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Aliases for FAM122B Gene
Aliases for FAM122B Gene
External Ids for FAM122B Gene
- HGNC: 30490
- Entrez Gene: 159090
- Ensembl: ENSG00000156504
- UniProtKB: Q7Z309
Previous GeneCards Identifiers for FAM122B Gene
- GC0XM133731
- GC0XM133903
- GC0XM123302
Summaries for FAM122B Gene
GeneCards Summary for FAM122B Gene
FAM122B (Family With Sequence Similarity 122B) is a Protein Coding gene. An important paralog of this gene is FAM122A.
Additional gene information for FAM122B Gene
- HGNC(30490)
- Entrez Gene(159090)
- Ensembl(ENSG00000156504)
- UniProtKB(Q7Z309)
- Open Targets Platform(ENSG00000156504)
- Search for FAM122B at DataMed
- Search for FAM122B at HumanCyc
No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FAM122B Gene
Genomics for FAM122B Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for FAM122B Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around FAM122B on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FAM122B
- Top Transcription factor binding sites by QIAGEN in the FAM122B gene promoter:
-
- AML1a
- AP-2gamma
- E2F
- E2F-1
- E47
- Evi-1
- Hand1
- NRSF form 1
- NRSF form 2
- Pbx1a
Genomic Locations for FAM122B Gene
Genomic Locations for FAM122B Gene
- chrX:134,769,566-134,797,232
- (GRCh38/hg38)
- Size:
- 27,667 bases
- Orientation:
- Minus strand
- chrX:133,903,596-133,931,262
- (GRCh37/hg19)
- Size:
- 27,667 bases
- Orientation:
- Minus strand
Genomic View for FAM122B Gene
Genes around FAM122B on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- Xq26.3 by HGNC
- Xq26.3 by Entrez Gene
- Xq26.3 by Ensembl
FAM122B Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for FAM122B Gene
Proteins for FAM122B Gene
-
Protein details for FAM122B Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q7Z309-F122B_HUMAN
- Recommended name:
- Protein FAM122B
- Protein Accession:
- Q7Z309
- A8K902
- Q6PIM2
- Q6ZU47
- Q6ZV64
- Q6ZVE4
- Q8TB75
Protein attributes for FAM122B Gene
- Size:
- 247 amino acids
- Molecular mass:
- 26928 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=AAH32419.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Protein Expression for FAM122B Gene
Post-translational modifications for FAM122B Gene
- Isoform 3 and isoform 4 are phosphorylated on Ser-62 and Ser-64.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for FAM122B Gene
- ENSEMBL proteins:
- REFSEQ proteins:
-
- XP_006724793.1
- XP_011529584.1
- XP_011529585.1
- XP_011529586.1
- XP_011529587.1
- XP_011529588.1
- XP_011529590.1
- XP_011529592.1
- XP_011529593.1
- XP_011529594.1
- NP_001160071.1
- NP_001160072.1
- NP_001164227.1
- NP_001164228.1
- NP_001318017.1
- NP_001318018.1
- NP_001318019.1
- NP_001318020.1
- NP_001318021.1
- NP_001318022.1
- NP_001318023.1
- NP_660327.2
Antibody Products
-
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- Novus Biologicals Antibodies for FAM122B
-
Abcam antibodies for FAM122B
- Invitrogen Antibodies for FAM122B (AFLGC-FAM122B)
- antibodies-online: Show 4 available FAM122B Antibodies ranked by validation data
-
Biorbyt antibodies for FAM122B
Protein Products
-
OriGene Purified Proteins for FAM122B
- Search Origene for MassSpec and Protein Over-expression Lysates for FAM122B
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No data available for DME Specific Peptides for FAM122B Gene
Domains & Families for FAM122B Gene
Gene Families for FAM122B Gene
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Suggested Antigen Peptide Sequences for FAM122B Gene
- GenScript: Design optimal peptide antigens:
-
- Protein FAM122B (F122B_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q7Z309- Family:
-
- Belongs to the FAM122 family.
