Aliases for FALEC Gene

Subcategory (RNA class) for FALEC Gene

lncRNA

Number of RNA Genes sources:

3 / 14

Aliases for FALEC Gene

  • Focally Amplified Long Non-Coding RNA In Epithelial Cancer 2 3 5
  • Long Intergenic Non-Protein Coding RNA 568 2 3
  • Focally Amplified LncRNA On Chromosome 1 2 3
  • FALEC 2 168
  • Noncoding RNA-Activating 1 3
  • HSALNG0007045 167
  • NONHSAG002854 92
  • LINC00568 3
  • NcRNA-A1 3
  • FAL1 3

External Ids for FALEC Gene

Previous HGNC Symbols for FALEC Gene

  • LINC00568

Summaries for FALEC Gene

GeneCards Summary for FALEC Gene

FALEC (Focally Amplified Long Non-Coding RNA In Epithelial Cancer) is an RNA Gene, and is affiliated with the lncRNA class. Diseases associated with FALEC include Thyroid Gland Cancer and Prostate Cancer.

Additional gene information for FALEC Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FALEC Gene

Genomics for FALEC Gene

GeneHancer (GH) Regulatory Elements for FALEC Gene

Promoters and enhancers for FALEC Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J150514 Promoter/Enhancer 1.7 Ensembl ENCODE CraniofacialAtlas 500.7 +0.9 861 2.7 ZNF217 CTCF ZSCAN5C TCF12 NRF1 POLR2G SP1 NCOR1 PHF8 ZIC2 FALEC RF00017-332 lnc-MCL1-6 ADAMTSL4 PRPF3 MRPS21 SETDB1 ARNT PIP5K1A GOLPH3L
GH01J150512 Enhancer 0.6 ENCODE 500.7 -1.5 -1463 1.6 FOSL1 ZNF592 POLR2A JUN SMAD4 JUND KLF17 ZBTB7A SMARCA4 KLF1 FALEC RF00017-332 MRPS21 ADAMTSL4 ENSG00000237781 ADAMTSL4-AS1 RPRD2 CA14 GOLPH3L TARS2
GH01J151054 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 11.4 +544.2 544181 10.1 HNRNPK ZBTB40 ZNF217 EP300 CTCF ZSCAN5C NRF1 TCF12 MYC POLR2G MLLT11 RF00017-343 CDC42SE1 GABPB2 BNIPL CTSK ARNT PRPF3 SETDB1 PI4KB
GH01J151456 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas 11.4 +943.5 943503 3.6 ZBTB40 ZNF217 EP300 ZSCAN5C NRF1 TCF12 POLR2G SP1 GTF2E2 PHF8 POGZ SETDB1 PI4KB PIP5K1A ZNF687 UBE2D3P3 SELENBP1 GABPB2 FLG-AS1 ARNT
GH01J150416 Enhancer 0.2 Ensembl 5.4 -98.1 -98052 0.2 ADAMTSL4 RPRD2 ENSG00000237781 ADAMTSL4-AS1 CA14 FALEC RF00017-328 RF00017-329
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FALEC on UCSC Golden Path with GeneCards custom track

Genomic Locations for FALEC Gene

Genomic Locations for FALEC Gene
chr1:150,514,953-150,522,860
(GRCh38/hg38)
Size:
7,908 bases
Orientation:
Plus strand
chr1:150,488,233-150,490,508
(GRCh37/hg19)
Size:
2,276 bases
Orientation:
Plus strand

Genomic View for FALEC Gene

Genes around FALEC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FALEC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FALEC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FALEC Gene

Proteins for FALEC Gene

Post-translational modifications for FALEC Gene

No Post-translational modifications

No data available for DME Specific Peptides for FALEC Gene

Domains & Families for FALEC Gene

Gene Families for FALEC Gene

genes like me logo Genes that share domains with FALEC: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for FALEC Gene

Function for FALEC Gene

Phenotypes From GWAS Catalog for FALEC Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FALEC Gene

Localization for FALEC Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FALEC gene
Compartment Confidence
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for FALEC Gene

Pathways & Interactions for FALEC Gene

PathCards logo

SuperPathways for FALEC Gene

No Data Available
;

Gene Ontology (GO) - Biological Process for FALEC Gene

None

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for FALEC Gene

Drugs & Compounds for FALEC Gene

No Compound Related Data Available

Transcripts for FALEC Gene

mRNA/cDNA for FALEC Gene

5 RNACentral transcripts :
1 REFSEQ mRNAs :
1 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
3 NONCODE transcripts :
5 LncBook transcripts :
4 LNCipedia transcripts :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for FALEC Gene

No ASD Table

Relevant External Links for FALEC Gene

GeneLoc Exon Structure for
FALEC

Expression for FALEC Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FALEC Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FALEC

genes like me logo Genes that share expression patterns with FALEC: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for FALEC Gene

Orthologs for FALEC Gene

Evolution for FALEC Gene

ENSEMBL:
Gene Tree for FALEC (if available)
TreeFam:
Gene Tree for FALEC (if available)

No data available for Orthologs for FALEC Gene

Paralogs for FALEC Gene

No data available for Paralogs for FALEC Gene

Variants for FALEC Gene

Additional dbSNP identifiers (rs#s) for FALEC Gene

Structural Variations from Database of Genomic Variants (DGV) for FALEC Gene

Variant ID Type Subtype PubMed ID
nsv1006838 CNV gain 25217958

Additional Variant Information for FALEC Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FALEC

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for FALEC Gene

Disorders for FALEC Gene

MalaCards: The human disease database

(4) MalaCards diseases for FALEC Gene - From: LncRNADisease and DISEASES

Disorder Aliases PubMed IDs
thyroid gland cancer
  • malignant neoplasm of thyroid gland
prostate cancer
  • prostate cancer, somatic
hepatocellular carcinoma
  • hcc
opitz-kaveggia syndrome
  • oks
- elite association - COSMIC cancer census association via MalaCards
Search FALEC in MalaCards View complete list of genes associated with diseases

Additional Disease Information for FALEC

genes like me logo Genes that share disorders with FALEC: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FALEC Gene

Publications for FALEC Gene

  1. Up-regulation of long noncoding RNA FALEC predicts poor prognosis and promotes melanoma cell proliferation through epigenetically silencing p21. (PMID: 29196104) Ni N … Sun J (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2017) 2 3 54
  2. A functional genomic approach identifies FAL1 as an oncogenic long noncoding RNA that associates with BMI1 and represses p21 expression in cancer. (PMID: 25203321) Hu X … Zhang L (Cancer cell 2014) 2 3 54
  3. Long noncoding RNAs with enhancer-like function in human cells. (PMID: 20887892) Ørom UA … Shiekhattar R (Cell 2010) 2 3 54
  4. LncRNA FAL1 promotes carcinogenesis by regulation of miR-637/NUPR1 pathway in colorectal cancer. (PMID: 30267804) Wang L … Zhang B (The international journal of biochemistry & cell biology 2019) 3 54
  5. The biological function of long noncoding RNA FAL1 in oesophageal carcinoma cells. (PMID: 30873881) Yang Z … Liu C (Artificial cells, nanomedicine, and biotechnology 2019) 3 54

Products for FALEC Gene

Sources for FALEC Gene