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FAM107A (Family With Sequence Similarity 107 Member A) is a Protein Coding gene. Diseases associated with FAM107A include Neuroblastoma and Brain Cancer. An important paralog of this gene is FAM107B.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003674 | molecular_function | ND | -- |
GO:0003779 | actin binding | IEA | -- |
GO:0005515 | protein binding | IPI | 20543869 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001725 | stress fiber | IDA | 20543869 |
GO:0005634 | nucleus | IEA,IDA | 10564580 |
GO:0005737 | cytoplasm | IEA,IDA | 28604741 |
GO:0005856 | cytoskeleton | IEA | -- |
GO:0005886 | plasma membrane | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001558 | regulation of cell growth | IDA | 10564580 |
GO:0007049 | cell cycle | IEA | -- |
GO:0030041 | actin filament polymerization | ISS | -- |
GO:0030335 | positive regulation of cell migration | IMP | 20543869 |
GO:0031398 | positive regulation of protein ubiquitination | IMP | 28604741 |
ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | · | 7c | · | 7d | ^ | 8 | ^ | 9a | · | 9b | · | 9c | · | 9d | · | 9e | ^ | 10a | · | 10b | · | 10c | · | 10d | ^ | 11a | · | 11b | · | 11c | ^ | 12a | · |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
SP2: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
SP3: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP4: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
SP5: | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
SP6: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
SP7: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
SP8: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
SP9: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
SP10: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
SP11: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP12: | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
SP13: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP14: | - | - | - | - | - | - | - | - | - |
ExUns: | 12b | · | 12c | ^ | 13 |
---|---|---|---|---|---|
SP1: | |||||
SP2: | |||||
SP3: | |||||
SP4: | |||||
SP5: | |||||
SP6: | |||||
SP7: | |||||
SP8: | |||||
SP9: | |||||
SP10: | |||||
SP11: | |||||
SP12: | - | - | |||
SP13: | |||||
SP14: |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | FAM107A 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | MGC143103 31 |
|
OneToOne | |
FAM107A 30 |
|
||||
Dog (Canis familiaris) |
Mammalia | FAM107A 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Fam107a 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Fam107a 30 17 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | FAM107A 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | FAM107A 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | FAM107A 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | fam107a 30 |
|
||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.9700 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | LOC794256 30 |
|
||
FAM107A 31 |
|
OneToOne |
SNP ID | Clinical significance and condition | Chr 03 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
751950 | Benign: not provided | 58,569,801(-) | T/C | SYNONYMOUS_VARIANT | |
VAR_017238 | Ovarian cancer | p.Leu15Met | |||
VAR_017238 | Renal cell carcinoma cell lines | p.Leu15Met | |||
VAR_017239 | Renal cell carcinoma cell line | p.Pro19Leu | |||
rs1043942 | - | p.Ala89Ser |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv4749n100 | CNV | gain | 25217958 |
esv3561938 | CNV | deletion | 23714750 |
esv3596253 | CNV | gain | 21293372 |
esv3893702 | CNV | loss | 25118596 |
nsv1109518 | CNV | deletion | 24896259 |
nsv1116992 | CNV | deletion | 24896259 |
nsv3839 | CNV | deletion | 18451855 |
nsv470605 | CNV | gain | 18288195 |
nsv524472 | CNV | gain | 19592680 |
Disorder | Aliases | PubMed IDs |
---|---|---|
neuroblastoma |
|
|
brain cancer |
|
|