Aliases for FAM107B Gene

Aliases for FAM107B Gene

  • Family With Sequence Similarity 107 Member B 2 3 5
  • Heat Shock-Inducible Tumor Small Protein 2 3
  • Protein FAM107B 3 4
  • C10orf45 3 4
  • HITS 2 3
  • Family With Sequence Similarity 107, Member B 2
  • Chromosome 10 Open Reading Frame 45 2
  • FAM107B/CDNF Fusion 3
  • FLJ45505 2
  • MGC11034 2
  • FAM107B 5

External Ids for FAM107B Gene

Previous HGNC Symbols for FAM107B Gene

  • C10orf45

Previous GeneCards Identifiers for FAM107B Gene

  • GC10M014601
  • GC10M014471

Summaries for FAM107B Gene

GeneCards Summary for FAM107B Gene

FAM107B (Family With Sequence Similarity 107 Member B) is a Protein Coding gene. Diseases associated with FAM107B include Alzheimer Disease 13 and Cardiomyopathy, Dilated, 1Dd. An important paralog of this gene is FAM107A.

Additional gene information for FAM107B Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FAM107B Gene

Genomics for FAM107B Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for FAM107B Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J014601 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 262.6 +171.3 171296 4.9 SP1 BCL11A MXD4 FEZF1 CEBPA POLR2A ZEB1 CEBPB SIN3A ZNF639 FAM107B lnc-HSPA14-3 lnc-FRMD4A-6 ENSG00000236495 CDNF HSPA14 HSALNG0076315 FRMD4A
GH10J014548 Promoter/Enhancer 0.8 EPDnew dbSUPER 250.1 +226.2 226240 0.1 POLR2A BHLHE40 RAD51 L3MBTL2 USF2 USF1 FAM107B ENSG00000236495 RF00017-598 HSALNG0076313 lnc-FRMD4A-5 FRMD4A
GH10J014647 Promoter/Enhancer 1.8 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 33.7 +125.7 125659 4.3 SP1 BCL11A IRF4 TRIM22 RXRA EBF1 SMC3 KLF9 CBFB SPI1 FAM107B RPP38-DT HSPA14 CDNF DCLRE1C RPP38 ENSG00000236495 piR-57460-040 FRMD4A
GH10J014651 Promoter/Enhancer 1.8 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 30 +120.8 120847 4.8 FEZF1 NR2C1 ZNF217 BRCA1 CEBPB SIN3A ZNF639 IRF4 EP300 EBF1 ENSG00000236495 LOC105376428 LOC105376429 FAM107B CDNF HSPA14 FRMD4A
GH10J014616 Promoter/Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 29.3 +157.5 157509 1.6 CEBPB RAD21 CTCF HLF MZF1 ZNF335 PRDM1 FAM107B ENSG00000236495 CDNF HSPA14 piR-57460-040 FRMD4A
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FAM107B on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FAM107B

Top Transcription factor binding sites by QIAGEN in the FAM107B gene promoter:
  • aMEF-2
  • Arnt
  • FAC1
  • Ik-3
  • MEF-2A
  • RREB-1
  • Sox5
  • SRF
  • SRF (504 AA)
  • SRY

Genomic Locations for FAM107B Gene

Latest Assembly
256,341 bases
Minus strand

Previous Assembly
(GRCh37/hg19 by Entrez Gene)
256,341 bases
Minus strand

(GRCh37/hg19 by Ensembl)
256,341 bases
Minus strand

Genomic View for FAM107B Gene

Genes around FAM107B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM107B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM107B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM107B Gene

Proteins for FAM107B Gene

  • Protein details for FAM107B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein FAM107B
    Protein Accession:
    Secondary Accessions:
    • A8K1P4
    • D3DRT2
    • Q5T9K7
    • Q5T9K8
    • Q6ZSI4

    Protein attributes for FAM107B Gene

    131 amino acids
    Molecular mass:
    15558 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FAM107B Gene


neXtProt entry for FAM107B Gene

Post-translational modifications for FAM107B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FAM107B Gene

Domains & Families for FAM107B Gene

Gene Families for FAM107B Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FAM107B Gene


Suggested Antigen Peptide Sequences for FAM107B Gene

GenScript: Design optimal peptide antigens:
  • Protein FAM107B (F107B_HUMAN)
  • Family with sequence similarity 107, member B (Q5T9K6_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the FAM107 family.
  • Belongs to the FAM107 family.
genes like me logo Genes that share domains with FAM107B: view

Function for FAM107B Gene

Phenotypes From GWAS Catalog for FAM107B Gene

genes like me logo Genes that share phenotypes with FAM107B: view

Animal Models for FAM107B Gene

MGI Knock Outs for FAM107B:

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FAM107B

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FAM107B Gene

Localization for FAM107B Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM107B gene
Compartment Confidence
nucleus 4
mitochondrion 3
extracellular 2
cytoskeleton 2
plasma membrane 1
endoplasmic reticulum 1
endosome 1
cytosol 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (3)
  • Golgi apparatus (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FAM107B Gene

Pathways & Interactions for FAM107B Gene

PathCards logo

SuperPathways for FAM107B Gene

No Data Available

Interacting Proteins for FAM107B Gene

STRING Interaction Network Preview (showing top 1 STRING interactants - click image to see details)
STRING Interaction Network
Selected Interacting proteins: ENSP00000181796 Q9H098-F107B_HUMAN for FAM107B Gene via STRING IID

Gene Ontology (GO) - Biological Process for FAM107B Gene


No data available for Pathways by source and SIGNOR curated interactions for FAM107B Gene

Drugs & Compounds for FAM107B Gene

No Compound Related Data Available

Transcripts for FAM107B Gene

mRNA/cDNA for FAM107B Gene

29 NCBI additional mRNA sequence :
29 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FAM107B

Alternative Splicing Database (ASD) splice patterns (SP) for FAM107B Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c
SP1: - -
SP2: - - - - -
SP3: - - -
SP5: - -

Relevant External Links for FAM107B Gene

GeneLoc Exon Structure for

Expression for FAM107B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FAM107B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FAM107B Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x4.3).

