Aliases for FAM102B Gene

Aliases for FAM102B Gene

  • Family With Sequence Similarity 102 Member B 2 3 5
  • Protein FAM102B 3 4
  • SYM-3B 2 3
  • Family With Sequence Similarity 102, Member B 2
  • Sym-3 Homolog B (C. Elegans) 2
  • Sym-3 Homolog B 3
  • DKFZp779B126 2
  • FAM102B 5

External Ids for FAM102B Gene

Previous GeneCards Identifiers for FAM102B Gene

  • GC01P108703
  • GC01P108904
  • GC01P109102
  • GC01P106996

Summaries for FAM102B Gene

GeneCards Summary for FAM102B Gene

FAM102B (Family With Sequence Similarity 102 Member B) is a Protein Coding gene. An important paralog of this gene is FAM102A.

Additional gene information for FAM102B Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FAM102B Gene

Genomics for FAM102B Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for FAM102B Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J108556 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 263.2 -0.9 -883 6.4 TBP SP1 NR2C1 DEK IKZF1 SMAD5 IRF2 HES1 MBD2 ZNF217 FAM102B lnc-HENMT1-4 PRPF38B SLC25A24 HSALNG0005815 NBPF6
GH01J109482 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas 10.9 +923.9 923935 2.4 ZSCAN16 TBP ZBTB10 SP1 FEZF1 SIX5 NR2C1 MNT SMAD5 IRF2 ATXN7L2 HSALNG0005891 ENSG00000258634 PRPF38B STRIP1 RPL17P7 SYPL2 ENSG00000273373 RBM15 ENSG00000228665
GH01J108583 Enhancer 1.1 FANTOM5 ENCODE dbSUPER 21.8 +24.9 24946 3.8 DEK BRCA1 ZIC2 CEBPB CUX1 FOXA2 EP300 RFX5 STAT3 JUND FAM102B PRPF38B HENMT1 STXBP3 piR-55361-031 HSALNG0005818
GH01J108071 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 10.1 -482.8 -482788 13.4 TBP IKZF1 ETS1 ZNF395 HCFC1 VEZF1 TRIM22 ELF1 ZEB2 TAL1 LINC02785 VAV3 VAV3-AS1 FAM102B SLC25A24 PRPF38B MN296833 HSALNG0005795
GH01J108512 Enhancer 0.9 Ensembl ENCODE 12.4 -46.9 -46923 1.5 MNT BRCA1 CTCF CEBPB REST MAX NBN TRIM22 EP300 PRDM1 FAM102B CLCC1 SLC25A24 ENSG00000226483 piR-49423-010 NBPF6
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FAM102B on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FAM102B

Top Transcription factor binding sites by QIAGEN in the FAM102B gene promoter:
  • aMEF-2
  • ATF
  • HOXA9
  • HOXA9B
  • LCR-F1
  • MEF-2
  • MEF-2A
  • Meis-1
  • Meis-1b
  • Nkx6-1

Genomic Locations for FAM102B Gene

Latest Assembly
84,812 bases
Plus strand

Previous Assembly
(GRCh37/hg19 by Entrez Gene)
79,223 bases
Plus strand

(GRCh37/hg19 by Ensembl)
84,812 bases
Plus strand

Genomic View for FAM102B Gene

Genes around FAM102B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM102B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM102B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM102B Gene

Proteins for FAM102B Gene

  • Protein details for FAM102B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein FAM102B
    Protein Accession:
    Secondary Accessions:
    • A1L1A1
    • B0QZ46
    • B0QZ47
    • Q68DH7

    Protein attributes for FAM102B Gene

    360 amino acids
    Molecular mass:
    39308 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAI27899.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAI40864.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAI40866.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAI50531.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for FAM102B Gene


neXtProt entry for FAM102B Gene

Post-translational modifications for FAM102B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAM102B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FAM102B Gene

Domains & Families for FAM102B Gene

Gene Families for FAM102B Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FAM102B Gene


Suggested Antigen Peptide Sequences for FAM102B Gene

GenScript: Design optimal peptide antigens:
  • Protein FAM102B (F102B_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the FAM102 family.
  • Belongs to the FAM102 family.
genes like me logo Genes that share domains with FAM102B: view

