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Aliases for FAM118B Gene

Aliases for FAM118B Gene

  • Family With Sequence Similarity 118 Member B 2 3 5
  • Family With Sequence Similarity 118, Member B 2
  • Protein FAM118B 3

External Ids for FAM118B Gene

Previous GeneCards Identifiers for FAM118B Gene

  • GC11P125587
  • GC11P126081
  • GC11P122023

Summaries for FAM118B Gene

GeneCards Summary for FAM118B Gene

FAM118B (Family With Sequence Similarity 118 Member B) is a Protein Coding gene. An important paralog of this gene is FAM118A.

UniProtKB/Swiss-Prot for FAM118B Gene

  • May play a role in Cajal bodies formation.

Additional gene information for FAM118B Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM118B Gene

Genomics for FAM118B Gene

GeneHancer (GH) Regulatory Elements for FAM118B Gene

Promoters and enhancers for FAM118B Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J126210 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 670.8 +0.6 614 3 CLOCK FOXA2 MLX ZFP64 ARID4B SIN3A DMAP1 YY1 POLR2B ZNF143 FAM118B RPUSD4 FOXRED1 ENSG00000254694 STT3A HP11014 SRPRA CDON RNU4-86P
GH11J126280 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 42.3 +71.0 71033 4.2 HDGF ATF1 ARID4B SIN3A DMAP1 ZNF48 YY1 ZNF143 RXRA SP5 TIRAP FOXRED1 FAM118B ENSG00000254694 DCPS HP11014 RPUSD4 RNU4-86P ENSG00000254905
GH11J126266 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 32.4 +57.1 57123 3.3 PKNOX1 SMAD1 ARID4B SIN3A DMAP1 YY1 POLR2B ZNF213 E2F8 ZNF207 FOXRED1 SRPRA FAM118B TIRAP HP11014 RN7SL351P
GH11J126302 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 27.2 +92.6 92619 2.4 PKNOX1 MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 DCPS GC11M126303 HP11014 FAM118B
GH11J126188 Enhancer 1.1 ENCODE dbSUPER 35.3 -22.2 -22191 2.1 PKNOX1 MLX ARID4B ZNF48 ATF7 RUNX3 SP5 NFYC JUNB PPARG FAM118B FOXRED1 RPUSD4 ENSG00000254833 ENSG00000254790 RNU4-86P DCPS ENSG00000254771 ENSG00000254694
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FAM118B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FAM118B gene promoter:
  • Arnt
  • Pax-4a
  • Chx10
  • Egr-2
  • MyoD
  • AML1a
  • COMP1
  • IRF-7A
  • STAT5A

Genomic Locations for FAM118B Gene

Genomic Locations for FAM118B Gene
51,573 bases
Plus strand
51,573 bases
Plus strand

Genomic View for FAM118B Gene

Genes around FAM118B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM118B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM118B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM118B Gene

Proteins for FAM118B Gene

  • Protein details for FAM118B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein FAM118B
    Protein Accession:
    Secondary Accessions:
    • Q9H7B0

    Protein attributes for FAM118B Gene

    351 amino acids
    Molecular mass:
    39499 Da
    Quaternary structure:
    No Data Available
    • Overexpression changes the morphology of Cajal bodies, while depletion disrupts the localization of components of Cajal bodies, reduces splicing capacity and inhibits cell proliferation.

neXtProt entry for FAM118B Gene

Post-translational modifications for FAM118B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Boster Bio Antibodies for FAM118B
  • Santa Cruz Biotechnology (SCBT) Antibodies for FAM118B

No data available for DME Specific Peptides for FAM118B Gene

Domains & Families for FAM118B Gene

Gene Families for FAM118B Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FAM118B Gene


Suggested Antigen Peptide Sequences for FAM118B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the FAM118 family.
  • Belongs to the FAM118 family.
genes like me logo Genes that share domains with FAM118B: view

Function for FAM118B Gene

Molecular function for FAM118B Gene

UniProtKB/Swiss-Prot Function:
May play a role in Cajal bodies formation.

Phenotypes From GWAS Catalog for FAM118B Gene

Gene Ontology (GO) - Molecular Function for FAM118B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with FAM118B: view
genes like me logo Genes that share phenotypes with FAM118B: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FAM118B Gene

Localization for FAM118B Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM118B Gene

Nucleus, Cajal body.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM118B gene
Compartment Confidence
nucleus 4
cytoskeleton 3
cytosol 3
plasma membrane 1
extracellular 1
mitochondrion 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Intermediate filaments (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for FAM118B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0015030 Cajal body IEA --
genes like me logo Genes that share ontologies with FAM118B: view

Pathways & Interactions for FAM118B Gene

SuperPathways for FAM118B Gene

No Data Available

Gene Ontology (GO) - Biological Process for FAM118B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030576 Cajal body organization IEA --
genes like me logo Genes that share ontologies with FAM118B: view

No data available for Pathways by source and SIGNOR curated interactions for FAM118B Gene

Drugs & Compounds for FAM118B Gene

No Compound Related Data Available

Transcripts for FAM118B Gene

Unigene Clusters for FAM118B Gene

Family with sequence similarity 118, member B:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM118B Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b · 10c
SP1: - - -
SP2: -
SP3: - - - - - - -
SP4: - - - -
SP5: -
SP6: - - -
SP7: -
SP9: -
SP10: - - - -

Relevant External Links for FAM118B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAM118B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM118B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FAM118B Gene

This gene is overexpressed in Bone (26.8) and Fetal ovary (18.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FAM118B Gene

Protein tissue co-expression partners for FAM118B Gene

NURSA nuclear receptor signaling pathways regulating expression of FAM118B Gene:


SOURCE GeneReport for Unigene cluster for FAM118B Gene:


Evidence on tissue expression from TISSUES for FAM118B Gene

  • Lung(4.2)
  • Nervous system(3.7)
genes like me logo Genes that share expression patterns with FAM118B: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM118B Gene

Orthologs for FAM118B Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM118B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FAM118B 34 33
  • 99.81 (n)
(Bos Taurus)
Mammalia -- 34
  • 97 (a)
FAM118B 34 33
  • 91.07 (n)
(Monodelphis domestica)
Mammalia FAM118B 34
  • 94 (a)
(Ornithorhynchus anatinus)
Mammalia FAM118B 34
  • 93 (a)
(Canis familiaris)
Mammalia FAM118B 34 33
  • 92.69 (n)
(Rattus norvegicus)
Mammalia Fam118b 33
  • 91.71 (n)
(Mus musculus)
Mammalia Fam118b 16 34 33
  • 91.64 (n)
(Gallus gallus)
Aves FAM118B 34 33
  • 80.29 (n)
(Anolis carolinensis)
Reptilia FAM118B 34
  • 88 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fam118b 33
  • 75.29 (n)
Str.19476 33
(Danio rerio)
Actinopterygii fam118b 34
  • 73 (a)
LOC799102 33
  • 70.98 (n)
Species where no ortholog for FAM118B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM118B Gene

Gene Tree for FAM118B (if available)
Gene Tree for FAM118B (if available)
Evolutionary constrained regions (ECRs) for FAM118B: view image

Paralogs for FAM118B Gene

Paralogs for FAM118B Gene

(1) SIMAP similar genes for FAM118B Gene using alignment to 6 proteins:

  • F118B_HUMAN
  • G3V179_HUMAN
  • J3KP39_HUMAN
genes like me logo Genes that share paralogs with FAM118B: view

Variants for FAM118B Gene

Sequence variations from dbSNP and Humsavar for FAM118B Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000001988 -- 126,211,625(+) C/T 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant
rs1000037247 -- 126,231,419(+) T/C intron_variant
rs1000108868 -- 126,257,842(+) C/A intron_variant
rs1000176021 -- 126,239,425(+) G/A intron_variant
rs1000207768 -- 126,246,573(+) C/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for FAM118B Gene

Variant ID Type Subtype PubMed ID
dgv715e59 CNV duplication 20981092
esv2447763 CNV deletion 19546169
esv3628000 CNV loss 21293372
nsv477761 CNV novel sequence insertion 20440878
nsv537 CNV insertion 18451855
nsv556529 CNV loss 21841781

Variation tolerance for FAM118B Gene

Residual Variation Intolerance Score: 29% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.03; 37.28% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FAM118B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM118B Gene

Disorders for FAM118B Gene

Additional Disease Information for FAM118B

No disorders were found for FAM118B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM118B Gene

Publications for FAM118B Gene

  1. Fam118B, a newly identified component of Cajal bodies, is required for Cajal body formation, snRNP biogenesis and cell viability. (PMID: 24569877) Li Y … Chen J (Journal of cell science 2014) 2 3 4 58
  2. Towards an understanding of regulating Cajal body activity by protein modification. (PMID: 27819531) Hebert MD … Poole AR (RNA biology 2017) 2 3 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58

Products for FAM118B Gene

Sources for FAM118B Gene

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