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Aliases for FAM107A Gene

Aliases for FAM107A Gene

  • Family With Sequence Similarity 107 Member A 2 3 5
  • Down-Regulated In Renal Cell Carcinoma 1 3 4
  • DRR1 3 4
  • TU3A 3 4
  • Family With Sequence Similarity 107, Member A 2
  • Down-Regulated In Renal Cell Carcinoma 2
  • Protein FAM107A 3
  • Protein TU3A 4

External Ids for FAM107A Gene

Previous GeneCards Identifiers for FAM107A Gene

  • GC03M058526

Summaries for FAM107A Gene

GeneCards Summary for FAM107A Gene

FAM107A (Family With Sequence Similarity 107 Member A) is a Protein Coding gene. An important paralog of this gene is FAM107B.

UniProtKB/Swiss-Prot for FAM107A Gene

  • When transfected into cell lines in which it is not expressed, suppresses cell growth. May play a role in tumor development.

Gene Wiki entry for FAM107A Gene

Additional gene information for FAM107A Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM107A Gene

Genomics for FAM107A Gene

GeneHancer (GH) Regulatory Elements for FAM107A Gene

Promoters and enhancers for FAM107A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J058575 Promoter/Enhancer 1.2 EPDnew Ensembl ENCODE 674.6 +50.7 50749 2.4 SP1 CTCF STAT1 GLIS1 ZNF143 ZIC2 NR2F2 FAM107A FAM3D-AS1 ENSG00000243384
GH03J058627 Enhancer 1.1 Ensembl ENCODE dbSUPER 661.5 -1.0 -1048 3.5 CTCF PKNOX1 FOXA2 JUN MAX RAD21 ZNF7 EGR1 POLR2A ZBTB48 FAM107A PXK GC03M058625 FAM3D-AS1
GH03J058587 Promoter 0.6 EPDnew 650.3 +40.6 40576 0.1 SIN3A FAM107A ENSG00000243384 FAM3D-AS1
GH03J058626 Enhancer 0.3 FANTOM5 657.8 +1.3 1309 0.1 FAM107A ENSG00000243384 ACOX2 PXK FAM3D-AS1 GC03M058625
GH03J058332 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 10.3 +293.2 293151 4.6 FOXA2 ARNT ARID4B SIN3A FEZF1 ZNF2 YY1 ZNF766 CBX5 ZNF416 PXK DENND6A FLNB-AS1 FLNB KCTD6 RPP14 PDE12 LOC105377110 HTD2 FAM107A
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around FAM107A on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FAM107A gene promoter:

Genomic Locations for FAM107A Gene

Genomic Locations for FAM107A Gene
chr3:58,564,112-58,627,610
(GRCh38/hg38)
Size:
63,499 bases
Orientation:
Minus strand
chr3:58,549,844-58,613,337
(GRCh37/hg19)

Genomic View for FAM107A Gene

Genes around FAM107A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM107A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM107A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM107A Gene

Proteins for FAM107A Gene

  • Protein details for FAM107A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95990-F107A_HUMAN
    Recommended name:
    Protein FAM107A
    Protein Accession:
    O95990
    Secondary Accessions:
    • B3KNQ4
    • B7ZAY5
    • J3KR61
    • Q96NH4

    Protein attributes for FAM107A Gene

    Size:
    144 amino acids
    Molecular mass:
    17455 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FAM107A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FAM107A Gene

Post-translational modifications for FAM107A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FAM107A Gene

Domains & Families for FAM107A Gene

Gene Families for FAM107A Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FAM107A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM107A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O95990

UniProtKB/Swiss-Prot:

F107A_HUMAN :
  • Belongs to the FAM107 family.
Family:
  • Belongs to the FAM107 family.
genes like me logo Genes that share domains with FAM107A: view

Function for FAM107A Gene

Molecular function for FAM107A Gene

UniProtKB/Swiss-Prot Function:
When transfected into cell lines in which it is not expressed, suppresses cell growth. May play a role in tumor development.

Phenotypes From GWAS Catalog for FAM107A Gene

Gene Ontology (GO) - Molecular Function for FAM107A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with FAM107A: view
genes like me logo Genes that share phenotypes with FAM107A: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM107A Gene

Localization for FAM107A Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM107A Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM107A gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear speckles (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for FAM107A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 10564580
GO:0016607 nuclear speck IDA --
GO:0043005 neuron projection IEA --
genes like me logo Genes that share ontologies with FAM107A: view

Pathways & Interactions for FAM107A Gene

SuperPathways for FAM107A Gene

No Data Available

Gene Ontology (GO) - Biological Process for FAM107A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001558 regulation of cell growth IDA 10564580
GO:0040008 regulation of growth IEA --
genes like me logo Genes that share ontologies with FAM107A: view

No data available for Pathways by source and SIGNOR curated interactions for FAM107A Gene

