Aliases for FAM104A Gene

Aliases for FAM104A Gene

  • Family With Sequence Similarity 104 Member A 2 3 5
  • Protein FAM104A 3 4
  • Family With Sequence Similarity 104, Member A 2
  • FLJ14775 2
  • FAM104A 5

External Ids for FAM104A Gene

Previous GeneCards Identifiers for FAM104A Gene

  • GC17M068716
  • GC17M071203
  • GC17M066612

Summaries for FAM104A Gene

GeneCards Summary for FAM104A Gene

FAM104A (Family With Sequence Similarity 104 Member A) is a Protein Coding gene.

Additional gene information for FAM104A Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FAM104A Gene

Genomics for FAM104A Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for FAM104A Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FAM104A on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FAM104A

Top Transcription factor binding sites by QIAGEN in the FAM104A gene promoter:
  • aMEF-2
  • AML1a
  • C/EBPalpha
  • MEF-2
  • MEF-2A
  • MyoD
  • Nkx2-5
  • STAT1
  • STAT1alpha

Genomic Locations for FAM104A Gene

Genomic Locations for FAM104A Gene
chr17:73,207,353-73,236,753
(GRCh38/hg38)
Size:
29,401 bases
Orientation:
Minus strand
chr17:71,203,492-71,232,892
(GRCh37/hg19)
Size:
29,401 bases
Orientation:
Minus strand

Genomic View for FAM104A Gene

Genes around FAM104A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM104A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM104A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM104A Gene

Proteins for FAM104A Gene

  • Protein details for FAM104A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q969W3-F104A_HUMAN
    Recommended name:
    Protein FAM104A
    Protein Accession:
    Q969W3
    Secondary Accessions:
    • B4E339

    Protein attributes for FAM104A Gene

    Size:
    186 amino acids
    Molecular mass:
    19484 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH11054.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=AAH25238.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=BAB55292.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=BAC11183.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};

    Alternative splice isoforms for FAM104A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FAM104A Gene

Post-translational modifications for FAM104A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FAM104A Gene

Domains & Families for FAM104A Gene

Gene Families for FAM104A Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FAM104A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM104A Gene

GenScript: Design optimal peptide antigens:
  • Protein FAM104A (F104A_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q969W3

UniProtKB/Swiss-Prot:

F104A_HUMAN :
  • Belongs to the FAM104 family.
Family:
  • Belongs to the FAM104 family.
genes like me logo Genes that share domains with FAM104A: view

Function for FAM104A Gene

Phenotypes From GWAS Catalog for FAM104A Gene

Gene Ontology (GO) - Molecular Function for FAM104A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with FAM104A: view
genes like me logo Genes that share phenotypes with FAM104A: view

Animal Models for FAM104A Gene

MGI Knock Outs for FAM104A:
  • Fam104a Fam104a<tm2a(EUCOMM)Wtsi>

Animal Model Products

CRISPR Products

miRNA for FAM104A Gene

miRTarBase miRNAs that target FAM104A

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FAM104A

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FAM104A Gene

Localization for FAM104A Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM104A gene
Compartment Confidence
nucleus 3
cytosol 3
extracellular 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FAM104A Gene

Pathways & Interactions for FAM104A Gene

PathCards logo

SuperPathways for FAM104A Gene

No Data Available

Gene Ontology (GO) - Biological Process for FAM104A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FAM104A Gene

Drugs & Compounds for FAM104A Gene

No Compound Related Data Available

Transcripts for FAM104A Gene

mRNA/cDNA for FAM104A Gene

5 REFSEQ mRNAs :
13 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FAM104A

Alternative Splicing Database (ASD) splice patterns (SP) for FAM104A Gene

No ASD Table

Relevant External Links for FAM104A Gene

GeneLoc Exon Structure for
FAM104A

Expression for FAM104A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FAM104A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

  • Testis (Reproductive System)

mRNA differential expression in normal tissues according to GTEx for FAM104A Gene

This gene is overexpressed in Testis (x13.0).

