Aliases for FAM110A Gene

Aliases for FAM110A Gene

  • Family With Sequence Similarity 110 Member A 2 3 5
  • Protein FAM110A 3 4
  • C20orf55 3 4
  • F10 3 4
  • Family With Sequence Similarity 110, Member A 2
  • Chromosome 20 Open Reading Frame 55 2
  • BA371L19.3 3

External Ids for FAM110A Gene

Previous HGNC Symbols for FAM110A Gene

  • C20orf55

Previous GeneCards Identifiers for FAM110A Gene

  • GC20P000762

Summaries for FAM110A Gene

GeneCards Summary for FAM110A Gene

FAM110A (Family With Sequence Similarity 110 Member A) is a Protein Coding gene. Diseases associated with FAM110A include Ichthyosis, Congenital, Autosomal Recessive 11 and Autosomal Recessive Congenital Ichthyosis. An important paralog of this gene is FAM110B.

Additional gene information for FAM110A Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FAM110A Gene

Genomics for FAM110A Gene

GeneHancer (GH) Regulatory Elements for FAM110A Gene

Promoters and enhancers for FAM110A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20J000840 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 777 +10.9 10886 7.6 SP1 ZBTB6 ZNF217 CEBPB RERE ELF3 ZNF384 MAFK CEBPG CREM FAM110A piR-43895 ANGPT4 RSPO4 RPS10P5
GH20J000833 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas 765.2 +0.8 797 3.8 ZBTB40 SP1 SREBF1 MLX RBPJ HCFC1 MYC ETV6 NFYC ELF1 FAM110A TBC1D20 SIRPG ACTG1P3 RPS10P5 piR-49900-003
GH20J000832 Enhancer 0.2 ENCODE 750.6 -1.5 -1462 0 FAM110A RF00017-3486
GH20J000828 Enhancer 1.1 FANTOM5 ENCODE 29.6 -4.1 -4073 1.7 GATA3 SMARCE1 TCF7L2 ZNF217 L3MBTL2 MNT TEAD4 ZNF148 GTF2F1 NCOA3 FAM110A SDCBP2 SRXN1 RF00017-3486
GH20J000368 Enhancer 1.5 FANTOM5 ENCODE dbSUPER 6.9 -461.2 -461177 8 MLX RBPJ SMARCE1 TCF7L2 USF2 NR2F1 NR2F6 ZNF217 MIXL1 MYC TBC1D20 TRIB3 CSNK2A1 NRSN2 ENSG00000272874 DEFB129 DEFB126 DEFB125 RBCK1 SOX12
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FAM110A on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FAM110A gene promoter:
  • Cart-1
  • CREB
  • deltaCREB
  • E47
  • p300

Genomic Locations for FAM110A Gene

Genomic Locations for FAM110A Gene
chr20:833,697-857,463
(GRCh38/hg38)
Size:
23,767 bases
Orientation:
Plus strand
chr20:814,356-838,106
(GRCh37/hg19)
Size:
23,751 bases
Orientation:
Plus strand

Genomic View for FAM110A Gene

Genes around FAM110A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM110A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM110A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM110A Gene

Proteins for FAM110A Gene

  • Protein details for FAM110A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BQ89-F110A_HUMAN
    Recommended name:
    Protein FAM110A
    Protein Accession:
    Q9BQ89
    Secondary Accessions:
    • D3DVW2
    • Q5R1M7

    Protein attributes for FAM110A Gene

    Size:
    295 amino acids
    Molecular mass:
    31271 Da
    Quaternary structure:
    • May interact with CSPP1.

neXtProt entry for FAM110A Gene

Post-translational modifications for FAM110A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for FAM110A Gene

Domains & Families for FAM110A Gene

Gene Families for FAM110A Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FAM110A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM110A Gene

GenScript: Design optimal peptide antigens:
  • Protein FAM110A (F110A_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9BQ89

UniProtKB/Swiss-Prot:

F110A_HUMAN :
  • Belongs to the FAM110 family.
Family:
  • Belongs to the FAM110 family.
genes like me logo Genes that share domains with FAM110A: view

Function for FAM110A Gene

Molecular function for FAM110A Gene

UniProtKB/Swiss-Prot Induction:
Up-regulated in stimulated lymphocytes.

