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Aliases for FAM126B Gene

Aliases for FAM126B Gene

  • Family With Sequence Similarity 126 Member B 2 3 5
  • Family With Sequence Similarity 126, Member B 2
  • Protein FAM126B 3
  • HYCC2 3

External Ids for FAM126B Gene

Previous GeneCards Identifiers for FAM126B Gene

  • GC02M201551
  • GC02M201838
  • GC02M193689

Summaries for FAM126B Gene

GeneCards Summary for FAM126B Gene

FAM126B (Family With Sequence Similarity 126 Member B) is a Protein Coding gene. An important paralog of this gene is FAM126A.

UniProtKB/Swiss-Prot for FAM126B Gene

  • Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane.

Additional gene information for FAM126B Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM126B Gene

Genomics for FAM126B Gene

GeneHancer (GH) Regulatory Elements for FAM126B Gene

Promoters and enhancers for FAM126B Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02I201070 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 550.8 -0.2 -151 2.8 CLOCK ZFP64 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 ZNF548 SP3 FAM126B NDUFB3 ORC2 CLK1 CDK15 KCTD18 RNU6-762P CFLAR-AS1 MPP4 ENSG00000273209
GH02I201114 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 11.3 -52.5 -52545 19 FEZF1 DMAP1 YBX1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 CFLAR PPIL3 CLK1 ORC2 CASP10 CFLAR-AS1 CDK15 KCTD18 FAM126B LOC105373835
GH02I201251 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 2.6 -186.8 -186831 13.4 HDGF PKNOX1 CLOCK SMAD1 ARID4B SIN3A FEZF1 DMAP1 IRF4 YY1 CASP8 ALS2CR12 STRADB PPIL3 CASP10 CLK1 CFLAR FAM126B
GH02I200962 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE 1.9 +107.9 107865 3 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 ORC2 LOC105373835 PPIL3 CDK15 LOC100420110 KCTD18 SGO2 CLK1 CASP8 FAM126B
GH02I201239 Enhancer 0.9 FANTOM5 Ensembl ENCODE dbSUPER 1.3 -168.0 -168030 1 CASP10 CFLAR CLK1 PPIL3 BZW1 CASP8 FAM126B ALS2CR12
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around FAM126B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FAM126B gene promoter:

Genomic Locations for FAM126B Gene

Genomic Locations for FAM126B Gene
97,954 bases
Minus strand

Genomic View for FAM126B Gene

Genes around FAM126B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM126B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM126B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM126B Gene

Proteins for FAM126B Gene

  • Protein details for FAM126B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein FAM126B
    Protein Accession:
    Secondary Accessions:
    • B2RCG7
    • Q4ZG87
    • Q53TX6

    Protein attributes for FAM126B Gene

    530 amino acids
    Molecular mass:
    58647 Da
    Quaternary structure:
    • Component of a phosphatidylinositol 4-kinase (PI4K) complex, composed of PI4KA, EFR3 (EFR3A or EFR3B), TTC7 (TTC7A or TTC7B) and FAM126 (FAM126A or FAM126B).

neXtProt entry for FAM126B Gene

Post-translational modifications for FAM126B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FAM126B Gene

Domains & Families for FAM126B Gene

Gene Families for FAM126B Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FAM126B Gene


Suggested Antigen Peptide Sequences for FAM126B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the FAM126 family.
  • Belongs to the FAM126 family.
genes like me logo Genes that share domains with FAM126B: view

Function for FAM126B Gene

Molecular function for FAM126B Gene

UniProtKB/Swiss-Prot Function:
Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane.

Phenotypes From GWAS Catalog for FAM126B Gene

Gene Ontology (GO) - Molecular Function for FAM126B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with FAM126B: view

Phenotypes for FAM126B Gene

GenomeRNAi human phenotypes for FAM126B:
genes like me logo Genes that share phenotypes with FAM126B: view

miRNA for FAM126B Gene

miRTarBase miRNAs that target FAM126B

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM126B Gene

Localization for FAM126B Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM126B Gene

Cytoplasm, cytosol. Cell membrane.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM126B gene
Compartment Confidence
nucleus 4
cytosol 4
plasma membrane 3
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cell Junctions (3)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for FAM126B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IDA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IEA --
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with FAM126B: view

Pathways & Interactions for FAM126B Gene

SuperPathways for FAM126B Gene

No Data Available

Interacting Proteins for FAM126B Gene

Gene Ontology (GO) - Biological Process for FAM126B Gene


No data available for Pathways by source and SIGNOR curated interactions for FAM126B Gene

Drugs & Compounds for FAM126B Gene

No Compound Related Data Available

Transcripts for FAM126B Gene

Unigene Clusters for FAM126B Gene

Family with sequence similarity 126, member B:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM126B Gene

No ASD Table

Relevant External Links for FAM126B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAM126B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM126B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FAM126B Gene

This gene is overexpressed in Whole Blood (x5.5).