Protein differential expression in normal tissues from HIPED for FAM104A Gene

This gene is overexpressed in CD8 Tcells (38.2), Rectum (14.2), CD4 Tcells (9.7), and Blymphocyte (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FAM104A Gene



Protein tissue co-expression partners for FAM104A Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FAM104A

SOURCE GeneReport for Unigene cluster for FAM104A Gene:

Hs.741276

Evidence on tissue expression from TISSUES for FAM104A Gene

  • Nervous system(3.9)
genes like me logo Genes that share expression patterns with FAM104A: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM104A Gene

Orthologs for FAM104A Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM104A Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia FAM104A 31
  • 100 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia FAM104A 30
  • 85.45 (n)
MGC128049 31
  • 85 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia FAM104A 30 31
  • 83.05 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Fam104a 30
  • 82.51 (n)
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 82 (a)
OneToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 80 (a)
OneToMany
Mouse
(Mus musculus)
Mammalia Fam104a 30 17 31
  • 76.99 (n)
OneToOne
Chicken
(Gallus gallus)
Aves FAM104A 30 31
  • 72.06 (n)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 66 (a)
OneToMany
Species where no ortholog for FAM104A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for FAM104A Gene

ENSEMBL:
Gene Tree for FAM104A (if available)
TreeFam:
Gene Tree for FAM104A (if available)
Aminode:
Evolutionary constrained regions (ECRs) for FAM104A: view image

Paralogs for FAM104A Gene

(1) SIMAP similar genes for FAM104A Gene using alignment to 5 proteins:

  • F104A_HUMAN
  • J3KSI9_HUMAN
  • J3KT35_HUMAN
  • J3KT52_HUMAN
  • J3KT76_HUMAN
genes like me logo Genes that share paralogs with FAM104A: view

No data available for Paralogs for FAM104A Gene

Variants for FAM104A Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for FAM104A Gene

SNP ID Clinical significance and condition Chr 17 pos Variation AA Info Type
644686 Uncertain Significance: COG1 congenital disorder of glycosylation 73,208,437(-) A/G MISSENSE_VARIANT,THREE_PRIME_UTR_VARIANT
724657 Likely Benign: not provided 73,208,310(-) G/T THREE_PRIME_UTR_VARIANT,INTRON_VARIANT
732020 Likely Benign: not provided 73,208,352(-) A/G SYNONYMOUS_VARIANT,THREE_PRIME_UTR_VARIANT
777070 Likely Benign: not provided 73,208,334(-) C/T SYNONYMOUS_VARIANT,THREE_PRIME_UTR_VARIANT
860420 Uncertain Significance: COG1 congenital disorder of glycosylation 73,208,356(-) C/T MISSENSE_VARIANT,THREE_PRIME_UTR_VARIANT

Additional dbSNP identifiers (rs#s) for FAM104A Gene

Structural Variations from Database of Genomic Variants (DGV) for FAM104A Gene

Variant ID Type Subtype PubMed ID
esv2186746 CNV deletion 18987734
esv2562139 CNV deletion 19546169
esv2667654 CNV deletion 23128226
esv3641214 CNV loss 21293372
nsv833534 CNV loss 17160897

Variation tolerance for FAM104A Gene

Residual Variation Intolerance Score: 67.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.29; 25.65% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FAM104A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM104A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM104A Gene

Disorders for FAM104A Gene

No disorders were found for FAM104A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM104A Gene

Publications for FAM104A Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  3. Mapping and characterization of novel (CAG)n repeat cDNAs from adult human brain derived by the oligo capture method. (PMID: 9417904) Reddy PH … Tagle DA (Genomics 1997) 3 4
  4. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  5. AP-SWATH Reveals Direct Involvement of VCP/p97 in Integrated Stress Response Signaling Through Facilitating CReP/PPP1R15B Degradation. (PMID: 29599191) Hülsmann J … Meyer H (Molecular & cellular proteomics : MCP 2018) 3

Products for FAM104A Gene

Sources for FAM104A Gene