Protein differential expression in normal tissues from HIPED for FAM107B Gene

This gene is overexpressed in Peripheral blood mononuclear cells (18.1), NK cells (8.5), and Skin (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FAM107B Gene

Protein tissue co-expression partners for FAM107B Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FAM107B

SOURCE GeneReport for Unigene cluster for FAM107B Gene:


Evidence on tissue expression from TISSUES for FAM107B Gene

  • Nervous system(4.7)
  • Kidney(3)
  • Liver(2.9)
  • Skin(2.8)
  • Lymph node(2.6)
  • Intestine(2.5)
  • Spleen(2.4)
  • Bone marrow(2.4)
  • Blood(2.4)
  • Lung(2.4)
  • Heart(2.3)
  • Stomach(2.3)
  • Muscle(2.1)
genes like me logo Genes that share expression patterns with FAM107B: view

Primer products for research

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM107B Gene

Orthologs for FAM107B Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM107B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC737061 30
  • 99.35 (n)
FAM107B 31
  • 99 (a)
(Bos Taurus)
Mammalia FAM107B 30 31
  • 93.13 (n)
(Mus musculus)
Mammalia Fam107b 30 17 31
  • 90.59 (n)
(Rattus norvegicus)
Mammalia Fam107b 30
  • 89.06 (n)
(Canis familiaris)
Mammalia FAM107B 30 31
  • 84.64 (n)
(Ornithorhynchus anatinus)
Mammalia FAM107B 31
  • 77 (a)
(Monodelphis domestica)
Mammalia FAM107B 31
  • 69 (a)
(Gallus gallus)
Aves FAM107B 31
  • 80 (a)
(Anolis carolinensis)
Reptilia FAM107B 31
  • 89 (a)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia fam107b 30
  • 73.54 (n)
(Danio rerio)
Actinopterygii fam107b 30 31
  • 73.33 (n)
zgc56216 30
Species where no ortholog for FAM107B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for FAM107B Gene

Gene Tree for FAM107B (if available)
Gene Tree for FAM107B (if available)
Evolutionary constrained regions (ECRs) for FAM107B: view image

Paralogs for FAM107B Gene

Paralogs for FAM107B Gene

(2) SIMAP similar genes for FAM107B Gene using alignment to 10 proteins:

  • F107B_HUMAN
  • C9J3Q3_HUMAN
  • C9J6N5_HUMAN
  • C9J6Y8_HUMAN
  • C9JP05_HUMAN
  • C9JQ40_HUMAN
  • C9JW51_HUMAN
genes like me logo Genes that share paralogs with FAM107B: view

Variants for FAM107B Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for FAM107B Gene

SNP ID Clinical significance and condition Chr 10 pos Variation AA Info Type
rs141291914 Benign: not provided 14,774,316(-) C/T
NM_031453.3(FAM107B):c.348G>A (p.Ala116=)
rs149371316 Benign: not provided 14,667,659(-) G/A
NM_031453.3(FAM107B):c.444C>T (p.Leu148=)
rs34265970 Benign: not provided 14,521,300(-) G/C
NM_031453.3(FAM107B):c.811C>G (p.Leu271Val)

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for FAM107B Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for FAM107B Gene

Variant ID Type Subtype PubMed ID
esv1027578 CNV deletion 17803354
esv1195185 CNV insertion 17803354
esv1292577 CNV insertion 17803354
esv1960476 CNV deletion 18987734
esv2658515 CNV deletion 23128226
esv2676128 CNV deletion 23128226
esv2733439 CNV deletion 23290073
esv2733450 CNV deletion 23290073
esv2733461 CNV deletion 23290073
esv2733473 CNV deletion 23290073
esv2750884 CNV gain 17911159
esv34151 CNV loss 18971310
esv3533 CNV loss 18987735
esv3622427 CNV loss 21293372
esv3622428 CNV loss 21293372
esv3622429 CNV loss 21293372
nsv1043133 CNV loss 25217958
nsv1068284 CNV deletion 25765185
nsv1068285 CNV deletion 25765185
nsv1113254 CNV deletion 24896259
nsv1113255 CNV deletion 24896259
nsv1118160 CNV deletion 24896259
nsv1124398 CNV deletion 24896259
nsv1129490 CNV tandem duplication 24896259
nsv1135769 CNV deletion 24896259
nsv437659 CNV loss 16327808
nsv471664 CNV gain+loss 15918152
nsv517896 CNV gain 19592680
nsv528028 CNV gain 19592680
nsv549997 CNV gain 21841781
nsv549998 CNV gain 21841781
nsv5877 CNV insertion 18451855
nsv5888 CNV deletion 18451855
nsv831791 CNV gain 17160897
nsv947744 CNV duplication 23825009
nsv958571 CNV deletion 24416366

Variation tolerance for FAM107B Gene

Residual Variation Intolerance Score: 25.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.21; 62.02% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FAM107B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM107B Gene

Disorders for FAM107B Gene

MalaCards: The human disease database

(5) MalaCards diseases for FAM107B Gene - From: COP

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for FAM107B

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with FAM107B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FAM107B Gene

Publications for FAM107B Gene

  1. Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S … Poustka A (Genome research 2001) 2 3 4
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 41
  4. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A … Goate A (American journal of human genetics 2006) 3 41
  5. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P … Rogers J (Nature 2004) 3 4

Products for FAM107B Gene

Sources for FAM107B Gene