Phenotypes From GWAS Catalog for FAM110A Gene

Gene Ontology (GO) - Molecular Function for FAM110A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17474147
genes like me logo Genes that share ontologies with FAM110A: view

Phenotypes for FAM110A Gene

genes like me logo Genes that share phenotypes with FAM110A: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FAM110A

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM110A Gene

Localization for FAM110A Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM110A Gene

Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Note=Distributed throughout the cytoplasm during mitosis, accumulating at spindle poles.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM110A gene
Compartment Confidence
cytoskeleton 3
mitochondrion 2
extracellular 0
peroxisome 0
nucleus 0
cytosol 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Vesicles (3)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for FAM110A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000922 spindle pole IEA --
GO:0005737 cytoplasm IEA --
GO:0005815 microtubule organizing center IEA --
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with FAM110A: view

Pathways & Interactions for FAM110A Gene

PathCards logo

SuperPathways for FAM110A Gene

No Data Available

Gene Ontology (GO) - Biological Process for FAM110A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FAM110A Gene

Drugs & Compounds for FAM110A Gene

No Compound Related Data Available

Transcripts for FAM110A Gene

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FAM110A

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM110A Gene

No ASD Table

Relevant External Links for FAM110A Gene

GeneLoc Exon Structure for
FAM110A
ECgene alternative splicing isoforms for
FAM110A

Expression for FAM110A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM110A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FAM110A Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x6.8), Skin - Not Sun Exposed (Suprapubic) (x6.0), Whole Blood (x5.8), and Esophagus - Mucosa (x4.1).

Protein differential expression in normal tissues from HIPED for FAM110A Gene

This gene is overexpressed in Placenta (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FAM110A Gene



Protein tissue co-expression partners for FAM110A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FAM110A Gene:

FAM110A

SOURCE GeneReport for Unigene cluster for FAM110A Gene:

Hs.574822

mRNA Expression by UniProt/SwissProt for FAM110A Gene:

Q9BQ89-F110A_HUMAN
Tissue specificity: Detected in thyroid, lymph node, trachea, adrenal gland, bone marrow, spleen, thymus, prostate, and peripheral blood leukocyte. Detected at lower levels in stomach, testis and spinal cord.

Evidence on tissue expression from TISSUES for FAM110A Gene

  • Nervous system(4.2)
  • Muscle(4.1)
genes like me logo Genes that share expression patterns with FAM110A: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM110A Gene

Orthologs for FAM110A Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM110A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM110A 33 32
  • 97.63 (n)
OneToOne
dog
(Canis familiaris)
Mammalia FAM110A 33 32
  • 86.67 (n)
OneToOne
cow
(Bos Taurus)
Mammalia FAM110A 33 32
  • 85.49 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Fam110a 17 33 32
  • 81.13 (n)
rat
(Rattus norvegicus)
Mammalia Fam110a 32
  • 80.9 (n)
chicken
(Gallus gallus)
Aves FAM110A 33 32
  • 66.55 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FAM110A 33
  • 45 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii wu:fa11c10 32
  • 61.8 (n)
fam110a 33
  • 38 (a)
OneToOne
Species where no ortholog for FAM110A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM110A Gene

ENSEMBL:
Gene Tree for FAM110A (if available)
TreeFam:
Gene Tree for FAM110A (if available)
Aminode:
Evolutionary constrained regions (ECRs) for FAM110A: view image

Paralogs for FAM110A Gene

Paralogs for FAM110A Gene

(1) SIMAP similar genes for FAM110A Gene using alignment to 2 proteins:

  • F110A_HUMAN
  • V9GZ26_HUMAN
genes like me logo Genes that share paralogs with FAM110A: view

Variants for FAM110A Gene

Sequence variations from dbSNP and Humsavar for FAM110A Gene

SNP ID Clin Chr 20 pos Variation AA Info Type
rs1000115395 -- 842,664(+) G/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000560747 -- 832,291(+) T/C upstream_transcript_variant
rs1001409298 -- 837,439(+) C/T genic_upstream_transcript_variant, intron_variant
rs1001497506 -- 844,530(+) G/A/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1001503030 -- 833,619(+) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for FAM110A Gene

Variant ID Type Subtype PubMed ID
esv3644952 CNV gain 21293372
nsv1062082 CNV gain 25217958
nsv1067424 CNV gain 25217958
nsv510778 CNV deletion 20534489
nsv585191 CNV gain 21841781
nsv585193 CNV gain 21841781
nsv979409 CNV duplication 23825009

Variation tolerance for FAM110A Gene

Gene Damage Index Score: 2.49; 43.69% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FAM110A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM110A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM110A Gene

Disorders for FAM110A Gene

MalaCards: The human disease database

(2) MalaCards diseases for FAM110A Gene - From: DISEASES

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for FAM110A

genes like me logo Genes that share disorders with FAM110A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FAM110A Gene

Publications for FAM110A Gene

  1. Characterization of the FAM110 gene family. (PMID: 17499476) Hauge H … Aasheim HC (Genomics 2007) 2 3 4 56
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 56
  3. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P … Rogers J (Nature 2001) 3 4 56
  4. An organelle-specific protein landscape identifies novel diseases and molecular mechanisms. (PMID: 27173435) Boldt K … UK10K Rare Diseases Group (Nature communications 2016) 3 56
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 56

Products for FAM110A Gene

Sources for FAM110A Gene