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Aliases for FAM104A Gene

Aliases for FAM104A Gene

  • Family With Sequence Similarity 104 Member A 2 3 5
  • Family With Sequence Similarity 104, Member A 2

External Ids for FAM104A Gene

Previous GeneCards Identifiers for FAM104A Gene

  • GC17M068716
  • GC17M071203
  • GC17M066612

Summaries for FAM104A Gene

GeneCards Summary for FAM104A Gene

FAM104A (Family With Sequence Similarity 104 Member A) is a Protein Coding gene. An important paralog of this gene is FAM104B.

Additional gene information for FAM104A Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM104A Gene

Genomics for FAM104A Gene

GeneHancer (GH) Regulatory Elements for FAM104A Gene

Promoters and enhancers for FAM104A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17I073230 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 550.8 +4.6 4598 3.1 HDGF FOXA2 MLX ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 POLR2B C17orf80 FAM104A COG1 GC17M073213
GH17I073226 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE 550.4 +8.4 8413 4 PKNOX1 ATF1 ARNT ARID4B SIN3A YY1 TCF12 FOS ATF7 RUNX3 FAM104A COG1 C17orf80 GC17M073213
GH17I073303 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 11.3 -71.4 -71418 9.8 CLOCK MLX DMAP1 YY1 SLC30A9 ZNF213 ZNF416 ZNF143 MCM3 SP3 CDC42EP4 C17orf80 FAM104A SSTR2 GC17M073290 GC17M073289
GH17I073191 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 11 +43.9 43935 2.8 HNRNPUL1 SMAD1 ZFP64 ARID4B SIN3A DMAP1 YY1 POLR2B ZNF207 ZNF143 COG1 C17orf80 SSTR2 FAM104A CDC42EP4 ENSG00000277728 ENSG00000264860
GH17I073287 Enhancer 1.9 VISTA FANTOM5 Ensembl ENCODE dbSUPER 11.2 -55.0 -54997 7.7 HDGF FOXA2 MLX ARID4B SIN3A DMAP1 ZBTB7B YY1 SLC30A9 ZNF143 CDC42EP4 CPSF4L FAM104A C17orf80 GC17M073288 GC17M073290 GC17P073281 GC17M073289
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around FAM104A on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FAM104A gene promoter:

Genomic Locations for FAM104A Gene

Genomic Locations for FAM104A Gene
chr17:73,207,353-73,236,753
(GRCh38/hg38)
Size:
29,401 bases
Orientation:
Minus strand
chr17:71,203,492-71,232,892
(GRCh37/hg19)

Genomic View for FAM104A Gene

Genes around FAM104A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM104A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM104A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM104A Gene

Proteins for FAM104A Gene

  • Protein details for FAM104A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q969W3-F104A_HUMAN
    Recommended name:
    Protein FAM104A
    Protein Accession:
    Q969W3
    Secondary Accessions:
    • B4E339

    Protein attributes for FAM104A Gene

    Size:
    186 amino acids
    Molecular mass:
    19484 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH11054.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH25238.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB55292.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAC11183.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for FAM104A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FAM104A Gene

Post-translational modifications for FAM104A Gene

No Post-translational modifications

No data available for DME Specific Peptides for FAM104A Gene

Domains & Families for FAM104A Gene

Gene Families for FAM104A Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FAM104A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FAM104A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q969W3

UniProtKB/Swiss-Prot:

F104A_HUMAN :
  • Belongs to the FAM104 family.
Family:
  • Belongs to the FAM104 family.
genes like me logo Genes that share domains with FAM104A: view

Function for FAM104A Gene

Gene Ontology (GO) - Molecular Function for FAM104A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with FAM104A: view
genes like me logo Genes that share phenotypes with FAM104A: view

Animal Models for FAM104A Gene

MGI Knock Outs for FAM104A:

