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Aliases for FAM124A Gene

Aliases for FAM124A Gene

  • Family With Sequence Similarity 124 Member A 2 3 5
  • Family With Sequence Similarity 124A 2

External Ids for FAM124A Gene

Previous GeneCards Identifiers for FAM124A Gene

  • GC13P050695
  • GC13P051796
  • GC13P032585

Summaries for FAM124A Gene

GeneCards Summary for FAM124A Gene

FAM124A (Family With Sequence Similarity 124 Member A) is a Protein Coding gene. An important paralog of this gene is FAM124B.

Additional gene information for FAM124A Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM124A Gene

Genomics for FAM124A Gene

GeneHancer (GH) Regulatory Elements for FAM124A Gene

Promoters and enhancers for FAM124A Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH13I051221 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE dbSUPER 559.3 +0.4 436 1.9 ARNT ZSCAN4 INSM2 KLF17 SIN3A GLI4 ZNF2 ZNF335 GLIS2 KLF7 FAM124A GC13P051237
GH13I051243 Enhancer 0.8 ENCODE dbSUPER 18.3 +22.0 22031 2.7 USF1 SMAD5 SIN3A USF2 ZNF664 SP1 POLR2A POU5F1 CTBP2 FAM124A GC13P051237 GC13P051260
GH13I051225 Enhancer 0.5 FANTOM5 dbSUPER 23.9 +3.7 3664 0 PRDM1 FAM124A DLEU7 GC13P051237
GH13I051286 Enhancer 1 Ensembl ENCODE dbSUPER 11.6 +64.2 64195 0.4 CTCF ZNF654 TRIM22 REST IRF4 RAD21 ZNF143 SMC3 RCOR1 ZBTB17 FAM124A CCDC70 GC13P051260 SERPINE3
GH13I051246 Enhancer 0.6 ENCODE dbSUPER 17.9 +23.8 23846 0.2 RCOR1 CHD2 FAM124A GC13P051237 GC13P051260
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around FAM124A on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FAM124A gene promoter:

Genomic Locations for FAM124A Gene

Genomic Locations for FAM124A Gene
61,908 bases
Plus strand

Genomic View for FAM124A Gene

Genes around FAM124A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM124A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM124A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM124A Gene

Proteins for FAM124A Gene

  • Protein details for FAM124A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein FAM124A
    Protein Accession:
    Secondary Accessions:
    • A2A324
    • Q8N8P9
    • Q8NE66
    • Q96NJ9

    Protein attributes for FAM124A Gene

    546 amino acids
    Molecular mass:
    60104 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH34497.1; Type=Frameshift; Positions=286; Evidence={ECO:0000305};

    Alternative splice isoforms for FAM124A Gene


neXtProt entry for FAM124A Gene

Post-translational modifications for FAM124A Gene

No Post-translational modifications

Other Protein References for FAM124A Gene

No data available for DME Specific Peptides for FAM124A Gene

Domains & Families for FAM124A Gene

Gene Families for FAM124A Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FAM124A Gene


Suggested Antigen Peptide Sequences for FAM124A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the FAM124 family.
  • Belongs to the FAM124 family.
genes like me logo Genes that share domains with FAM124A: view

Function for FAM124A Gene

Phenotypes From GWAS Catalog for FAM124A Gene

Gene Ontology (GO) - Molecular Function for FAM124A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with FAM124A: view

Phenotypes for FAM124A Gene

GenomeRNAi human phenotypes for FAM124A:
genes like me logo Genes that share phenotypes with FAM124A: view

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM124A Gene

Localization for FAM124A Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM124A gene
Compartment Confidence
nucleus 3
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleus (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FAM124A Gene

Pathways & Interactions for FAM124A Gene

SuperPathways for FAM124A Gene

No Data Available

Gene Ontology (GO) - Biological Process for FAM124A Gene


No data available for Pathways by source and SIGNOR curated interactions for FAM124A Gene

Drugs & Compounds for FAM124A Gene

No Compound Related Data Available

Transcripts for FAM124A Gene

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM124A Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b
SP1: -
SP2: - -

Relevant External Links for FAM124A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAM124A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM124A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FAM124A Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x6.2).

Protein differential expression in normal tissues from HIPED for FAM124A Gene

This gene is overexpressed in Monocytes (18.0), Spleen (11.1), Uterus (7.7), and Lymph node (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FAM124A Gene

NURSA nuclear receptor signaling pathways regulating expression of FAM124A Gene:


SOURCE GeneReport for Unigene cluster for FAM124A Gene:


Evidence on tissue expression from TISSUES for FAM124A Gene

  • Nervous system(2.9)
genes like me logo Genes that share expression patterns with FAM124A: view

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM124A Gene

Orthologs for FAM124A Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM124A Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FAM124A 33 34
  • 99.54 (n)
(Canis familiaris)
Mammalia FAM124A 33 34
  • 86.88 (n)
(Bos Taurus)
Mammalia FAM124A 33 34
  • 82.29 (n)
(Mus musculus)
Mammalia Fam124a 33 16 34
  • 79.23 (n)
(Rattus norvegicus)
Mammalia Fam124a 33
  • 78.79 (n)
(Ornithorhynchus anatinus)
Mammalia FAM124A 34
  • 72 (a)
(Monodelphis domestica)
Mammalia FAM124A 34
  • 65 (a)
(Gallus gallus)
Aves FAM124A 33 34
  • 63.69 (n)
(Anolis carolinensis)
Reptilia FAM124A 34
  • 47 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fam124a 33
  • 60.03 (n)
(Danio rerio)
Actinopterygii LOC556683 33
  • 56.03 (n)
FAM124A 34
  • 39 (a)
Species where no ortholog for FAM124A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM124A Gene

Gene Tree for FAM124A (if available)
Gene Tree for FAM124A (if available)

Paralogs for FAM124A Gene

Paralogs for FAM124A Gene

(1) SIMAP similar genes for FAM124A Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FAM124A: view

Variants for FAM124A Gene

Sequence variations from dbSNP and Humsavar for FAM124A Gene

SNP ID Clin Chr 13 pos Variation AA Info Type
rs1000043224 -- 51,227,988(+) A/G intron_variant
rs1000083001 -- 51,246,408(+) G/C/T intron_variant
rs1000143233 -- 51,272,928(+) G/A genic_downstream_transcript_variant, intron_variant
rs1000160926 -- 51,241,302(+) G/A intron_variant
rs1000225685 -- 51,259,164(+) C/A genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for FAM124A Gene

Variant ID Type Subtype PubMed ID
esv2747418 CNV deletion 23290073
esv3550464 CNV deletion 23714750
nsv1069753 CNV deletion 25765185
nsv1118264 CNV deletion 24896259
nsv1145663 CNV deletion 24896259
nsv561618 CNV loss 21841781
nsv832610 CNV gain 17160897
nsv832611 CNV loss 17160897

Variation tolerance for FAM124A Gene

Residual Variation Intolerance Score: 74.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.81; 79.14% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FAM124A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM124A Gene

Disorders for FAM124A Gene

Additional Disease Information for FAM124A

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for FAM124A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM124A Gene

Publications for FAM124A Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 2 3 58
  4. A genome-wide association study of rheumatoid arthritis without antibodies against citrullinated peptides. (PMID: 24532677) Bossini-Castillo L … Koeleman BP (Annals of the rheumatic diseases 2015) 3 58
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58

Products for FAM124A Gene

Sources for FAM124A Gene

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