Protein differential expression in normal tissues from HIPED for FAM126B Gene

This gene is overexpressed in Retina (19.7), Peripheral blood mononuclear cells (15.5), Frontal cortex (12.3), Placenta (11.2), and CD8 Tcells (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FAM126B Gene

Protein tissue co-expression partners for FAM126B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FAM126B Gene:


SOURCE GeneReport for Unigene cluster for FAM126B Gene:


Evidence on tissue expression from TISSUES for FAM126B Gene

  • Nervous system(4.4)
  • Liver(4.2)
genes like me logo Genes that share expression patterns with FAM126B: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM126B Gene

Orthologs for FAM126B Gene

This gene was present in the common ancestor of animals.

Orthologs for FAM126B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FAM126B 33 34
  • 99.87 (n)
(Canis familiaris)
Mammalia FAM126B 33 34
  • 94.91 (n)
(Bos Taurus)
Mammalia FAM126B 33 34
  • 94.21 (n)
(Mus musculus)
Mammalia Fam126b 33 16 34
  • 91.82 (n)
(Rattus norvegicus)
Mammalia Fam126b 33
  • 90.99 (n)
(Monodelphis domestica)
Mammalia FAM126B 34
  • 85 (a)
(Ornithorhynchus anatinus)
Mammalia FAM126B 34
  • 81 (a)
(Gallus gallus)
Aves FAM126B 33 34
  • 82.2 (n)
(Anolis carolinensis)
Reptilia FAM126B 34
  • 87 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fam126b 33
  • 75.17 (n)
(Danio rerio)
Actinopterygii FAM126B (2 of 3) 34
  • 71 (a)
FAM126B (3 of 3) 34
  • 66 (a)
LOC100536464 33
  • 65.05 (n)
FAM126B (1 of 3) 34
  • 55 (a)
Dr.16317 33
fruit fly
(Drosophila melanogaster)
Insecta CG6406 34
  • 24 (a)
(Caenorhabditis elegans)
Secernentea D1069.3 34
  • 19 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 20 (a)
Species where no ortholog for FAM126B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FAM126B Gene

Gene Tree for FAM126B (if available)
Gene Tree for FAM126B (if available)

Paralogs for FAM126B Gene

Paralogs for FAM126B Gene

(2) SIMAP similar genes for FAM126B Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with FAM126B: view

Variants for FAM126B Gene

Sequence variations from dbSNP and Humsavar for FAM126B Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs190804887 benign, not specified 201,072,325(-) T/C upstream_transcript_variant
rs539378055 benign, not specified 201,072,375(-) A/G upstream_transcript_variant
rs1000006773 -- 201,038,882(-) C/A intron_variant
rs1000043165 -- 201,063,890(-) A/C genic_upstream_transcript_variant, intron_variant
rs1000071001 -- 201,022,743(-) AAAGAAAA/AAA intron_variant

Structural Variations from Database of Genomic Variants (DGV) for FAM126B Gene

Variant ID Type Subtype PubMed ID
esv3560818 CNV deletion 23714750
esv3593970 CNV loss 21293372
nsv584160 CNV loss 21841781
nsv963759 CNV duplication 23825009

Variation tolerance for FAM126B Gene

Residual Variation Intolerance Score: 7.16% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.14; 23.09% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FAM126B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM126B Gene

Disorders for FAM126B Gene

Additional Disease Information for FAM126B

No disorders were found for FAM126B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM126B Gene

Publications for FAM126B Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  4. A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome. (PMID: 28065597) Yao Z … Stagljar I (Molecular cell 2017) 3 58
  5. The leukodystrophy protein FAM126A (hyccin) regulates PtdIns(4)P synthesis at the plasma membrane. (PMID: 26571211) Baskin JM … De Camilli P (Nature cell biology 2016) 4 58

Products for FAM126B Gene

Sources for FAM126B Gene

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