Animal Model Products

miRNA for FAM104A Gene

miRTarBase miRNAs that target FAM104A

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FAM104A Gene

Localization for FAM104A Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM104A gene
Compartment Confidence
nucleus 4
cytosol 3
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FAM104A Gene

Pathways & Interactions for FAM104A Gene

SuperPathways for FAM104A Gene

No Data Available

Gene Ontology (GO) - Biological Process for FAM104A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FAM104A Gene

Drugs & Compounds for FAM104A Gene

No Compound Related Data Available

Transcripts for FAM104A Gene

Unigene Clusters for FAM104A Gene

Family with sequence similarity 104, member A:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM104A Gene

No ASD Table

Relevant External Links for FAM104A Gene

GeneLoc Exon Structure for
FAM104A
ECgene alternative splicing isoforms for
FAM104A

Expression for FAM104A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM104A Gene

mRNA differential expression in normal tissues according to GTEx for FAM104A Gene

This gene is overexpressed in Testis (x13.0).

Protein differential expression in normal tissues from HIPED for FAM104A Gene

This gene is overexpressed in CD8 Tcells (38.2), Rectum (14.2), CD4 Tcells (9.7), and Blymphocyte (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FAM104A Gene



Protein tissue co-expression partners for FAM104A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FAM104A Gene:

FAM104A

SOURCE GeneReport for Unigene cluster for FAM104A Gene:

Hs.741276

Evidence on tissue expression from TISSUES for FAM104A Gene

  • Nervous system(3.9)
genes like me logo Genes that share expression patterns with FAM104A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM104A Gene

Orthologs for FAM104A Gene

This gene was present in the common ancestor of chordates.

Orthologs for FAM104A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM104A 34
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FAM104A 33
  • 85.45 (n)
MGC128049 34
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FAM104A 33 34
  • 83.05 (n)
rat
(Rattus norvegicus)
Mammalia Fam104a 33
  • 82.51 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 82 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 80 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Fam104a 33 16 34
  • 76.99 (n)
chicken
(Gallus gallus)
Aves FAM104A 33 34
  • 72.06 (n)
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 66 (a)
OneToMany
Species where no ortholog for FAM104A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FAM104A Gene

ENSEMBL:
Gene Tree for FAM104A (if available)
TreeFam:
Gene Tree for FAM104A (if available)

Paralogs for FAM104A Gene

Paralogs for FAM104A Gene

(1) SIMAP similar genes for FAM104A Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with FAM104A: view

Variants for FAM104A Gene

Sequence variations from dbSNP and Humsavar for FAM104A Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs141573449 uncertain-significance, Congenital disorder of glycosylation 73,208,301(-) C/T 3_prime_UTR_variant
rs147588256 uncertain-significance, Congenital disorder of glycosylation 73,208,408(-) C/G/T 3_prime_UTR_variant
rs201733537 uncertain-significance, Congenital disorder of glycosylation 73,207,203(-) A/G downstream_transcript_variant
rs774479733 uncertain-significance, COG1 congenital disorder of glycosylation 73,207,242(-) G/A downstream_transcript_variant
rs139440017 uncertain-significance, not provided 73,208,344(-) G/A/C 3_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for FAM104A Gene

Variant ID Type Subtype PubMed ID
nsv833534 CNV loss 17160897
esv3641214 CNV loss 21293372
esv2667654 CNV deletion 23128226
esv2562139 CNV deletion 19546169
esv2186746 CNV deletion 18987734

Variation tolerance for FAM104A Gene

Residual Variation Intolerance Score: 67.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.29; 25.65% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FAM104A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAM104A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM104A Gene

Disorders for FAM104A Gene

Additional Disease Information for FAM104A

No disorders were found for FAM104A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM104A Gene

Publications for FAM104A Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Mapping and characterization of novel (CAG)n repeat cDNAs from adult human brain derived by the oligo capture method. (PMID: 9417904) Reddy PH … Tagle DA (Genomics 1997) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58

Products for FAM104A Gene

Sources for FAM104A Gene

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