Drugs & Compounds for FAM107A Gene

No Compound Related Data Available

Transcripts for FAM107A Gene

mRNA/cDNA for FAM107A Gene

Unigene Clusters for FAM107A Gene

Family with sequence similarity 107, member A:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM107A Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d ^ 8 ^ 9a · 9b · 9c · 9d · 9e ^ 10a · 10b · 10c · 10d ^ 11a · 11b · 11c ^ 12a ·
SP1: - -
SP2: - - - - - - - - -
SP3: -
SP4: - - -
SP5: - - - - - - - - - -
SP6: - - - - - - -
SP7: - -
SP8: - - -
SP9: - - - - - -
SP10: - - - - - -
SP11: -
SP12: - - - - - - - - - - - - -
SP13:
SP14: - - - - - - - - -

ExUns: 12b · 12c ^ 13
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12: - -
SP13:
SP14:

Relevant External Links for FAM107A Gene

GeneLoc Exon Structure for
FAM107A
ECgene alternative splicing isoforms for
FAM107A

Expression for FAM107A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM107A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FAM107A Gene

This gene is overexpressed in Brain - Amygdala (x5.8), Brain - Hippocampus (x4.7), and Brain - Spinal cord (cervical c-1) (x4.6).

Protein differential expression in normal tissues from HIPED for FAM107A Gene

This gene is overexpressed in Brain (50.3), Prostate (12.3), and Adipocyte (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FAM107A Gene



Protein tissue co-expression partners for FAM107A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FAM107A Gene:

FAM107A

SOURCE GeneReport for Unigene cluster for FAM107A Gene:

Hs.506357

mRNA Expression by UniProt/SwissProt for FAM107A Gene:

O95990-F107A_HUMAN
Tissue specificity: Widely expressed in normal tissues. Expression is reduced or absent in a number of cancer cell lines.

Evidence on tissue expression from TISSUES for FAM107A Gene

  • Nervous system(5)
  • Eye(2.9)
genes like me logo Genes that share expression patterns with FAM107A: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM107A Gene

Orthologs for FAM107A Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM107A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM107A 34 33
  • 99.31 (n)
OneToOne
cow
(Bos Taurus)
Mammalia MGC143103 34
  • 96 (a)
OneToOne
FAM107A 33
  • 92.36 (n)
dog
(Canis familiaris)
Mammalia FAM107A 34 33
  • 90.48 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fam107a 33
  • 87.04 (n)
mouse
(Mus musculus)
Mammalia Fam107a 16 34 33
  • 86.34 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia FAM107A 34
  • 56 (a)
OneToOne
chicken
(Gallus gallus)
Aves FAM107A 34 33
  • 68.41 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FAM107A 34
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fam107a 33
  • 72.77 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.9700 33
zebrafish
(Danio rerio)
Actinopterygii LOC794256 33
  • 58.59 (n)
FAM107A 34
  • 42 (a)
OneToOne
Species where no ortholog for FAM107A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FAM107A Gene

ENSEMBL:
Gene Tree for FAM107A (if available)
TreeFam:
Gene Tree for FAM107A (if available)
Aminode:
Evolutionary constrained regions (ECRs) for FAM107A: view image

Paralogs for FAM107A Gene

Paralogs for FAM107A Gene

(2) SIMAP similar genes for FAM107A Gene using alignment to 4 proteins:

  • F107A_HUMAN
  • B7ZAY5_HUMAN
  • C9JAU5_HUMAN
  • J3KR61_HUMAN
genes like me logo Genes that share paralogs with FAM107A: view

Variants for FAM107A Gene

Sequence variations from dbSNP and Humsavar for FAM107A Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
VAR_017238 Ovarian cancer p.Leu15Met
VAR_017238 Renal cell carcinoma cell lines p.Leu15Met
VAR_017239 Renal cell carcinoma cell line p.Pro19Leu
rs1000051946 -- 58,589,999(-) G/A genic_upstream_transcript_variant, intron_variant
rs1000103643 -- 58,576,815(-) G/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for FAM107A Gene

Variant ID Type Subtype PubMed ID
dgv4749n100 CNV gain 25217958
esv3561938 CNV deletion 23714750
esv3596253 CNV gain 21293372
esv3893702 CNV loss 25118596
nsv1109518 CNV deletion 24896259
nsv1116992 CNV deletion 24896259
nsv3839 CNV deletion 18451855
nsv470605 CNV gain 18288195
nsv524472 CNV gain 19592680

Variation tolerance for FAM107A Gene

Residual Variation Intolerance Score: 53.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.57; 82.51% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FAM107A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM107A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM107A Gene

Disorders for FAM107A Gene

Additional Disease Information for FAM107A

No disorders were found for FAM107A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM107A Gene

Publications for FAM107A Gene

  1. Loss of expression of the DRR 1 gene at chromosomal segment 3p21.1 in renal cell carcinoma. (PMID: 10564580) Wang L … Smith DI (Genes, chromosomes & cancer 2000) 2 3 4 58
  2. Isolation and characterization of the novel gene, TU3A, in a commonly deleted region on 3p14.3-->p14.2 in renal cell carcinoma. (PMID: 10702698) Yamato T … Horii A (Cytogenetics and cell genetics 1999) 2 3 4 58
  3. Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci. (PMID: 20453842) Stahl EA … Plenge RM (Nature genetics 2010) 3 44 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for FAM107A Gene

Sources for FAM107A Gene

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