Rattus norvegicus)
Mammalia Fam131a 33
  • 88.98 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia FAM131A 34
  • 76 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FAM131A 34
  • 73 (a)
OneToOne
chicken
(Gallus gallus)
Aves FAM131A 33 34
  • 68.87 (n)
lizard
(Anolis carolinensis)
Reptilia FAM131A 34
  • 53 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fam131a 33
  • 59.24 (n)
zebrafish
(Danio rerio)
Actinopterygii zgc:165508 33
  • 59.95 (n)
FAM131A 34
  • 51 (a)
OneToOne
Species where no ortholog for FAM131A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM131A Gene

ENSEMBL:
Gene Tree for FAM131A (if available)
TreeFam:
Gene Tree for FAM131A (if available)

Paralogs for FAM131A Gene

Paralogs for FAM131A Gene

(2) SIMAP similar genes for FAM131A Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with FAM131A: view

Variants for FAM131A Gene

Sequence variations from dbSNP and Humsavar for FAM131A Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
VAR_036118 A breast cancer sample p.Ser260Asn
rs1000149334 -- 184,335,906(+) G/A upstream_transcript_variant
rs1001329374 -- 184,336,084(+) G/C 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant
rs1001399296 -- 184,340,648(+) T/C intron_variant
rs1001446165 -- 184,336,149(+) T/G genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for FAM131A Gene

Variant ID Type Subtype PubMed ID
nsv829813 CNV loss 17160897
esv2726297 CNV deletion 23290073
esv2422400 CNV duplication 17116639

Variation tolerance for FAM131A Gene

Residual Variation Intolerance Score: 23.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.66; 31.69% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FAM131A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM131A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM131A Gene

Disorders for FAM131A Gene

Additional Disease Information for FAM131A

No disorders were found for FAM131A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM131A Gene

Publications for FAM131A Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 2 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K … Gorospe M (The EMBO journal 2009) 3 58
  4. The DNA sequence, annotation and analysis of human chromosome 3. (PMID: 16641997) Muzny DM … Gibbs RA (Nature 2006) 4 58
  5. The consensus coding sequences of human breast and colorectal cancers. (PMID: 16959974) Sjöblom T … Velculescu VE (Science (New York, N.Y.) 2006) 4 58

Products for FAM131A Gene

Sources for FAM131A Gene

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