Function for FAM102B Gene

Phenotypes From GWAS Catalog for FAM102B Gene

Phenotypes for FAM102B Gene

genes like me logo Genes that share phenotypes with FAM102B: view

miRNA for FAM102B Gene

miRTarBase miRNAs that target FAM102B

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FAM102B

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM102B Gene

Localization for FAM102B Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM102B gene
Compartment Confidence
nucleus 3
cytosol 2
plasma membrane 1
endosome 1
extracellular 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoli (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FAM102B Gene

Pathways & Interactions for FAM102B Gene

PathCards logo

SuperPathways for FAM102B Gene

No Data Available

Interacting Proteins for FAM102B Gene

Gene Ontology (GO) - Biological Process for FAM102B Gene


No data available for Pathways by source and SIGNOR curated interactions for FAM102B Gene

Drugs & Compounds for FAM102B Gene

No Compound Related Data Available

Transcripts for FAM102B Gene

mRNA/cDNA for FAM102B Gene

12 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FAM102B

Alternative Splicing Database (ASD) splice patterns (SP) for FAM102B Gene

No ASD Table

Relevant External Links for FAM102B Gene

GeneLoc Exon Structure for

Expression for FAM102B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FAM102B Gene

Protein differential expression in normal tissues from HIPED for FAM102B Gene

This gene is overexpressed in Peripheral blood mononuclear cells (42.1), Pancreas (14.0), and Fetal heart (12.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FAM102B Gene

Protein tissue co-expression partners for FAM102B Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FAM102B

SOURCE GeneReport for Unigene cluster for FAM102B Gene:

genes like me logo Genes that share expression patterns with FAM102B: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM102B Gene

Orthologs for FAM102B Gene

This gene was present in the common ancestor of animals.

Orthologs for FAM102B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FAM102B 30 31
  • 99.81 (n)
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 96 (a)
-- 31
  • 80 (a)
(Bos Taurus)
Mammalia FAM102B 30 31
  • 92.95 (n)
(Canis familiaris)
Mammalia FAM102B 30 31
  • 91.93 (n)
(Monodelphis domestica)
Mammalia -- 31
  • 90 (a)
-- 31
  • 88 (a)
(Mus musculus)
Mammalia Fam102b 30 17 31
  • 89.63 (n)
(Rattus norvegicus)
Mammalia Fam102b 30
  • 88.33 (n)
(Gallus gallus)
Aves FAM102B 30
  • 81.08 (n)
-- 31
  • 76 (a)
-- 31
  • 64 (a)
(Anolis carolinensis)
Reptilia FAM102B 31
  • 82 (a)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia fam102b 30
  • 73.63 (n)
(Danio rerio)
Actinopterygii fam102bb 30 31
  • 70.29 (n)
fam102ba 31
  • 69 (a)
Fruit Fly
(Drosophila melanogaster)
Insecta CG8671 31
  • 13 (a)
(Caenorhabditis elegans)
Secernentea sym-3 31
  • 25 (a)
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 33 (a)
-- 31
  • 32 (a)
Species where no ortholog for FAM102B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for FAM102B Gene

Gene Tree for FAM102B (if available)
Gene Tree for FAM102B (if available)
Evolutionary constrained regions (ECRs) for FAM102B: view image

Paralogs for FAM102B Gene

Paralogs for FAM102B Gene

(1) SIMAP similar genes for FAM102B Gene using alignment to 1 proteins:

  • F102B_HUMAN
genes like me logo Genes that share paralogs with FAM102B: view

Variants for FAM102B Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for FAM102B Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for FAM102B Gene

Variant ID Type Subtype PubMed ID
esv1009643 CNV deletion 20482838
nsv1126201 CNV deletion 24896259

Variation tolerance for FAM102B Gene

Residual Variation Intolerance Score: 54.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.60; 12.86% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FAM102B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for FAM102B Gene

Disorders for FAM102B Gene

Additional Disease Information for FAM102B

Genetic Association Database
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform

No disorders were found for FAM102B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM102B Gene

Publications for FAM102B Gene

  1. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4
  3. Quantitative mapping of RNA-mediated nuclear estrogen receptor β interactome in human breast cancer cells. (PMID: 29509190) Giurato G … Tarallo R (Scientific data 2018) 3
  4. Histone-binding of DPF2 mediates its repressive role in myeloid differentiation. (PMID: 28533407) Huber FM … Hoelz A (Proceedings of the National Academy of Sciences of the United States of America 2017) 3
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3

Products for FAM102B Gene

Sources for FAM102B Gene