Function for FAM122B Gene
Phenotypes for FAM122B Gene
- MGI mutant phenotypes for FAM122B:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for FAM122B:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for FAM122B - Select products 50% OFF >
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-
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miRNA for FAM122B Gene
- miRTarBase miRNAs that target FAM122B
-
- hsa-miR-425-5p (MIRT016650)
- hsa-miR-124-3p (MIRT022784)
- hsa-miR-103a-3p (MIRT027061)
- hsa-miR-16-5p (MIRT031788)
- hsa-miR-877-3p (MIRT036810)
- hsa-miR-877-5p (MIRT037269)
- hsa-miR-3148 (MIRT502491)
- hsa-miR-3610 (MIRT502492)
- hsa-miR-144-3p (MIRT502493)
- hsa-miR-548e-5p (MIRT502494)
- hsa-miR-6838-5p (MIRT502495)
- hsa-miR-15a-5p (MIRT502496)
- hsa-miR-497-5p (MIRT502497)
- hsa-miR-424-5p (MIRT502498)
- hsa-miR-195-5p (MIRT502499)
- hsa-miR-15b-5p (MIRT502500)
- hsa-miR-891a-3p (MIRT558003)
- hsa-miR-3688-5p (MIRT558004)
- hsa-miR-299-3p (MIRT558005)
- hsa-miR-4491 (MIRT558006)
- hsa-miR-4657 (MIRT558007)
- mmu-miR-5101 (MIRT583688)
- mmu-miR-5098 (MIRT583689)
- mmu-miR-181a-5p (MIRT583690)
- mmu-miR-181b-5p (MIRT583691)
- mmu-miR-181d-5p (MIRT583692)
- mmu-miR-181c-5p (MIRT583693)
miRNA Products
Inhibitory RNA Products
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Clone Products
- Applied Biological Materials (abm): Clones for FAM122B - Select products 50% OFF >
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- RG222071
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- MR203297L3V
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- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for FAM122B
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Cell Line Products
-
Horizon Cell Lines for FAM122B
No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM122B Gene
Localization for FAM122B Gene
| Compartment | Confidence |
|---|---|
| nucleus | 3 |
| cytosol | 2 |
- Nucleoplasm (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005581 | collagen trimer | IEA | -- |
No data available for Subcellular locations from UniProtKB/Swiss-Prot for FAM122B Gene
Pathways & Interactions for FAM122B Gene
Interacting Proteins for FAM122B Gene
GPS-Prot Interaction Network for FAM122B
No data available for Pathways by source and SIGNOR curated interactions for FAM122B Gene
Transcripts for FAM122B Gene
mRNA/cDNA for FAM122B Gene
- 12 REFSEQ mRNAs :
- 15 NCBI additional mRNA sequence :
- 8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000298090 2706 nts (view in UCSC)
- ENST00000343004 4326 nts (view in UCSC)
- ENST00000370790 4246 nts (view in UCSC)
- ENST00000465128 733 nts (view in UCSC)
- ENST00000478384 743 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for FAM122B - Select products 50% OFF >
- * FAM122B CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
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-
OriGene CRISPR knockouts for FAM122B
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for FAM122B
-
Santa Cruz Biotechnology (SCBT) CRISPR for FAM122B
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for FAM122B
- Browse OriGene Inhibitory RNA Products For FAM122B
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Clone Products
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-
- MG203297
- MG226554
- MG226556
- MR203297
- MR203297L3
- MR203297L4
- MR226554
- MR226554L3
- MR226554L4
- MR226556
- MR226556L3
- MR226556L4
- RC222071
- RC222071L3
- RC222071L4
- RC229653
- RC229653L3
- RC229653L4
- RC229748
- RC229748L3
- RC229748L4
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- RC229760L3
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- RC229792L3
- RC229792L4
- RG222071
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- RR216161
- MR203297L3V
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- MR226554L4V
- MR226556L3V
- MR226556L4V
- RC222071L3V
- RC222071L4V
- RC229653L3V
- RC229653L4V
- RC229748L3V
- RC229748L4V
- RC229760L3V
- RC229760L4V
- RC229792L3V
- RC229792L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for FAM122B
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| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | · | 11c | ^ | 12a | · | 12b | · | 12c | · | 12d |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||
| SP2: | - | - | |||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | ||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | ||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||
| SP6: | |||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||
| SP8: | - | - | |||||||||||||||||||||||||||||||||||||||
| SP9: | - | - |
Relevant External Links for FAM122B Gene
- GeneLoc Exon Structure for
- FAM122B
Expression for FAM122B Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
This gene is overexpressed in Fetal testis (35.1), Testis (20.4), and Fetal ovary (13.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FAM122B Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FAM122B
SOURCE GeneReport for Unigene cluster for FAM122B Gene:
Hs.404706Evidence on tissue expression from TISSUES for FAM122B Gene
- Nervous system(2.4)
Primer Products
-
OriGene qPCR primer pairs for FAM122B
-
OriGene qPCR primer pairs and template standards for FAM122B
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM122B Gene
Orthologs for FAM122B Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | FAM122B 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | FAM122B 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Fam122b 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Fam122b 30 17 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | FAM122B 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | FAM122B 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | FAM122B 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | FAM122B 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | FAM122B 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | LOC550042 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | fam122b 31 |
|
OneToMany | |
| Fruit Fly (Drosophila melanogaster) |
Insecta | CG4497 31 |
|
OneToMany |
- Species where no ortholog for FAM122B was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for FAM122B Gene
- ENSEMBL:
- Gene Tree for FAM122B (if available)
- TreeFam:
- Gene Tree for FAM122B (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for FAM122B: view image
Paralogs for FAM122B Gene
Variants for FAM122B Gene
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv1323e201 | CNV | deletion | 23290073 |
| dgv1324e201 | CNV | deletion | 23290073 |
| esv2740487 | CNV | deletion | 23290073 |
| esv2740488 | CNV | deletion | 23290073 |
| esv2740489 | CNV | deletion | 23290073 |
Residual Variation Intolerance Score:
66.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.57;
12.29% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for FAM122B Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- FAM122B
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for FAM122B Gene
Disorders for FAM122B Gene
Additional Disease Information for FAM122B
No disorders were found for FAM122B Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM122B Gene
Publications for FAM122B Gene
- A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil SA … Gygi SP (Nature biotechnology 2006) 3 4
- The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 3 4
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3
ExternalLinks
Products for FAM122B Gene
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- OriGene qPCR primer pairs for FAM122B
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- OriGene CRISPR knockouts for FAM122B
- MG203297
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- antibodies-online: Show 4 available FAM122B Antibodies ranked by validation data
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- Biorbyt antibodies for FAM122B
Sources for FAM122B Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
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- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
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- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
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- (115) NCBI Bookshelf
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- (119) UDN
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- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB