Aliases for FAM110C Gene

Aliases for FAM110C Gene

  • Family With Sequence Similarity 110 Member C 2 3 5
  • Protein FAM110C 3 4
  • Family With Sequence Similarity 110, Member C 2
  • FAM110C 5

External Ids for FAM110C Gene

Summaries for FAM110C Gene

GeneCards Summary for FAM110C Gene

FAM110C (Family With Sequence Similarity 110 Member C) is a Protein Coding gene. Diseases associated with FAM110C include Meier-Gorlin Syndrome 4 and Adult Astrocytic Tumour. Gene Ontology (GO) annotations related to this gene include alpha-tubulin binding. An important paralog of this gene is FAM110A.

UniProtKB/Swiss-Prot Summary for FAM110C Gene

  • May play a role in microtubule organization. May play a role in cell spreading and cell migration of epithelial cells; the function may involve the AKT1 signaling pathway.

Additional gene information for FAM110C Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FAM110C Gene

Genomics for FAM110C Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for FAM110C Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J000043 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 600.7 +1.5 1450 5.1 PRDM10 REST FOXA1 PRDM1 RFX1 RXRB PATZ1 SP1 EZH2 GABPA FAM110C lnc-FAM110C-1 SH3YL1 lnc-FAM110C-2
GH02J000033 Enhancer 1.1 Ensembl ENCODE dbSUPER 5.9 +11.0 10976 7 CREB1 TARDBP FOXA1 GABPA GTF2F1 SCRT2 BMI1 CTBP1 NFE2 CEBPB ENSG00000228643 ALKAL2 FAM110C ENSG00000227061 ENSG00000235779 SH3YL1 lnc-FAM110C-2 lnc-FAM110C-1
GH02J000142 Enhancer 0.5 Ensembl 4.4 -95.2 -95215 1 CTCF REST RAD21 USF1 GATA3 SMC3 ZNF654 USF2 TRIM22 ENSG00000227061 SH3YL1 FAM110C HSALNG0012343 piR-31951-012 ACP1
GH02J000023 Enhancer 0.9 Ensembl ENCODE dbSUPER 0.4 +22.7 22686 1.6 SP1 FOXA2 ATF3 YY1 ZBTB33 JUND HNF4A RXRA MAX REST lnc-FAM110C-2 FAM110C
GH02J000068 Enhancer 0.9 Ensembl ENCODE 0.4 -23.3 -23331 4.6 IKZF1 PRDM1 GABPA NFE2 ZNF316 NR2C2 ZBTB11 FOSL1 MAFG ZNF282 SH3YL1 HSALNG0012337 FAM110C ACP1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FAM110C on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FAM110C

Top Transcription factor binding sites by QIAGEN in the FAM110C gene promoter:
  • AREB6
  • FOXO4
  • GCNF-1
  • GCNF-2
  • MZF-1
  • Nkx2-5
  • Olf-1
  • POU2F1
  • POU2F1a
  • POU3F2

Genomic Locations for FAM110C Gene

Genomic Locations for FAM110C Gene
chr2:38,814-47,077
(GRCh38/hg38)
Size:
8,264 bases
Orientation:
Minus strand
chr2:38,814-46,870
(GRCh37/hg19)
Size:
8,057 bases
Orientation:
Minus strand

Genomic View for FAM110C Gene

Genes around FAM110C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM110C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM110C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM110C Gene

Proteins for FAM110C Gene

  • Protein details for FAM110C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q1W6H9-F110C_HUMAN
    Recommended name:
    Protein FAM110C
    Protein Accession:
    Q1W6H9

    Protein attributes for FAM110C Gene

    Size:
    321 amino acids
    Molecular mass:
    33863 Da
    Quaternary structure:
    • Interacts with AKT1; the interaction is transient and follows AKT1 activation. Interacts with PPP2CA and alpha-tubulin.

neXtProt entry for FAM110C Gene

Post-translational modifications for FAM110C Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM110C Gene

No data available for DME Specific Peptides for FAM110C Gene

Domains & Families for FAM110C Gene

Gene Families for FAM110C Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FAM110C Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM110C Gene

GenScript: Design optimal peptide antigens:
  • Protein FAM110C (F110C_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q1W6H9

UniProtKB/Swiss-Prot:

F110C_HUMAN :
  • Belongs to the FAM110 family.
Family:
  • Belongs to the FAM110 family.
genes like me logo Genes that share domains with FAM110C: view

Function for FAM110C Gene

Molecular function for FAM110C Gene

UniProtKB/Swiss-Prot Function:
May play a role in microtubule organization. May play a role in cell spreading and cell migration of epithelial cells; the function may involve the AKT1 signaling pathway.

Phenotypes From GWAS Catalog for FAM110C Gene

Gene Ontology (GO) - Molecular Function for FAM110C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 19698782
GO:0043014 alpha-tubulin binding IBA,IDA 19698782
genes like me logo Genes that share ontologies with FAM110C: view
genes like me logo Genes that share phenotypes with FAM110C: view

Animal Model Products

CRISPR Products

miRNA for FAM110C Gene

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FAM110C

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM110C Gene

Localization for FAM110C Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM110C Gene

Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Nucleus. Note=Colocalizes with microtubules during interphase (PubMed:17499476). Detected at the mitotic spindle poles (PubMed:17499476). Colocalizes with AKT1 at the cell cortex (PubMed:19698782). {ECO:0000269 PubMed:17499476, ECO:0000269 PubMed:19698782}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM110C gene
Compartment Confidence
nucleus 4
cytoskeleton 3
cytosol 2
extracellular 1
mitochondrion 0

Gene Ontology (GO) - Cellular Components for FAM110C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000922 spindle pole IEA --
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005815 microtubule organizing center IEA --
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with FAM110C: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for FAM110C Gene

Pathways & Interactions for FAM110C Gene

PathCards logo

SuperPathways for FAM110C Gene

No Data Available

Gene Ontology (GO) - Biological Process for FAM110C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030335 positive regulation of cell migration IBA,IMP 19698782
GO:0051897 positive regulation of protein kinase B signaling IMP 19698782
GO:0060491 regulation of cell projection assembly IBA,IMP 19698782
genes like me logo Genes that share ontologies with FAM110C: view

No data available for Pathways by source and SIGNOR curated interactions for FAM110C Gene

Drugs & Compounds for FAM110C Gene

No Compound Related Data Available

Transcripts for FAM110C Gene

mRNA/cDNA for FAM110C Gene

1 REFSEQ mRNAs :
3 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FAM110C

Alternative Splicing Database (ASD) splice patterns (SP) for FAM110C Gene

No ASD Table

Relevant External Links for FAM110C Gene

GeneLoc Exon Structure for
FAM110C

Expression for FAM110C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FAM110C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FAM110C Gene

This gene is overexpressed in Esophagus - Mucosa (x7.2).

Protein differential expression in normal tissues from HIPED for FAM110C Gene

This gene is overexpressed in Heart (59.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FAM110C Gene



Protein tissue co-expression partners for FAM110C Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FAM110C

SOURCE GeneReport for Unigene cluster for FAM110C Gene:

Hs.8379

mRNA Expression by UniProt/SwissProt for FAM110C Gene:

Q1W6H9-F110C_HUMAN
Tissue specificity: Detected in stomach, thyroid, trachea, adrenal gland and testis, and at low levels in prostate, ovary, intestine, colon, spinal cord and lymph node.
genes like me logo Genes that share expression patterns with FAM110C: view

No data available for Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM110C Gene

Orthologs for FAM110C Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM110C Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia FAM110C 30 31
  • 98.86 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia LOC100337320 30
  • 80.49 (n)
Mouse
(Mus musculus)
Mammalia Fam110c 30 17 31
  • 71.92 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Fam110c 30
  • 67.64 (n)
Dog
(Canis familiaris)
Mammalia FAM110C 31
  • 50 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia FAM110C 31
  • 48 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia FAM110C 31
  • 38 (a)
OneToOne
Chicken
(Gallus gallus)
Aves FAM110C 31
  • 39 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia FAM110C 31
  • 39 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii FAM110C 31
  • 29 (a)
OneToOne
Species where no ortholog for FAM110C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for FAM110C Gene

ENSEMBL:
Gene Tree for FAM110C (if available)
TreeFam:
Gene Tree for FAM110C (if available)
Aminode:
Evolutionary constrained regions (ECRs) for FAM110C: view image

Paralogs for FAM110C Gene

Paralogs for FAM110C Gene

genes like me logo Genes that share paralogs with FAM110C: view

Variants for FAM110C Gene

Additional dbSNP identifiers (rs#s) for FAM110C Gene

Structural Variations from Database of Genomic Variants (DGV) for FAM110C Gene

Variant ID Type Subtype PubMed ID
dgv3689n100 CNV gain 25217958
dgv3690n100 CNV gain+loss 25217958
dgv3691n100 CNV gain 25217958
dgv3692n100 CNV gain 25217958
dgv3693n100 CNV gain 25217958
dgv3694n100 CNV loss 25217958
dgv3695n100 CNV gain 25217958
esv2751887 CNV loss 17911159
esv3589587 CNV gain 21293372
esv3589589 CNV gain 21293372
nsv1010002 CNV loss 25217958
nsv1011864 CNV loss 25217958
nsv1013177 CNV gain 25217958

Variation tolerance for FAM110C Gene

Residual Variation Intolerance Score: 41.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.81; 34.01% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FAM110C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM110C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for FAM110C Gene

Disorders for FAM110C Gene

MalaCards: The human disease database

(2) MalaCards diseases for FAM110C Gene - From: DISEASES

Disorder Aliases PubMed IDs
meier-gorlin syndrome 4
  • mgors4
adult astrocytic tumour
  • adult astrocytoma
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for FAM110C

genes like me logo Genes that share disorders with FAM110C: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FAM110C Gene

Publications for FAM110C Gene

  1. Evidence for the involvement of FAM110C protein in cell spreading and migration. (PMID: 19698782) Hauge H … Aasheim HC (Cellular signalling 2009) 2 3 4
  2. Characterization of the FAM110 gene family. (PMID: 17499476) Hauge H … Aasheim HC (Genomics 2007) 2 3 4
  3. Whole genome association scan for genetic polymorphisms influencing information processing speed. (PMID: 21130836) Luciano M … Deary IJ (Biological psychology 2011) 3 41
  4. The Functional Proximal Proteome of Oncogenic Ras Includes mTORC2. (PMID: 30639242) Kovalski JR … Khavari PA (Molecular cell 2019) 3
  5. E-cadherin interactome complexity and robustness resolved by quantitative proteomics. (PMID: 25468996) Guo Z … Zaidel-Bar R (Science signaling 2014) 3

Products for FAM110C Gene

Sources for FAM110C Gene